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Aliases for LATS1 Gene

Aliases for LATS1 Gene

  • Large Tumor Suppressor Kinase 1 2 3
  • LATS (Large Tumor Suppressor, Drosophila) Homolog 1 2 3
  • Large Tumor Suppressor Homolog 1 3 4
  • WARTS Protein Kinase 3 4
  • EC 2.7.11.1 4 63
  • H-Warts 3 4
  • WARTS 3 4
  • LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) 2
  • LATS, Large Tumor Suppressor, Homolog 1 3
  • EC 2.7.11 63
  • Wts 3

External Ids for LATS1 Gene

Previous GeneCards Identifiers for LATS1 Gene

  • GC06M149558
  • GC06M149892
  • GC06M9Q0072
  • GC06M150023
  • GC06M147548

Summaries for LATS1 Gene

Entrez Gene Summary for LATS1 Gene

  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for LATS1 Gene

LATS1 (Large Tumor Suppressor Kinase 1) is a Protein Coding gene. Diseases associated with LATS1 include tetraploidy and epithelial predominant wilms' tumor. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK38L.

UniProtKB/Swiss-Prot for LATS1 Gene

  • Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Gene Wiki entry for LATS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LATS1 Gene

Genomics for LATS1 Gene

Regulatory Elements for LATS1 Gene

Transcription factor binding sites by QIAGEN in the LATS1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LATS1 Gene

Chromosome:
6
Start:
149,658,153 bp from pter
End:
149,718,256 bp from pter
Size:
60,104 bases
Orientation:
Minus strand

Genomic View for LATS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LATS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LATS1 Gene

Proteins for LATS1 Gene

  • Protein details for LATS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95835-LATS1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LATS1
    Protein Accession:
    O95835
    Secondary Accessions:
    • Q6PKD0

    Protein attributes for LATS1 Gene

    Size:
    1130 amino acids
    Molecular mass:
    126870 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Complexes with CDK1 in early mitosis. LATS1-associated CDK1 has no mitotic cyclin partner and no apparent kinase activity. Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. Interacts (via PPxY motif 2) with YAP1 (via WW domains). Interacts with MOB1A and MOB1B. Interacts with LIMD1, WTIP and AJUBA.

    Three dimensional structures from OCA and Proteopedia for LATS1 Gene

    Alternative splice isoforms for LATS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LATS1 Gene

Proteomics data for LATS1 Gene at MOPED

Selected DME Specific Peptides for LATS1 Gene

Post-translational modifications for LATS1 Gene

  • Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LATS1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for LATS1 (LATS1)

Domains & Families for LATS1 Gene

Suggested Antigen Peptide Sequences for LATS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95835

UniProtKB/Swiss-Prot:

LATS1_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with LATS1: view

Function for LATS1 Gene

Molecular function for LATS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.

Enzyme Numbers (IUBMB) for LATS1 Gene

Gene Ontology (GO) - Molecular Function for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10518011
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 9988268
GO:0005524 ATP binding IDA 10518011
genes like me logo Genes that share ontologies with LATS1: view
genes like me logo Genes that share phenotypes with LATS1: view

Animal Models for LATS1 Gene

MGI Knock Outs for LATS1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LATS1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for LATS1 Gene

Localization for LATS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LATS1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LATS1 Gene COMPARTMENTS Subcellular localization image for LATS1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 2
nucleus 2
plasma membrane 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 10518011
GO:0005622 intracellular --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with LATS1: view

Pathways & Interactions for LATS1 Gene

genes like me logo Genes that share pathways with LATS1: view

Pathways by source for LATS1 Gene

2 Cell Signaling Technology pathways for LATS1 Gene
2 Reactome pathways for LATS1 Gene
1 KEGG pathway for LATS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for LATS1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for LATS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA --
GO:0000086 G2/M transition of mitotic cell cycle IDA 15122335
GO:0000819 sister chromatid segregation IDA 15122335
GO:0006468 protein phosphorylation IDA 10518011
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with LATS1: view

Drugs & Compounds for LATS1 Gene

(4) Drugs for LATS1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0
serine Nutra 420
threonine Nutra 16

(1) Additional Compounds for LATS1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with LATS1: view

Transcripts for LATS1 Gene

Unigene Clusters for LATS1 Gene

LATS, large tumor suppressor, homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LATS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LATS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5:

