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Aliases for CCNB2 Gene

Aliases for CCNB2 Gene

  • Cyclin B2 2 3 5
  • HsT17299 3

External Ids for CCNB2 Gene

Previous GeneCards Identifiers for CCNB2 Gene

  • GC15P054954
  • GC15P052444
  • GC15P056976
  • GC15P057113
  • GC15P057184
  • GC15P059397
  • GC15P036219

Summaries for CCNB2 Gene

Entrez Gene Summary for CCNB2 Gene

  • Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNB2 Gene

CCNB2 (Cyclin B2) is a Protein Coding gene. Diseases associated with CCNB2 include Anauxetic Dysplasia and Breast Cancer. Among its related pathways are HTLV-I infection and Cell Cycle Checkpoints. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNB2 Gene

  • Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Gene Wiki entry for CCNB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNB2 Gene

Genomics for CCNB2 Gene

Regulatory Elements for CCNB2 Gene

Enhancers for CCNB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCNB2 on UCSC Golden Path with GeneCards custom track

Promoters for CCNB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCNB2 Gene

59,105,078 bp from pter
59,125,045 bp from pter
19,968 bases
Plus strand

Genomic View for CCNB2 Gene

Genes around CCNB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNB2 Gene

Proteins for CCNB2 Gene

  • Protein details for CCNB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Protein Accession:
    Secondary Accessions:
    • B3KM93
    • Q6FI99

    Protein attributes for CCNB2 Gene

    398 amino acids
    Molecular mass:
    45282 Da
    Quaternary structure:
    • Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

neXtProt entry for CCNB2 Gene

Proteomics data for CCNB2 Gene at MOPED

Post-translational modifications for CCNB2 Gene

  • Ubiquitination at Lys 328, Lys 360, and Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCNB2 Gene

Domains & Families for CCNB2 Gene

Gene Families for CCNB2 Gene

Protein Domains for CCNB2 Gene


Suggested Antigen Peptide Sequences for CCNB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin AB subfamily.
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNB2: view

Function for CCNB2 Gene

Molecular function for CCNB2 Gene

UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
genes like me logo Genes that share phenotypes with CCNB2: view

Animal Models for CCNB2 Gene

MGI Knock Outs for CCNB2:

Animal Model Products

miRNA for CCNB2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNB2 Gene

Localization for CCNB2 Gene

Subcellular locations from

Jensen Localization Image for CCNB2 Gene COMPARTMENTS Subcellular localization image for CCNB2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCNB2 Gene

Pathways & Interactions for CCNB2 Gene

genes like me logo Genes that share pathways with CCNB2: view

Gene Ontology (GO) - Biological Process for CCNB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001701 in utero embryonic development IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0043029 T cell homeostasis IEA --
GO:0048538 thymus development IEA --
genes like me logo Genes that share ontologies with CCNB2: view

No data available for SIGNOR curated interactions for CCNB2 Gene

Drugs & Compounds for CCNB2 Gene

(3) Drugs for CCNB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCNB2: view

Transcripts for CCNB2 Gene

Unigene Clusters for CCNB2 Gene

Cyclin B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9

Relevant External Links for CCNB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNB2 Gene

mRNA expression in normal human tissues for CCNB2 Gene

mRNA differential expression in normal tissues according to GTEx for CCNB2 Gene

This gene is overexpressed in Testis (x12.5).

Protein differential expression in normal tissues from HIPED for CCNB2 Gene

This gene is overexpressed in Testis (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNB2 Gene

SOURCE GeneReport for Unigene cluster for CCNB2 Gene Hs.194698

genes like me logo Genes that share expression patterns with CCNB2: view

Protein tissue co-expression partners for CCNB2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCNB2 Gene

