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Aliases for FIBP Gene

Aliases for FIBP Gene

  • Fibroblast Growth Factor (Acidic) Intracellular Binding Protein 2 3
  • FGF-1 Intracellular-Binding Protein 3 4
  • AFGF Intracellular-Binding Protein 3 4
  • FGFIBP 3
  • FIBP-1 3

External Ids for FIBP Gene

Previous GeneCards Identifiers for FIBP Gene

  • GC11M068185
  • GC11M067333
  • GC11M065426
  • GC11M065407
  • GC11M065651
  • GC11M061977

Summaries for FIBP Gene

Entrez Gene Summary for FIBP Gene

  • Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIBP Gene

FIBP (Fibroblast Growth Factor (Acidic) Intracellular Binding Protein) is a Protein Coding gene. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FIBP Gene

  • May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Wiki entry for FIBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBP Gene

Genomics for FIBP Gene

Regulatory Elements for FIBP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FIBP Gene

Chromosome:
11
Start:
65,883,740 bp from pter
End:
65,888,539 bp from pter
Size:
4,800 bases
Orientation:
Minus strand

Genomic View for FIBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FIBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBP Gene

Proteins for FIBP Gene

  • Protein details for FIBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43427-FIBP_HUMAN
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Protein Accession:
    O43427
    Secondary Accessions:
    • A8K0J7
    • Q27Q85
    • Q6IBQ3
    • Q9HD65

    Protein attributes for FIBP Gene

    Size:
    364 amino acids
    Molecular mass:
    41878 Da
    Quaternary structure:
    • Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1

    Alternative splice isoforms for FIBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIBP Gene

Proteomics data for FIBP Gene at MOPED

Post-translational modifications for FIBP Gene

  • Ubiquitination at Lys 245, Lys 251, and Lys 268
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBP Gene

Antibody Products

No data available for DME Specific Peptides for FIBP Gene

Domains & Families for FIBP Gene

Protein Domains for FIBP Gene

Suggested Antigen Peptide Sequences for FIBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FIBP Gene

Function for FIBP Gene

Molecular function for FIBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Ontology (GO) - Molecular Function for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IPI 9806903
genes like me logo Genes that share ontologies with FIBP: view

Phenotypes for FIBP Gene

GenomeRNAi human phenotypes for FIBP:
genes like me logo Genes that share phenotypes with FIBP: view

Animal Model Products

miRNA for FIBP Gene

miRTarBase miRNAs that target FIBP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIBP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBP Gene

Localization for FIBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBP Gene

Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FIBP Gene COMPARTMENTS Subcellular localization image for FIBP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9806903
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion TAS 9806903
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 9806903
genes like me logo Genes that share ontologies with FIBP: view

Pathways & Interactions for FIBP Gene

SuperPathways for FIBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS 9806903
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with FIBP: view

No data available for Pathways by source and SIGNOR curated interactions for FIBP Gene

Drugs & Compounds for FIBP Gene

(2) Drugs for FIBP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
serine Nutra 420

(2) Additional Compounds for FIBP Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
Steroid
genes like me logo Genes that share compounds with FIBP: view

Transcripts for FIBP Gene

Unigene Clusters for FIBP Gene

Fibroblast growth factor (acidic) intracellular binding protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FIBP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c ^ 12
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FIBP Gene

GeneLoc Exon Structure for
FIBP
ECgene alternative splicing isoforms for
FIBP

Expression for FIBP Gene

mRNA expression in normal human tissues for FIBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIBP Gene

This gene is overexpressed in Brain (15.8), Peripheral blood mononuclear cells (9.7), and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FIBP Gene



SOURCE GeneReport for Unigene cluster for FIBP Gene Hs.7768

mRNA Expression by UniProt/SwissProt for FIBP Gene

O43427-FIBP_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney
genes like me logo Genes that share expression patterns with FIBP: view

Protein tissue co-expression partners for FIBP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FIBP Gene

Orthologs for FIBP Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FIBP 35
  • 92.06 (n)
  • 98.88 (a)
FIBP 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FIBP 35
  • 92.4 (n)
  • 98.08 (a)
FIBP 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fibp 35
  • 90.75 (n)
  • 97.25 (a)
Fibp 16
Fibp 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FIBP 35
  • 99.54 (n)
  • 100 (a)
FIBP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fibp 35
  • 89.08 (n)
  • 95.8 (a)
oppossum
(Monodelphis domestica)
Mammalia FIBP 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fibp 35
  • 68.54 (n)
  • 76.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3720 35
zebrafish
(Danio rerio)
Actinopterygii fibpa 35
  • 69.09 (n)
  • 72.27 (a)
zgc64086 35
fibpa 36
  • 73 (a)
OneToMany
fibpb 36
  • 71 (a)
OneToMany
fibpb 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Fibp 37
  • 45 (a)
Fibp 35
  • 53.75 (n)
  • 47.56 (a)
Fibp 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002269 35
  • 54.79 (n)
  • 45.11 (a)
Species with no ortholog for FIBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBP Gene

ENSEMBL:
Gene Tree for FIBP (if available)
TreeFam:
Gene Tree for FIBP (if available)

Paralogs for FIBP Gene

Pseudogenes.org Pseudogenes for FIBP Gene

genes like me logo Genes that share paralogs with FIBP: view

No data available for Paralogs for FIBP Gene

Variants for FIBP Gene

Sequence variations from dbSNP and Humsavar for FIBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs568617 -- 65,885,771(+) TGCCT(C/T)AAGTC intron-variant
rs641018 -- 65,887,922(-) ACCCT(C/G)TGGGA intron-variant
rs658938 -- 65,884,359(+) GGCAA(A/G)GCCAA intron-variant
rs663491 -- 65,886,252(+) TTGGG(C/G)TAGGG intron-variant
rs677835 -- 65,887,122(+) GGTCA(C/T)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FIBP Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897

Variation tolerance for FIBP Gene

Residual Variation Intolerance Score: 34.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIBP Gene

HapMap Linkage Disequilibrium report
FIBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBP Gene

Disorders for FIBP Gene

Relevant External Links for FIBP

Genetic Association Database (GAD)
FIBP
Human Genome Epidemiology (HuGE) Navigator
FIBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIBP
genes like me logo Genes that share disorders with FIBP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIBP Gene

Publications for FIBP Gene

  1. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S. … Chen J. (Mol. Cell Proteomics 2014) 2 67
  2. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PMID: 19411256) Liu R. … Chen C. (J. Biol. Chem. 2009) 23 67
  3. Expression of fibroblast growth factor binding protein in head and neck cancer. (PMID: 19770422) Li W. … Lin J. (Arch. Otolaryngol. Head Neck Surg. 2009) 23 67
  4. An attempt to understand kidney's protein handling function by comparing plasma and urine proteomes. (PMID: 19381340) Jia L. … Gao Y. (PLoS ONE 2009) 23 67
  5. Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction. (PMID: 19591553) Baker MAcio M.D. … Moura A.S. (J Perinat Med 2009) 23 67

Products for FIBP Gene

Sources for FIBP Gene

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