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Aliases for FIBP Gene

Aliases for FIBP Gene

  • FGF1 Intracellular Binding Protein 2 3 5
  • AFGF Intracellular-Binding Protein 3 4
  • Fibroblast Growth Factor (Acidic) Intracellular Binding Protein 2
  • Acidic Fibroblast Growth Factor Intracellular-Binding Protein 3
  • FGF-1 Intracellular-Binding Protein 4
  • FGFIBP 3
  • FIBP-1 3
  • TROFAS 3

External Ids for FIBP Gene

Previous GeneCards Identifiers for FIBP Gene

  • GC11M068185
  • GC11M067333
  • GC11M065426
  • GC11M065407
  • GC11M065651
  • GC11M061977

Summaries for FIBP Gene

Entrez Gene Summary for FIBP Gene

  • Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIBP Gene

FIBP (FGF1 Intracellular Binding Protein) is a Protein Coding gene. Diseases associated with FIBP include Thauvin-Robinet-Faivre Syndrome and Renal Dysplasia. GO annotations related to this gene include fibroblast growth factor binding.

UniProtKB/Swiss-Prot for FIBP Gene

  • May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Gene Wiki entry for FIBP Gene

Additional gene information for FIBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBP Gene

Genomics for FIBP Gene

Regulatory Elements for FIBP Gene

Enhancers for FIBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065910 1.8 FANTOM5 ENCODE dbSUPER 5.2 -27.2 -27189 11.4 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5 LOC105369352 RBM14 ZFPL1 ENSG00000254461 ENSG00000258297 MUS81 EIF1AD KAT5 DPF2 SF3B2
GH11H065945 0.8 Ensembl ENCODE 11.2 -57.3 -57257 1.2 GATAD2A RFX1 POLR2A FOXA3 SCRT2 CEBPG RARA DRAP1 C11orf68 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2 CFL1 MUS81
GH11H065811 0.8 Ensembl ENCODE 10.9 +76.3 76333 2 PKNOX1 ATF1 PRDM6 IKZF1 EBF1 CEBPG SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 CCDC85B FIBP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FIBP on UCSC Golden Path with GeneCards custom track

Promoters for FIBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040903 -161 1401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Locations for FIBP Gene

Genomic Locations for FIBP Gene
4,800 bases
Minus strand

Genomic View for FIBP Gene

Genes around FIBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBP Gene

Proteins for FIBP Gene

  • Protein details for FIBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Protein Accession:
    Secondary Accessions:
    • A8K0J7
    • Q27Q85
    • Q6IBQ3
    • Q9HD65

    Protein attributes for FIBP Gene

    364 amino acids
    Molecular mass:
    41878 Da
    Quaternary structure:
    • Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

    Alternative splice isoforms for FIBP Gene


neXtProt entry for FIBP Gene

Post-translational modifications for FIBP Gene

  • Ubiquitination at isoforms=2245, posLast=251251, and isoforms=2268
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBP Gene

No data available for DME Specific Peptides for FIBP Gene

Domains & Families for FIBP Gene

Gene Families for FIBP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FIBP Gene

Suggested Antigen Peptide Sequences for FIBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBP: view

No data available for UniProtKB/Swiss-Prot for FIBP Gene

Function for FIBP Gene

Molecular function for FIBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Phenotypes From GWAS Catalog for FIBP Gene

Gene Ontology (GO) - Molecular Function for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017134 fibroblast growth factor binding IEA,IPI 9806903
genes like me logo Genes that share ontologies with FIBP: view

Phenotypes for FIBP Gene

GenomeRNAi human phenotypes for FIBP:
genes like me logo Genes that share phenotypes with FIBP: view

Animal Model Products

CRISPR Products

miRNA for FIBP Gene

miRTarBase miRNAs that target FIBP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBP Gene

Localization for FIBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBP Gene

Nucleus. Endomembrane system; Peripheral membrane protein. Note=Also associated with cytoplasmic membranes, particularly of mitochondria.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIBP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9806903
GO:0005739 mitochondrion TAS 9806903
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 9806903
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with FIBP: view

Pathways & Interactions for FIBP Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008543 fibroblast growth factor receptor signaling pathway TAS 9806903
GO:0070527 platelet aggregation IMP 23382103
genes like me logo Genes that share ontologies with FIBP: view

No data available for Pathways by source and SIGNOR curated interactions for FIBP Gene

Drugs & Compounds for FIBP Gene

(2) Drugs for FIBP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FIBP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FIBP: view

