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Aliases for CD5 Gene

Aliases for CD5 Gene

  • CD5 Molecule 2 3
  • LEU1 3 4 6
  • Lymphocyte Antigen T1/Leu-1 3 4
  • CD5 Antigen (P56-62) 2 3
  • T-Cell Surface Glycoprotein CD5 3
  • CD5 Antigen 4
  • T1 3

External Ids for CD5 Gene

Previous HGNC Symbols for CD5 Gene

  • LEU1

Previous GeneCards Identifiers for CD5 Gene

  • GC11P063262
  • GC11P062382
  • GC11P061120
  • GC11P060646
  • GC11P060647
  • GC11P060626
  • GC11P060869
  • GC11P057229

Summaries for CD5 Gene

GeneCards Summary for CD5 Gene

CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include richter's syndrome and thymic carcinoma. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways) and Hematopoietic cell lineage. GO annotations related to this gene include receptor activity and scavenger receptor activity.

UniProtKB/Swiss-Prot for CD5 Gene

  • May act as a receptor in regulating T-cell proliferation

Gene Wiki entry for CD5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD5 Gene

Genomics for CD5 Gene

Regulatory Elements for CD5 Gene

Genomic Location for CD5 Gene

61,102,395 bp from pter
61,127,852 bp from pter
25,458 bases
Plus strand

Genomic View for CD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD5 Gene

Proteins for CD5 Gene

  • Protein details for CD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD5
    Protein Accession:
    Secondary Accessions:
    • A0N0P4
    • A8K9I3

    Protein attributes for CD5 Gene

    495 amino acids
    Molecular mass:
    54578 Da
    Quaternary structure:
    • Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD5 Gene

neXtProt entry for CD5 Gene

Proteomics data for CD5 Gene at MOPED

Post-translational modifications for CD5 Gene

  • Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.
  • Ubiquitination at Lys43, Lys273, and Lys346
  • Glycosylation at Asn116 and Asn241
  • Modification sites at PhosphoSitePlus

Other Protein References for CD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD5 Gene

Domains for CD5 Gene

Gene Families for CD5 Gene

Suggested Antigen Peptide Sequences for CD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 SRCR domains.
  • Contains 3 SRCR domains.
genes like me logo Genes that share domains with CD5: view

Function for CD5 Gene

Molecular function for CD5 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single chain,identified by monoclonal antibodies T1,UCHT2,T101,HH9,AMG4
UniProtKB/Swiss-Prot Function:
May act as a receptor in regulating T-cell proliferation

Gene Ontology (GO) - Molecular Function for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 1711157
GO:0004888 transmembrane signaling receptor activity NAS 3093892
GO:0005044 scavenger receptor activity IEA --
GO:0005515 protein binding IPI 1711157
genes like me logo Genes that share ontologies with CD5: view

Phenotypes for CD5 Gene

genes like me logo Genes that share phenotypes with CD5: view

Animal Models for CD5 Gene

MGI Knock Outs for CD5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CD5 Gene

Localization for CD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD5 Gene COMPARTMENTS Subcellular localization image for CD5 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 11390434
GO:0005887 integral component of plasma membrane NAS 1711157
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CD5: view

Pathways for CD5 Gene

genes like me logo Genes that share pathways with CD5: view

Pathways by source for CD5 Gene

1 BioSystems pathway for CD5 Gene
1 KEGG pathway for CD5 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0008037 cell recognition NAS 1711157
GO:0008283 cell proliferation NAS 3093892
GO:0031295 T cell costimulation IEA --
GO:0097190 apoptotic signaling pathway IEA --
genes like me logo Genes that share ontologies with CD5: view

Drugs for CD5 Gene

(5) Novoseek inferred chemical compound relationships for CD5 Gene

Compound -log(P) Hits PubMed IDs
gelonin 69.6 2
ricin 51.7 1
paraffin 18.9 4
calcium 0 1
tyrosine 0 7
genes like me logo Genes that share compounds with CD5: view

Transcripts for CD5 Gene

mRNA/cDNA for CD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD5 Gene

CD5 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD5 Gene

No ASD Table

Relevant External Links for CD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD5 Gene

mRNA expression in normal human tissues for CD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD5 Gene

This gene is overexpressed in Whole Blood (24.2), Spleen (5.6), and Small Intestine - Terminal Ileum (4.4).

