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Aliases for DHX57 Gene

Aliases for DHX57 Gene

  • DExH-Box Helicase 57 2 3 5
  • DEAH (Asp-Glu-Ala-Asp/His) Box Polypeptide 57 2 3
  • DEAH Box Protein 57 3 4
  • Putative ATP-Dependent RNA Helicase DHX57 3
  • DEAH-Box RNA/DNA Helicase AAM73547 3
  • DEAH-Box Helicase 57 3
  • EC 3.6.4.13 4
  • EC 3.6.1 56
  • DDX57 3

External Ids for DHX57 Gene

Previous GeneCards Identifiers for DHX57 Gene

  • GC02M038982
  • GC02M038999
  • GC02M038936
  • GC02M038878
  • GC02M039025

Summaries for DHX57 Gene

GeneCards Summary for DHX57 Gene

DHX57 (DExH-Box Helicase 57) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX36.

UniProtKB/Swiss-Prot for DHX57 Gene

  • Probable ATP-binding RNA helicase.

Gene Wiki entry for DHX57 Gene

Additional gene information for DHX57 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DHX57 Gene

Genomics for DHX57 Gene

GeneHancer (GH) Regulatory Elements for DHX57 Gene

Promoters and enhancers for DHX57 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I038874 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.3 +0.1 68 1.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 E2F8 DHX57 MORN2 ENSG00000225284
GH02I038070 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.9 +801.7 801711 7.6 PKNOX1 FOXA2 ARNT SIN3A YY1 GLIS2 E2F8 ZNF143 KLF7 FOS CYP1B1 CYP1B1-AS1 ENSG00000272054 SRSF7 DHX57 ASS1P2 CEBPZ HEATR5B RMDN2
GH02I038749 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.9 +125.0 124974 3.5 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 SRSF7 GEMIN6 SOS1 DHX57 ARHGEF33 GALM ASS1P2 LOC728730 ENSG00000232518
GH02I038238 Enhancer 0.7 ENCODE 40.6 +636.4 636394 1.2 ZFP64 ZNF140 ZNF266 ZNF697 ZNF664 ZNF213 ZNF433 ZNF202 ZNF680 ZBTB11 LOC102723739 SRSF7 SOS1 DHX57 ARHGEF33 ASS1P2 HNRNPLL ENSG00000229160 ATL2 GC02P038231
GH02I038598 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.1 +274.7 274670 6.2 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 PIR45803 HNRNPLL ENSG00000235586 SRSF7 DHX57 LOC101929596 GALM GC02M038560
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DHX57 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DHX57 gene promoter:

Genomic Locations for DHX57 Gene

Genomic Locations for DHX57 Gene
chr2:38,797,729-38,875,934
(GRCh38/hg38)
Size:
78,206 bases
Orientation:
Minus strand
chr2:39,024,871-39,103,075
(GRCh37/hg19)

Genomic View for DHX57 Gene

Genes around DHX57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DHX57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DHX57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DHX57 Gene

Proteins for DHX57 Gene

  • Protein details for DHX57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P158-DHX57_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DHX57
    Protein Accession:
    Q6P158
    Secondary Accessions:
    • A2RRC7
    • Q53SI4
    • Q6P9G1
    • Q7Z6H3
    • Q8NG17
    • Q96M33

    Protein attributes for DHX57 Gene

    Size:
    1386 amino acids
    Molecular mass:
    155604 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM73547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY24256.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DHX57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DHX57 Gene

Selected DME Specific Peptides for DHX57 Gene

Q6P158:
  • DVVYVID
  • VDEVHER
  • AETSITI
  • VILMSAT
  • TNIAETS
  • TQPRRISA
  • GKTTQIPQ

Post-translational modifications for DHX57 Gene

No Post-translational modifications

Domains & Families for DHX57 Gene

Gene Families for DHX57 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DHX57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P158

UniProtKB/Swiss-Prot:

DHX57_HUMAN :
  • Belongs to the DEAD box helicase family. DEAH subfamily.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with DHX57: view

Function for DHX57 Gene

Molecular function for DHX57 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase.

