Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHRS3 Gene

Aliases for DHRS3 Gene

  • Dehydrogenase/Reductase 3 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 16C Member 1 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 3 2 3
  • Retinal Short-Chain Dehydrogenase/Reductase 1 3 4
  • Retinol Dehydrogenase 17 3 4
  • SDR16C1 3 4
  • RetSDR1 3 4
  • DD83.1 3 4
  • RDH17 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 1 2
  • Short-Chain Dehydrogenase/Reductase 1 3
  • Short-Chain Dehydrogenase/Reductase 3 3
  • Dehydrogenase/Reductase Member 3 3
  • EC 4
  • EC 1.1.1 58
  • Rsdr1 3
  • SDR1 3

External Ids for DHRS3 Gene

Previous GeneCards Identifiers for DHRS3 Gene

  • GC01M012309
  • GC01M012562
  • GC01M012550
  • GC01M012627
  • GC01M011781

Summaries for DHRS3 Gene

Entrez Gene Summary for DHRS3 Gene

  • Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

GeneCards Summary for DHRS3 Gene

DHRS3 (Dehydrogenase/Reductase 3) is a Protein Coding gene. Diseases associated with DHRS3 include Neuroblastoma. Among its related pathways are the visual cycle I (vertebrates) and Metabolism of fat-soluble vitamins. GO annotations related to this gene include nucleotide binding and electron carrier activity. An important paralog of this gene is RDH10.

UniProtKB/Swiss-Prot for DHRS3 Gene

  • Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.

Gene Wiki entry for DHRS3 Gene

Additional gene information for DHRS3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHRS3 Gene

Genomics for DHRS3 Gene

Regulatory Elements for DHRS3 Gene

Enhancers for DHRS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H012548 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +68.7 68710 2.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YY1 ZNF766 FOS SP3 RNU6ATAC18P SNORA59A DHRS3 PIR43536 PIR41325
GH01H012452 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +162.8 162760 6 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF766 GATA2 SNORA59A DHRS3 RNU6ATAC18P AADACL4 VPS13D GC01M012433 GC01M012461
GH01H011907 1.8 FANTOM5 ENCODE dbSUPER 10.4 +709.6 709564 3.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A PPARGC1A TARDBP UBIAD1 ENSG00000226849 EXOSC10 SNORA59A ENSG00000271895 CLCN6 RNU5E-4P RNU5E-1 LOC102724659
GH01H012343 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +272.8 272778 3.4 ELF3 FOXA2 SAP130 MAX EBF1 BATF RAD21 HNF4G ATF7 GATAD2A DHRS3 GC01P012422 PIR35697 GC01P012251
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DHRS3 on UCSC Golden Path with GeneCards custom track

Promoters for DHRS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001591 961 4001 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF766

Genomic Locations for DHRS3 Gene

Genomic Locations for DHRS3 Gene
50,452 bases
Minus strand

Genomic View for DHRS3 Gene

Genes around DHRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHRS3 Gene

Proteins for DHRS3 Gene

  • Protein details for DHRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Short-chain dehydrogenase/reductase 3
    Protein Accession:
    Secondary Accessions:
    • B2R7F3
    • Q5VUY3
    • Q6UY38
    • Q9BUC8

    Protein attributes for DHRS3 Gene

    302 amino acids
    Molecular mass:
    33548 Da
    Quaternary structure:
    No Data Available
    • Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors.
    • Sequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305};

    Alternative splice isoforms for DHRS3 Gene


neXtProt entry for DHRS3 Gene

Selected DME Specific Peptides for DHRS3 Gene


Post-translational modifications for DHRS3 Gene

  • Ubiquitination at posLast=3232 and isoforms=156
  • Modification sites at PhosphoSitePlus

Other Protein References for DHRS3 Gene

Domains & Families for DHRS3 Gene

Gene Families for DHRS3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DHRS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with DHRS3: view

Function for DHRS3 Gene

Molecular function for DHRS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Enzyme Numbers (IUBMB) for DHRS3 Gene

Phenotypes From GWAS Catalog for DHRS3 Gene

Gene Ontology (GO) - Molecular Function for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 9705317
GO:0004745 retinol dehydrogenase activity IEA --
GO:0009055 electron carrier activity TAS 9705317
GO:0016491 oxidoreductase activity IEA --
GO:0052650 NADP-retinol dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with DHRS3: view
genes like me logo Genes that share phenotypes with DHRS3: view

Animal Models for DHRS3 Gene

MGI Knock Outs for DHRS3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DHRS3 Gene

Localization for DHRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DHRS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHRS3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0042622 photoreceptor outer segment membrane TAS --
genes like me logo Genes that share ontologies with DHRS3: view

