Aliases for CD3G Gene
External Ids for CD3G Gene
Previous GeneCards Identifiers for CD3G Gene
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD3G Gene
CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17, Cd3 Gamma Deficient and Immunodeficiency Due To Defect In Cd3-Gamma. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.
UniProtKB/Swiss-Prot for CD3G Gene
The CD3 complex mediates signal transduction.