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Aliases for CD3G Gene

Aliases for CD3G Gene

  • CD3g Molecule 2 3 5
  • CD3g Antigen, Gamma Polypeptide (TiT3 Complex) 2 3
  • CD3g Molecule, Gamma (CD3-TCR Complex) 2 3
  • T-Cell Receptor T3 Gamma Chain 3 4
  • T3G 3 4
  • T-Cell Antigen Receptor Complex, Gamma Subunit Of T3 3
  • T-Cell Surface Glycoprotein CD3 Gamma Chain 3
  • CD3g Molecule, Epsilon (CD3-TCR Complex) 3
  • CD3g Antigen 4
  • CD3-GAMMA 3
  • IMD17 3

External Ids for CD3G Gene

Previous GeneCards Identifiers for CD3G Gene

  • GC11P120571
  • GC11P119726
  • GC11P118248
  • GC11P117752
  • GC11P117720
  • GC11P114148

Summaries for CD3G Gene

Entrez Gene Summary for CD3G Gene

  • The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD3G Gene

CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17, Cd3 Gamma Deficient and Immunodeficiency Due To Defect In Cd3-Gamma. Among its related pathways are Hematopoietic cell lineage and G-protein signaling N-RAS regulation pathway. GO annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.

UniProtKB/Swiss-Prot for CD3G Gene

  • The CD3 complex mediates signal transduction.

Gene Wiki entry for CD3G Gene

Additional gene information for CD3G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD3G Gene

Genomics for CD3G Gene

Regulatory Elements for CD3G Gene

Enhancers for CD3G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H118309 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.6 -29.2 -29216 11 HDGF PKNOX1 FOXA2 ATF1 ARNT FEZF1 ZNF766 CBX5 GATA2 ZNF143 CD3G CD3D MPZL3 UBE4A KMT2A CD3E ENSG00000255384 HMBS ARCN1 ENSG00000271751
GH11H117949 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -392.5 -392525 5.4 HDAC1 HDGF FOXA2 PKNOX1 NFIB TBL1XR1 RAD21 ZNF766 GATA2 ATF7 IL10RA TMPRSS13 CD3E CD3G DSCAML1 ENSG00000254844 FXYD6 FXYD6-FXYD2 ENSG00000254528 FXYD2
GH11H118210 1.5 Ensembl ENCODE dbSUPER 12 -129.9 -129933 8 HDGF FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ZNF143 ATF7 RUNX3 MPZL3 JAML CD3D CD3G CD3E MPZL2 GC11M118201 HSPE1P18
GH11H118321 1.3 Ensembl ENCODE dbSUPER 13.3 -22.6 -22608 1.4 HDAC1 FOXA2 ZBTB40 RAD21 RFX5 YY1 TCF12 RCOR1 ELF1 REST CD3D CD3G ENSG00000255384 KMT2A IFT46 ENSG00000254992 CD3E
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD3G on UCSC Golden Path with GeneCards custom track

Genomic Locations for CD3G Gene

Genomic Locations for CD3G Gene
10,846 bases
Plus strand

Genomic View for CD3G Gene

Genes around CD3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD3G Gene

Proteins for CD3G Gene

  • Protein details for CD3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell surface glycoprotein CD3 gamma chain
    Protein Accession:
    Secondary Accessions:
    • Q2HIZ6

    Protein attributes for CD3G Gene

    182 amino acids
    Molecular mass:
    20469 Da
    Quaternary structure:
    • The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

    Three dimensional structures from OCA and Proteopedia for CD3G Gene

neXtProt entry for CD3G Gene

Post-translational modifications for CD3G Gene

  • Ubiquitination at posLast=3232, Lys79, Lys93, posLast=9595, posLast=150150, and posLast=164164
  • Glycosylation at Asn52 and posLast=9292
  • Modification sites at PhosphoSitePlus

Other Protein References for CD3G Gene

No data available for DME Specific Peptides for CD3G Gene

Domains & Families for CD3G Gene

Gene Families for CD3G Gene

Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
  • A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.
genes like me logo Genes that share domains with CD3G: view

Function for CD3G Gene

Molecular function for CD3G Gene

GENATLAS Biochemistry:
cell differentiation antigen CD3G (gp26),,gamma polypeptide (see CD3@),including an alternative splicing product pTAC12,component of the pre-T cell antigen receptor complex
UniProtKB/Swiss-Prot Function:
The CD3 complex mediates signal transduction.

