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Aliases for ZBED1 Gene

Aliases for ZBED1 Gene

  • Zinc Finger BED-Type Containing 1 2 3
  • Zinc Finger, BED-Type Containing 1 3 5
  • Ac-Like Transposable Element 2 3
  • DREF Homolog 3 4
  • TRAMP 3 4
  • ALTE 3 4
  • DREF 3 4
  • BED-Type Zinc Finger Domain-Containing Protein 1 3
  • DNA Replication-Related Element Binding Factor 3
  • Putative Ac-Like Transposable Element 4
  • KIAA0785 4
  • HDREF 3

External Ids for ZBED1 Gene

Previous HGNC Symbols for ZBED1 Gene

  • ALTE

Previous GeneCards Identifiers for ZBED1 Gene

  • GC0XM001999
  • GC0YM002320
  • GC0XM002320
  • GC0XM002148
  • GC0XM000346

Summaries for ZBED1 Gene

Entrez Gene Summary for ZBED1 Gene

  • This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZBED1 Gene

ZBED1 (Zinc Finger BED-Type Containing 1) is a Protein Coding gene. Diseases associated with ZBED1 include Laryngostenosis. GO annotations related to this gene include nucleic acid binding and transposase activity. An important paralog of this gene is ZBED4.

UniProtKB/Swiss-Prot for ZBED1 Gene

  • Binds to 5-TGTCG[CT]GA[CT]A-3 DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.

Gene Wiki entry for ZBED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED1 Gene

Genomics for ZBED1 Gene

Regulatory Elements for ZBED1 Gene

Enhancers for ZBED1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZBED1 on UCSC Golden Path with GeneCards custom track

Promoters for ZBED1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZBED1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZBED1 Gene

Chromosome:
X
Start:
2,486,414 bp from pter
End:
2,500,967 bp from pter
Size:
14,554 bases
Orientation:
Minus strand

Genomic View for ZBED1 Gene

Genes around ZBED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZBED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZBED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED1 Gene

Proteins for ZBED1 Gene

  • Protein details for ZBED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96006-ZBED1_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 1
    Protein Accession:
    O96006
    Secondary Accessions:
    • Q96BY4

    Protein attributes for ZBED1 Gene

    Size:
    694 amino acids
    Molecular mass:
    78156 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
    SequenceCaution:
    • Sequence=BAA34505.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBED1 Gene

neXtProt entry for ZBED1 Gene

Proteomics data for ZBED1 Gene at MOPED

Post-translational modifications for ZBED1 Gene

  • Ubiquitination at Lys 113 and Lys 607
  • Modification sites at PhosphoSitePlus

Other Protein References for ZBED1 Gene

No data available for DME Specific Peptides for ZBED1 Gene

Domains & Families for ZBED1 Gene

Gene Families for ZBED1 Gene

Protein Domains for ZBED1 Gene

Suggested Antigen Peptide Sequences for ZBED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O96006

UniProtKB/Swiss-Prot:

ZBED1_HUMAN :
  • Contains 1 BED-type zinc finger.
Similarity:
  • Contains 1 BED-type zinc finger.
genes like me logo Genes that share domains with ZBED1: view

Function for ZBED1 Gene

Molecular function for ZBED1 Gene

UniProtKB/Swiss-Prot Function:
Binds to 5-TGTCG[CT]GA[CT]A-3 DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.
UniProtKB/Swiss-Prot Induction:
Expression is linked to the cell cycle: low in serum-starved fibroblasts, increasing during the G1/S phase, highest during the S/G2 phase and then decreasing again.

