Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD5 Gene

Aliases for CD5 Gene

  • CD5 Molecule 2 3 5
  • Lymphocyte Antigen T1/Leu-1 3 4
  • CD5 Antigen (P56-62) 2 3
  • LEU1 3 4
  • CD5 Antigen 4
  • T1 3

External Ids for CD5 Gene

Previous HGNC Symbols for CD5 Gene

  • LEU1

Previous GeneCards Identifiers for CD5 Gene

  • GC11P063262
  • GC11P062382
  • GC11P061120
  • GC11P060646
  • GC11P060647
  • GC11P060626
  • GC11P060869
  • GC11P057229
  • GC11P061105
  • GC11P061106

Summaries for CD5 Gene

GeneCards Summary for CD5 Gene

CD5 (CD5 Molecule) is a Protein Coding gene. Diseases associated with CD5 include Thymus Cancer and Richter's Syndrome. Among its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include receptor activity and scavenger receptor activity.

UniProtKB/Swiss-Prot for CD5 Gene

  • May act as a receptor in regulating T-cell proliferation.

Gene Wiki entry for CD5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD5 Gene

Genomics for CD5 Gene

Regulatory Elements for CD5 Gene

Enhancers for CD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CD5 on UCSC Golden Path with GeneCards custom track

Promoters for CD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD5 Gene

61,102,395 bp from pter
61,127,852 bp from pter
25,458 bases
Plus strand

Genomic View for CD5 Gene

Genes around CD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD5 Gene

Proteins for CD5 Gene

  • Protein details for CD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD5
    Protein Accession:
    Secondary Accessions:
    • A0N0P4
    • A8K9I3

    Protein attributes for CD5 Gene

    495 amino acids
    Molecular mass:
    54578 Da
    Quaternary structure:
    • Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CD5 Gene

neXtProt entry for CD5 Gene

Proteomics data for CD5 Gene at MOPED

Post-translational modifications for CD5 Gene

  • Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.
  • Ubiquitination at Lys 43, Lys 273, and Lys 346
  • Glycosylation at Asn 116 and Asn 241
  • Modification sites at PhosphoSitePlus

Other Protein References for CD5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CD5 Gene

Domains & Families for CD5 Gene

Gene Families for CD5 Gene

Suggested Antigen Peptide Sequences for CD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 SRCR domains.
  • Contains 3 SRCR domains.
genes like me logo Genes that share domains with CD5: view

Function for CD5 Gene

Molecular function for CD5 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD5 (p56-62),expressed on thymocytes,T and B cells,single chain,identified by monoclonal antibodies T1,UCHT2,T101,HH9,AMG4
UniProtKB/Swiss-Prot Function:
May act as a receptor in regulating T-cell proliferation.

Gene Ontology (GO) - Molecular Function for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with CD5: view
genes like me logo Genes that share phenotypes with CD5: view

Animal Models for CD5 Gene

MGI Knock Outs for CD5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD5 Gene

Localization for CD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD5 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD5 Gene COMPARTMENTS Subcellular localization image for CD5 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 2
nucleus 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD5: view

Pathways & Interactions for CD5 Gene

genes like me logo Genes that share pathways with CD5: view

Pathways by source for CD5 Gene

SIGNOR curated interactions for CD5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0008037 cell recognition NAS 1711157
genes like me logo Genes that share ontologies with CD5: view

Drugs & Compounds for CD5 Gene

(2) Drugs for CD5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CD5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD5: view

Transcripts for CD5 Gene

mRNA/cDNA for CD5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(56) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD5 Gene

CD5 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD5 Gene

No ASD Table

Relevant External Links for CD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD5 Gene

mRNA expression in normal human tissues for CD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD5 Gene

This gene is overexpressed in Whole Blood (x24.2), Spleen (x5.6), and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for CD5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.1), CD8 Tcells (9.8), and Tlymphocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD5 Gene

SOURCE GeneReport for Unigene cluster for CD5 Gene Hs.58685

genes like me logo Genes that share expression patterns with CD5: view

Protein tissue co-expression partners for CD5 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CD5 Gene

Orthologs for CD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD5 35
  • 74.75 (n)
  • 64.56 (a)
CD5 36
  • 64 (a)
(Canis familiaris)
Mammalia CD5 35
  • 78.5 (n)
  • 69.39 (a)
CD5 36
  • 68 (a)
(Mus musculus)
Mammalia Cd5 35
  • 73.53 (n)
  • 64.61 (a)
Cd5 16
Cd5 36
  • 63 (a)
(Pan troglodytes)
Mammalia CD5 35
  • 99.64 (n)
  • 99.35 (a)
CD5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100911215 35
  • 74.15 (n)
  • 64.71 (a)
(Monodelphis domestica)
Mammalia CD5 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia CD5 36
  • 52 (a)
(Gallus gallus)
Aves CD5 35
  • 52.35 (n)
  • 42.26 (a)
CD5 36
  • 38 (a)
(Anolis carolinensis)
Reptilia CD5 36
  • 31 (a)
Species with no ortholog for CD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD5 Gene

Gene Tree for CD5 (if available)
Gene Tree for CD5 (if available)

Paralogs for CD5 Gene

No data available for Paralogs for CD5 Gene

Variants for CD5 Gene

Sequence variations from dbSNP and Humsavar for CD5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2241002 - 61,119,441(+) AGACC(C/T)AGGGG reference, missense
rs637186 - 61,125,134(+) CTCCC(A/G)CCTGT reference, missense
rs2229177 - 61,125,763(+) AGGGG(C/T)TCTGC reference, missense
rs522073 -- 61,111,190(+) CTGCA(C/T)GAGCG intron-variant
rs522093 -- 61,124,188(-) AAGGA(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD5 Gene

Variant ID Type Subtype PubMed ID
nsv832176 CNV Gain+Loss 17160897
nsv428259 CNV Gain+Loss 18775914
nsv509412 CNV Insertion 20534489
nsv897602 CNV Loss 21882294
nsv526162 CNV Loss 19592680

Variation tolerance for CD5 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD5 Gene

Disorders for CD5 Gene

MalaCards: The human disease database

(63) MalaCards diseases for CD5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thymus cancer
  • neoplasm of thymus
richter's syndrome
  • richter syndrome
prolymphocytic leukemia
  • leukemia prolymphocytic
splenic marginal zone lymphoma
  • smzl
chronic lymphocytic leukemia
  • cll
- elite association - COSMIC cancer census association via MalaCards
Search CD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD5 Gene

Publications for CD5 Gene

  1. The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. (PMID: 1711157) van de Velde H. … Thielemans K. (Nature 1991) 2 3 4 67
  2. CD5 does not regulate the signaling triggered through BCR in B cells from a subset of B-CLL patients. (PMID: 17325858) Perez-Chacon G. … Perez-Aciego P. (Leuk. Lymphoma 2007) 3 23
  3. An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes. (PMID: 15998834) Renaudineau Y. … Youinou P. (Blood 2005) 3 23
  4. Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes. (PMID: 16107871) Renaudineau Y. … Youinou P. (Genes Immun. 2005) 3 23
  5. Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases. (PMID: 11298344) VilA J.M. … Lozano F. (Eur. J. Immunol. 2001) 3 23

Products for CD5 Gene

Sources for CD5 Gene