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Aliases for ZNF300 Gene

Aliases for ZNF300 Gene

  • Zinc Finger Protein 300 2 3 5

External Ids for ZNF300 Gene

Previous GeneCards Identifiers for ZNF300 Gene

  • GC21U990107
  • GC05M150303
  • GC05M150254
  • GC05M145419

Summaries for ZNF300 Gene

Entrez Gene Summary for ZNF300 Gene

  • The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

GeneCards Summary for ZNF300 Gene

ZNF300 (Zinc Finger Protein 300) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF34.

UniProtKB/Swiss-Prot for ZNF300 Gene

  • Has a transcriptional repressor activity.

Gene Wiki entry for ZNF300 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF300 Gene

Genomics for ZNF300 Gene

Regulatory Elements for ZNF300 Gene

Enhancers for ZNF300 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF300 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF300 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF300 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF300 Gene

Chromosome:
5
Start:
150,894,383 bp from pter
End:
150,904,983 bp from pter
Size:
10,601 bases
Orientation:
Minus strand

Genomic View for ZNF300 Gene

Genes around ZNF300 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF300 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF300 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF300 Gene

Proteins for ZNF300 Gene

  • Protein details for ZNF300 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RE9-ZN300_HUMAN
    Recommended name:
    Zinc finger protein 300
    Protein Accession:
    Q96RE9
    Secondary Accessions:
    • A8MY91
    • B3KU35
    • B4DU78
    • F5GWS1
    • Q06DQ3
    • Q17RP3
    • Q5H9N5

    Protein attributes for ZNF300 Gene

    Size:
    604 amino acids
    Molecular mass:
    68743 Da
    Quaternary structure:
    • Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).
    SequenceCaution:
    • Sequence=EAW61702.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF300 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF300 Gene

Proteomics data for ZNF300 Gene at MOPED

Post-translational modifications for ZNF300 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF300 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF300

No data available for DME Specific Peptides for ZNF300 Gene

Domains & Families for ZNF300 Gene

Gene Families for ZNF300 Gene

Protein Domains for ZNF300 Gene

Suggested Antigen Peptide Sequences for ZNF300 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RE9

UniProtKB/Swiss-Prot:

ZN300_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF300: view

Function for ZNF300 Gene

Molecular function for ZNF300 Gene

UniProtKB/Swiss-Prot Function:
Has a transcriptional repressor activity.

Gene Ontology (GO) - Molecular Function for ZNF300 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23665872
genes like me logo Genes that share ontologies with ZNF300: view
genes like me logo Genes that share phenotypes with ZNF300: view

Animal Model Products

CRISPR Products

miRNA for ZNF300 Gene

miRTarBase miRNAs that target ZNF300

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF300 Gene

Localization for ZNF300 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF300 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF300 Gene COMPARTMENTS Subcellular localization image for ZNF300 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF300 Gene

Pathways & Interactions for ZNF300 Gene

SuperPathways for ZNF300 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF300: view

Pathways by source for ZNF300 Gene

2 Reactome pathways for ZNF300 Gene

Interacting Proteins for ZNF300 Gene

Gene Ontology (GO) - Biological Process for ZNF300 Gene

None

No data available for SIGNOR curated interactions for ZNF300 Gene

Drugs & Compounds for ZNF300 Gene

No Compound Related Data Available

Transcripts for ZNF300 Gene

Unigene Clusters for ZNF300 Gene

Zinc finger protein 300:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF300 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: - - - - -
SP7: - -
SP8:

Relevant External Links for ZNF300 Gene

GeneLoc Exon Structure for
ZNF300
ECgene alternative splicing isoforms for
ZNF300

Expression for ZNF300 Gene

mRNA expression in normal human tissues for ZNF300 Gene

Protein differential expression in normal tissues from HIPED for ZNF300 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF300 Gene



SOURCE GeneReport for Unigene cluster for ZNF300 Gene Hs.134885

mRNA Expression by UniProt/SwissProt for ZNF300 Gene

Q96RE9-ZN300_HUMAN
Tissue specificity: Expressed mostly in heart, skeletal muscle and brain. Isoform 1 and isoform 2 are highly expressed in testis.
genes like me logo Genes that share expression patterns with ZNF300: view

Protein tissue co-expression partners for ZNF300 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF300 Gene

Orthologs for ZNF300 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF300 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF300 35
  • 87.74 (n)
  • 85.02 (a)
ZNF300 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF300 35
  • 89.87 (n)
  • 87.31 (a)
ZNF300 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF300 35
  • 99.46 (n)
  • 99.19 (a)
ZNF300 36
  • 100 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS04929.3 37
  • 44 (a)
CG11902 37
  • 33 (a)
Species with no ortholog for ZNF300:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF300 Gene

ENSEMBL:
Gene Tree for ZNF300 (if available)
TreeFam:
Gene Tree for ZNF300 (if available)

Paralogs for ZNF300 Gene

(535) SIMAP similar genes for ZNF300 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF300 Gene

genes like me logo Genes that share paralogs with ZNF300: view

Variants for ZNF300 Gene

Sequence variations from dbSNP and Humsavar for ZNF300 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_012355 -
rs1478386 -- 150,904,138(+) TGTTT(C/G)GTCTT intron-variant
rs7716458 -- 150,906,963(+) tttag(G/T)ctctc upstream-variant-2KB
rs1947773 -- 150,905,389(+) GGGAA(A/T)TTGAT upstream-variant-2KB
rs7724036 -- 150,905,246(+) TTCGA(C/T)TGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF300 Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850
nsv428129 CNV Loss 18775914
dgv1863e1 CNV Complex 17122850
nsv883032 CNV Loss 21882294
nsv482091 CNV Loss 20164927
nsv10760 CNV Loss 18304495

Variation tolerance for ZNF300 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF300 Gene

Disorders for ZNF300 Gene

Relevant External Links for ZNF300

Genetic Association Database (GAD)
ZNF300
Human Genome Epidemiology (HuGE) Navigator
ZNF300
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF300

No disorders were found for ZNF300 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF300 Gene

Publications for ZNF300 Gene

  1. Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300. (PMID: 14746915) Gou D.-M. … Li W.-X. (Biochim. Biophys. Acta 2004) 2 3 4 67
  2. Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis. (PMID: 17541838) Cao Y. … Wu M. (DNA Seq. 2007) 3 23
  3. ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer. (PMID: 24393131) Gloss B. … Samimi G. (Mol. Cancer 2014) 3
  4. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W. … Huang Z. (Cell. Mol. Life Sci. 2013) 3
  5. Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway. (PMID: 21777376) Wang T. … Li W.X. (J. Cell. Mol. Med. 2012) 3

Products for ZNF300 Gene

Sources for ZNF300 Gene

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