Relevant External Links for LATS1 Gene

GeneLoc Exon Structure for
LATS1
ECgene alternative splicing isoforms for
LATS1

Expression for LATS1 Gene

mRNA expression in normal human tissues for LATS1 Gene

Protein differential expression in normal tissues from HIPED for LATS1 Gene

This gene is overexpressed in Adipocyte (24.2), Synovial fluid (16.8), Plasma (13.4), and Pancreas (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LATS1 Gene



SOURCE GeneReport for Unigene cluster for LATS1 Gene Hs.549084

mRNA Expression by UniProt/SwissProt for LATS1 Gene

O95835-LATS1_HUMAN
Tissue specificity: Expressed in all adult tissues examined except for lung and kidney.
genes like me logo Genes that share expression patterns with LATS1: view

Protein tissue co-expression partners for LATS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LATS1 Gene

Orthologs for LATS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LATS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LATS1 35
  • 92.94 (n)
  • 95.55 (a)
LATS1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lats1 35
  • 88.04 (n)
  • 93.18 (a)
Lats1 16
Lats1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LATS1 35
  • 99.53 (n)
  • 99.65 (a)
LATS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lats1 35
  • 87.82 (n)
  • 93.54 (a)
dog
(Canis familiaris)
Mammalia LATS1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LATS1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LATS1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LATS1 35
  • 80.04 (n)
  • 84.94 (a)
LATS1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LATS1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lats1 35
  • 70.51 (n)
  • 75.53 (a)
zebrafish
(Danio rerio)
Actinopterygii lats1 35
  • 63.23 (n)
  • 68.1 (a)
lats1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wts 37
  • 73 (a)
wts 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T20F10.1 37
  • 50 (a)
wts-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4187 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToMany
Species with no ortholog for LATS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LATS1 Gene

ENSEMBL:
Gene Tree for LATS1 (if available)
TreeFam:
Gene Tree for LATS1 (if available)

Paralogs for LATS1 Gene

(7) SIMAP similar genes for LATS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LATS1: view

Variants for LATS1 Gene

Sequence variations from dbSNP and Humsavar for LATS1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1125 -- 149,658,280(+) TATGC(A/G)AAACA utr-variant-3-prime, nc-transcript-variant
rs1934534 -- 149,711,896(-) GGGCC(A/G)CAGTA intron-variant
rs2185352 -- 149,714,640(-) CTTTC(A/C)TTTTT intron-variant
rs2343263 -- 149,709,493(-) attct(C/T)tcctg intron-variant
rs3798761 -- 149,683,643(+) GTAGC(A/G)GAAGG synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for LATS1 Gene

Variant ID Type Subtype PubMed ID
nsv886762 CNV Loss 21882294
esv2671976 CNV Deletion 23128226
esv2732861 CNV Deletion 23290073

Variation tolerance for LATS1 Gene

Residual Variation Intolerance Score: 6.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LATS1 Gene

HapMap Linkage Disequilibrium report
LATS1
Human Gene Mutation Database (HGMD)
LATS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LATS1 Gene

Disorders for LATS1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for LATS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tetraploidy
  • tetraploidy syndrome
epithelial predominant wilms' tumor
  • epithelial predominant renal wilms tumor
pancreatic somatostatinoma
  • pancreatic delta cell somatostatin producing neoplasm
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
soft tissue sarcoma
  • sarcoma
- elite association
Search LATS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LATS1

Genetic Association Database (GAD)
LATS1
Human Genome Epidemiology (HuGE) Navigator
LATS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LATS1
genes like me logo Genes that share disorders with LATS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LATS1 Gene

Publications for LATS1 Gene

  1. Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray. (PMID: 19799973) Visser S. … Yang X. (Gene 2010) 23 67
  2. Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. (PMID: 19913529) Ho L.L. … Lai Z.C. (Dev. Biol. 2010) 23 67
  3. Molecular characterization of human homologs of yeast MOB1. (PMID: 19739119) Chow A. … Yang X. (Int. J. Cancer 2010) 23 67
  4. In vivo analysis of Yorkie phosphorylation sites. (PMID: 19330023) Oh H. … Irvine K.D. (Oncogene 2009) 23 67
  5. ATM regulates a RASSF1A-dependent DNA damage response. (PMID: 19962312) Hamilton G. … O'Neill E. (Curr. Biol. 2009) 23 67

Products for LATS1 Gene

Sources for LATS1 Gene

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