Aliases for PRPF4 Gene
External Ids for PRPF4 Gene
Previous GeneCards Identifiers for PRPF4 Gene
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
GeneCards Summary for PRPF4 Gene
PRPF4 (Pre-MRNA Processing Factor 4) is a Protein Coding gene. Diseases associated with PRPF4 include Retinitis Pigmentosa 70 and Prpf4-Related Retinitis Pigmentosa. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include U6 snRNA binding and U4 snRNA binding. An important paralog of this gene is SPAG16.
UniProtKB/Swiss-Prot for PRPF4 Gene
Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.