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Aliases for NLRP12 Gene

Aliases for NLRP12 Gene

  • NLR Family, Pyrin Domain Containing 12 2 3 5
  • PYRIN-Containing APAF1-Like Protein 7 3 4
  • Regulated By Nitric Oxide 3 4
  • PYPAF7 3 4
  • NALP12 3 4
  • RNO 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 12 3
  • Leucine Rich Repeat And Pyrin Domain Containing 12 2
  • NACHT, Leucine Rich Repeat And PYD Containing 12 2
  • Nucleotide-Binding Oligomerization Domain 2
  • Monarch 1 3
  • Monarch-1 4
  • CLR19.3 3
  • FCAS2 3
  • PAN6 3
  • RNO2 3

External Ids for NLRP12 Gene

Previous HGNC Symbols for NLRP12 Gene

  • NALP12

Previous GeneCards Identifiers for NLRP12 Gene

  • GC19M058989
  • GC19M054296
  • GC19M050616

Summaries for NLRP12 Gene

Entrez Gene Summary for NLRP12 Gene

  • This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for NLRP12 Gene

NLRP12 (NLR Family, Pyrin Domain Containing 12) is a Protein Coding gene. Diseases associated with NLRP12 include Familial Cold Autoinflammatory Syndrome 2 and Nlrp12-Associated Hereditary Periodic Fever Syndrome. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include cysteine-type endopeptidase activator activity involved in apoptotic process. An important paralog of this gene is NLRP7.

UniProtKB/Swiss-Prot for NLRP12 Gene

  • May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.

Gene Wiki entry for NLRP12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP12 Gene

Genomics for NLRP12 Gene

Regulatory Elements for NLRP12 Gene

Enhancers for NLRP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NLRP12 on UCSC Golden Path with GeneCards custom track

Promoters for NLRP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NLRP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for NLRP12 Gene

53,793,584 bp from pter
53,824,403 bp from pter
30,820 bases
Minus strand

Genomic View for NLRP12 Gene

Genes around NLRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP12 Gene

Proteins for NLRP12 Gene

  • Protein details for NLRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 12
    Protein Accession:
    Secondary Accessions:
    • A8MTQ2
    • B3KTE7
    • Q8NEU4
    • Q9BY26

    Protein attributes for NLRP12 Gene

    1061 amino acids
    Molecular mass:
    120173 Da
    Quaternary structure:
    • Binds to ASC with its pyrin domain. Interacts with FAF1 UBA domain via its pyrin domain.

    Three dimensional structures from OCA and Proteopedia for NLRP12 Gene

    Alternative splice isoforms for NLRP12 Gene

neXtProt entry for NLRP12 Gene

Proteomics data for NLRP12 Gene at MOPED

Post-translational modifications for NLRP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP12 Gene

Antibody Products

No data available for DME Specific Peptides for NLRP12 Gene

Domains & Families for NLRP12 Gene

Gene Families for NLRP12 Gene

Suggested Antigen Peptide Sequences for NLRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NACHT domain.
  • Belongs to the NLRP family.
  • Contains 8 LRR (leucine-rich) repeats.
  • Contains 1 NACHT domain.
  • Contains 1 pyrin domain.
  • Belongs to the NLRP family.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NLRP12: view

Function for NLRP12 Gene

Molecular function for NLRP12 Gene

UniProtKB/Swiss-Prot Function:
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
UniProtKB/Swiss-Prot Induction:
By nitric oxide and DMSO in HL-60 cells, an acute myeloid leukemia cell line.
genes like me logo Genes that share phenotypes with NLRP12: view

Human Phenotype Ontology for NLRP12 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NLRP12 Gene

MGI Knock Outs for NLRP12:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for NLRP12 Gene

Localization for NLRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP12 Gene


Subcellular locations from

Jensen Localization Image for NLRP12 Gene COMPARTMENTS Subcellular localization image for NLRP12 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NLRP12 Gene

Pathways & Interactions for NLRP12 Gene

genes like me logo Genes that share pathways with NLRP12: view

Pathways by source for NLRP12 Gene

1 BioSystems pathway for NLRP12 Gene
1 R&D Systems pathway for NLRP12 Gene

Gene Ontology (GO) - Biological Process for NLRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 12019269
GO:0009968 negative regulation of signal transduction IDA 16203735
GO:0031953 negative regulation of protein autophosphorylation IDA 16203735
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 18230725
GO:0036336 dendritic cell migration IEA --
genes like me logo Genes that share ontologies with NLRP12: view

No data available for SIGNOR curated interactions for NLRP12 Gene

Drugs & Compounds for NLRP12 Gene

(6) Drugs for NLRP12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NLRP12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NLRP12: view

Transcripts for NLRP12 Gene

Unigene Clusters for NLRP12 Gene

NLR family, pyrin domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP3: -
SP4: - -

Relevant External Links for NLRP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP12 Gene

mRNA expression in normal human tissues for NLRP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP12 Gene

This gene is overexpressed in Whole Blood (x47.4).

