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Aliases for MTMR6 Gene

Aliases for MTMR6 Gene

  • Myotubularin Related Protein 6 2 3
  • EC 3.1.3.48 63
  • EC 3.1.3.- 4
  • EC 3.1.3 63

External Ids for MTMR6 Gene

Previous GeneCards Identifiers for MTMR6 Gene

  • GC13M023801
  • GC13M019801
  • GC13M024732
  • GC13M023619
  • GC13M024719
  • GC13M025820
  • GC13M006634

Summaries for MTMR6 Gene

GeneCards Summary for MTMR6 Gene

MTMR6 (Myotubularin Related Protein 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein tyrosine phosphatase activity and calcium-activated potassium channel activity. An important paralog of this gene is MTMR2.

UniProtKB/Swiss-Prot for MTMR6 Gene

  • Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.

Gene Wiki entry for MTMR6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTMR6 Gene

Genomics for MTMR6 Gene

Regulatory Elements for MTMR6 Gene

Genomic Location for MTMR6 Gene

Start:
25,246,201 bp from pter
End:
25,288,009 bp from pter
Size:
41,809 bases
Orientation:
Minus strand

Genomic View for MTMR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTMR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTMR6 Gene

Proteins for MTMR6 Gene

  • Protein details for MTMR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y217-MTMR6_HUMAN
    Recommended name:
    Myotubularin-related protein 6
    Protein Accession:
    Q9Y217
    Secondary Accessions:
    • B2RBB5
    • B3KSB4
    • Q5JRG6
    • Q86TB7
    • Q86YH4
    • Q96P80

    Protein attributes for MTMR6 Gene

    Size:
    621 amino acids
    Molecular mass:
    71968 Da
    Quaternary structure:
    • Interacts with ALKBH4, KCNN4, MTMR7, MTMR8 and MTMR9.

    Three dimensional structures from OCA and Proteopedia for MTMR6 Gene

    Alternative splice isoforms for MTMR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTMR6 Gene

Proteomics data for MTMR6 Gene at MOPED

Selected DME Specific Peptides for MTMR6 Gene

Post-translational modifications for MTMR6 Gene

  • Ubiquitination at Lys135, Lys179, and Lys253
  • Modification sites at PhosphoSitePlus

Other Protein References for MTMR6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MTMR6 Gene

Gene Families for MTMR6 Gene

HGNC:
  • DUSPM :Protein tyrosine phosphatases / Class I Cys-based PTPs : Myotubularins

Suggested Antigen Peptide Sequences for MTMR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y217

UniProtKB/Swiss-Prot:

MTMR6_HUMAN :
  • Q9Y217
Domain:
  • Contains 1 myotubularin phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
genes like me logo Genes that share domains with MTMR6: view

Function for MTMR6 Gene

Molecular function for MTMR6 Gene

GENATLAS Biochemistry: myotubularin related protein 6,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.

Enzyme Numbers (IUBMB) for MTMR6 Gene

Gene Ontology (GO) - Molecular Function for MTMR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity NAS 9736772
GO:0004725 protein tyrosine phosphatase activity NAS 9736772
GO:0005515 protein binding IPI 21516116
GO:0015269 calcium-activated potassium channel activity IDA 15831468
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with MTMR6: view

Phenotypes for MTMR6 Gene

GenomeRNAi human phenotypes for MTMR6:
genes like me logo Genes that share phenotypes with MTMR6: view

miRNA for MTMR6 Gene

miRTarBase miRNAs that target MTMR6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MTMR6 Gene

Localization for MTMR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTMR6 Gene

Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTMR6 Gene COMPARTMENTS Subcellular localization image for MTMR6 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MTMR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MTMR6: view

Pathways for MTMR6 Gene

genes like me logo Genes that share pathways with MTMR6: view

Gene Ontology (GO) - Biological Process for MTMR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation NAS 9736772
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation NAS 9736772
genes like me logo Genes that share ontologies with MTMR6: view

Compounds for MTMR6 Gene

(2) Novoseek inferred chemical compound relationships for MTMR6 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 3-phosphate 89.8 4
lipid 19.4 2
genes like me logo Genes that share compounds with MTMR6: view

Transcripts for MTMR6 Gene

Unigene Clusters for MTMR6 Gene

Myotubularin related protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTMR6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: -
SP3:

Relevant External Links for MTMR6 Gene

GeneLoc Exon Structure for
MTMR6
ECgene alternative splicing isoforms for
MTMR6

Expression for MTMR6 Gene

mRNA expression in normal human tissues for MTMR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MTMR6 Gene

