Aliases for PRPF4 Gene
External Ids for PRPF4 Gene
Previous GeneCards Identifiers for PRPF4 Gene
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for PRPF4 Gene
PRPF4 (Pre-MRNA Processing Factor 4) is a Protein Coding gene. Diseases associated with PRPF4 include retinitis pigmentosa 70 and retinitis pigmentosa. Among its related pathways are Gene Expression and Spliceosome. An important paralog of this gene is SPAG16.
UniProtKB/Swiss-Prot for PRPF4 Gene
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome