Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DHX57 Gene

Aliases for DHX57 Gene

  • DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57 2 3
  • DEAH Box Protein 57 3 4
  • Putative ATP-Dependent RNA Helicase DHX57 3
  • DEAH-Box RNA/DNA Helicase AAM73547 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64
  • DDX57 3

External Ids for DHX57 Gene

Summaries for DHX57 Gene

GeneCards Summary for DHX57 Gene

DHX57 (DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for DHX57 Gene

  • Probable ATP-binding RNA helicase

Gene Wiki entry for DHX57 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX57 Gene

Genomics for DHX57 Gene

Genomic Location for DHX57 Gene

Start:
38,797,729 bp from pter
End:
38,875,934 bp from pter
Size:
78,206 bases
Orientation:
Minus strand

Genomic View for DHX57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DHX57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX57 Gene

Regulatory Elements for DHX57 Gene

Proteins for DHX57 Gene

  • Protein details for DHX57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P158-DHX57_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57
    Protein Accession:
    Q6P158
    Secondary Accessions:
    • A2RRC7
    • Q53SI4
    • Q6P9G1
    • Q7Z6H3
    • Q8NG17
    • Q96M33

    Protein attributes for DHX57 Gene

    Size:
    1386 amino acids
    Molecular mass:
    155604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY24256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX57 Gene

Proteomics data for DHX57 Gene at MOPED

Selected DME Specific Peptides for DHX57 Gene

Post-translational modifications for DHX57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DHX57 Gene

Domains for DHX57 Gene

Gene Families for DHX57 Gene

HGNC:
  • DHX :DEAH-boxes

UniProtKB/Swiss-Prot:

DHX57_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q6P158
  • Contains 1 helicase C-terminal domain.:
    • Q6P158
  • Contains 1 UBA domain.:
    • Q6P158
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.:
    • Q6P158
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q6P158
genes like me logo Genes that share domains with DHX57: view

Function for DHX57 Gene

Molecular function for DHX57 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase

Enzyme Numbers (IUBMB) for DHX57 Gene

Gene Ontology (GO) - Molecular Function for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DHX57 Gene

Localization for DHX57 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DHX57 Gene COMPARTMENTS Subcellular localization image for DHX57 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with DHX57: view

Pathways for DHX57 Gene

SuperPathways for DHX57 Gene

No Data Available

Interacting Proteins for DHX57 Gene

Gene Ontology (GO) - Biological Process for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Pathways by source for DHX57 Gene

Transcripts for DHX57 Gene

Unigene Clusters for DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DHX57 Gene

GeneLoc Exon Structure for
DHX57
ECgene alternative splicing isoforms for
DHX57

Expression for DHX57 Gene

mRNA expression in normal human tissues for DHX57 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DHX57 Gene

SOURCE GeneReport for Unigene cluster for DHX57 Gene Hs.468226

genes like me logo Genes that share expressions with DHX57: view

Orthologs for DHX57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX57 36
  • 99.51 (n)
  • 99.71 (a)
DHX57 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DHX57 36
  • 90.39 (n)
  • 92.44 (a)
DHX57 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DHX57 36
  • 91.22 (n)
  • 92.81 (a)
DHX57 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dhx57 36
  • 84.33 (n)
  • 86.98 (a)
Dhx57 16
Dhx57 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DHX57 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX57 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dhx57 36
  • 84.16 (n)
  • 86.83 (a)
chicken
(Gallus gallus)
Aves DHX57 36
  • 73.18 (n)
  • 76.59 (a)
DHX57 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DHX57 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx57 36
  • 66.27 (n)
  • 68.44 (a)
zebrafish
(Danio rerio)
Actinopterygii dhx57 36
  • 61.41 (n)
  • 61.76 (a)
dhx57 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002223 36
  • 48.14 (n)
  • 45.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1582 36
  • 49.81 (n)
  • 44.68 (a)
CG1582 37
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 22 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.2502 36
Species with no ortholog for DHX57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX57 Gene

ENSEMBL:
Gene Tree for DHX57 (if available)
TreeFam:
Gene Tree for DHX57 (if available)

Paralogs for DHX57 Gene

Paralogs for DHX57 Gene

Selected SIMAP similar genes for DHX57 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DHX57: view

Variants for DHX57 Gene

Sequence variations from dbSNP and Humsavar for DHX57 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10219 -- 38,856,898(-) TCTGA(A/G)TAAAG intron-variant
rs756162 -- 38,820,923(-) AAAGG(A/T)TTTTT intron-variant
rs756338 -- 38,821,078(-) AGTTC(A/G)CAATT intron-variant
rs1063636 -- 38,797,901(-) TTTTT(C/T)TTTTC utr-variant-3-prime
rs1063637 -- 38,797,875(-) GACTG(A/C)GAGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DHX57 Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV Loss 18304495
esv268479 CNV Insertion 20981092
nsv2692 CNV Loss 18451855
esv4781 CNV Deletion 18987735
esv2719952 CNV Deletion 23290073
esv1005417 CNV Deletion 20482838
esv1777011 CNV Deletion 17803354
esv6905 CNV Loss 19470904

Relevant External Links for DHX57 Gene

HapMap Linkage Disequilibrium report
DHX57

Disorders for DHX57 Gene

No disorders were found for DHX57 Gene.

No data available for UniProtKB/Swiss-Prot for DHX57 Gene

Publications for DHX57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3

Products for DHX57 Gene

Sources for DHX57 Gene

Back to Top

Content