SOURCE GeneReport for Unigene cluster for MTMR6 Gene Hs.643702

mRNA Expression by UniProt/SwissProt for MTMR6 Gene

Q9Y217-MTMR6_HUMAN
Tissue specificity: Expressed in CD4+ T-cells.
genes like me logo Genes that share expressions with MTMR6: view

No data available for mRNA differential expression in normal tissues for MTMR6 Gene

Orthologs for MTMR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MTMR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTMR6 35
  • 99.79 (n)
  • 99.84 (a)
MTMR6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTMR6 35
  • 87.28 (n)
  • 93.72 (a)
MTMR6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTMR6 35
  • 93.18 (n)
  • 96.3 (a)
MTMR6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtmr6 35
  • 86.28 (n)
  • 90.76 (a)
Mtmr6 16
Mtmr6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTMR6 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTMR6 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtmr6 35
  • 86.83 (n)
  • 92.28 (a)
chicken
(Gallus gallus)
Aves MTMR6 35
  • 78.87 (n)
  • 86.13 (a)
MTMR6 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTMR6 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtmr6 35
  • 71.68 (n)
  • 77.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1836 35
zebrafish
(Danio rerio)
Actinopterygii mtmr6 35
  • 65.46 (n)
  • 71.92 (a)
mtmr6 36
  • 67 (a)
OneToOne
wufi04a11 35
fruit fly
(Drosophila melanogaster)
Insecta CG3530 36
  • 39 (a)
OneToMany
BcDNA:GH04637 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea mtm-6 36
  • 32 (a)
OneToMany
T24A11.1a 37
  • 36 (a)
T24A11.1b 37
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR152C 35
  • 48.54 (n)
  • 41.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMR1 35
  • 49.58 (n)
  • 40.55 (a)
YMR1 36
  • 28 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05853g 35
  • 50.89 (n)
  • 42.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11185 35
  • 45.78 (n)
  • 38.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC19A8.03 35
  • 48.85 (n)
  • 41.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for MTMR6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTMR6 Gene

ENSEMBL:
Gene Tree for MTMR6 (if available)
TreeFam:
Gene Tree for MTMR6 (if available)

Paralogs for MTMR6 Gene

Paralogs for MTMR6 Gene

Selected SIMAP similar genes for MTMR6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MTMR6: view

Variants for MTMR6 Gene

Sequence variations from dbSNP and Humsavar for MTMR6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs8262 -- 25,247,465(-) ACATA(C/T)ATTTG utr-variant-3-prime
rs3809333 -- 25,287,632(-) GTCTT(C/T)CTCCC upstream-variant-2KB
rs3809334 -- 25,287,518(-) CTGTC(C/T)GGGAC utr-variant-5-prime, upstream-variant-2KB
rs3809335 -- 25,287,439(-) GGGTT(C/T)GGGGA utr-variant-5-prime
rs3923860 -- 25,285,564(+) GAGTC(C/T)CGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTMR6 Gene

Variant ID Type Subtype PubMed ID
nsv435952 OTHER Inversion 17901297
esv2747161 CNV Deletion 23290073
nsv899943 CNV Gain 21882294
dgv1566n71 CNV Gain 21882294
nsv820184 CNV Loss 19587683
esv2629441 CNV Deletion 19546169
nsv526439 CNV Loss 19592680

Relevant External Links for MTMR6 Gene

HapMap Linkage Disequilibrium report
MTMR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTMR6 Gene

Disorders for MTMR6 Gene

(2) University of Copenhagen DISEASES for MTMR6 Gene

genes like me logo Genes that share disorders with MTMR6: view

No data available for UniProtKB/Swiss-Prot for MTMR6 Gene

Publications for MTMR6 Gene

  1. The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. (PMID: 15831468) Srivastava S. … Skolnik E.Y. (Mol. Cell. Biol. 2005) 3 4 23
  2. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. (PMID: 16847315) Srivastava S. … Skolnik E.Y. (Mol. Cell. Biol. 2006) 3 4 23
  3. Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. (PMID: 9736772) Laporte J. … Mandel J.-L. (Hum. Mol. Genet. 1998) 2 3 4
  4. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. (PMID: 12646134) Schaletzky J. … Barr F.A. (Curr. Biol. 2003) 3 23
  5. MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. (PMID: 19038970) Zou J. … Majerus P.W. (J. Biol. Chem. 2009) 3 23

Products for MTMR6 Gene

Sources for MTMR6 Gene

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