Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJA3 Gene

Aliases for DNAJA3 Gene

  • DnaJ (Hsp40) Homolog, Subfamily A, Member 3 2 3
  • TID1 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 57 3 4
  • Tumorous Imaginal Discs Protein Tid56 Homolog 3 4
  • DnaJ Protein Tid-1 3 4
  • HTID-1 3 4
  • HCA57 3 4
  • DnaJ Homolog Subfamily A Member 3, Mitochondrial 3

External Ids for DNAJA3 Gene

Previous Symbols for DNAJA3 Gene

  • TID1

Summaries for DNAJA3 Gene

Entrez Gene Summary for DNAJA3 Gene

  • This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for DNAJA3 Gene

DNAJA3 (DnaJ (Hsp40) Homolog, Subfamily A, Member 3) is a Protein Coding gene. Diseases associated with DNAJA3 include hepatocellular carcinoma. Among its related pathways are Apoptosis and Autophagy and Viral carcinogenesis. GO annotations related to this gene include protein kinase binding and unfolded protein binding.

UniProtKB/Swiss-Prot for DNAJA3 Gene

  • Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway

Gene Wiki entry for DNAJA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA3 Gene

Genomics for DNAJA3 Gene

Genomic Location for DNAJA3 Gene

Start:
4,425,805 bp from pter
End:
4,456,775 bp from pter
Size:
30,971 bases
Orientation:
Plus strand

Genomic View for DNAJA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA3 Gene

Regulatory Elements for DNAJA3 Gene

Proteins for DNAJA3 Gene

  • Protein details for DNAJA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EY1-DNJA3_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 3, mitochondrial
    Protein Accession:
    Q96EY1
    Secondary Accessions:
    • B2RAJ5
    • B4DI33
    • E7ES32
    • O75472
    • Q8WUJ6
    • Q8WXJ3
    • Q96D76
    • Q96IV1
    • Q9NYH8

    Protein attributes for DNAJA3 Gene

    Size:
    480 amino acids
    Molecular mass:
    52489 Da
    Quaternary structure:
    • Interacts with JAK2, HSPA9B and IFN-gammaR2 chain. Interacts with Ras GTPase-activating protein 1 (RASA1). Isoform 2 interacts with MUSK (via the cytoplasmic domain) (By similarity).
    SequenceCaution:
    • Sequence=AAF66245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF66245.1; Type=Frameshift; Positions=408, 411; Evidence={ECO:0000305}; Sequence=AAH12343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNAJA3 Gene

    Alternative splice isoforms for DNAJA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA3 Gene

Proteomics data for DNAJA3 Gene at MOPED

Post-translational modifications for DNAJA3 Gene

No data available for DME Specific Peptides for DNAJA3 Gene

Domains for DNAJA3 Gene

Gene Families for DNAJA3 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Suggested Antigen Peptide Sequences for DNAJA3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EY1

UniProtKB/Swiss-Prot:

DNJA3_HUMAN
Domain:
  • Modulation of apoptosis, i.e. proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent:
    • Q96EY1
  • Contains 1 J domain.:
    • Q96EY1
Similarity:
  • Contains 1 CR-type zinc finger.:
    • Q96EY1
genes like me logo Genes that share domains with DNAJA3: view

Function for DNAJA3 Gene

Molecular function for DNAJA3 Gene

UniProtKB/Swiss-Prot Function: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway

Gene Ontology (GO) - Molecular Function for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005133 interferon-gamma receptor binding IDA 11679576
GO:0005515 protein binding IPI 10411904
GO:0005524 ATP binding IEA --
GO:0008134 transcription factor binding IPI 16531398
GO:0019901 protein kinase binding IPI 11679576
genes like me logo Genes that share ontologies with DNAJA3: view
genes like me logo Genes that share phenotypes with DNAJA3: view

Animal Models for DNAJA3 Gene

MGI Knock Outs for DNAJA3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DNAJA3 Gene

Localization for DNAJA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA3 Gene

Mitochondrion matrix. Cytoplasm, cytosol. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJA3 Gene COMPARTMENTS Subcellular localization image for DNAJA3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11679576
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix IDA 10411904
GO:0005829 cytosol IMP 16531398
genes like me logo Genes that share ontologies with DNAJA3: view

Pathways for DNAJA3 Gene

genes like me logo Genes that share pathways with DNAJA3: view

Pathways by source for DNAJA3 Gene

1 Qiagen pathway for DNAJA3 Gene
1 Cell Signaling Technology pathway for DNAJA3 Gene
1 BioSystems pathway for DNAJA3 Gene
1 KEGG pathway for DNAJA3 Gene

Gene Ontology (GO) - Biological Process for DNAJA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21106534
GO:0006264 mitochondrial DNA replication IEA --
GO:0006457 protein folding IDA 16531398
GO:0006469 negative regulation of protein kinase activity IDA 15601829
GO:0006915 apoptotic process --
genes like me logo Genes that share ontologies with DNAJA3: view

Compounds for DNAJA3 Gene

(2) Novoseek inferred chemical compound relationships for DNAJA3 Gene

Compound -log(P) Hits PubMed IDs
mitomycin c 39 1
tyrosine 16.7 5
genes like me logo Genes that share compounds with DNAJA3: view

Transcripts for DNAJA3 Gene

Unigene Clusters for DNAJA3 Gene

DnaJ (Hsp40) homolog, subfamily A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5: - - -
SP6: - - - - -
SP7: -
SP8:

