Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD4 Gene

Aliases for CD4 Gene

  • CD4 Molecule 2 3 5
  • T-Cell Surface Antigen T4/Leu-3 3 4
  • CD4 Antigen (P55) 2 3
  • T-Cell Surface Glycoprotein CD4 2
  • CD4 Receptor 3
  • CD4 Antigen 4
  • CD4mut 3

External Ids for CD4 Gene

Previous GeneCards Identifiers for CD4 Gene

  • GC12M007045
  • GC12M007130
  • GC12P006777
  • GC12P006769
  • GC12P006899

Summaries for CD4 Gene

Entrez Gene Summary for CD4 Gene

  • This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for CD4 Gene

CD4 (CD4 Molecule) is a Protein Coding gene. Diseases associated with CD4 include okt4 epitope deficiency and acquired immunodeficiency syndrome. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and enzyme binding.

UniProtKB/Swiss-Prot for CD4 Gene

  • Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

  • (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Wiki entry for CD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD4 Gene

Genomics for CD4 Gene

Regulatory Elements for CD4 Gene

Promoters for CD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD4 Gene

Chromosome:
12
Start:
6,786,858 bp from pter
End:
6,820,810 bp from pter
Size:
33,953 bases
Orientation:
Plus strand

Genomic View for CD4 Gene

Genes around CD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD4 Gene

Proteins for CD4 Gene

  • Protein details for CD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01730-CD4_HUMAN
    Recommended name:
    T-cell surface glycoprotein CD4
    Protein Accession:
    P01730
    Secondary Accessions:
    • B2R737
    • D3DUS5
    • Q4ZGK2
    • Q5U066
    • Q9UDE5

    Protein attributes for CD4 Gene

    Size:
    458 amino acids
    Molecular mass:
    51111 Da
    Quaternary structure:
    • Associates with LCK. Interacts with PTK2/FAK1. Binds to P4HB/PDI.
    • (Microbial infection) Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu (PubMed:2214026, PubMed:16331979, PubMed:9641677).
    • (Microbial infection) Interacts with Human Herpes virus 7 surface proteins.
    Miscellaneous:
    • Primary receptor for HIV-1.

    Three dimensional structures from OCA and Proteopedia for CD4 Gene

neXtProt entry for CD4 Gene

Proteomics data for CD4 Gene at MOPED

Post-translational modifications for CD4 Gene

  • Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
  • Ubiquitination at Lys 453
  • Glycosylation at Asn 296 and Asn 325
  • Modification sites at PhosphoSitePlus

Other Protein References for CD4 Gene

No data available for DME Specific Peptides for CD4 Gene

Domains & Families for CD4 Gene

Suggested Antigen Peptide Sequences for CD4 Gene

Graphical View of Domain Structure for InterPro Entry

P01730

UniProtKB/Swiss-Prot:

CD4_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD4: view

Function for CD4 Gene

Molecular function for CD4 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD4 (p55),59kDa,HIV & MHC class II receptor,identified by monoclonal antibodies T4,Leu-3a,91D6,transmembrane glycoprotein (see LAG3),containing a tissue-specific promoter made of an initiator-like sequence,an ETS and an ATF consensus site, and a locus control region like,see LCR-CD4
UniProtKB/Swiss-Prot Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Gene Ontology (GO) - Molecular Function for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001948 glycoprotein binding IPI 10922058
GO:0015026 coreceptor activity NAS 8512039
GO:0019901 protein kinase binding IEA,IPI 7486703
genes like me logo Genes that share ontologies with CD4: view
genes like me logo Genes that share phenotypes with CD4: view

Human Phenotype Ontology for CD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD4 Gene

MGI Knock Outs for CD4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD4 Gene

Localization for CD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD4 Gene

Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD4 Gene COMPARTMENTS Subcellular localization image for CD4 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
plasma membrane 5
cytosol 3
extracellular 3
nucleus 3
vacuole 3
cytoskeleton 2
golgi apparatus 2
lysosome 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with CD4: view

Pathways & Interactions for CD4 Gene

genes like me logo Genes that share pathways with CD4: view

Gene Ontology (GO) - Biological Process for CD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006948 induction by virus of host cell-cell fusion IDA 9166430
GO:0006955 immune response NAS 8512039
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 9558100
genes like me logo Genes that share ontologies with CD4: view

No data available for SIGNOR curated interactions for CD4 Gene

Drugs & Compounds for CD4 Gene

(126) Drugs for CD4 Gene - From: Novoseek, ClinicalTrials, DGIdb, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antithymocyte globulin Approved Pharma binder, Target 0
Primaquine Approved Pharma 64
Zidovudine Approved Pharma 491
Abacavir Approved, Investigational Pharma 203
Atovaquone Approved Pharma 32

