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Aliases for SLC16A3 Gene

Aliases for SLC16A3 Gene

  • Solute Carrier Family 16 Member 3 2 3 4
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 2 3 5
  • Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 2 3
  • MCT 4 3 4
  • MCT4 3 4
  • Monocarboxylate Transporter 3 3
  • MCT 3 3
  • MCT-3 3
  • MCT-4 3
  • MCT3 3

External Ids for SLC16A3 Gene

Previous GeneCards Identifiers for SLC16A3 Gene

  • GC17P079025
  • GC17P082998
  • GC17P080716
  • GC17P080865
  • GC17P077780
  • GC17P080186
  • GC17P075585

Summaries for SLC16A3 Gene

Entrez Gene Summary for SLC16A3 Gene

  • Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC16A3 Gene

SLC16A3 (Solute Carrier Family 16 Member 3) is a Protein Coding gene. Diseases associated with SLC16A3 include lacrimal gland carcinoma and lacrimal gland adenocarcinoma. Among its related pathways are Platelet activation, signaling and aggregation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A11.

UniProtKB/Swiss-Prot for SLC16A3 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A3 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Gene Wiki entry for SLC16A3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A3 Gene

Genomics for SLC16A3 Gene

Regulatory Elements for SLC16A3 Gene

Promoters for SLC16A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC16A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC16A3 Gene

Chromosome:
17
Start:
82,228,397 bp from pter
End:
82,261,129 bp from pter
Size:
32,733 bases
Orientation:
Plus strand

Genomic View for SLC16A3 Gene

Genes around SLC16A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A3 Gene

Proteins for SLC16A3 Gene

  • Protein details for SLC16A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15427-MOT4_HUMAN
    Recommended name:
    Monocarboxylate transporter 4
    Protein Accession:
    O15427
    Secondary Accessions:
    • B3KXG8
    • Q2M1P8

    Protein attributes for SLC16A3 Gene

    Size:
    465 amino acids
    Molecular mass:
    49469 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A3 Gene

Proteomics data for SLC16A3 Gene at MOPED

Post-translational modifications for SLC16A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC16A3 Gene

Domains & Families for SLC16A3 Gene

Gene Families for SLC16A3 Gene

Protein Domains for SLC16A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15427

UniProtKB/Swiss-Prot:

MOT4_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A3: view

Function for SLC16A3 Gene

Molecular function for SLC16A3 Gene

GENATLAS Biochemistry:
solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment epithelium
UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Ontology (GO) - Molecular Function for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IEA,TAS --
GO:0015129 lactate transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC16A3: view
genes like me logo Genes that share phenotypes with SLC16A3: view

Animal Model Products

CRISPR Products

miRNA for SLC16A3 Gene

miRTarBase miRNAs that target SLC16A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A3 Gene

Localization for SLC16A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC16A3 Gene COMPARTMENTS Subcellular localization image for SLC16A3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
extracellular 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 9425115
genes like me logo Genes that share ontologies with SLC16A3: view

Pathways & Interactions for SLC16A3 Gene

genes like me logo Genes that share pathways with SLC16A3: view

Gene Ontology (GO) - Biological Process for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A3: view

No data available for SIGNOR curated interactions for SLC16A3 Gene

Drugs & Compounds for SLC16A3 Gene

(11) Drugs for SLC16A3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma Hydroxybutyric Acid Approved, Illicit Pharma Transporter, substrate 0
Pyruvic acid Approved Nutra Target, Transporter, substrate 0
Niacin Approved, Investigational Nutra Unknown, Agonist, Transporter 361,361
alpha-ketoisovalerate Experimental Pharma Transporter, substrate 0
D-Lactic acid Experimental Pharma Transporter, substrate 0

(6) Additional Compounds for SLC16A3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AR-C155858
496791-37-8
CHC
28166-41-8
SR 13800
227321-12-2
UK 5099
56396-35-1

(4) Tocris Compounds for SLC16A3 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A3: view

Transcripts for SLC16A3 Gene

Unigene Clusters for SLC16A3 Gene

Solute carrier family 16, member 3 (monocarboxylic acid transporter 4):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SLC16A3 Gene

GeneLoc Exon Structure for
SLC16A3
ECgene alternative splicing isoforms for
SLC16A3

