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Aliases for CXorf40A Gene

Aliases for CXorf40A Gene

  • Chromosome X Open Reading Frame 40A 2 3 5
  • Endothelial-Overexpressed Lipopolysaccharide-Associated Factor 1 2 3 4
  • CXorf40 3 4
  • EOLA1 3 4
  • Chromosome X Open Reading Frame 40 2
  • FLJ16423 3

External Ids for CXorf40A Gene

Previous HGNC Symbols for CXorf40A Gene

  • CXorf40

Previous GeneCards Identifiers for CXorf40A Gene

  • GC0XP148328
  • GC0XP148432
  • GC0XP148623
  • GC0XP137575

Summaries for CXorf40A Gene

GeneCards Summary for CXorf40A Gene

CXorf40A (Chromosome X Open Reading Frame 40A) is a Protein Coding gene. An important paralog of this gene is CXorf40B.

UniProtKB/Swiss-Prot for CXorf40A Gene

  • May have an important role of cell protection in inflammation reaction.

Gene Wiki entry for CXorf40A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CXorf40A Gene

Genomics for CXorf40A Gene

Regulatory Elements for CXorf40A Gene

Enhancers for CXorf40A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CXorf40A on UCSC Golden Path with GeneCards custom track

Promoters for CXorf40A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CXorf40A on UCSC Golden Path with GeneCards custom track

Genomic Location for CXorf40A Gene

Chromosome:
X
Start:
149,540,355 bp from pter
End:
149,555,340 bp from pter
Size:
14,986 bases
Orientation:
Plus strand

Genomic View for CXorf40A Gene

Genes around CXorf40A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CXorf40A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CXorf40A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CXorf40A Gene

Proteins for CXorf40A Gene

  • Protein details for CXorf40A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE69-CX04A_HUMAN
    Recommended name:
    Protein CXorf40A
    Protein Accession:
    Q8TE69
    Secondary Accessions:
    • A8K784
    • B7Z6H6
    • B7ZL96
    • D6RA72
    • E7ENU3
    • Q2M3E9

    Protein attributes for CXorf40A Gene

    Size:
    158 amino acids
    Molecular mass:
    17921 Da
    Quaternary structure:
    • Interacts with MT2A.

    Alternative splice isoforms for CXorf40A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CXorf40A Gene

Proteomics data for CXorf40A Gene at MOPED

Post-translational modifications for CXorf40A Gene

No Post-translational modifications

No data available for DME Specific Peptides for CXorf40A Gene

Domains & Families for CXorf40A Gene

Protein Domains for CXorf40A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CXorf40A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CXorf40A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CXorf40A Gene

Function for CXorf40A Gene

Molecular function for CXorf40A Gene

UniProtKB/Swiss-Prot Function:
May have an important role of cell protection in inflammation reaction.

Phenotypes for CXorf40A Gene

genes like me logo Genes that share phenotypes with CXorf40A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CXorf40A Gene

Localization for CXorf40A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CXorf40A Gene

Pathways & Interactions for CXorf40A Gene

SuperPathways for CXorf40A Gene

No Data Available

Interacting Proteins for CXorf40A Gene

Selected Interacting proteins: Q8TE69-CX04A_HUMAN for CXorf40A Gene via UniProtKB I2D

Symbol External ID(s) Details
MT2A

Gene Ontology (GO) - Biological Process for CXorf40A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CXorf40A Gene

Drugs & Compounds for CXorf40A Gene

No Compound Related Data Available

Transcripts for CXorf40A Gene

Unigene Clusters for CXorf40A Gene

Chromosome X open reading frame 40A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CXorf40A Gene

No ASD Table

Relevant External Links for CXorf40A Gene

GeneLoc Exon Structure for
CXorf40A
ECgene alternative splicing isoforms for
CXorf40A

Expression for CXorf40A Gene

mRNA expression in normal human tissues for CXorf40A Gene

Protein differential expression in normal tissues from HIPED for CXorf40A Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CXorf40A Gene



SOURCE GeneReport for Unigene cluster for CXorf40A Gene Hs.534641

mRNA Expression by UniProt/SwissProt for CXorf40A Gene

Q8TE69-CX04A_HUMAN
Tissue specificity: Expressed primarily in heart, skeletal muscle, kidney, liver and placenta. Relatively high level of expression in spleen, colon and small intestine. Almost no expression in brain, thymus, lung and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with CXorf40A: view

Protein tissue co-expression partners for CXorf40A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CXorf40A Gene

Orthologs for CXorf40A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CXorf40A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CXHXorf40A 35
  • 80.38 (n)
  • 79.11 (a)
-- 36
  • 78 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 1110012L19Rik 35
  • 80.68 (n)
  • 77.07 (a)
1110012L19Rik 36
  • 78 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CXHXorf40A 35
  • 98.31 (n)
  • 97.47 (a)
-- 36
  • 97 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1562747 35
  • 81.53 (n)
  • 80.25 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 60 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC772269 35
  • 66.45 (n)
  • 67.32 (a)
-- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cxorf40a 35
  • 64.71 (n)
  • 64.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16160 35
zebrafish
(Danio rerio)
Actinopterygii zgc:110222 35
  • 56.75 (n)
  • 57.59 (a)
C21HXorf40A 36
  • 53 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1060 35
Species with no ortholog for CXorf40A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CXorf40A Gene

ENSEMBL:
Gene Tree for CXorf40A (if available)
TreeFam:
Gene Tree for CXorf40A (if available)

Paralogs for CXorf40A Gene

Paralogs for CXorf40A Gene

(1) SIMAP similar genes for CXorf40A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CXorf40A Gene

genes like me logo Genes that share paralogs with CXorf40A: view

Variants for CXorf40A Gene

Sequence variations from dbSNP and Humsavar for CXorf40A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs598 -- 149,554,560(+) CATGG(A/G)GGGGT utr-variant-3-prime
rs599 -- 149,554,585(+) GTTTC(C/T)GCAGT utr-variant-3-prime
rs600 -- 149,554,730(+) aaaaa(C/G)agaaa utr-variant-3-prime
rs7378 -- 149,547,013(-) AGGTG(C/T)CATGA intron-variant, utr-variant-3-prime
rs7379 -- 149,547,032(-) CGTCA(C/T)GATGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CXorf40A Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489

Variation tolerance for CXorf40A Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CXorf40A Gene

Disorders for CXorf40A Gene

Relevant External Links for CXorf40A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CXorf40A

No disorders were found for CXorf40A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CXorf40A Gene

Publications for CXorf40A Gene

  1. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. (PMID: 8717057) Timms K.M. … Gibbs R.A. (Genome Res. 1995) 2 3 4 67
  2. [Purification of human endothelial overexpressed lipopolysaccharide-associated factor 1 protein]. (PMID: 16383041) Cai Z. … Su Y.Y. (Zhonghua Shao Shang Za Zhi 2005) 2 3 23
  3. [The effect of inhibiting EOLA1 expression in ECV304 cells]. (PMID: 17557240) Liang Z.W. … Wang X.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 23
  4. [Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation]. (PMID: 16215939) Liang Z.W. … Luo X.D. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 3 23
  5. Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation. (PMID: 15541360) Liang Z. … Yang Z. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for CXorf40A Gene

Sources for CXorf40A Gene

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