Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SART1 Gene

Aliases for SART1 Gene

  • Squamous Cell Carcinoma Antigen Recognized By T-Cells 1 2 3 4 5
  • Squamous Cell Carcinoma Antigen Recognized By T Cells 1 2 3
  • Squamous Cell Carcinoma Antigen Recognised By T Cells 2 3
  • Small Nuclear Ribonucleoprotein 110kDa (U4/U6.U5) 2 3
  • U4/U6.U5 Tri-SnRNP-Associated 110 KDa Protein 3 4
  • SNU66 Homolog 3 4
  • HSART-1 3 4
  • SART-1 3 4
  • HSnu66 3 4
  • SART1(259) Protein 3
  • SART1(800) Protein 3
  • Allergen Hom S 1 4
  • IgE Autoantigen 3
  • SART1259 3
  • SNRNP110 3
  • HOMS1 3
  • Snu66 3
  • Ara1 3

External Ids for SART1 Gene

Previous GeneCards Identifiers for SART1 Gene

  • GC11P068263
  • GC11P067410
  • GC11P065504
  • GC11P065485
  • GC11P065730
  • GC11P062055

Summaries for SART1 Gene

Entrez Gene Summary for SART1 Gene

  • This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for SART1 Gene

SART1 (Squamous Cell Carcinoma Antigen Recognized By T-Cells 1) is a Protein Coding gene. Diseases associated with SART1 include atopy and esophagus squamous cell carcinoma. Among its related pathways are mRNA Splicing - Major Pathway and HIF Repressor Pathways. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SART1 Gene

  • Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.

Gene Wiki entry for SART1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SART1 Gene

Genomics for SART1 Gene

Regulatory Elements for SART1 Gene

Enhancers for SART1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SART1 on UCSC Golden Path with GeneCards custom track

Promoters for SART1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SART1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SART1 Gene

Chromosome:
11
Start:
65,961,689 bp from pter
End:
65,980,136 bp from pter
Size:
18,448 bases
Orientation:
Plus strand

Genomic View for SART1 Gene

Genes around SART1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SART1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SART1 Gene

Proteins for SART1 Gene

  • Protein details for SART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43290-SNUT1_HUMAN
    Recommended name:
    U4/U6.U5 tri-snRNP-associated protein 1
    Protein Accession:
    O43290
    Secondary Accessions:
    • A6NDN1
    • Q53GB5

    Protein attributes for SART1 Gene

    Size:
    800 amino acids
    Molecular mass:
    90255 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39.

    Three dimensional structures from OCA and Proteopedia for SART1 Gene

    Alternative splice isoforms for SART1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SART1 Gene

Proteomics data for SART1 Gene at MOPED

Post-translational modifications for SART1 Gene

Other Protein References for SART1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SART1 Gene

Domains & Families for SART1 Gene

Protein Domains for SART1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SART1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43290

UniProtKB/Swiss-Prot:

SNUT1_HUMAN :
  • Belongs to the SNU66/SART1 family.
Family:
  • Belongs to the SNU66/SART1 family.
genes like me logo Genes that share domains with SART1: view

No data available for Gene Families for SART1 Gene

Function for SART1 Gene

Molecular function for SART1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA.
genes like me logo Genes that share phenotypes with SART1: view

Animal Model Products

miRNA for SART1 Gene

miRTarBase miRNAs that target SART1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SART1 Gene

Localization for SART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SART1 Gene

Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells (PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated PBMCs, suggesting preferential expression in proliferating cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SART1 Gene COMPARTMENTS Subcellular localization image for SART1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9856836
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA --
genes like me logo Genes that share ontologies with SART1: view

Pathways & Interactions for SART1 Gene

genes like me logo Genes that share pathways with SART1: view

Pathways by source for SART1 Gene

1 R&D Systems pathway for SART1 Gene

Gene Ontology (GO) - Biological Process for SART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000387 spliceosomal snRNP assembly TAS 16687569
GO:0000398 mRNA splicing, via spliceosome IEA,TAS --
GO:0097193 intrinsic apoptotic signaling pathway NAS 16158934
genes like me logo Genes that share ontologies with SART1: view

No data available for SIGNOR curated interactions for SART1 Gene

Drugs & Compounds for SART1 Gene

(1) Drugs for SART1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SART1: view