Orthologs for CCNB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNB2 35
  • 87.86 (n)
  • 92.96 (a)
CCNB2 36
  • 93 (a)
(Canis familiaris)
Mammalia CCNB2 35
  • 90.85 (n)
  • 93.2 (a)
-- 36
  • 83 (a)
-- 36
  • 93 (a)
(Mus musculus)
Mammalia Ccnb2 35
  • 86.62 (n)
  • 89.9 (a)
Ccnb2 16
Ccnb2 36
  • 89 (a)
(Pan troglodytes)
Mammalia CCNB2 35
  • 99.58 (n)
  • 99.25 (a)
CCNB2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccnb2 35
  • 87.57 (n)
  • 90.43 (a)
(Monodelphis domestica)
Mammalia CCNB2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CCNB2 36
  • 74 (a)
(Gallus gallus)
Aves CCNB2 35
  • 69.71 (n)
  • 70.56 (a)
CCNB2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Ccnb2 35
ccnb2 35
  • 63.73 (n)
  • 61.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397743 35
(Danio rerio)
Actinopterygii ccnb2 35
  • 62.28 (n)
  • 60.78 (a)
ccnb2 36
  • 54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4250 35
fruit fly
(Drosophila melanogaster)
Insecta CycB 37
  • 42 (a)
CycB 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea cyb-1 37
  • 32 (a)
cyb-2.1 37
  • 34 (a)
cyb-2.2 37
  • 34 (a)
cyb-1 36
  • 30 (a)
cyb-2.1 36
  • 30 (a)
cyb-2.2 36
  • 29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR099W 35
  • 48.39 (n)
  • 40.96 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15543g 35
  • 50.38 (n)
  • 44.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB2 35
  • 54.32 (n)
  • 47.41 (a)
CLB1 36
  • 27 (a)
CLB2 36
  • 27 (a)
CLB3 36
  • 27 (a)
CLB4 36
  • 22 (a)
CLB5 36
  • 22 (a)
CLB6 36
  • 23 (a)
CLB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCB2;4 35
  • 52.17 (n)
  • 41.5 (a)
(Glycine max)
eudicotyledons Gma.174 35
(Oryza sativa)
Liliopsida Os04g0563700 35
  • 49.41 (n)
  • 43.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3299 36
  • 39 (a)
Species with no ortholog for CCNB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNB2 Gene

Gene Tree for CCNB2 (if available)
Gene Tree for CCNB2 (if available)

Paralogs for CCNB2 Gene

Paralogs for CCNB2 Gene

(5) SIMAP similar genes for CCNB2 Gene using alignment to 2 proteins: Pseudogenes for CCNB2 Gene

genes like me logo Genes that share paralogs with CCNB2: view

Variants for CCNB2 Gene

Sequence variations from dbSNP and Humsavar for CCNB2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs16941036 - 59,114,475(+) CTCCA(C/T)GAAGG reference, missense
rs28383563 - 59,124,864(+) ACTGA(C/T)AGGAA reference, missense
rs2306785 - 59,114,579(-) CTTAA(C/G/T)GTAGT reference, missense
rs10185 -- 59,124,916(-) AAAAA(A/G)GGCAC utr-variant-3-prime
rs5812964 -- 59,124,397(+) TTTTA(-/TTGTCTTTTA)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNB2 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv527307 CNV Gain 19592680
nsv833025 CNV Gain 17160897

Variation tolerance for CCNB2 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCNB2 Gene

Disorders for CCNB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCNB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
anauxetic dysplasia
  • spondylometaepiphyseal dysplasia anauxetic type
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search CCNB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCNB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNB2 Gene

Publications for CCNB2 Gene

  1. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PMID: 19738611) Cunningham J.M. … Goode E.L. (Br. J. Cancer 2009) 3 48 67
  2. HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. (PMID: 19223528) De Martino I. … Fusco A. (Cancer Res. 2009) 3 23
  3. [Molecular mechanism of radiosensitizing effect of paclitaxel]. (PMID: 19664331) Weng W.W. … Hong C.J. (Ai Zheng 2009) 3 23
  4. NF-Y-dependent cyclin B2 expression in colorectal adenocarcinoma. (PMID: 17289878) Park S.H. … Kim D.G. (Clin. Cancer Res. 2007) 3 23
  5. Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2. (PMID: 17533373) Bellanger S. … Sobczak-ThAcpot J. (Oncogene 2007) 3 23

Products for CCNB2 Gene

Sources for CCNB2 Gene