Relevant External Links for DNAJA3 Gene

GeneLoc Exon Structure for
DNAJA3
ECgene alternative splicing isoforms for
DNAJA3

Expression for DNAJA3 Gene

mRNA expression in normal human tissues for DNAJA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJA3 Gene

SOURCE GeneReport for Unigene cluster for DNAJA3 Gene Hs.459779

mRNA Expression by UniProt/SwissProt for DNAJA3 Gene

Q96EY1-DNJA3_HUMAN
Tissue specificity: Widely expressed with highest levels in heart, liver, lung and skeletal muscles. Also expressed in keratinocytes.
genes like me logo Genes that share expressions with DNAJA3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DNAJA3 Gene

Orthologs for DNAJA3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJA3 35
  • 99.51 (n)
  • 99.58 (a)
DNAJA3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJA3 35
  • 88.07 (n)
  • 90.16 (a)
DNAJA3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJA3 35
  • 87.64 (n)
  • 88.96 (a)
DNAJA3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja3 35
  • 86.74 (n)
  • 87.5 (a)
Dnaja3 16
Dnaja3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJA3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnaja3 35
  • 87.08 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves DNAJA3 35
  • 74.85 (n)
  • 81.79 (a)
DNAJA3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA3 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15457 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja3 35
  • 67.7 (n)
  • 71.96 (a)
Str.11816 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12924 35
zebrafish
(Danio rerio)
Actinopterygii dnaja3a 35
  • 68.59 (n)
  • 70.28 (a)
dnaja3a 36
  • 66 (a)
OneToMany
dnaja3b 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007565 35
  • 58.54 (n)
  • 58.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)tid 35
  • 56.02 (n)
  • 54.88 (a)
l(2)tid 36
  • 43 (a)
OneToOne
CG7387 37
  • 31 (a)
l(2)tid 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-10 36
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR507W 35
  • 48.96 (n)
  • 37.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MDJ1 35
  • 46.77 (n)
  • 36.32 (a)
MDJ1 36
  • 28 (a)
OneToOne
MDJ1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07656g 35
  • 47.52 (n)
  • 37.95 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GFA2 35
  • 48.94 (n)
  • 39.67 (a)
rice
(Oryza sativa)
Liliopsida Os12g0168400 35
  • 49.7 (n)
  • 42.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05196 35
  • 49.37 (n)
  • 38.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mdj1 35
  • 43.24 (n)
  • 37.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11768 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4105 36
  • 50 (a)
OneToOne
Species with no ortholog for DNAJA3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJA3 Gene

ENSEMBL:
Gene Tree for DNAJA3 (if available)
TreeFam:
Gene Tree for DNAJA3 (if available)

Paralogs for DNAJA3 Gene

genes like me logo Genes that share paralogs with DNAJA3: view

No data available for Paralogs for DNAJA3 Gene

Variants for DNAJA3 Gene

Sequence variations from dbSNP and Humsavar for DNAJA3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1043460 -- 4,456,851(+) TGGCT(A/G)GCCTC downstream-variant-500B
rs1062706 -- 4,437,485(+) TATGA(A/G)GTAAT synonymous-codon, reference, intron-variant
rs1139652 -- 4,426,088(+) AGCCT(C/T)ACAGG synonymous-codon, reference, missense
rs1139653 -- 4,434,395(+) AACAT(A/T)ACCCT reference, missense, intron-variant
rs1802346 -- 4,456,645(+) TCAAC(A/G)GTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DNAJA3 Gene

Variant ID Type Subtype PubMed ID
nsv905224 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
esv23732 CNV Gain 19812545
nsv833132 CNV Loss 17160897

Relevant External Links for DNAJA3 Gene

HapMap Linkage Disequilibrium report
DNAJA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA3 Gene

Disorders for DNAJA3 Gene

(1) MalaCards Diseases for DNAJA3 Gene

Search for DNAJA3 Gene in MalaCards »

(4) Novoseek inferred disease relationships for DNAJA3 Gene

Disease -log(P) Hits PubMed IDs
tumors 30.7 18
shock 9.78 2
necrosis 0 1
cancer 0 4

Relevant External Links for DNAJA3

Genetic Association Database (GAD)
DNAJA3
Human Genome Epidemiology (HuGE) Navigator
DNAJA3
genes like me logo Genes that share disorders with DNAJA3: view

No data available for UniProtKB/Swiss-Prot for DNAJA3 Gene

Publications for DNAJA3 Gene

  1. A novel human DnaJ protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. (PMID: 9683573) Schilling B. … Munger K. (Virology 1998) 2 3 4 23
  2. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. (PMID: 10411904) Syken J. … Muenger K. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. hTid-1, a human DnaJ protein, modulates the interferon signaling pathway. (PMID: 11679576) Sarkar S. … Pestka S. (J. Biol. Chem. 2001) 3 4 23
  4. Genomic organization and expression of the human tumorous imaginal disc (TID1) gene. (PMID: 11707338) Yin X. … Rozakis-Adcock M. (Gene 2001) 3 23
  5. Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70. (PMID: 11719219) Cheng H. … Cheng-Mayer C. (Curr. Biol. 2001) 3 23

Products for DNAJA3 Gene

Sources for DNAJA3 Gene

Back to Top

Content