Enzyme Numbers (IUBMB) for DHX57 Gene

Phenotypes From GWAS Catalog for DHX57 Gene

Gene Ontology (GO) - Molecular Function for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DHX57: view
genes like me logo Genes that share phenotypes with DHX57: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DHX57 Gene

Localization for DHX57 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DHX57 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DHX57 Gene

Pathways & Interactions for DHX57 Gene

SuperPathways for DHX57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DHX57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
genes like me logo Genes that share ontologies with DHX57: view

No data available for Pathways by source and SIGNOR curated interactions for DHX57 Gene

Drugs & Compounds for DHX57 Gene

(3) Drugs for DHX57 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for DHX57 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DHX57: view

Transcripts for DHX57 Gene

Unigene Clusters for DHX57 Gene

DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DHX57 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DHX57 Gene

GeneLoc Exon Structure for
DHX57
ECgene alternative splicing isoforms for
DHX57

Expression for DHX57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DHX57 Gene

Protein differential expression in normal tissues from HIPED for DHX57 Gene

This gene is overexpressed in Lung (29.5), Adrenal (12.7), and Pancreatic juice (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DHX57 Gene



Protein tissue co-expression partners for DHX57 Gene

NURSA nuclear receptor signaling pathways regulating expression of DHX57 Gene:

DHX57

SOURCE GeneReport for Unigene cluster for DHX57 Gene:

Hs.468226

Evidence on tissue expression from TISSUES for DHX57 Gene

  • Skin(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with DHX57: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DHX57 Gene

Orthologs for DHX57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DHX57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DHX57 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia DHX57 33 34
  • 91.22 (n)
cow
(Bos Taurus)
Mammalia DHX57 33 34
  • 90.39 (n)
mouse
(Mus musculus)
Mammalia Dhx57 33 16 34
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Dhx57 33
  • 84.16 (n)
oppossum
(Monodelphis domestica)
Mammalia DHX57 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DHX57 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DHX57 33 34
  • 73.18 (n)
lizard
(Anolis carolinensis)
Reptilia DHX57 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dhx57 33
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii dhx57 33 34
  • 61.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1582 33 34
  • 49.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002223 33
  • 48.14 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 22 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.2502 33
Species where no ortholog for DHX57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DHX57 Gene

ENSEMBL:
Gene Tree for DHX57 (if available)
TreeFam:
Gene Tree for DHX57 (if available)

Paralogs for DHX57 Gene

Paralogs for DHX57 Gene

(4) SIMAP similar genes for DHX57 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DHX57: view

Variants for DHX57 Gene

Sequence variations from dbSNP and Humsavar for DHX57 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000008139 -- 38,839,024(-) C/T intron_variant
rs1000053160 -- 38,821,631(-) T/C intron_variant
rs1000085753 -- 38,803,460(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000120840 -- 38,805,087(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000124861 -- 38,821,384(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DHX57 Gene

Variant ID Type Subtype PubMed ID
dgv1893n106 CNV deletion 24896259
esv1005417 CNV deletion 20482838
esv1777011 CNV deletion 17803354
esv2719952 CNV deletion 23290073
esv3304200 CNV mobile element insertion 20981092
esv3337224 CNV insertion 20981092
esv3555300 CNV deletion 23714750
esv3575234 CNV gain 25503493
esv4781 CNV loss 18987735
esv6905 CNV loss 19470904
nsv1071988 CNV deletion 25765185
nsv1110738 CNV insertion 24896259
nsv1114078 CNV deletion 24896259
nsv1153058 CNV deletion 26484159
nsv2692 CNV deletion 18451855
nsv955026 CNV deletion 24416366
nsv9646 CNV loss 18304495
nsv978996 CNV duplication 23825009

Variation tolerance for DHX57 Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DHX57 Gene

Human Gene Mutation Database (HGMD)
DHX57
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DHX57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DHX57 Gene

Disorders for DHX57 Gene

Additional Disease Information for DHX57

No disorders were found for DHX57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DHX57 Gene

Publications for DHX57 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DHX57 Gene

Sources for DHX57 Gene

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