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Aliases for DPP9 Gene

Aliases for DPP9 Gene

  • Dipeptidyl Peptidase 9 2 3 5
  • Dipeptidyl Peptidase-Like Protein 9 3 4
  • Dipeptidyl Peptidase IX 3 4
  • Dipeptidylpeptidase 9 2 3
  • DPP IX 3 4
  • DPRP-2 3 4
  • DPLP9 3 4
  • DPRP2 3 4
  • DP9 3 4
  • Dipeptidyl Peptidase IV-Related Protein-2 3
  • Dipeptidyl Peptidase IV-Related Protein 2 4
  • EC 3.4.14.5 4

External Ids for DPP9 Gene

Previous GeneCards Identifiers for DPP9 Gene

  • GC19M004768
  • GC19M004616
  • GC19M004626
  • GC19M004435

Summaries for DPP9 Gene

Entrez Gene Summary for DPP9 Gene

  • This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPP9 Gene

DPP9 (Dipeptidyl Peptidase 9) is a Protein Coding gene. Diseases associated with DPP9 include Pulmonary Fibrosis, Idiopathic. Among its related pathways are Lung fibrosis. GO annotations related to this gene include identical protein binding and serine-type peptidase activity. An important paralog of this gene is DPP8.

UniProtKB/Swiss-Prot for DPP9 Gene

  • Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.

Gene Wiki entry for DPP9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPP9 Gene

Genomics for DPP9 Gene

Regulatory Elements for DPP9 Gene

Enhancers for DPP9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G004744 1.1 Ensembl ENCODE 12 -20.4 -20425 1.1 FOXA2 SIN3A INSM2 KLF17 EGR1 ZNF366 ZMIZ1 FOS CREM EGR2 MIR7-3HG MIR7-3 FEM1A DPP9 PLIN3 TRV-CAC3-1 GC19M004737
GH19G004644 1 Ensembl ENCODE 12.3 +77.8 77801 4.4 BCOR CTCF PTBP1 ZMYM3 EBF1 POLR2A EED ADNP RELB ZNF600 MYDGF DPP9 TNFAIP8L1 GC19M004643 PIR47904
GH19G004716 1.3 Ensembl ENCODE dbSUPER 9 +6.8 6840 2.4 CTCF SOX13 ESRRA NFIB SIN3A ZIC2 RARA ZNF335 ZNF121 GATA3 DPP9 HSD11B1L LOC105372250 GC19M004658
GH19G004860 1 ENCODE dbSUPER 10.9 -136.9 -136932 2.5 HDGF NFIB SIN3A ZIC2 HIC1 CTBP1 ZFHX2 ZNF280D NFIA ZHX2 PLIN3 TICAM1 ARRDC5 DPP9 GC19M004858
GH19G004722 1.4 ENCODE dbSUPER 5.8 +0.6 570 4.5 CREB3L1 MLX AGO1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21 SAFB SAFB2 ENSG00000267030 ENSG00000267769 APBA3 DPP9-AS1 SNRPEP4 ENSG00000269807 TICAM1 ENSG00000267138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPP9 on UCSC Golden Path with GeneCards custom track

Promoters for DPP9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106265 673 2401 CREB3L1 MLX AGO1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC TBX21

Genomic Location for DPP9 Gene

Chromosome:
19
Start:
4,675,224 bp from pter
End:
4,724,673 bp from pter
Size:
49,450 bases
Orientation:
Minus strand

Genomic View for DPP9 Gene

Genes around DPP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPP9 Gene

Proteins for DPP9 Gene

  • Protein details for DPP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TI2-DPP9_HUMAN
    Recommended name:
    Dipeptidyl peptidase 9
    Protein Accession:
    Q86TI2
    Secondary Accessions:
    • O75273
    • O75868
    • Q1ZZB8
    • Q6AI37
    • Q6UAL0
    • Q6ZMT2
    • Q6ZNJ5
    • Q8N2J7
    • Q8N3F5
    • Q8WXD8
    • Q96NT8
    • Q9BVR3

    Protein attributes for DPP9 Gene

    Size:
    863 amino acids
    Molecular mass:
    98263 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC33801.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC62840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH37948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL47179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO73880.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB70784.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11362.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC85150.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAD18643.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAD39039.3; Type=Frameshift; Positions=432, 460; Evidence={ECO:0000305};

    Alternative splice isoforms for DPP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPP9 Gene

Post-translational modifications for DPP9 Gene

  • Ubiquitination at isoforms=2828
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DPP9 Gene

Domains & Families for DPP9 Gene

Gene Families for DPP9 Gene

Protein Domains for DPP9 Gene

Graphical View of Domain Structure for InterPro Entry

Q86TI2

UniProtKB/Swiss-Prot:

DPP9_HUMAN :
  • Belongs to the peptidase S9B family. DPPIV subfamily.
Family:
  • Belongs to the peptidase S9B family. DPPIV subfamily.
genes like me logo Genes that share domains with DPP9: view

Function for DPP9 Gene

Molecular function for DPP9 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=161 uM for Ala-Pro-AMC {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913}; KM=180 uM for Ala-Pro-AFC {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913}; pH dependence: Optimum pH is 7.5-8.5. Little activity below pH 6.5. {ECO:0000269 PubMed:12662155, ECO:0000269 PubMed:15245913};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal dipeptide, Xaa-Yaa- -Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate.
UniProtKB/Swiss-Prot Function:
Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.

Enzyme Numbers (IUBMB) for DPP9 Gene

Gene Ontology (GO) - Molecular Function for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 22001206
genes like me logo Genes that share ontologies with DPP9: view
genes like me logo Genes that share phenotypes with DPP9: view

Animal Models for DPP9 Gene

MGI Knock Outs for DPP9:
  • Dpp9 tm1b(EUCOMM)Hmgu
  • Dpp9 tm1a(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for DPP9

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPP9 Gene

Localization for DPP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPP9 Gene

Isoform 1: Cytoplasm, cytosol.
Isoform 2: Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPP9 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DPP9: view

Pathways & Interactions for DPP9 Gene

SuperPathway Contained pathways
1 Lung fibrosis
genes like me logo Genes that share pathways with DPP9: view

Pathways by source for DPP9 Gene

1 BioSystems pathway for DPP9 Gene

Gene Ontology (GO) - Biological Process for DPP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DPP9: view

No data available for SIGNOR curated interactions for DPP9 Gene

Drugs & Compounds for DPP9 Gene

(2) Drugs for DPP9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DPP9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPP9: view

Transcripts for DPP9 Gene

Unigene Clusters for DPP9 Gene

Dipeptidyl-peptidase 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPP9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d · 12e ·
SP1: - - - - - - - - -
SP2:
SP3:
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10:
SP11: - - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15:
SP16: - - - - - - -
SP17: -
SP18: - - - -

ExUns: 12f · 12g ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a ·
SP1: - - -
SP2: -
SP3:
SP4: - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - - - - -
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:

ExUns: 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DPP9 Gene

GeneLoc Exon Structure for
DPP9
ECgene alternative splicing isoforms for
DPP9

Expression for DPP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPP9 Gene

Protein differential expression in normal tissues from HIPED for DPP9 Gene

This gene is overexpressed in Cardia (23.5) and Lymph node (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPP9 Gene



Protein tissue co-expression partners for DPP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPP9 Gene:

DPP9

SOURCE GeneReport for Unigene cluster for DPP9 Gene:

Hs.515081

mRNA Expression by UniProt/SwissProt for DPP9 Gene:

Q86TI2-DPP9_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain.

Evidence on tissue expression from TISSUES for DPP9 Gene

  • Skin(4.5)
  • Intestine(4.3)
  • Spleen(4.2)
  • Nervous system(3.8)
  • Pancreas(2.1)
  • Liver(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DPP9 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • head
  • mouth
  • salivary gland
Thorax:
  • breast
  • bronchus
  • esophagus
  • heart
  • lung
  • trachea
Abdomen:
  • kidney
  • liver
  • spleen
Pelvis:
  • testicle
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with DPP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPP9 Gene