Transcripts for SART1 Gene

Unigene Clusters for SART1 Gene

Squamous cell carcinoma antigen recognized by T cells:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SART1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8:

ExUns: 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for SART1 Gene

GeneLoc Exon Structure for
SART1
ECgene alternative splicing isoforms for
SART1

Expression for SART1 Gene

mRNA expression in normal human tissues for SART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SART1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.8), CD8 Tcells (11.3), and Testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SART1 Gene



SOURCE GeneReport for Unigene cluster for SART1 Gene Hs.502883

mRNA Expression by UniProt/SwissProt for SART1 Gene

O43290-SNUT1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SART1: view

Protein tissue co-expression partners for SART1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SART1 Gene

Orthologs for SART1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SART1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SART1 35
  • 90.62 (n)
  • 95.48 (a)
SART1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SART1 35
  • 89.83 (n)
  • 96.37 (a)
SART1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sart1 35
  • 88.29 (n)
  • 95.12 (a)
Sart1 16
Sart1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SART1 35
  • 99.5 (n)
  • 99.12 (a)
SART1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sart1 35
  • 87.15 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia SART1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SART1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sart1 35
  • 66.32 (n)
  • 74.18 (a)
Str.8940 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53679 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1088 35
sart1 35
  • 66.84 (n)
  • 70.33 (a)
sart1 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12399 35
fruit fly
(Drosophila melanogaster)
Insecta CG6686 37
  • 38 (a)
CG6686 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F19F10.9 37
  • 29 (a)
F19F10.9 36
  • 31 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4237 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9207 36
  • 36 (a)
OneToOne
Species with no ortholog for SART1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SART1 Gene

ENSEMBL:
Gene Tree for SART1 (if available)
TreeFam:
Gene Tree for SART1 (if available)

Paralogs for SART1 Gene

No data available for Paralogs for SART1 Gene

Variants for SART1 Gene

Sequence variations from dbSNP and Humsavar for SART1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs660118 - 65,967,703(-) GGGAC(C/G)CCGGC nc-transcript-variant, reference, missense
rs35036096 - 65,967,544(+) TGCCG(G/T)CGGAC nc-transcript-variant, reference, missense
rs688862 - 65,965,922(-) TCCAC(A/G)GTGAG nc-transcript-variant, reference, synonymous-codon
rs542332 -- 65,976,950(-) CACTG(A/G)TCACC intron-variant, downstream-variant-500B
rs543952 -- 65,976,804(-) TGAGC(A/G/T)CCCCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SART1 Gene

Variant ID Type Subtype PubMed ID
dgv1185n71 CNV Loss 21882294
nsv832191 CNV Loss 17160897
dgv1186n71 CNV Loss 21882294
esv25439 CNV Loss 19812545
esv1062790 CNV Insertion 17803354

Variation tolerance for SART1 Gene

Residual Variation Intolerance Score: 9.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.49; 85.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SART1 Gene

HapMap Linkage Disequilibrium report
SART1
Human Gene Mutation Database (HGMD)
SART1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SART1 Gene

Disorders for SART1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SART1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
atopy
  • atopic hypersensitivity
esophagus squamous cell carcinoma
  • esophageal squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SART1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SART1

Genetic Association Database (GAD)
SART1
Human Genome Epidemiology (HuGE) Navigator
SART1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SART1
genes like me logo Genes that share disorders with SART1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SART1 Gene

Publications for SART1 Gene

  1. A gene encoding antigenic peptides of human squamous cell carcinoma recognized cytotoxic T lymphocytes. (PMID: 9449708) Shichijo S. … Itoh K. (J. Exp. Med. 1998) 2 3 4 67
  2. A proteomic study of SUMO-2 target proteins. (PMID: 15175327) Vertegaal A.C.O. … Lamond A.I. (J. Biol. Chem. 2004) 3 23
  3. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. (PMID: 11410364) Bolland D.J. … Hewitt J.E. (Gene 2001) 3 23
  4. Expression of the SART1 tumor-rejection antigen in human osteosarcomas. (PMID: 10853014) Ishida H. … Itoh K. (Int. J. Oncol. 2000) 3 23
  5. Expression of the SART1 tumor rejection antigen in renal cell carcinoma. (PMID: 10929426) Shintaku I. … Itoh K. (Urol. Res. 2000) 3 23

Products for SART1 Gene

Sources for SART1 Gene

Content