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Aliases for FIBP Gene

Aliases for FIBP Gene

  • FGF1 Intracellular Binding Protein 2 3 5
  • AFGF Intracellular-Binding Protein 3 4
  • Fibroblast Growth Factor (Acidic) Intracellular Binding Protein 2
  • Acidic Fibroblast Growth Factor Intracellular-Binding Protein 3
  • FGF-1 Intracellular-Binding Protein 4
  • FGFIBP 3
  • FIBP-1 3
  • TROFAS 3

External Ids for FIBP Gene

Previous GeneCards Identifiers for FIBP Gene

  • GC11M068185
  • GC11M067333
  • GC11M065426
  • GC11M065407
  • GC11M065651
  • GC11M061977

Summaries for FIBP Gene

Entrez Gene Summary for FIBP Gene

  • Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIBP Gene

FIBP (FGF1 Intracellular Binding Protein) is a Protein Coding gene. Diseases associated with FIBP include Coloboma, Ocular and Learning Disability. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FIBP Gene

  • May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Wiki entry for FIBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBP Gene

Genomics for FIBP Gene

Regulatory Elements for FIBP Gene

Enhancers for FIBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065927 1.6 FANTOM5 Ensembl ENCODE 12.4 -39.7 -39706 2.4 HDGF FOXA2 TCF12 ZNF766 ZNF143 ZNF592 ZNF579 NFIL3 CREB3 SMARCA4 EIF1AD CST6 CCDC85B FIBP CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11G065940 1.2 Ensembl ENCODE 11.7 -52.8 -52830 2.0 PKNOX1 ATF1 ARNT TCF12 GATA2 ELK1 FOS ZNF263 NCOA1 RFX3 SART1 C11orf68 DRAP1 FOSL1 FIBP CCDC85B CTSW EFEMP2 CFL1 BANF1
GH11G065945 1.1 Ensembl ENCODE 11.2 -57.3 -57257 1.2 HDGF PKNOX1 ATF1 ZNF76 RARA ZNF121 SCRT2 IKZF2 SP3 ZBTB11 C11orf68 DRAP1 FOSL1 EIF1AD BANF1 CST6 CTSW EFEMP2 CFL1 MUS81
GH11G065811 1 Ensembl ENCODE 10.9 +76.3 76333 2.0 CTCF PKNOX1 ATF1 AGO1 ZNF223 CEBPG EBF1 BCL11B NCOR1 POLR2A SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 FIBP CCDC85B
GH11G065910 1.8 FANTOM5 ENCODE dbSUPER 5.2 -27.2 -27189 11.4 MLX AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 GLIS1 LOC105369352 ZFPL1 ENSG00000258297 RBM14 MUS81 KAT5 DPF2 ENSG00000254461 RNASEH2C EIF1AD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FIBP on UCSC Golden Path with GeneCards custom track

Promoters for FIBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040903 -161 1401 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for FIBP Gene

Chromosome:
11
Start:
65,883,740 bp from pter
End:
65,888,539 bp from pter
Size:
4,800 bases
Orientation:
Minus strand

Genomic View for FIBP Gene

Genes around FIBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBP Gene

Proteins for FIBP Gene

  • Protein details for FIBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43427-FIBP_HUMAN
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Protein Accession:
    O43427
    Secondary Accessions:
    • A8K0J7
    • Q27Q85
    • Q6IBQ3
    • Q9HD65

    Protein attributes for FIBP Gene

    Size:
    364 amino acids
    Molecular mass:
    41878 Da
    Quaternary structure:
    • Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

    Alternative splice isoforms for FIBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIBP Gene

Post-translational modifications for FIBP Gene

  • Ubiquitination at isoforms=2245, isoforms=2251, and Lys268
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBP Gene

No data available for DME Specific Peptides for FIBP Gene

Domains & Families for FIBP Gene

Protein Domains for FIBP Gene

Suggested Antigen Peptide Sequences for FIBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FIBP Gene

Function for FIBP Gene

Molecular function for FIBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Ontology (GO) - Molecular Function for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IPI,IEA 9806903
genes like me logo Genes that share ontologies with FIBP: view

Phenotypes for FIBP Gene

GenomeRNAi human phenotypes for FIBP:
genes like me logo Genes that share phenotypes with FIBP: view

Animal Model Products

CRISPR Products

miRNA for FIBP Gene

miRTarBase miRNAs that target FIBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBP Gene

Localization for FIBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBP Gene

Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIBP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9806903
GO:0005739 mitochondrion TAS 9806903
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 9806903
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FIBP: view

Pathways & Interactions for FIBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS 9806903
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with FIBP: view

No data available for Pathways by source and SIGNOR curated interactions for FIBP Gene

Drugs & Compounds for FIBP Gene

(2) Drugs for FIBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FIBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FIBP: view

Transcripts for FIBP Gene

Unigene Clusters for FIBP Gene

Fibroblast growth factor (acidic) intracellular binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FIBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13: -

ExUns: 11a · 11b · 11c ^ 12
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FIBP Gene

GeneLoc Exon Structure for
FIBP
ECgene alternative splicing isoforms for
FIBP

Expression for FIBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIBP Gene

This gene is overexpressed in Brain (15.8), Peripheral blood mononuclear cells (9.7), and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FIBP Gene



Protein tissue co-expression partners for FIBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIBP Gene:

FIBP

SOURCE GeneReport for Unigene cluster for FIBP Gene:

Hs.7768

mRNA Expression by UniProt/SwissProt for FIBP Gene:

O43427-FIBP_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.

Evidence on tissue expression from TISSUES for FIBP Gene

  • Nervous system(4.8)
  • Heart(4.3)
  • Lung(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FIBP: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIBP Gene

Orthologs for FIBP Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIBP 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia FIBP 34 35
  • 92.4 (n)
cow
(Bos Taurus)
Mammalia FIBP 34 35
  • 92.06 (n)
oppossum
(Monodelphis domestica)
Mammalia FIBP 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fibp 34 16 35
  • 90.75 (n)
rat
(Rattus norvegicus)
Mammalia Fibp 34
  • 89.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fibp 34
  • 68.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3720 34
zebrafish
(Danio rerio)
Actinopterygii fibpb 35 35
  • 71 (a)
OneToMany
fibpa 34 35
  • 69.09 (n)
zgc64086 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002269 34
  • 54.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fibp 36 34 35
  • 53.75 (n)
Species where no ortholog for FIBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBP Gene

ENSEMBL:
Gene Tree for FIBP (if available)
TreeFam:
Gene Tree for FIBP (if available)

Paralogs for FIBP Gene

Pseudogenes.org Pseudogenes for FIBP Gene

genes like me logo Genes that share paralogs with FIBP: view

No data available for Paralogs for FIBP Gene

Variants for FIBP Gene

Sequence variations from dbSNP and Humsavar for FIBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs786204849 Pathogenic 65,885,181(-) ACTCA(C/T)AGATG nc-transcript-variant, reference, stop-gained
rs886037928 Pathogenic 65,888,042(-) GGACC(-/TAA)ATTAC nc-transcript-variant, cds-indel
rs1000326802 -- 65,888,271(+) GCCCC(C/G)CCCCC intron-variant
rs1000765021 -- 65,884,006(+) GCCGC(A/G)GAGGG nc-transcript-variant, downstream-variant-500B, reference, missense
rs1001384988 -- 65,888,785(+) TGCCC(A/T)CTTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FIBP Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for FIBP Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIBP Gene

Human Gene Mutation Database (HGMD)
FIBP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBP Gene

Disorders for FIBP Gene

MalaCards: The human disease database

(3) MalaCards diseases for FIBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coloboma, ocular
  • coloboma, ocular, autosomal dominant
learning disability
  • academic skill disorder
mental retardation-hypotonic facies syndrome, x-linked
  • mental retardation-hypotonic facies syndrome, x-linked, 1
- elite association - COSMIC cancer census association via MalaCards
Search FIBP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FIBP_HUMAN
  • Thauvin-Robinet-Faivre syndrome (TROFAS) [MIM:617107]: A rare autosomal recessive syndrome characterized by generalized overgrowth, developmental delay, learning disabilities, and variable congenital abnormalities including congenital heart defects, renal dysplasia, and skeletal defects. {ECO:0000269 PubMed:26660953, ECO:0000269 PubMed:27183861}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FIBP

Genetic Association Database (GAD)
FIBP
Human Genome Epidemiology (HuGE) Navigator
FIBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FIBP
genes like me logo Genes that share disorders with FIBP: view

No data available for Genatlas for FIBP Gene

Publications for FIBP Gene

  1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. (PMID: 11104667) Kolpakova E. … Olsnes S. (Biochem. J. 2000) 3 4 22 64
  2. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. (PMID: 9806903) Kolpakova E. … Olsnes S. (Biochem. J. 1998) 2 3 4 64
  3. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S. … Chen J. (Mol. Cell Proteomics 2014) 2 3 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for FIBP Gene

Sources for FIBP Gene

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