Pathways & Interactions for DHRS3 Gene

genes like me logo Genes that share pathways with DHRS3: view

Pathways by source for DHRS3 Gene

Interacting Proteins for DHRS3 Gene

Selected Interacting proteins: O75911-DHRS3_HUMAN for DHRS3 Gene via IID

Gene Ontology (GO) - Biological Process for DHRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS,IEA --
GO:0003151 outflow tract morphogenesis IEA --
GO:0007601 visual perception TAS 9705317
GO:0030278 regulation of ossification IEA --
GO:0042572 retinol metabolic process TAS,IEA 9705317
genes like me logo Genes that share ontologies with DHRS3: view

No data available for SIGNOR curated interactions for DHRS3 Gene

Drugs & Compounds for DHRS3 Gene

(1) Drugs for DHRS3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin A Approved, Vet_approved Nutra Target 511

(3) Additional Compounds for DHRS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
  • All-E-Retinal
  • All-epsilon-Retinal
  • All-trans-Retinal
  • All-trans-Retinaldehyde
genes like me logo Genes that share compounds with DHRS3: view

Transcripts for DHRS3 Gene

Unigene Clusters for DHRS3 Gene

Dehydrogenase/reductase (SDR family) member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHRS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - - - - - -
SP4: - -
SP5: - - -

Relevant External Links for DHRS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DHRS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHRS3 Gene

mRNA differential expression in normal tissues according to GTEx for DHRS3 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for DHRS3 Gene

This gene is overexpressed in Nasal epithelium (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHRS3 Gene

Protein tissue co-expression partners for DHRS3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DHRS3 Gene:


SOURCE GeneReport for Unigene cluster for DHRS3 Gene:


mRNA Expression by UniProt/SwissProt for DHRS3 Gene:

Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.

Evidence on tissue expression from TISSUES for DHRS3 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Eye(4.2)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with DHRS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHRS3 Gene

Orthologs for DHRS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DHRS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DHRS3 33 34
  • 99.78 (n)
(Bos Taurus)
Mammalia DHRS3 33 34
  • 94.04 (n)
(Ornithorhynchus anatinus)
Mammalia DHRS3 34
  • 93 (a)
(Canis familiaris)
Mammalia DHRS3 33 34
  • 92.83 (n)
(Rattus norvegicus)
Mammalia Dhrs3 33
  • 88.74 (n)
(Mus musculus)
Mammalia Dhrs3 33 16 34
  • 88.19 (n)
(Monodelphis domestica)
Mammalia DHRS3 34
  • 84 (a)
(Gallus gallus)
Aves DHRS3 33 34
  • 80.57 (n)
(Anolis carolinensis)
Reptilia DHRS3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dhrs3 33
  • 74.17 (n)
Str.2573 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13360 33
(Danio rerio)
Actinopterygii dhrs3a 34
  • 77 (a)
dhrs3b 33 34
  • 74.61 (n)
wufc04h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5264 33
fruit fly
(Drosophila melanogaster)
Insecta CG15629 34
  • 31 (a)
CG14946 34
  • 28 (a)
CG2254 34
  • 27 (a)
CG13833 34
  • 24 (a)
CG9265 34
  • 24 (a)
CG17121 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea dhs-29 34
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
TDA5 34
  • 20 (a)
Species where no ortholog for DHRS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DHRS3 Gene

Gene Tree for DHRS3 (if available)
Gene Tree for DHRS3 (if available)

Paralogs for DHRS3 Gene

Paralogs for DHRS3 Gene

(5) SIMAP similar genes for DHRS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DHRS3: view

Variants for DHRS3 Gene

Sequence variations from dbSNP and Humsavar for DHRS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000003768 -- 12,611,032(+) AGAAA(C/G)GACAC intron-variant
rs1000006077 -- 12,587,384(+) AGTGA(G/T)TCTCC intron-variant
rs1000055528 -- 12,573,208(+) CCTTC(A/G)GGACA intron-variant
rs1000065730 -- 12,596,747(+) GAAAA(C/G)TGAAA intron-variant, upstream-variant-2KB
rs1000095329 -- 12,590,223(+) GGGTG(G/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DHRS3 Gene

Variant ID Type Subtype PubMed ID
nsv955253 CNV deletion 24416366
nsv545443 CNV gain 21841781
nsv545442 CNV loss 21841781
nsv521737 CNV loss 19592680
nsv517848 CNV gain 19592680
nsv475178 CNV novel sequence insertion 20440878
nsv475134 CNV novel sequence insertion 20440878
nsv466283 CNV gain 19166990
nsv466172 CNV loss 19166990
nsv1126179 CNV deletion 24896259
nsv1011540 CNV loss 25217958

Variation tolerance for DHRS3 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DHRS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHRS3 Gene

Disorders for DHRS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DHRS3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search DHRS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DHRS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DHRS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DHRS3 Gene

Publications for DHRS3 Gene

  1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. (PMID: 9705317) Haeseleer F … Palczewski K (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B … Oppermann U (Chemico-biological interactions 2009) 2 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DHRS3 Gene

Sources for DHRS3 Gene

Loading form....