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Aliases for RPS6KA5 Gene

Aliases for RPS6KA5 Gene

  • Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 2 3
  • MSK1 3 4 6
  • Nuclear Mitogen- And Stress-Activated Protein Kinase 1 3 4
  • 90 KDa Ribosomal Protein S6 Kinase 5 3 4
  • RSK-Like Protein Kinase 3 4
  • S6K-Alpha-5 3 4
  • EC 2.7.11.1 4 64
  • RSKL 3 4
  • Ribosomal Protein S6 Kinase, 90kD, Polypeptide 5 2
  • Ribosomal Protein S6 Kinase Alpha-5 3
  • EC 2.7.11 64
  • MSPK1 3
  • RLPK 3

External Ids for RPS6KA5 Gene

Summaries for RPS6KA5 Gene

GeneCards Summary for RPS6KA5 Gene

RPS6KA5 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5) is a Protein Coding gene. Diseases associated with RPS6KA5 include coffin-lowry syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MKNK2.

UniProtKB/Swiss-Prot for RPS6KA5 Gene

  • Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at Ser-276 during oxidative stress. In erythropoietin-stimulated cells, is necessary for the Ser-727 phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at Ser-191 and Ser-216, and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of Ser-1 of histone H2A. Phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate Ser-28 of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.

Gene Wiki entry for RPS6KA5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS6KA5 Gene

Genomics for RPS6KA5 Gene

Genomic Location for RPS6KA5 Gene

Start:
90,847,862 bp from pter
End:
91,060,649 bp from pter
Size:
212,788 bases
Orientation:
Minus strand

Genomic View for RPS6KA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS6KA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS6KA5 Gene

Regulatory Elements for RPS6KA5 Gene

Proteins for RPS6KA5 Gene

  • Protein details for RPS6KA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75582-KS6A5_HUMAN
    Recommended name:
    Ribosomal protein S6 kinase alpha-5
    Protein Accession:
    O75582
    Secondary Accessions:
    • B7Z2Y5
    • O95316
    • Q96AF7

    Protein attributes for RPS6KA5 Gene

    Size:
    802 amino acids
    Molecular mass:
    89865 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA. Interacts with CREBBP and EP300.
    Miscellaneous:
    • Enzyme activity requires the presence of both kinase domains.
    SequenceCaution:
    • Sequence=AAC69577.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RPS6KA5 Gene

    Alternative splice isoforms for RPS6KA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS6KA5 Gene

Proteomics data for RPS6KA5 Gene at MOPED

Post-translational modifications for RPS6KA5 Gene

  • Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain. Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha. Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RPS6KA5 Gene

Domains for RPS6KA5 Gene

UniProtKB/Swiss-Prot:

KS6A5_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • O75582
  • Contains 2 protein kinase domains.:
    • O75582
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.:
    • O75582
genes like me logo Genes that share domains with RPS6KA5: view

Function for RPS6KA5 Gene

Molecular function for RPS6KA5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha, and by further autophosphorylation of Ser-212, Ser-376 and Ser-381 by the activated C-terminal kinase domain. The active N-terminal kinase domain finally phosphorylates downstream substrates, as well as Ser-750, Ser-752 and Ser-758 in its own C-terminal region.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at Ser-276 during oxidative stress. In erythropoietin-stimulated cells, is necessary for the Ser-727 phosphorylation of STAT3 and regulation of its transcriptional potential. Phosphorylates ETV1/ER81 at Ser-191 and Ser-216, and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation. Directly represses transcription via phosphorylation of Ser-1 of histone H2A. Phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate Ser-28 of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury.

Enzyme Numbers (IUBMB) for RPS6KA5 Gene

Gene Ontology (GO) - Molecular Function for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004672 protein kinase activity IDA 9873047
GO:0004674 protein serine/threonine kinase activity IMP 12773393
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12628924
genes like me logo Genes that share ontologies with RPS6KA5: view
genes like me logo Genes that share phenotypes with RPS6KA5: view

Animal Models for RPS6KA5 Gene

MGI Knock Outs for RPS6KA5:

No data available for Transcription Factor Targeting and HOMER Transcription for RPS6KA5 Gene

Localization for RPS6KA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS6KA5 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS6KA5 Gene COMPARTMENTS Subcellular localization image for RPS6KA5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 12628924
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18511904
GO:0005840 ribosome --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RPS6KA5: view

Pathways for RPS6KA5 Gene

genes like me logo Genes that share pathways with RPS6KA5: view

Gene Ontology (GO) - Biological Process for RPS6KA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production TAS 18508628
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RPS6KA5: view

Compounds for RPS6KA5 Gene

(4) HMDB Compounds for RPS6KA5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Cyclic AMP
  • Cyclic AMP
60-92-4
Magnesium
  • Magnesium
7439-95-4

