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Aliases for DCLK1 Gene

Aliases for DCLK1 Gene

  • Doublecortin-Like Kinase 1 2 3 4
  • DCAMKL1 3 4 6
  • Doublecortin Domain-Containing Protein 3A 3 4
  • Doublecortin-Like And CAM Kinase-Like 1 3 4
  • EC 2.7.11.1 4 63
  • KIAA0369 4 6
  • CLICK1 3 6
  • DCDC3A 3 4
  • CL1 3 6
  • Serine/Threonine-Protein Kinase DCLK1 3
  • Doublecortin And CaM Kinase-Like 1 2
  • EC 2.7.11 63
  • DCLK 3

External Ids for DCLK1 Gene

Previous Symbols for DCLK1 Gene

  • DCAMKL1

Summaries for DCLK1 Gene

Entrez Gene Summary for DCLK1 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK1 Gene

DCLK1 (Doublecortin-Like Kinase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and receptor signaling protein activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for DCLK1 Gene

  • Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system

Gene Wiki entry for DCLK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK1 Gene

Genomics for DCLK1 Gene

Genomic Location for DCLK1 Gene

Start:
35,768,652 bp from pter
End:
36,132,020 bp from pter
Size:
363,369 bases
Orientation:
Minus strand

Genomic View for DCLK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK1 Gene

Regulatory Elements for DCLK1 Gene

Proteins for DCLK1 Gene

  • Protein details for DCLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15075-DCLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK1
    Protein Accession:
    O15075
    Secondary Accessions:
    • B7Z3E9
    • Q5VZY8
    • Q5VZZ0
    • Q5VZZ1

    Protein attributes for DCLK1 Gene

    Size:
    740 amino acids
    Molecular mass:
    82224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20824.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCLK1 Gene

    Alternative splice isoforms for DCLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK1 Gene

Proteomics data for DCLK1 Gene at MOPED

Post-translational modifications for DCLK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DCLK1 Gene

Gene Families for DCLK1 Gene

Suggested Antigen Peptide Sequences for DCLK1 Gene

Graphical View of Domain Structure for InterPro Entry

O15075

UniProtKB/Swiss-Prot:

DCLK1_HUMAN
Domain:
  • Contains 2 doublecortin domains.:
    • O15075
  • Contains 1 protein kinase domain.:
    • O15075
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • O15075
genes like me logo Genes that share domains with DCLK1: view

Function for DCLK1 Gene

Molecular function for DCLK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system
UniProtKB/Swiss-Prot Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for DCLK1 Gene

Gene Ontology (GO) - Molecular Function for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9747029
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005057 receptor signaling protein activity TAS 10036192
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCLK1: view
genes like me logo Genes that share phenotypes with DCLK1: view

Animal Models for DCLK1 Gene

MGI Knock Outs for DCLK1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DCLK1 Gene

Localization for DCLK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLK1 Gene COMPARTMENTS Subcellular localization image for DCLK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10036192
genes like me logo Genes that share ontologies with DCLK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCLK1 Gene

Pathways for DCLK1 Gene

SuperPathways for DCLK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007399 nervous system development TAS 10036192
GO:0007409 axonogenesis --
GO:0007417 central nervous system development TAS 10051403
genes like me logo Genes that share ontologies with DCLK1: view

No data available for Pathways by source for DCLK1 Gene

Compounds for DCLK1 Gene

(1) HMDB Compounds for DCLK1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for DCLK1 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 3
genes like me logo Genes that share compounds with DCLK1: view

Transcripts for DCLK1 Gene

Unigene Clusters for DCLK1 Gene

Doublecortin-like kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2:
SP3: -

Relevant External Links for DCLK1 Gene

GeneLoc Exon Structure for
DCLK1
ECgene alternative splicing isoforms for
DCLK1

Expression for DCLK1 Gene

mRNA expression in normal human tissues for DCLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.8), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Hypothalamus (4.1), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCLK1 Gene