Transcripts for FIBP Gene

Unigene Clusters for FIBP Gene

Fibroblast growth factor (acidic) intracellular binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: - - -
SP13: -

ExUns: 11a · 11b · 11c ^ 12
SP1: -
SP2: -
SP9: -

Relevant External Links for FIBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FIBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIBP Gene

This gene is overexpressed in Brain (15.8), Peripheral blood mononuclear cells (9.7), and Stomach (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FIBP Gene

Protein tissue co-expression partners for FIBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIBP Gene:


SOURCE GeneReport for Unigene cluster for FIBP Gene:


mRNA Expression by UniProt/SwissProt for FIBP Gene:

Tissue specificity: Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.

Evidence on tissue expression from TISSUES for FIBP Gene

  • Nervous system(4.8)
  • Heart(4.3)
  • Lung(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FIBP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIBP Gene

Orthologs for FIBP Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FIBP 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia FIBP 33 34
  • 92.4 (n)
(Bos Taurus)
Mammalia FIBP 33 34
  • 92.06 (n)
(Monodelphis domestica)
Mammalia FIBP 34
  • 91 (a)
(Mus musculus)
Mammalia Fibp 33 16 34
  • 90.75 (n)
(Rattus norvegicus)
Mammalia Fibp 33
  • 89.08 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fibp 33
  • 68.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3720 33
(Danio rerio)
Actinopterygii fibpb 34 34
  • 71 (a)
fibpa 33 34
  • 69.09 (n)
zgc64086 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002269 33
  • 54.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fibp 35 33 34
  • 53.75 (n)
Species where no ortholog for FIBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBP Gene

Gene Tree for FIBP (if available)
Gene Tree for FIBP (if available)

Paralogs for FIBP Gene Pseudogenes for FIBP Gene

genes like me logo Genes that share paralogs with FIBP: view

No data available for Paralogs for FIBP Gene

Variants for FIBP Gene

Sequence variations from dbSNP and Humsavar for FIBP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs786204849 Pathogenic 65,885,181(-) ACTCA(C/T)AGATG nc-transcript-variant, reference, stop-gained
rs886037928 Pathogenic 65,888,042(-) GGACC(-/TAA)ATTAC nc-transcript-variant, cds-indel
rs1000326802 -- 65,888,271(+) GCCCC(C/G)CCCCC intron-variant
rs1000765021 -- 65,884,006(+) GCCGC(A/G)GAGGG nc-transcript-variant, downstream-variant-500B, reference, missense
rs1001384988 -- 65,888,785(+) TGCCC(A/T)CTTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FIBP Gene

Variant ID Type Subtype PubMed ID
nsv951019 CNV deletion 24416366
nsv832191 CNV loss 17160897
nsv555215 CNV loss 21841781
nsv1159905 CNV duplication 26073780
esv2759834 CNV gain 17122850

Variation tolerance for FIBP Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FIBP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBP Gene

Disorders for FIBP Gene

MalaCards: The human disease database

(3) MalaCards diseases for FIBP Gene - From: HGMD, OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thauvin-robinet-faivre syndrome
  • trofas
renal dysplasia
  • renal cell dysplasia
  • coloboma of eye
- elite association - COSMIC cancer census association via MalaCards
Search FIBP in MalaCards View complete list of genes associated with diseases


  • Thauvin-Robinet-Faivre syndrome (TROFAS) [MIM:617107]: A rare autosomal recessive syndrome characterized by generalized overgrowth, developmental delay, learning disabilities, and variable congenital abnormalities including congenital heart defects, renal dysplasia, and skeletal defects. {ECO:0000269 PubMed:26660953, ECO:0000269 PubMed:27183861}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FIBP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FIBP: view

No data available for Genatlas for FIBP Gene

Publications for FIBP Gene

  1. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. (PMID: 11104667) Kolpakova E … Olsnes S (The Biochemical journal 2000) 3 4 22 60
  2. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. (PMID: 9806903) Kolpakova E … Olsnes S (The Biochemical journal 1998) 2 3 4 60
  3. A recessive syndrome of intellectual disability, moderate overgrowth, and renal dysplasia predisposing to Wilms tumor is caused by a mutation in FIBP gene. (PMID: 27183861) Akawi N … Al-Gazali L (American journal of medical genetics. Part A 2016) 3 4 60
  4. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. (PMID: 25096995) Xu S … Chen J (Molecular & cellular proteomics : MCP 2014) 2 3 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for FIBP Gene

Sources for FIBP Gene

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