(11) Novoseek inferred chemical compound relationships for RPS6KA5 Gene

Compound -log(P) Hits PubMed IDs
pd 169316 67.5 1
anisomycin 65.5 3
sb 203580 64.2 4
pd 98,059 59 5
cyclic amp 30.4 2
genes like me logo Genes that share compounds with RPS6KA5: view

Transcripts for RPS6KA5 Gene

Unigene Clusters for RPS6KA5 Gene

Ribosomal protein S6 kinase, 90kDa, polypeptide 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS6KA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: -
SP2:

Relevant External Links for RPS6KA5 Gene

GeneLoc Exon Structure for
RPS6KA5
ECgene alternative splicing isoforms for
RPS6KA5

Expression for RPS6KA5 Gene

mRNA expression in normal human tissues for RPS6KA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS6KA5 Gene

SOURCE GeneReport for Unigene cluster for RPS6KA5 Gene Hs.510225

mRNA Expression by UniProt/SwissProt for RPS6KA5 Gene

O75582-KS6A5_HUMAN
Tissue specificity: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
genes like me logo Genes that share expressions with RPS6KA5: view

Orthologs for RPS6KA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RPS6KA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS6KA5 36
  • 99.49 (n)
  • 100 (a)
RPS6KA5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RPS6KA5 36
  • 87.86 (n)
  • 94.85 (a)
RPS6KA5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS6KA5 36
  • 90.61 (n)
  • 97.39 (a)
RPS6KA5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rps6ka5 36
  • 89.43 (n)
  • 96.94 (a)
Rps6ka5 16
Rps6ka5 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RPS6KA5 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS6KA5 37
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS6KA5 36
  • 82.8 (n)
  • 91.48 (a)
RPS6KA5 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS6KA5 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps6ka5 36
  • 77.33 (n)
  • 87.23 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565173 36
  • 71.87 (n)
  • 79.86 (a)
RPS6KA5 37
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta JIL-1 36
  • 50.89 (n)
  • 48.79 (a)
JIL-1 37
  • 28 (a)
OneToMany
Pk17E 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea rskn-2 36
  • 56.5 (n)
  • 51.59 (a)
rskn-2 37
  • 48 (a)
OneToMany
F28C10.3 38
  • 33 (a)
R04A9.5 38
  • 46 (a)
C54G4.1 38
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToMany
Species with no ortholog for RPS6KA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS6KA5 Gene

ENSEMBL:
Gene Tree for RPS6KA5 (if available)
TreeFam:
Gene Tree for RPS6KA5 (if available)

Paralogs for RPS6KA5 Gene

genes like me logo Genes that share paralogs with RPS6KA5: view

Variants for RPS6KA5 Gene

Sequence variations from dbSNP and Humsavar for RPS6KA5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs727257 -- 91,058,332(+) GATTC(A/G)CACAG intron-variant
rs727258 -- 91,058,624(+) CTGAG(C/T)GTGGC intron-variant
rs927391 -- 90,974,060(+) AAAAA(A/T)AGTGT intron-variant
rs941846 -- 90,974,142(-) ATTAC(A/C)TAGTG intron-variant
rs941847 -- 90,965,427(-) AAATG(C/T)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RPS6KA5 Gene

Variant ID Type Subtype PubMed ID
nsv832855 CNV Loss 17160897
nsv832856 CNV Loss 17160897
esv2749012 CNV Deletion 23290073
esv2749013 CNV Deletion 23290073
esv2749014 CNV Deletion 23290073

Relevant External Links for RPS6KA5 Gene

HapMap Linkage Disequilibrium report
RPS6KA5

Disorders for RPS6KA5 Gene

(1) MalaCards Diseases for RPS6KA5 Gene

Search for RPS6KA5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RPS6KA5 Gene

(5) Novoseek inferred disease relationships for RPS6KA5 Gene

Disease -log(P) Hits PubMed IDs
inflammation 26.4 1
psoriasis 24.8 3
necrosis 7.4 3
tumors 0 4
cancer 0 2

Relevant External Links for RPS6KA5

Genetic Association Database (GAD)
RPS6KA5
Human Genome Epidemiology (HuGE) Navigator
RPS6KA5
genes like me logo Genes that share disorders with RPS6KA5: view

No data available for UniProtKB/Swiss-Prot for RPS6KA5 Gene

Publications for RPS6KA5 Gene

  1. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. (PMID: 9687510) Deak M. … Alessi D.R. (EMBO J. 1998) 2 3 4 23
  2. Cloning and characterization of RLPK, a novel RSK-related protein kinase. (PMID: 9873047) New L. … Han J. (J. Biol. Chem. 1999) 3 4 23
  3. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). (PMID: 12569367) Janknecht R. (Oncogene 2003) 3 4 23
  4. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). (PMID: 12628924) Vermeulen L. … Haegeman G. (EMBO J. 2003) 3 4 23
  5. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. (PMID: 12763138) Wierenga A.T. … Vellenga E. (Exp. Hematol. 2003) 3 4 23

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