Aliases for VAPB Gene
External Ids for VAPB Gene
Previous GeneCards Identifiers for VAPB Gene
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
GeneCards Summary for VAPB Gene
VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B And C) is a Protein Coding gene. Diseases associated with VAPB include amyotrophic lateral sclerosis 8 and spinal muscular atrophy, late-onset, finkel type. Among its related pathways are Sphingolipid metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and enzyme binding. An important paralog of this gene is VAPA.
UniProtKB/Swiss-Prot for VAPB Gene
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.