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Aliases for ZBED1 Gene

Aliases for ZBED1 Gene

  • Zinc Finger, BED-Type Containing 1 2 3
  • TRAMP 3 4 6
  • ALTE 3 4 6
  • Ac-Like Transposable Element 2 3
  • DREF Homolog 3 4
  • KIAA0785 4 6
  • DREF 3 4
  • BED-Type Zinc Finger Domain-Containing Protein 1 3
  • DNA Replication-Related Element Binding Factor 3
  • Zinc Finger BED Domain-Containing Protein 1 3
  • Putative Ac-Like Transposable Element 4
  • HDREF 3

External Ids for ZBED1 Gene

Previous Symbols for ZBED1 Gene

  • ALTE

Summaries for ZBED1 Gene

Entrez Gene Summary for ZBED1 Gene

  • This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ZBED1 Gene

ZBED1 (Zinc Finger, BED-Type Containing 1) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity and transposase activity. An important paralog of this gene is ZBED4.

UniProtKB/Swiss-Prot for ZBED1 Gene

  • Binds to 5-TGTCG[CT]GA[CT]A-3 DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.

Gene Wiki entry for ZBED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZBED1 Gene

Genomics for ZBED1 Gene

Genomic Location for ZBED1 Gene

Start:
2,486,414 bp from pter
End:
2,500,967 bp from pter
Size:
14,554 bases
Orientation:
Minus strand

Genomic View for ZBED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZBED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZBED1 Gene

No data available for Regulatory Elements for ZBED1 Gene

Proteins for ZBED1 Gene

  • Protein details for ZBED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96006-ZBED1_HUMAN
    Recommended name:
    Zinc finger BED domain-containing protein 1
    Protein Accession:
    O96006
    Secondary Accessions:
    • Q96BY4

    Protein attributes for ZBED1 Gene

    Size:
    694 amino acids
    Molecular mass:
    78156 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes
    SequenceCaution:
    • Sequence=BAA34505.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZBED1 Gene

neXtProt entry for ZBED1 Gene

Proteomics data for ZBED1 Gene at MOPED

Post-translational modifications for ZBED1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys113 and Lys607

Other Protein References for ZBED1 Gene

No data available for DME Specific Peptides for ZBED1 Gene

Domains for ZBED1 Gene

Gene Families for ZBED1 Gene

HGNC:
  • PAR1 :Pseudoautosomal regions / PAR1
  • ZBED :Zinc fingers, BED-type

Protein Domains for ZBED1 Gene

UniProtKB/Swiss-Prot:

ZBED1_HUMAN
Similarity:
  • Contains 1 BED-type zinc finger.:
    • O96006
genes like me logo Genes that share domains with ZBED1: view

Function for ZBED1 Gene

Molecular function for ZBED1 Gene

UniProtKB/Swiss-Prot Function: Binds to 5-TGTCG[CT]GA[CT]A-3 DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity.
UniProtKB/Swiss-Prot Induction: Expression is linked to the cell cycle: low in serum-starved fibroblasts, increasing during the G1/S phase, highest during the S/G2 phase and then decreasing again.

Gene Ontology (GO) - Molecular Function for ZBED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004803 transposase activity TAS 9887332
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZBED1: view

miRNA for ZBED1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZBED1 Gene

Localization for ZBED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZBED1 Gene

Nucleus. Note=In granular structures.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZBED1 Gene COMPARTMENTS Subcellular localization image for ZBED1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZBED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome TAS 9887332
genes like me logo Genes that share ontologies with ZBED1: view

Pathways for ZBED1 Gene

SuperPathways for ZBED1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZBED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process TAS 9887332
genes like me logo Genes that share ontologies with ZBED1: view

No data available for Pathways by source for ZBED1 Gene

Transcripts for ZBED1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZBED1 Gene

No ASD Table

Relevant External Links for ZBED1 Gene

GeneLoc Exon Structure for
ZBED1
ECgene alternative splicing isoforms for
ZBED1

Expression for ZBED1 Gene

mRNA expression in normal human tissues for ZBED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZBED1 Gene

mRNA Expression by UniProt/SwissProt for ZBED1 Gene

O96006-ZBED1_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta
genes like me logo Genes that share expressions with ZBED1: view

Orthologs for ZBED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZBED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZBED1 36
  • 98.87 (n)
  • 99.23 (a)
cow
(Bos Taurus)
Mammalia ZBED1 36
  • 83.91 (n)
  • 81.27 (a)
ZBED1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 13 (a)
ManyToMany
ZBED1 36
  • 87.9 (n)
  • 89.48 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ZBED1 37
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZBED1 36
  • 74.46 (n)
  • 84.13 (a)
ZBED1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZBED1 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495088 36
  • 67.87 (n)
  • 78.87 (a)
zebrafish
(Danio rerio)
Actinopterygii CU570689.1 37
  • 25 (a)
OneToMany
LOC101884285 36
  • 42.7 (n)
  • 29.72 (a)
ZBED1 (1 of 11) 37
  • 27 (a)
OneToMany
ZBED1 (10 of 11) 37
  • 20 (a)
OneToMany
ZBED1 (11 of 11) 37
  • 28 (a)
OneToMany
ZBED1 (3 of 11) 37
  • 25 (a)
OneToMany
ZBED1 (4 of 11) 37
  • 26 (a)
OneToMany
ZBED1 (5 of 11) 37
  • 27 (a)
OneToMany
ZBED1 (6 of 11) 37
  • 27 (a)
OneToMany
ZBED1 (7 of 11) 37
  • 27 (a)
OneToMany
ZBED1 (8 of 11) 37
  • 27 (a)
OneToMany
ZBED1 (9 of 11) 37
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0545.4 37
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.758 37
  • 24 (a)
OneToMany
Species with no ortholog for ZBED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZBED1 Gene

ENSEMBL:
Gene Tree for ZBED1 (if available)
TreeFam:
Gene Tree for ZBED1 (if available)

Paralogs for ZBED1 Gene

Paralogs for ZBED1 Gene

Pseudogenes.org Pseudogenes for ZBED1 Gene

genes like me logo Genes that share paralogs with ZBED1: view

Variants for ZBED1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZBED1 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv2432e1 CNV Complex 17122850
nsv9930 CNV Gain 18304495
nsv10010 CNV Gain 18304495

Relevant External Links for ZBED1 Gene

HapMap Linkage Disequilibrium report
ZBED1
Locus Specific Mutation Databases (LSDB)
ZBED1

No data available for Sequence variations from dbSNP and Humsavar for ZBED1 Gene

Disorders for ZBED1 Gene

No disorders were found for ZBED1 Gene.

No data available for UniProtKB/Swiss-Prot for ZBED1 Gene

Publications for ZBED1 Gene

  1. A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. (PMID: 9887332) Esposito T. … Forabosco A. (Hum. Mol. Genet. 1999) 2 3 4 23
  2. Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. (PMID: 12663651) Ohshima N. … Hirose F. (J. Biol. Chem. 2003) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  4. ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions. (PMID: 23533661) Hayward A. … Jern P. (PLoS ONE 2013) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZBED1 Gene

Sources for ZBED1 Gene

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