Expression for SLC16A3 Gene

mRNA expression in normal human tissues for SLC16A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A3 Gene

This gene is overexpressed in Whole Blood (x21.2) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for SLC16A3 Gene

This gene is overexpressed in Nasal epithelium (32.8) and Breast (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC16A3 Gene



SOURCE GeneReport for Unigene cluster for SLC16A3 Gene Hs.500761

mRNA Expression by UniProt/SwissProt for SLC16A3 Gene

O15427-MOT4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with SLC16A3: view

Protein tissue co-expression partners for SLC16A3 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC16A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC16A3 35
  • 86.1 (n)
  • 87.34 (a)
SLC16A3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A3 35
  • 85.93 (n)
  • 88.53 (a)
SLC16A3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a3 35
  • 84.27 (n)
  • 89.87 (a)
Slc16a3 16
Slc16a3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC16A3 35
  • 99.06 (n)
  • 98.92 (a)
SLC16A3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a3 35
  • 84.66 (n)
  • 89.89 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC16A3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A3 35
  • 71.13 (n)
  • 79.91 (a)
SLC16A3 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a3 35
  • 68.39 (n)
  • 78.28 (a)
Str.19 35
African clawed frog
(Xenopus laevis)
Amphibia mct3-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7337 35
slc16a3 35
  • 68.64 (n)
  • 74.51 (a)
slc16a3 36
  • 67 (a)
OneToMany
SLC16A3 (1 of 2) 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8271 37
  • 35 (a)
Species with no ortholog for SLC16A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A3 Gene

ENSEMBL:
Gene Tree for SLC16A3 (if available)
TreeFam:
Gene Tree for SLC16A3 (if available)

Paralogs for SLC16A3 Gene

genes like me logo Genes that share paralogs with SLC16A3: view

Variants for SLC16A3 Gene

Sequence variations from dbSNP and Humsavar for SLC16A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12280 -- 82,238,997(+) CGGCA(C/G)GCACA utr-variant-3-prime
rs1804955 -- 82,239,147(+) TGGGA(A/G)CCGTG utr-variant-3-prime
rs3176827 -- 82,232,300(-) TGGAC(C/T)GTCAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs3176828 -- 82,232,138(-) TCCCA(G/T)GAGCT intron-variant, upstream-variant-2KB
rs4239022 -- 82,237,399(+) GGGGC(A/C/T)GCCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC16A3 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3341n71 CNV Loss 21882294
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv833572 CNV Loss 17160897
dgv3355n71 CNV Loss 21882294
nsv909208 CNV Loss 21882294
nsv2166 CNV Insertion 18451855
nsv909210 CNV Loss 21882294
nsv909211 CNV Loss 21882294
esv995451 CNV Deletion 20482838

Variation tolerance for SLC16A3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC16A3 Gene

HapMap Linkage Disequilibrium report
SLC16A3
Human Gene Mutation Database (HGMD)
SLC16A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A3 Gene

Disorders for SLC16A3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC16A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
breast mucinous carcinoma
  • invasive mucinous breast carcinoma
lacrimal system cancer
  • lacrimal system neoplasm
lacrimal gland adenoid cystic carcinoma
  • adenoid cystic carcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC16A3

Genetic Association Database (GAD)
SLC16A3
Human Genome Epidemiology (HuGE) Navigator
SLC16A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC16A3
genes like me logo Genes that share disorders with SLC16A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A3 Gene

Publications for SLC16A3 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price N.T. … Halestrap A.P. (Biochem. J. 1998) 2 3 4 67
  2. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PMID: 17502341) Wang Q. … Morris M.E. (Drug Metab. Dispos. 2007) 3 23
  3. Functional characteristics of H+ -dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. (PMID: 16213084) Shimada A. … Fujita T. (Neurosci. Lett. 2006) 25 26
  4. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. (PMID: 12657613) Philp N.J. … Hjelmeland L.M. (Invest. Ophthalmol. Vis. Sci. 2003) 3 23
  5. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. (PMID: 11101640) Manning Fox J.E. … Halestrap A.P. (J. Physiol. (Lond.) 2000) 25 26

Products for SLC16A3 Gene

Sources for SLC16A3 Gene

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