Aliases for ATP6V0D1 Gene
- ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D1 2 3
- ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump), Member D 2 3
- V-ATPase 40 KDa Accessory Protein 3 4
- Vacuolar Proton Pump Subunit D 1 3 4
- 32 KDa Accessory Protein 3 4
- V-ATPase AC39 Subunit 3 4
- V-ATPase Subunit D 1 3 4
- VPATPD 3 4
- ATP6D 3 4
External Ids for ATP6V0D1 Gene
Previous HGNC Symbols for ATP6V0D1 Gene
Previous GeneCards Identifiers for ATP6V0D1 Gene
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
GeneCards Summary for ATP6V0D1 Gene
ATP6V0D1 (ATPase, H+ Transporting, Lysosomal 38kDa, V0 Subunit D1) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include protein complex binding and hydrogen-exporting ATPase activity, phosphorylative mechanism. An important paralog of this gene is ATP6V0D2.
UniProtKB/Swiss-Prot for ATP6V0D1 Gene
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).
H+-ATPase (also known as vacuolar ATPase, V-ATPase) is a enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes and endosomes.