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Aliases for P2RX6 Gene

Aliases for P2RX6 Gene

  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 6 2 3
  • P2RXL1 3 4 6
  • P2X6 3 4 6
  • P2XM 3 4 6
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 6 2 3
  • Purinergic Receptor P2X-Like 1, Orphan Receptor 2 3
  • ATP Receptor 3 4
  • Purinergic Receptor P2X-Like 1 4
  • Skeletal Muscle-Expressed P2X 3
  • Purinergic Receptor 4
  • Purinoreceptor P2X6 3
  • P2X Purinoceptor 6 3
  • Purinoceptor P2X6 3

External Ids for P2RX6 Gene

Previous HGNC Symbols for P2RX6 Gene

  • P2RXL1

Previous GeneCards Identifiers for P2RX6 Gene

  • GC22P019699
  • GC22P021399
  • GC22P021406
  • GC22P004637
  • GC22P021415
  • GC22P021423
  • GC22P021430
  • GC22P021440
  • GC22P021364

Summaries for P2RX6 Gene

Entrez Gene Summary for P2RX6 Gene

  • The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]

GeneCards Summary for P2RX6 Gene

P2RX6 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 6) is a Protein Coding gene. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include identical protein binding and channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX6 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel.

Tocris Summary for P2RX6 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility and nociception.

Gene Wiki entry for P2RX6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX6 Gene

Genomics for P2RX6 Gene

Regulatory Elements for P2RX6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RX6 Gene

Start:
21,009,808 bp from pter
End:
21,028,830 bp from pter
Size:
19,023 bases
Orientation:
Plus strand

Genomic View for P2RX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX6 Gene

Proteins for P2RX6 Gene

  • Protein details for P2RX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15547-P2RX6_HUMAN
    Recommended name:
    P2X purinoceptor 6
    Protein Accession:
    O15547
    Secondary Accessions:
    • F6V3D7
    • Q32MB6
    • Q58F04
    • Q6IC33
    • Q9UL50

    Protein attributes for P2RX6 Gene

    Size:
    441 amino acids
    Molecular mass:
    48829 Da
    Quaternary structure:
    • Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.
    SequenceCaution:
    • Sequence=AAF13303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF13303.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAH33488.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI09210.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA22046.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA22047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for P2RX6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for P2RX6 Gene

Proteomics data for P2RX6 Gene at MOPED

Post-translational modifications for P2RX6 Gene

Other Protein References for P2RX6 Gene

No data available for DME Specific Peptides for P2RX6 Gene

Domains for P2RX6 Gene

Gene Families for P2RX6 Gene

HGNC:
  • P2RX :Ligand-gated ion channels / Purinergic receptors, ionotropic
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RX6 Gene

Suggested Antigen Peptide Sequences for P2RX6 Gene

Graphical View of Domain Structure for InterPro Entry

O15547

UniProtKB/Swiss-Prot:

P2RX6_HUMAN :
  • O15547
Family:
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX6: view

Function for P2RX6 Gene

Molecular function for P2RX6 Gene

UniProtKB/Swiss-Prot Function: Receptor for ATP that acts as a ligand-gated ion channel.

Gene Ontology (GO) - Molecular Function for P2RX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity NAS 12088286
GO:0004888 transmembrane signaling receptor activity TAS 9242461
GO:0004931 extracellular ATP-gated cation channel activity NAS 12088286
GO:0005216 ion channel activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with P2RX6: view
genes like me logo Genes that share phenotypes with P2RX6: view

Animal Model Products

CRISPR Products

miRNA for P2RX6 Gene

miRTarBase miRNAs that target P2RX6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for P2RX6 Gene

Localization for P2RX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RX6 Gene COMPARTMENTS Subcellular localization image for P2RX6 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for P2RX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005737 cytoplasm IDA 12088286
GO:0005887 integral component of plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with P2RX6: view

Pathways for P2RX6 Gene

genes like me logo Genes that share pathways with P2RX6: view

Pathways by source for P2RX6 Gene

1 Qiagen pathway for P2RX6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for P2RX6 Gene

Gene Ontology (GO) - Biological Process for P2RX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9242461
GO:0006811 ion transport --
GO:0006812 cation transport IBA --
GO:0006936 muscle contraction TAS 9242461
GO:0007165 signal transduction TAS 9242461
genes like me logo Genes that share ontologies with P2RX6: view