Gene Ontology (GO) - Molecular Function for ZBED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0004803 transposase activity TAS 9887332
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZBED1: view

Phenotypes for ZBED1 Gene

genes like me logo Genes that share phenotypes with ZBED1: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZBED1 Gene

Localization for ZBED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED1 Gene

Nucleus. Note=In granular structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED1 Gene COMPARTMENTS Subcellular localization image for ZBED1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZBED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ZBED1: view

Pathways & Interactions for ZBED1 Gene

SuperPathways for ZBED1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBED1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZBED1 Gene

Drugs & Compounds for ZBED1 Gene

No Compound Related Data Available

Transcripts for ZBED1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED1 Gene

No ASD Table

Relevant External Links for ZBED1 Gene

GeneLoc Exon Structure for
ZBED1
ECgene alternative splicing isoforms for
ZBED1

Expression for ZBED1 Gene

mRNA expression in normal human tissues for ZBED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZBED1 Gene

This gene is overexpressed in Placenta (21.1), Spleen (13.4), and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBED1 Gene



mRNA Expression by UniProt/SwissProt for ZBED1 Gene

O96006-ZBED1_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
genes like me logo Genes that share expression patterns with ZBED1: view

Protein tissue co-expression partners for ZBED1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ZBED1 Gene

Orthologs for ZBED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZBED1 35
  • 83.91 (n)
  • 81.27 (a)
ZBED1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZBED1 35
  • 87.9 (n)
  • 89.48 (a)
-- 36
  • 13 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZBED1 35
  • 98.87 (n)
  • 99.23 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBED1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBED1 35
  • 74.46 (n)
  • 84.13 (a)
ZBED1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBED1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495088 35
  • 67.87 (n)
  • 78.87 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101884285 35
  • 42.7 (n)
  • 29.72 (a)
CU570689.1 36
  • 25 (a)
OneToMany
ZBED1 (1 of 11) 36
  • 27 (a)
OneToMany
ZBED1 (10 of 11) 36
  • 20 (a)
OneToMany
ZBED1 (11 of 11) 36
  • 28 (a)
OneToMany
ZBED1 (3 of 11) 36
  • 25 (a)
OneToMany
ZBED1 (4 of 11) 36
  • 26 (a)
OneToMany
ZBED1 (5 of 11) 36
  • 27 (a)
OneToMany
ZBED1 (6 of 11) 36
  • 27 (a)
OneToMany
ZBED1 (7 of 11) 36
  • 27 (a)
OneToMany
ZBED1 (8 of 11) 36
  • 27 (a)
OneToMany
ZBED1 (9 of 11) 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0545.4 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.758 36
  • 24 (a)
OneToMany
Species with no ortholog for ZBED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED1 Gene

ENSEMBL:
Gene Tree for ZBED1 (if available)
TreeFam:
Gene Tree for ZBED1 (if available)

Paralogs for ZBED1 Gene

Paralogs for ZBED1 Gene

Pseudogenes.org Pseudogenes for ZBED1 Gene

genes like me logo Genes that share paralogs with ZBED1: view

Variants for ZBED1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED1 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv2432e1 CNV Complex 17122850
nsv9930 CNV Gain 18304495
nsv10010 CNV Gain 18304495

Variation tolerance for ZBED1 Gene

Residual Variation Intolerance Score: 1.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for ZBED1 Gene

Disorders for ZBED1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZBED1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngostenosis
  • stenosis of larynx
- elite association - COSMIC cancer census association via MalaCards
Search ZBED1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZBED1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZBED1
genes like me logo Genes that share disorders with ZBED1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZBED1 Gene

Publications for ZBED1 Gene

  1. A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. (PMID: 9887332) Esposito T. … Forabosco A. (Hum. Mol. Genet. 1999) 2 3 4 23 67
  2. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3
  3. hDREF regulates cell proliferation and expression of ribosomal protein genes. (PMID: 17220279) Yamashita D. … Hirose F. (Mol. Cell. Biol. 2007) 3 23
  4. Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. (PMID: 12663651) Ohshima N. … Hirose F. (J. Biol. Chem. 2003) 3 23
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3

Products for ZBED1 Gene

Sources for ZBED1 Gene

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