Orthologs for DPP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPP9 34 35
  • 99.48 (n)
oppossum
(Monodelphis domestica)
Mammalia DPP9 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPP9 34 35
  • 90.01 (n)
cow
(Bos Taurus)
Mammalia DPP9 34 35
  • 88.63 (n)
mouse
(Mus musculus)
Mammalia Dpp9 34 16 35
  • 84.94 (n)
rat
(Rattus norvegicus)
Mammalia Dpp9 34
  • 82.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPP9 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPP9 34 35
  • 77.19 (n)
lizard
(Anolis carolinensis)
Reptilia DPP9 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpp9 34
  • 68.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5231 34
zebrafish
(Danio rerio)
Actinopterygii dpp9 34 35
  • 71.91 (n)
Dr.11668 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003138 34
  • 55.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3744 36 34 35
  • 52.32 (n)
worm
(Caenorhabditis elegans)
Secernentea K02F2.1a 36
  • 32 (a)
K02F2.1b 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G24260 34
  • 43.87 (n)
rice
(Oryza sativa)
Liliopsida Os02g0290600 34
  • 42.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4146 34
Species where no ortholog for DPP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPP9 Gene

ENSEMBL:
Gene Tree for DPP9 (if available)
TreeFam:
Gene Tree for DPP9 (if available)

Paralogs for DPP9 Gene

Paralogs for DPP9 Gene

genes like me logo Genes that share paralogs with DPP9: view

Variants for DPP9 Gene

Sequence variations from dbSNP and Humsavar for DPP9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000084817 -- 4,722,592(+) TAATG(A/G)AAGCA intron-variant, upstream-variant-2KB
rs1000196516 -- 4,724,171(+) AAATT(C/T)TCATT intron-variant, upstream-variant-2KB
rs1000202622 -- 4,703,273(+) AATGC(C/T)CAGGG intron-variant
rs1000267748 -- 4,699,377(+) GTCTG(C/T)GAGTT intron-variant
rs1000303806 -- 4,719,826(+) ACGGA(C/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPP9 Gene

Variant ID Type Subtype PubMed ID
dgv6233n54 CNV loss 21841781
esv2666899 CNV deletion 23128226
esv26771 CNV loss 19812545
esv3643509 CNV loss 21293372
nsv1062709 CNV loss 25217958
nsv428361 CNV loss 18775914
nsv477186 CNV novel sequence insertion 20440878
nsv480151 CNV novel sequence insertion 20440878
nsv578452 CNV loss 21841781
nsv833721 CNV loss 17160897
nsv953950 CNV deletion 24416366
nsv978760 CNV duplication 23825009

Variation tolerance for DPP9 Gene

Residual Variation Intolerance Score: 7.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.14; 51.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPP9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPP9 Gene

Disorders for DPP9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPP9 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
pulmonary fibrosis, idiopathic
  • idiopathic pulmonary fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search DPP9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DPP9

Genetic Association Database (GAD)
DPP9
Human Genome Epidemiology (HuGE) Navigator
DPP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPP9
genes like me logo Genes that share disorders with DPP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPP9 Gene

Publications for DPP9 Gene

  1. Association study between adolescent idiopathic scoliosis and the DPP9 gene which is located in the candidate region identified by linkage analysis. (PMID: 18940951) Qiu X.S. … Cheng J.C. (Postgrad Med J 2008) 3 22 46 64
  2. Dipeptidyl peptidase 9 has two forms, a broad tissue distribution, cytoplasmic localization and DPIV-like peptidase activity. (PMID: 15245913) Ajami K. … Gorrell M.D. (Biochim. Biophys. Acta 2004) 3 4 22 64
  3. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. (PMID: 12662155) Qi S.Y. … Akinsanya K.O. (Biochem. J. 2003) 3 4 22 64
  4. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV. (PMID: 12459266) Olsen C. … Wagtmann N. (Gene 2002) 3 4 22 64
  5. The amino terminus extension in the long dipeptidyl peptidase 9 isoform contains a nuclear localization signal targeting the active peptidase to the nucleus. (PMID: 24562348) Justa-Schuch D. … Geiss-Friedlander R. (Cell. Mol. Life Sci. 2014) 3 4 64

Products for DPP9 Gene

Sources for DPP9 Gene

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