Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM50A Gene

Aliases for FAM50A Gene

  • Family With Sequence Similarity 50 Member A 2 3 5
  • Family With Sequence Similarity 50, Member A 2 3
  • Protein XAP-5 3 4
  • DXS9928E 3 4
  • HXC26 3 4
  • XAP5 3 4
  • DNA Segment On Chromosome X (Unique) 9928 Expressed Sequence 2
  • Protein HXC-26 4
  • HXC-26 3
  • 9F 3

External Ids for FAM50A Gene

Previous GeneCards Identifiers for FAM50A Gene

  • GC0XP153236
  • GC0XP153325
  • GC0XP153672
  • GC0XP142251

Summaries for FAM50A Gene

Entrez Gene Summary for FAM50A Gene

  • This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009]

GeneCards Summary for FAM50A Gene

FAM50A (Family With Sequence Similarity 50 Member A) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is FAM50B.

UniProtKB/Swiss-Prot for FAM50A Gene

  • May be a DNA-binding protein or transcriptional factor.

Gene Wiki entry for FAM50A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM50A Gene

Genomics for FAM50A Gene

Regulatory Elements for FAM50A Gene

Enhancers for FAM50A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FAM50A on UCSC Golden Path with GeneCards custom track

Promoters for FAM50A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FAM50A on UCSC Golden Path with GeneCards custom track

Genomic Location for FAM50A Gene

Chromosome:
X
Start:
154,444,126 bp from pter
End:
154,450,654 bp from pter
Size:
6,529 bases
Orientation:
Plus strand

Genomic View for FAM50A Gene

Genes around FAM50A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM50A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM50A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM50A Gene

Proteins for FAM50A Gene

  • Protein details for FAM50A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14320-FA50A_HUMAN
    Recommended name:
    Protein FAM50A
    Protein Accession:
    Q14320
    Secondary Accessions:
    • A8KAQ4
    • B2R997
    • Q5HY37
    • Q6PJH5

    Protein attributes for FAM50A Gene

    Size:
    339 amino acids
    Molecular mass:
    40242 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM50A Gene

Proteomics data for FAM50A Gene at MOPED

Post-translational modifications for FAM50A Gene

  • Ubiquitination at Lys 271 and Lys 305
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM50A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM50A

No data available for DME Specific Peptides for FAM50A Gene

Domains & Families for FAM50A Gene

Protein Domains for FAM50A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM50A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14320

UniProtKB/Swiss-Prot:

FA50A_HUMAN :
  • Belongs to the FAM50 family.
Family:
  • Belongs to the FAM50 family.
genes like me logo Genes that share domains with FAM50A: view

No data available for Gene Families for FAM50A Gene

Function for FAM50A Gene

Molecular function for FAM50A Gene

UniProtKB/Swiss-Prot Function:
May be a DNA-binding protein or transcriptional factor.
genes like me logo Genes that share phenotypes with FAM50A: view

Animal Model Products

CRISPR Products

miRNA for FAM50A Gene

miRTarBase miRNAs that target FAM50A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM50A Gene

Localization for FAM50A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM50A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FAM50A Gene COMPARTMENTS Subcellular localization image for FAM50A gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FAM50A Gene

Pathways & Interactions for FAM50A Gene

SuperPathways for FAM50A Gene

No Data Available

Interacting Proteins for FAM50A Gene

Gene Ontology (GO) - Biological Process for FAM50A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM50A Gene

Drugs & Compounds for FAM50A Gene

No Compound Related Data Available

Transcripts for FAM50A Gene

Unigene Clusters for FAM50A Gene

Family with sequence similarity 50, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FAM50A Gene

No ASD Table

Relevant External Links for FAM50A Gene

GeneLoc Exon Structure for
FAM50A
ECgene alternative splicing isoforms for
FAM50A

Expression for FAM50A Gene

mRNA expression in normal human tissues for FAM50A Gene

Protein differential expression in normal tissues from HIPED for FAM50A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Bone marrow stromal cell (8.5), and Spleen (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FAM50A Gene



SOURCE GeneReport for Unigene cluster for FAM50A Gene Hs.54277

mRNA Expression by UniProt/SwissProt for FAM50A Gene

Q14320-FA50A_HUMAN
Tissue specificity: Expressed in all tissues examined. Mostly abundant in fetal brain, liver and kidney; in the adult, high levels were also observed in heart, skeletal muscle, spleen, thymus, prostate and small intestine.
genes like me logo Genes that share expression patterns with FAM50A: view

Protein tissue co-expression partners for FAM50A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FAM50A Gene

Orthologs for FAM50A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FAM50A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM50A 35
  • 90.66 (n)
  • 97.05 (a)
FAM50A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM50A 35
  • 91.54 (n)
  • 97.05 (a)
FAM50A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam50a 35
  • 88.2 (n)
  • 98.23 (a)
Fam50a 16
Fam50a 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM50A 35
  • 99.12 (n)
  • 99.71 (a)
FAM50A 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM50A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM50A 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10920 35
African clawed frog
(Xenopus laevis)
Amphibia mgdb03h09-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fam50a 36
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta FAM50_ANOGA 35
  • 66.86 (n)
  • 64.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12259 35
  • 70.34 (n)
  • 64.88 (a)
CG12259 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C47E8.4 36
  • 45 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons XCT 35
  • 55.14 (n)
  • 48.77 (a)
soybean
(Glycine max)
eudicotyledons Gma.8107 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9535 35
barley
(Hordeum vulgare)
Liliopsida Hv.6934 35
rice
(Oryza sativa)
Liliopsida Os.11434 35
Os09g0535300 35
  • 55.62 (n)
  • 49.23 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.26958 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4681 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3121 36
  • 64 (a)
OneToMany
Species with no ortholog for FAM50A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for FAM50A Gene

ENSEMBL:
Gene Tree for FAM50A (if available)
TreeFam:
Gene Tree for FAM50A (if available)

Paralogs for FAM50A Gene

Paralogs for FAM50A Gene

(1) SIMAP similar genes for FAM50A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM50A: view

Variants for FAM50A Gene

Sequence variations from dbSNP and Humsavar for FAM50A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs762513 -- 154,446,823(+) GGGGC(A/G)CTAAA intron-variant
rs762514 -- 154,446,885(+) TTCCG(A/G)GGCTA intron-variant
rs2070823 -- 154,446,699(+) AGACC(A/G)GGGAG intron-variant
rs3788801 -- 154,447,952(-) CCTGT(A/G)GAGGG intron-variant
rs5945191 -- 154,448,215(+) aggtg(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FAM50A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Variation tolerance for FAM50A Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FAM50A Gene

HapMap Linkage Disequilibrium report
FAM50A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM50A Gene

Disorders for FAM50A Gene

Relevant External Links for FAM50A

Genetic Association Database (GAD)
FAM50A
Human Genome Epidemiology (HuGE) Navigator
FAM50A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FAM50A

No disorders were found for FAM50A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM50A Gene

Publications for FAM50A Gene

  1. Differential expression of XAP5, a candidate disease gene. (PMID: 9339379) Mazzarella R. … Schlessinger D. (Genomics 1997) 2 3 4 23 67
  2. Isolation and analysis of a novel gene, HXC-26, adjacent to the rab GDP dissociation inhibitor gene located at human chromosome Xq28 region. (PMID: 9039504) Toyoda A. … Maeda H. (DNA Res. 1996) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for FAM50A Gene

Sources for FAM50A Gene

Content