(34) Additional Compounds for CD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD4: view

Transcripts for CD4 Gene

mRNA/cDNA for CD4 Gene

(6) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD4 Gene

CD4 molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^
SP1: - - - - - - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: -
SP12: -
SP13:

ExUns: 14 ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for CD4 Gene

GeneLoc Exon Structure for
CD4
ECgene alternative splicing isoforms for
CD4

Expression for CD4 Gene

mRNA expression in normal human tissues for CD4 Gene

mRNA differential expression in normal tissues according to GTEx for CD4 Gene

This gene is overexpressed in Spleen (x8.4) and Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for CD4 Gene

This gene is overexpressed in Lymph node (26.9), Tlymphocyte (15.4), Peripheral blood mononuclear cells (13.9), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD4 Gene



SOURCE GeneReport for Unigene cluster for CD4 Gene Hs.631659

genes like me logo Genes that share expression patterns with CD4: view

Protein tissue co-expression partners for CD4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD4 Gene

Orthologs for CD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD4 35
  • 72.34 (n)
  • 60.47 (a)
CD4 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD4 35
  • 74.68 (n)
  • 62.14 (a)
mouse
(Mus musculus)
Mammalia Cd4 35
  • 69.48 (n)
  • 57.04 (a)
Cd4 16
Cd4 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD4 35
  • 99.13 (n)
  • 98.91 (a)
CD4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd4 35
  • 68.67 (n)
  • 55.23 (a)
oppossum
(Monodelphis domestica)
Mammalia CD4 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD4 36
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD4 35
  • 43.76 (n)
  • 31.03 (a)
CD4 36
  • 24 (a)
OneToOne
Species with no ortholog for CD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD4 Gene

ENSEMBL:
Gene Tree for CD4 (if available)
TreeFam:
Gene Tree for CD4 (if available)

Paralogs for CD4 Gene

No data available for Paralogs for CD4 Gene

Variants for CD4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD4 Gene

P01730-CD4_HUMAN
The OKT monoclonal antibodies are widely used for the analysis of human peripheral blood T-lymphocytes. OKT4 reacts with T-helper/inducer lymphocytes. The OKT4 epitope of the CD4 cell-surface protein is polymorphic in white, black, and Japanese populations. The variable phenotypic expression is due a CD4 polymorphism. OKT4 positive individuals carry Arg-265 and OKT4 negative individuals carry Trp-265 [MIM:613949].

Sequence variations from dbSNP and Humsavar for CD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28919570 - 6,816,241(+) TAAAA(C/T)GGGTT reference, missense, utr-variant-5-prime
rs28917504 - 6,814,956(+) ACCAG(A/G)AGAAG reference, missense, utr-variant-5-prime
rs11064419 - 6,816,128(+) CGCCT(C/T)TACAG reference, missense, utr-variant-5-prime
rs743600 -- 6,797,153(-) AGCAG(C/T)GGCAA intron-variant
rs1055141 -- 6,817,197(+) CTGAG(C/T)TTGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CD4 Gene

Variant ID Type Subtype PubMed ID
nsv832323 CNV Loss 17160897
nsv593 CNV Loss 18451855
nsv832324 CNV Loss 17160897
esv2663865 CNV Deletion 23128226
nsv52513 CNV Loss 16902084
esv2745479 CNV Deletion 23290073
nsv898638 CNV Loss 21882294
dgv1353n71 CNV Loss 21882294

Variation tolerance for CD4 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD4 Gene

HapMap Linkage Disequilibrium report
CD4
Human Gene Mutation Database (HGMD)
CD4

Disorders for CD4 Gene

MalaCards: The human disease database

(183) MalaCards diseases for CD4 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD4

Genetic Association Database (GAD)
CD4
Human Genome Epidemiology (HuGE) Navigator
CD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD4
genes like me logo Genes that share disorders with CD4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD4 Gene

Publications for CD4 Gene

  1. Structural basis for the interaction between focal adhesion kinase and CD4. (PMID: 18078954) Garron M.L. … Arold S.T. (J. Mol. Biol. 2008) 3 4 23 67
  2. Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120. (PMID: 19170639) Brower E.T. … Freire E. (Biochemistry 2009) 3 23
  3. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. (PMID: 19333378) Py B. … Benichou S. (PLoS ONE 2009) 3 23
  4. Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors. (PMID: 18205925) Peters P.J. … Clapham P.R. (Retrovirology 2008) 3 23
  5. HIV-1 envelope glycoprotein-mediated fusion and pathogenesis: implications for therapy and vaccine development. (PMID: 18242797) Jacobs A. … Blumenthal R. (Vaccine 2008) 3 23

Products for CD4 Gene

Sources for CD4 Gene

Back to Top

Content