Protein differential expression in normal tissues for CD5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.1), CD8 Tcells (9.8), and Tlymphocyte (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD5 Gene

SOURCE GeneReport for Unigene cluster for CD5 Gene Hs.58685

genes like me logo Genes that share expressions with CD5: view

Expression partners for CD5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD5 Gene

Orthologs for CD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD5 35
  • 74.75 (n)
  • 64.56 (a)
CD5 36
  • 64 (a)
(Canis familiaris)
Mammalia CD5 35
  • 78.5 (n)
  • 69.39 (a)
CD5 36
  • 68 (a)
(Mus musculus)
Mammalia Cd5 35
  • 73.53 (n)
  • 64.61 (a)
Cd5 16
Cd5 36
  • 63 (a)
(Pan troglodytes)
Mammalia CD5 35
  • 99.64 (n)
  • 99.35 (a)
CD5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100911215 35
  • 74.15 (n)
  • 64.71 (a)
(Monodelphis domestica)
Mammalia CD5 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia CD5 36
  • 52 (a)
(Gallus gallus)
Aves CD5 35
  • 52.35 (n)
  • 42.26 (a)
CD5 36
  • 38 (a)
(Anolis carolinensis)
Reptilia CD5 36
  • 31 (a)
Species with no ortholog for CD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD5 Gene

Gene Tree for CD5 (if available)
Gene Tree for CD5 (if available)

Paralogs for CD5 Gene

No data available for Paralogs for CD5 Gene

Variants for CD5 Gene

Sequence variations from dbSNP and Humsavar for CD5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs149268422 -- 61,118,277(+) GGGCC(A/G)GAGCT missense, reference
rs149268860 -- 61,110,471(+) TCACA(A/C)AGCAC intron-variant
rs149436588 -- 61,119,961(+) CCTTG(-/C)AGGAA intron-variant
rs149222240 -- 61,119,095(+) TCTAC(A/G)CAATA intron-variant
rs149213410 -- 61,102,240(+) CCCTG(C/T)AGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CD5 Gene

Variant ID Type Subtype PubMed ID
nsv832176 CNV Gain+Loss 17160897
nsv428259 CNV Gain+Loss 18775914
nsv509412 CNV Insertion 20534489
nsv897602 CNV Loss 21882294
nsv526162 CNV Loss 19592680

Relevant External Links for CD5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD5 Gene

Disorders for CD5 Gene

(28) Novoseek inferred disease relationships for CD5 Gene

Disease -log(P) Hits PubMed IDs
lymphoma small lymphocytic 76.3 4
lymphocytic leukemia chronic b-cell 75.3 8
leukemia lymphocytic chronic 74.3 10
leukemia prolymphocytic 70.3 1
leukaemia lymphocytic 69.2 7

Relevant External Links for CD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD5: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CD5 Gene

Publications for CD5 Gene

  1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PMID: 1711157) van de Velde H. … Thielemans K. (Nature 1991) 2 3 4
  2. Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. (PMID: 3093892) Jones N.H. … Strominger J.L. (Nature 1986) 3 4
  3. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. (PMID: 15998834) Renaudineau Y. … Youinou P. (Blood 2005) 3 23
  4. CD5 does not regulate the signaling triggered through BCR in B cells from a subset of B-CLL patients. (PMID: 17325858) Perez-Chacon G. … Perez-Aciego P. (Leuk. Lymphoma 2007) 3 23
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee K.M. … Lan Q. (Am. J. Hematol. 2010) 3 48

Products for CD5 Gene

Sources for CD5 Gene

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