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Aliases for TMSB4Y Gene

Aliases for TMSB4Y Gene

  • Thymosin, Beta 4, Y Chromosome 2 3
  • Thymosin Beta 4, Y-Linked 2 3
  • TB4Y 3 4
  • Thymosin Beta-4, Y-Chromosomal 3
  • Thymosin Beta-4, Y Isoform 3

External Ids for TMSB4Y Gene

Previous GeneCards Identifiers for TMSB4Y Gene

  • GC0YP015133
  • GC0YP014824
  • GC0YP014253
  • GC0YP015815
  • GC0YP010461

Summaries for TMSB4Y Gene

Entrez Gene Summary for TMSB4Y Gene

  • This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TMSB4Y Gene

TMSB4Y is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and ERK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is TMSB15B.

UniProtKB/Swiss-Prot for TMSB4Y Gene

  • Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Wiki entry for TMSB4Y Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMSB4Y Gene

Genomics for TMSB4Y Gene

Regulatory Elements for TMSB4Y Gene

Transcription factor binding sites by QIAGEN in the TMSB4Y gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMSB4Y Gene

13,703,567 bp from pter
13,706,024 bp from pter
2,458 bases
Plus strand

Genomic View for TMSB4Y Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMSB4Y Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMSB4Y Gene

Proteins for TMSB4Y Gene

  • Protein details for TMSB4Y Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymosin beta-4, Y-chromosomal
    Protein Accession:
    Secondary Accessions:
    • Q0VDA2

    Protein attributes for TMSB4Y Gene

    44 amino acids
    Molecular mass:
    5013 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMSB4Y Gene

Proteomics data for TMSB4Y Gene at MOPED

Post-translational modifications for TMSB4Y Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMSB4Y Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMSB4Y Gene

Domains for TMSB4Y Gene

Protein Domains for TMSB4Y Gene

Suggested Antigen Peptide Sequences for TMSB4Y Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O14604
  • Belongs to the thymosin beta family.
genes like me logo Genes that share domains with TMSB4Y: view

No data available for Gene Families for TMSB4Y Gene

Function for TMSB4Y Gene

Molecular function for TMSB4Y Gene

GENATLAS Biochemistry:
thymosin-beta 4,identical to the interferon inducible gene 6-26 (4/26),potential actin sequestering protein,ubiquitous in a AZF deleted region
UniProtKB/Swiss-Prot Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

Gene Ontology (GO) - Molecular Function for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0003785 actin monomer binding IEA --
genes like me logo Genes that share ontologies with TMSB4Y: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMSB4Y

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMSB4Y Gene

Localization for TMSB4Y Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMSB4Y Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TMSB4Y Gene COMPARTMENTS Subcellular localization image for TMSB4Y gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TMSB4Y: view

Pathways for TMSB4Y Gene

genes like me logo Genes that share pathways with TMSB4Y: view

Pathways by source for TMSB4Y Gene

1 Qiagen pathway for TMSB4Y Gene
1 KEGG pathway for TMSB4Y Gene

Interacting Proteins for TMSB4Y Gene

Gene Ontology (GO) - Biological Process for TMSB4Y Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0007010 cytoskeleton organization --
GO:0007015 actin filament organization IEA --
GO:0008064 regulation of actin polymerization or depolymerization TAS 8838802
GO:0030036 actin cytoskeleton organization --
genes like me logo Genes that share ontologies with TMSB4Y: view

Transcripts for TMSB4Y Gene

mRNA/cDNA for TMSB4Y Gene

(17) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMSB4Y Gene

Thymosin beta 4, Y-linked:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMSB4Y

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMSB4Y Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -

Relevant External Links for TMSB4Y Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMSB4Y Gene

mRNA expression in normal human tissues for TMSB4Y Gene

SOURCE GeneReport for Unigene cluster for TMSB4Y Gene Hs.159201

mRNA Expression by UniProt/SwissProt for TMSB4Y Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TMSB4Y: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for TMSB4Y Gene

Orthologs for TMSB4Y Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMSB4Y Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 86 (a)
TMSB4 36
  • 66 (a)
  • 80 (a)
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Mus musculus)
Mammalia Tmsb4x 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TMSB4Y 36
  • 91 (a)
(Pan troglodytes)
Mammalia TMSB4Y 36
  • 95 (a)
(Gallus gallus)
Aves TMSB4X 36
  • 93 (a)
(Anolis carolinensis)
Reptilia TMSB4Y 36
  • 93 (a)
(Danio rerio)
Actinopterygii si:ch211-11c15.3 36
  • 67 (a)
tmsb 36
  • 69 (a)
tmsb4x 36
  • 77 (a)
Species with no ortholog for TMSB4Y:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMSB4Y Gene

Gene Tree for TMSB4Y (if available)
Gene Tree for TMSB4Y (if available)

Paralogs for TMSB4Y Gene

Paralogs for TMSB4Y Gene

Selected SIMAP similar genes for TMSB4Y Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMSB4Y: view

Variants for TMSB4Y Gene

Sequence variations from dbSNP and Humsavar for TMSB4Y Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs1541511 -- 13,702,607(+) GACCC(C/T)TAAAT upstream-variant-2KB
rs2319533 -- 13,703,962(+) TTTTA(C/G)GAATT utr-variant-5-prime
rs9786077 -- 13,703,563(+) GCTGA(A/G)ATGTG upstream-variant-2KB
rs9786413 -- 13,703,636(+) CCTCA(A/G)ACGGC utr-variant-5-prime
rs9786739 -- 13,703,713(+) TTGCA(A/G)AGGCA utr-variant-5-prime

Relevant External Links for TMSB4Y Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMSB4Y Gene

Disorders for TMSB4Y Gene

No disorders were found for TMSB4Y Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMSB4Y Gene

Publications for TMSB4Y Gene

  1. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3 4
  2. A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene. (PMID: 15557202) Torikai H. … Takahashi T. (J. Immunol. 2004) 3 23
  3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for TMSB4Y Gene

Sources for TMSB4Y Gene

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