Compounds for P2RX6 Gene

(5) Tocris Compounds for P2RX6 Gene

Compound Action Cas Number
A 438079 hydrochloride Competitive P2X7 antagonist [899431-18-6]
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog [93839-89-5]
NF 449 Highly selective P2X1 antagonist [627034-85-9]
Suramin hexasodium salt Non-selective P2 antagonist [129-46-4]
TNP-ATP triethylammonium salt Potent, selective P2X antagonist [61368-63-6]

(1) Novoseek inferred chemical compound relationships for P2RX6 Gene

Compound -log(P) Hits PubMed IDs
atp 53.7 2
genes like me logo Genes that share compounds with P2RX6: view

Transcripts for P2RX6 Gene

Unigene Clusters for P2RX6 Gene

Purinergic receptor P2X, ligand-gated ion channel, 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RX6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:
SP8:

Relevant External Links for P2RX6 Gene

GeneLoc Exon Structure for
P2RX6
ECgene alternative splicing isoforms for
P2RX6

Expression for P2RX6 Gene

mRNA expression in normal human tissues for P2RX6 Gene

mRNA differential expression in normal tissues according to GTEx for P2RX6 Gene

This gene is overexpressed in Muscle - Skeletal (14.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RX6 Gene

SOURCE GeneReport for Unigene cluster for P2RX6 Gene Hs.113275

mRNA Expression by UniProt/SwissProt for P2RX6 Gene

O15547-P2RX6_HUMAN
Tissue specificity: Expressed predominantly in skeletal muscle
genes like me logo Genes that share expressions with P2RX6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for P2RX6 Gene

Orthologs for P2RX6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RX6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RX6 35
  • 80.41 (n)
  • 78.05 (a)
P2RX6 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RX6 35
  • 81.03 (n)
  • 78.33 (a)
P2RX6 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2rx6 35
  • 82.38 (n)
  • 82.12 (a)
P2rx6 16
P2rx6 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia P2RX6 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2rx6 35
  • 81 (n)
  • 79.79 (a)
chicken
(Gallus gallus)
Aves LOC429367 35
  • 66.95 (n)
  • 61.14 (a)
P2RX6 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RX6 36
  • 58 (a)
OneToOne
Species with no ortholog for P2RX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for P2RX6 Gene

ENSEMBL:
Gene Tree for P2RX6 (if available)
TreeFam:
Gene Tree for P2RX6 (if available)

Paralogs for P2RX6 Gene

Paralogs for P2RX6 Gene

Selected SIMAP similar genes for P2RX6 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for P2RX6 Gene

genes like me logo Genes that share paralogs with P2RX6: view

Variants for P2RX6 Gene

Sequence variations from dbSNP and Humsavar for P2RX6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs372351 -- 21,022,574(+) GGAAG(G/T)GGGCC intron-variant
rs425174 -- 21,020,812(+) GTCTC(A/G)AACTC intron-variant
rs929139 -- 21,023,695(+) CACAC(A/C)CAGGC intron-variant
rs929140 -- 21,023,814(+) CCTGA(A/G)CCCTC intron-variant
rs929671 -- 21,023,669(+) CTCTC(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RX6 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
nsv914423 CNV Gain 21882294
nsv828960 CNV Loss 20364138
nsv471185 CNV Loss 18288195
nsv834142 CNV Gain 17160897
nsv828961 CNV Gain 20364138
nsv3563 CNV Loss 18451855
nsv914429 CNV Gain 21882294

Relevant External Links for P2RX6 Gene

HapMap Linkage Disequilibrium report
P2RX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX6 Gene

Disorders for P2RX6 Gene

Relevant External Links for P2RX6

Genetic Association Database (GAD)
P2RX6
Human Genome Epidemiology (HuGE) Navigator
P2RX6
genes like me logo Genes that share disorders with P2RX6: view

No data available for UniProtKB/Swiss-Prot for P2RX6 Gene

Publications for P2RX6 Gene

  1. Cloning of P2XM, a novel human P2X receptor gene regulated by p53. (PMID: 9242461) Urano T. … Tokino T. (Cancer Res. 1997) 2 3 4
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  3. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PMID: 18852390) Palomino-Doza J. … Keavney B. (Hypertension 2008) 3 23 48
  4. Identification of the phosphotyrosine proteome from thrombin activated platelets. (PMID: 12112843) Maguire P.B. … Fitzgerald D.J. (Proteomics 2002) 3 4
  5. Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. (PMID: 8786426) Collo G. … Buell G. (J. Neurosci. 1996) 2 23

Products for P2RX6 Gene

Sources for P2RX6 Gene

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