Phenotypes From GWAS Catalog for CD3G Gene

Gene Ontology (GO) - Molecular Function for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 12794121
GO:0030159 receptor signaling complex scaffold activity NAS 12794121
GO:0042608 T cell receptor binding NAS 11186279
GO:0042803 protein homodimerization activity IMP 14967045
GO:0046982 protein heterodimerization activity IPI 9485181
genes like me logo Genes that share ontologies with CD3G: view
genes like me logo Genes that share phenotypes with CD3G: view

Human Phenotype Ontology for CD3G Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD3G Gene

MGI Knock Outs for CD3G:

miRNA for CD3G Gene

miRTarBase miRNAs that target CD3G

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD3G Gene

Localization for CD3G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD3G Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD3G gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
golgi apparatus 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 9485181
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030665 clathrin-coated vesicle membrane TAS --
genes like me logo Genes that share ontologies with CD3G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD3G Gene

Pathways & Interactions for CD3G Gene

genes like me logo Genes that share pathways with CD3G: view

SIGNOR curated interactions for CD3G Gene


Gene Ontology (GO) - Biological Process for CD3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 12794121
GO:0007163 establishment or maintenance of cell polarity IMP 12407027
GO:0007166 cell surface receptor signaling pathway IMP,IEA 12407027
GO:0015031 protein transport IMP 12794121
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD3G: view

Drugs & Compounds for CD3G Gene

(9) Drugs for CD3G Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Muromonab Approved, Investigational Pharma binder, Target 0
Otelixizumab Investigational Pharma antibody 0
Visilizumab Investigational Pharma 0
Catumaxomab Pharma Antibody Others 0
genes like me logo Genes that share compounds with CD3G: view

Transcripts for CD3G Gene

Unigene Clusters for CD3G Gene

CD3g molecule, gamma (CD3-TCR complex):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD3G Gene

No ASD Table

Relevant External Links for CD3G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD3G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD3G Gene

This gene is overexpressed in Whole Blood (x22.0), Spleen (x7.1), and Small Intestine - Terminal Ileum (x5.8).

Protein differential expression in normal tissues from HIPED for CD3G Gene

This gene is overexpressed in CD4 Tcells (26.1), CD8 Tcells (21.0), Peripheral blood mononuclear cells (9.8), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD3G Gene

Protein tissue co-expression partners for CD3G Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD3G Gene:


SOURCE GeneReport for Unigene cluster for CD3G Gene:


Evidence on tissue expression from TISSUES for CD3G Gene

  • Blood(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD3G Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
Head and neck:
  • brain
  • head
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with CD3G: view

No data available for mRNA Expression by UniProt/SwissProt for CD3G Gene

Orthologs for CD3G Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD3G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD3G 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia CD3G 33 34
  • 80.77 (n)
(Bos Taurus)
Mammalia CD3G 33 34
  • 80.15 (n)
(Mus musculus)
Mammalia Cd3g 33 16 34
  • 79.56 (n)
(Rattus norvegicus)
Mammalia Cd3g 33
  • 79.19 (n)
(Monodelphis domestica)
Mammalia CD3G 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia CD3G 34
  • 53 (a)
(Gallus gallus)
Aves CD3D 34
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
Species where no ortholog for CD3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD3G Gene

Gene Tree for CD3G (if available)
Gene Tree for CD3G (if available)

Paralogs for CD3G Gene

Paralogs for CD3G Gene

(1) SIMAP similar genes for CD3G Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CD3G: view

Variants for CD3G Gene

Sequence variations from dbSNP and Humsavar for CD3G Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs104894199 Pathogenic 118,344,424(+) CTGAC(A/G)TGGAA upstream-variant-2KB, reference, missense
rs199676861 Pathogenic 118,349,868(+) AAGAT(A/T)AAAAA reference, stop-gained
rs483352927 Pathogenic 118,349,743(+) TTCAG(-/GAAACCACTTGGTTAAG)GTGTA reference, frameshift-variant
rs150376137 Likely benign 118,344,361(+) GCTGG(-/GGCT)CTGCT upstream-variant-2KB, utr-variant-5-prime
rs3753058 Likely benign 118,350,635(-) CCCAA(A/C)AGCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CD3G Gene

Variant ID Type Subtype PubMed ID
nsv820176 CNV loss 19587683

Variation tolerance for CD3G Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.80; 91.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD3G Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD3G Gene

Disorders for CD3G Gene

MalaCards: The human disease database

(11) MalaCards diseases for CD3G Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD3G in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 17 (IMD17) [MIM:615607]: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. {ECO:0000269 PubMed:1635567, ECO:0000269 PubMed:17277165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CD3G Gene

immunodeficiency,severe,combined,defect in surface expression of T-cell receptor-CD3 complex and defective signal transduction,through the TCR

Relevant External Links for CD3G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CD3G: view

Publications for CD3G Gene

  1. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PMID: 20478055) Brophy K … McManus R (BMC medical genetics 2010) 3 45 60
  2. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S … Plenge RM (Nature genetics 2009) 3 45 60
  3. Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing. (PMID: 17822534) Akl H … Willard-Gallo KE (Virology journal 2007) 3 22 60
  4. Transcriptional regulation of the human CD3 gamma gene: the TATA-less CD3 gamma promoter functions via an initiator and contiguous Sp-binding elements. (PMID: 15879122) Badran BM … Willard-Gallo KE (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 22 60
  5. Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. (PMID: 14967045) Sigalov A … Stern L (Biochemistry 2004) 3 22 60

Products for CD3G Gene

Sources for CD3G Gene

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