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Aliases for COG7 Gene

Aliases for COG7 Gene

  • Component Of Oligomeric Golgi Complex 7 2 3 4
  • COG Complex Subunit 7 3 4
  • CDG2E 3 6
  • Conserved Oligomeric Golgi Complex Subunit 7 3

External Ids for COG7 Gene

Previous GeneCards Identifiers for COG7 Gene

  • GC16M022808
  • GC16M023487
  • GC16M023327
  • GC16M023366
  • GC16M021487

Summaries for COG7 Gene

Entrez Gene Summary for COG7 Gene

  • The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

GeneCards Summary for COG7 Gene

COG7 (Component Of Oligomeric Golgi Complex 7) is a Protein Coding gene. Diseases associated with COG7 include congenital disorder of glycosylation, type ii.

UniProtKB/Swiss-Prot for COG7 Gene

  • Required for normal Golgi function.

Gene Wiki entry for COG7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COG7 Gene

Genomics for COG7 Gene

Regulatory Elements for COG7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COG7 Gene

23,388,493 bp from pter
23,453,210 bp from pter
64,718 bases
Minus strand

Genomic View for COG7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COG7 Gene

Proteins for COG7 Gene

  • Protein details for COG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Conserved oligomeric Golgi complex subunit 7
    Protein Accession:
    Secondary Accessions:
    • Q6UWU7

    Protein attributes for COG7 Gene

    770 amino acids
    Molecular mass:
    86344 Da
    Quaternary structure:
    • Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
    • Sequence=AAQ88995.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COG7 Gene

Proteomics data for COG7 Gene at MOPED

Post-translational modifications for COG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COG7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COG7 Gene

Domains for COG7 Gene

Gene Families for COG7 Gene

Protein Domains for COG7 Gene


Suggested Antigen Peptide Sequences for COG7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COG7 family.
  • Belongs to the COG7 family.
genes like me logo Genes that share domains with COG7: view

Function for COG7 Gene

Molecular function for COG7 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi function.

Gene Ontology (GO) - Molecular Function for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15047703
genes like me logo Genes that share ontologies with COG7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COG7 Gene

Localization for COG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COG7 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for COG7 Gene COMPARTMENTS Subcellular localization image for COG7 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane --
GO:0017119 Golgi transport complex IDA 15047703
genes like me logo Genes that share ontologies with COG7: view

Pathways for COG7 Gene

SuperPathways for COG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IMP 15107842
GO:0006886 intracellular protein transport IMP 15107842
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 16420527
GO:0033365 protein localization to organelle IMP 16420527
GO:0034067 protein localization to Golgi apparatus IMP 16510524
genes like me logo Genes that share ontologies with COG7: view

No data available for Pathways by source for COG7 Gene

Transcripts for COG7 Gene

Unigene Clusters for COG7 Gene

Component of oligomeric golgi complex 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COG7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COG7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - - - -
SP3: - -
SP4: -
SP5: -

ExUns: 18b

Relevant External Links for COG7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COG7 Gene

mRNA expression in normal human tissues for COG7 Gene

Protein differential expression in normal tissues for COG7 Gene

This gene is overexpressed in Bone (51.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COG7 Gene

SOURCE GeneReport for Unigene cluster for COG7 Gene Hs.185807

genes like me logo Genes that share expressions with COG7: view

Expression partners for COG7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COG7 Gene

Orthologs for COG7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COG7 35
  • 89.13 (n)
  • 92.08 (a)
COG7 36
  • 92 (a)
(Canis familiaris)
Mammalia COG7 35
  • 89.65 (n)
  • 93.25 (a)
COG7 36
  • 93 (a)
(Mus musculus)
Mammalia Cog7 35
  • 88.05 (n)
  • 92.47 (a)
Cog7 16
Cog7 36
  • 92 (a)
(Pan troglodytes)
Mammalia COG7 35
  • 99.48 (n)
  • 99.61 (a)
COG7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cog7 35
  • 86.71 (n)
  • 91.43 (a)
(Monodelphis domestica)
Mammalia COG7 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia COG7 36
  • 85 (a)
(Gallus gallus)
Aves COG7 35
  • 74.71 (n)
  • 79.14 (a)
COG7 36
  • 79 (a)
(Anolis carolinensis)
Reptilia COG7 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cog7 35
  • 71.27 (n)
  • 75.91 (a)
Str.16611 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33970 35
(Danio rerio)
Actinopterygii cog7 35
  • 66.88 (n)
  • 70.8 (a)
cog7 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1624 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004439 35
  • 42.38 (n)
  • 28.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cog7 35
  • 43.76 (n)
  • 30.72 (a)
Cog7 36
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons EYE 35
  • 42.92 (n)
  • 29.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for COG7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COG7 Gene

Gene Tree for COG7 (if available)
Gene Tree for COG7 (if available)

Paralogs for COG7 Gene

No data available for Paralogs for COG7 Gene

Variants for COG7 Gene

Sequence variations from dbSNP and Humsavar for COG7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs30009 -- 23,412,766(-) GGAGG(C/T)TGAAG intron-variant
rs30010 -- 23,411,337(-) TGATG(C/G)GCACT intron-variant
rs30011 -- 23,410,873(-) CAAAA(A/C)TTAGC intron-variant
rs30012 -- 23,409,622(-) TGCCT(C/T)TATTC intron-variant
rs30013 -- 23,408,540(-) GACGG(A/G)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COG7 Gene

Variant ID Type Subtype PubMed ID
nsv1768 CNV Insertion 18451855

Relevant External Links for COG7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COG7 Gene

Disorders for COG7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for COG7 Gene in MalaCards »

(1) Disease for COG7 Gene

(1) OMIM Diseases for COG7 Gene (606978)


  • Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:15107842}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for COG7 Gene

Relevant External Links for COG7

genes like me logo Genes that share disorders with COG7: view

No data available for Novoseek inferred disease relationships and Genatlas for COG7 Gene

Publications for COG7 Gene

  1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. (PMID: 11980916) Ungar D. … Waters M.G. (J. Cell Biol. 2002) 2 3 4
  2. A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia. (PMID: 17356545) Morava E. … Wevers R.A. (Eur. J. Hum. Genet. 2007) 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder. (PMID: 15107842) Wu X. … Freeze H.H. (Nat. Med. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for COG7 Gene

Sources for COG7 Gene

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