Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BPY2 Gene

Aliases for BPY2 Gene

  • Basic Charge, Y-Linked, 2 2 3
  • Variable Charge, Y-Linked, 2 2 3
  • Variably Charged Protein Y 2 3 4
  • BPY2A 3 4
  • VCY2A 3 4
  • VCY2 3 4
  • Testis-Specific Basic Protein On Y, 2 3
  • Basic Protein On Y Chromosome 2 3
  • Basic Charge, Y-Linked 2 4
  • BPY2 BPY2B BPY2C 4
  • VCY2B 4
  • VCY2C 4

External Ids for BPY2 Gene

Previous HGNC Symbols for BPY2 Gene

  • VCY2

Previous GeneCards Identifiers for BPY2 Gene

  • GC0YU900229
  • GC0YP023468
  • GC0YP023539
  • GC0YP025130

Summaries for BPY2 Gene

Entrez Gene Summary for BPY2 Gene

  • This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPY2 Gene

BPY2 (Basic Charge, Y-Linked, 2) is a Protein Coding gene. Diseases associated with BPY2 include y chromosome infertility. GO annotations related to this gene include HECT domain binding. An important paralog of this gene is BPY2B.

Gene Wiki entry for BPY2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPY2 Gene

Genomics for BPY2 Gene

Genomic Location for BPY2 Gene

Chromosome:
Y
Start:
22,973,819 bp from pter
End:
23,005,465 bp from pter
Size:
31,647 bases
Orientation:
Plus strand

Genomic View for BPY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPY2 Gene

No data available for Regulatory Elements for BPY2 Gene

Proteins for BPY2 Gene

  • Protein details for BPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14599-VCY2_HUMAN
    Recommended name:
    Testis-specific basic protein Y 2
    Protein Accession:
    O14599

    Protein attributes for BPY2 Gene

    Size:
    106 amino acids
    Molecular mass:
    12063 Da
    Quaternary structure:
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).

neXtProt entry for BPY2 Gene

Proteomics data for BPY2 Gene at MOPED

Post-translational modifications for BPY2 Gene

No Post-translational modifications

Other Protein References for BPY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPY2 Gene

Domains & Families for BPY2 Gene

Protein Domains for BPY2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O14599

UniProtKB/Swiss-Prot:

VCY2_HUMAN :
  • Belongs to the VCX/VCY family.
Family:
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with BPY2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BPY2 Gene

Function for BPY2 Gene

Molecular function for BPY2 Gene

GENATLAS Biochemistry:
basic protein on chromosome Y,2,testis specific,1,testis specific,in the AZFC deleted region

Gene Ontology (GO) - Molecular Function for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14627543
GO:0032399 HECT domain binding IPI 12207887
genes like me logo Genes that share ontologies with BPY2: view

Phenotypes for BPY2 Gene

GenomeRNAi human phenotypes for BPY2:
genes like me logo Genes that share phenotypes with BPY2: view

Animal Model Products

CRISPR Products

miRNA for BPY2 Gene

miRTarBase miRNAs that target BPY2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for BPY2 Gene

Localization for BPY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPY2 Gene COMPARTMENTS Subcellular localization image for BPY2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12724276
genes like me logo Genes that share ontologies with BPY2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPY2 Gene

Pathways & Interactions for BPY2 Gene

SuperPathways for BPY2 Gene

No Data Available

Interacting Proteins for BPY2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329106%0d%0a9606.ENSP00000325313%0d%0a9606.ENSP00000381045%0d%0a
Selected Interacting proteins: O14599-VCY2_HUMAN ENSP00000329106 for BPY2 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IMP 12724276
GO:0007338 single fertilization TAS 9381176
genes like me logo Genes that share ontologies with BPY2: view

No data available for Pathways by source and SIGNOR curated interactions for BPY2 Gene

Drugs & Compounds for BPY2 Gene

No Compound Related Data Available

Transcripts for BPY2 Gene

mRNA/cDNA for BPY2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPY2 Gene

Basic charge, Y-linked, 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPY2 Gene

No ASD Table

Relevant External Links for BPY2 Gene

GeneLoc Exon Structure for
BPY2
ECgene alternative splicing isoforms for
BPY2

Expression for BPY2 Gene

mRNA expression in normal human tissues for BPY2 Gene

mRNA differential expression in normal tissues according to GTEx for BPY2 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for BPY2 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BPY2 Gene



SOURCE GeneReport for Unigene cluster for BPY2 Gene Hs.664724

mRNA Expression by UniProt/SwissProt for BPY2 Gene

O14599-VCY2_HUMAN
Tissue specificity: Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).
genes like me logo Genes that share expression patterns with BPY2: view

Protein tissue co-expression partners for BPY2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPY2 Gene

Orthologs for BPY2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BPY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPY2 36
  • 98 (a)
ManyToMany
BPY2 36
  • 98 (a)
ManyToMany
Species with no ortholog for BPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPY2 Gene

ENSEMBL:
Gene Tree for BPY2 (if available)
TreeFam:
Gene Tree for BPY2 (if available)

Paralogs for BPY2 Gene

Paralogs for BPY2 Gene

genes like me logo Genes that share paralogs with BPY2: view

Variants for BPY2 Gene

Sequence variations from dbSNP and Humsavar for BPY2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs163701 -- 22,986,148(+) tggga(C/G)agtgg intron-variant
rs163702 -- 22,991,755(+) GATGT(A/G)AAATC intron-variant
rs163704 -- 22,998,928(+) CATGT(A/G)CCAGA intron-variant
rs163705 -- 23,000,507(+) ctctt(A/G)gctag intron-variant
rs163707 -- 23,004,577(+) AGGAT(A/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPY2 Gene

Variant ID Type Subtype PubMed ID
dgv2504e1 CNV Complex 17122850
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2508e1 CNV Complex 17122850
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
nsv469740 CNV Complex 16826518
nsv442826 CNV CNV 18776908
nsv515231 CNV Complex 21397061
dgv2513e1 CNV Complex 17122850

Relevant External Links for BPY2 Gene

HapMap Linkage Disequilibrium report
BPY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BPY2 Gene

Disorders for BPY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BPY2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
y chromosome infertility
  • oligozoospermia
- elite association
Search BPY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BPY2

Genetic Association Database (GAD)
BPY2
Human Genome Epidemiology (HuGE) Navigator
BPY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BPY2
genes like me logo Genes that share disorders with BPY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BPY2 Gene

Publications for BPY2 Gene

  1. Uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in Taiwan. (PMID: 16491273) Hsu C.C. … Lin Y.M. (Asian J. Androl. 2006) 23 67
  2. Identification in chromosome 8q11 of a region of homology with the g1 amplicon of the Y chromosome and functional analysis of the BEYLA gene. (PMID: 15676287) Stuppia L. … Palka G. (Genomics 2005) 23 67
  3. VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A. (PMID: 12207887) Wong E.Y. … Yeung W.S. (Biochem. Biophys. Res. Commun. 2002) 23 67
  4. Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients. (PMID: 26162009) Ahmadi Rastegar D. … Salekdeh G.H. (J. Proteome Res. 2015) 67
  5. Gene copy number alterations in the azoospermia-associated AZFc region and their effect on spermatogenic impairment. (PMID: 24935076) Lu C. … Wang X. (Mol. Hum. Reprod. 2014) 67

Products for BPY2 Gene

Sources for BPY2 Gene

Back to Top

Content