SOURCE GeneReport for Unigene cluster for DCLK1 Gene Hs.507755

mRNA Expression by UniProt/SwissProt for DCLK1 Gene

O15075-DCLK1_HUMAN
Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
genes like me logo Genes that share expressions with DCLK1: view

Orthologs for DCLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK1 35
  • 99.73 (n)
  • 100 (a)
DCLK1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCLK1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK1 35
  • 93.73 (n)
  • 99.85 (a)
DCLK1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dclk1 35
  • 89.89 (n)
  • 98.4 (a)
Dclk1 16
Dclk1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCLK1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK1 35
  • 86.1 (n)
  • 96.71 (a)
DCLK1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dckl1b 36
  • 77 (a)
OneToMany
dclk1a 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17528 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 35
  • 49.81 (n)
  • 45.35 (a)
zyg-8 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NNK1 38
rice
(Oryza sativa)
Liliopsida Os.4465 35
Species with no ortholog for DCLK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK1 Gene

ENSEMBL:
Gene Tree for DCLK1 (if available)
TreeFam:
Gene Tree for DCLK1 (if available)

Paralogs for DCLK1 Gene

genes like me logo Genes that share paralogs with DCLK1: view

Variants for DCLK1 Gene

Sequence variations from dbSNP and Humsavar for DCLK1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs728985 -- 35,978,068(-) AATTT(A/G)TAATG intron-variant
rs730904 -- 36,083,457(-) TATCA(C/T)TGTGT intron-variant
rs744190 -- 36,082,735(+) CACTA(A/G)AAGTT intron-variant
rs744191 -- 36,082,836(+) ACTTT(A/G)TCTTC intron-variant
rs744523 -- 36,083,454(-) CATTG(G/T)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK1 Gene

Variant ID Type Subtype PubMed ID
nsv832580 CNV Loss 17160897
esv4657 CNV Deletion 18987735
esv2747262 CNV Deletion 23290073
esv2670454 CNV Deletion 23128226
nsv64246 CNV Loss 16902084
nsv524786 CNV Loss 19592680
nsv510948 CNV Complex 20534489
nsv509501 CNV Insertion 20534489
esv3500 CNV Duplication 18987735
esv2674324 CNV Deletion 23128226
esv4059 CNV Complex 18987735
esv2772 CNV Deletion 18987735
esv2429709 CNV Insertion 19546169
esv2671550 CNV Deletion 23128226
esv22934 CNV Loss 19812545
esv27255 CNV Loss 19812545
nsv518674 CNV Loss 19592680
nsv522911 CNV Loss 19592680
esv267546 CNV Insertion 20981092
nsv899992 CNV Loss 21882294
nsv899993 CNV Gain 21882294

Relevant External Links for DCLK1 Gene

HapMap Linkage Disequilibrium report
DCLK1
Human Gene Mutation Database (HGMD)
DCLK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK1 Gene

Disorders for DCLK1 Gene

(1) University of Copenhagen DISEASES for DCLK1 Gene

Relevant External Links for DCLK1

Genetic Association Database (GAD)
DCLK1
Human Genome Epidemiology (HuGE) Navigator
DCLK1
genes like me logo Genes that share disorders with DCLK1: view

No data available for UniProtKB/Swiss-Prot for DCLK1 Gene

Publications for DCLK1 Gene

  1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PMID: 9747029) Omori Y. … Fujiwara T. (J. Hum. Genet. 1998) 2 3 4 23
  2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PMID: 10036192) Sossey-Alaoui K. … Srivastava A.K. (Genomics 1999) 2 3 4
  3. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). (PMID: 10051403) Matsumoto N. … Ledbetter D.H. (Genomics 1999) 3 4
  4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong W.F. … Chow V.T. (Cell. Microbiol. 2006) 3 4
  5. Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain. (PMID: 11473121) Burgess H.A. … Reiner O. (J. Biol. Chem. 2001) 3 23

Products for DCLK1 Gene

Sources for DCLK1 Gene

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