Protein differential expression in normal tissues from HIPED for NLRP12 Gene

This gene is overexpressed in Testis (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NLRP12 Gene

SOURCE GeneReport for Unigene cluster for NLRP12 Gene Hs.631573

mRNA Expression by UniProt/SwissProt for NLRP12 Gene

Tissue specificity: Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
genes like me logo Genes that share expression patterns with NLRP12: view

Protein tissue co-expression partners for NLRP12 Gene

Primer Products

Orthologs for NLRP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NLRP12 35
  • 80.66 (n)
  • 77.96 (a)
NLRP12 36
  • 78 (a)
(Canis familiaris)
Mammalia NLRP12 35
  • 83.02 (n)
  • 80.57 (a)
-- 36
  • 80 (a)
-- 36
  • 82 (a)
(Mus musculus)
Mammalia Nlrp12 35
  • 76.31 (n)
  • 73.06 (a)
Nlrp12 16
Nlrp12 36
  • 73 (a)
(Pan troglodytes)
Mammalia NLRP12 35
  • 99.12 (n)
  • 98.58 (a)
NLRP12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nlrp12 35
  • 77.51 (n)
  • 75.24 (a)
(Monodelphis domestica)
Mammalia NLRP12 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia NLRP12 36
  • 53 (a)
(Gallus gallus)
Aves -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
(Danio rerio)
Actinopterygii CABZ01068060.1 36
  • 16 (a)
CABZ01071909.1 36
  • 18 (a)
CU693495.1 36
  • 24 (a)
nlrb5 36
  • 24 (a)
si:ch211-66k16.2 36
  • 27 (a)
si:ch211-66k16.28 36
  • 17 (a)
Species with no ortholog for NLRP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRP12 Gene

Gene Tree for NLRP12 (if available)
Gene Tree for NLRP12 (if available)

Paralogs for NLRP12 Gene

(14) SIMAP similar genes for NLRP12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NLRP12: view

Variants for NLRP12 Gene

Sequence variations from dbSNP and Humsavar for NLRP12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34436714 - 53,824,059(+) CTTCT(A/C)CCAGC reference, missense
rs34971363 - 53,810,453(+) GGGAC(C/G)AAGCA reference, missense
rs7258561 -- 53,801,448(+) ttttt(C/T)ttttt intron-variant
rs7258858 -- 53,818,618(+) cgaga(A/T)cgcac intron-variant
rs7260563 -- 53,819,150(+) CTATA(C/T)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP12 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
nsv912388 CNV Gain 21882294
esv2666040 CNV Deletion 23128226
esv1103808 CNV Insertion 17803354

Variation tolerance for NLRP12 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.08; 92.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NLRP12 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP12 Gene

Disorders for NLRP12 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NLRP12 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards


  • Familial cold autoinflammatory syndrome 2 (FCAS2) [MIM:611762]: A rare autosomal dominant systemic inflammatory disease characterized by recurrent episodes of maculopapular rash associated with arthralgias, myalgias, fever and chills, swelling of the extremities, and conjunctivitis after generalized exposure to cold. {ECO:0000269 PubMed:18230725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NLRP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NLRP12: view

No data available for Genatlas for NLRP12 Gene

Publications for NLRP12 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J. … Burns K. (Nat. Rev. Mol. Cell Biol. 2003) 2 3 4 67
  2. Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. (PMID: 19234190) Lord C.A. … Williams K.L. (J. Immunol. 2009) 3 23
  3. Inflammasome mRNA expression in human monocytes during early septic shock. (PMID: 18263805) Fahy R.J. … Wewers M.D. (Am. J. Respir. Crit. Care Med. 2008) 3 23
  4. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PMID: 12019269) Wang L. … Bertin J. (J. Biol. Chem. 2002) 2 3
  5. Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders. (PMID: 26122175) van Schouwenburg P.A. … Patel S.Y. (Clin. Immunol. 2015) 3

Products for NLRP12 Gene

Sources for NLRP12 Gene