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Aliases for PYGO2 Gene

Aliases for PYGO2 Gene

  • Pygopus Family PHD Finger 2 2 3
  • Pygopus Homolog 2 (Drosophila) 2
  • Pygopus Homolog 2 3
  • 1190004M21Rik 3
  • Pygopus 2 3

External Ids for PYGO2 Gene

Previous GeneCards Identifiers for PYGO2 Gene

  • GC01P148193
  • GC01M150660
  • GC01M151704
  • GC01M152146
  • GC01M151742
  • GC01M153196
  • GC01M154929
  • GC01M126291

Summaries for PYGO2 Gene

GeneCards Summary for PYGO2 Gene

PYGO2 (Pygopus Family PHD Finger 2) is a Protein Coding gene. Diseases associated with PYGO2 include oligospermia. Among its related pathways are Wnt signaling pathway (KEGG) and WNT Signaling. GO annotations related to this gene include histone binding. An important paralog of this gene is PYGO1.

UniProtKB/Swiss-Prot for PYGO2 Gene

  • Involved in signal transduction through the Wnt pathway

Gene Wiki entry for PYGO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PYGO2 Gene

Genomics for PYGO2 Gene

Regulatory Elements for PYGO2 Gene

Genomic Location for PYGO2 Gene

154,957,026 bp from pter
154,963,853 bp from pter
6,828 bases
Minus strand

Genomic View for PYGO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PYGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PYGO2 Gene

Proteins for PYGO2 Gene

  • Protein details for PYGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pygopus homolog 2
    Protein Accession:
    Secondary Accessions:
    • Q8WYZ4
    • Q96CY2

    Protein attributes for PYGO2 Gene

    406 amino acids
    Molecular mass:
    41244 Da
    Quaternary structure:
    • Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex
    • Sequence=AAL55782.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PYGO2 Gene

neXtProt entry for PYGO2 Gene

Proteomics data for PYGO2 Gene at MOPED

Post-translational modifications for PYGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PYGO2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PYGO2 Gene

Domains for PYGO2 Gene

Gene Families for PYGO2 Gene

  • PHF :Zinc fingers, PHD-type

Suggested Antigen Peptide Sequences for PYGO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BRQ0
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PYGO2: view

Function for PYGO2 Gene

Molecular function for PYGO2 Gene

UniProtKB/Swiss-Prot Function: Involved in signal transduction through the Wnt pathway

Gene Ontology (GO) - Molecular Function for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 17113272
GO:0008270 zinc ion binding IEA --
GO:0035034 histone acetyltransferase regulator activity IEA --
GO:0042393 histone binding IEA --
genes like me logo Genes that share ontologies with PYGO2: view
genes like me logo Genes that share phenotypes with PYGO2: view

Animal Models for PYGO2 Gene

MGI Knock Outs for PYGO2:

Animal Model Products

miRNA for PYGO2 Gene

miRTarBase miRNAs that target PYGO2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYGO2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PYGO2 Gene

Localization for PYGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PYGO2 Gene

Subcellular locations from

Jensen Localization Image for PYGO2 Gene COMPARTMENTS Subcellular localization image for PYGO2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PYGO2: view

Pathways for PYGO2 Gene

genes like me logo Genes that share pathways with PYGO2: view

Pathways by source for PYGO2 Gene

1 Qiagen pathway for PYGO2 Gene
1 R&D Systems pathway for PYGO2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PYGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0002088 lens development in camera-type eye IEA --
GO:0007286 spermatid development --
GO:0007289 spermatid nucleus differentiation IEA --
genes like me logo Genes that share ontologies with PYGO2: view

Transcripts for PYGO2 Gene

mRNA/cDNA for PYGO2 Gene

Unigene Clusters for PYGO2 Gene

Pygopus homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PYGO2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PYGO2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for PYGO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PYGO2 Gene

mRNA expression in normal human tissues for PYGO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PYGO2 Gene

SOURCE GeneReport for Unigene cluster for PYGO2 Gene Hs.533597

genes like me logo Genes that share expressions with PYGO2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PYGO2 Gene

Orthologs for PYGO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PYGO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PYGO2 35
  • 99.75 (n)
  • 99.75 (a)
PYGO2 36
  • 100 (a)
(Bos Taurus)
Mammalia PYGO2 35
  • 93.5 (n)
  • 98.27 (a)
PYGO2 36
  • 98 (a)
(Canis familiaris)
Mammalia PYGO2 35
  • 92.1 (n)
  • 97.04 (a)
PYGO2 36
  • 97 (a)
(Mus musculus)
Mammalia Pygo2 35
  • 88.59 (n)
  • 96.74 (a)
Pygo2 16
Pygo2 36
  • 97 (a)
(Monodelphis domestica)
Mammalia PYGO2 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Pygo2 35
  • 89.05 (n)
  • 96.54 (a)
(Gallus gallus)
Aves LOC100857999 35
  • 75.41 (n)
  • 82.3 (a)
PYGO2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia PYGO2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11797 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3192 35
(Danio rerio)
Actinopterygii pygo2 36
  • 35 (a)
wufc56f02 35
fruit fly
(Drosophila melanogaster)
Insecta pygo 36
  • 12 (a)
Species with no ortholog for PYGO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PYGO2 Gene

Gene Tree for PYGO2 (if available)
Gene Tree for PYGO2 (if available)

Paralogs for PYGO2 Gene

Paralogs for PYGO2 Gene

Selected SIMAP similar genes for PYGO2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PYGO2: view

Variants for PYGO2 Gene

Sequence variations from dbSNP and Humsavar for PYGO2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2456269 -- 154,959,550(+) GGACC(A/C)TGGGG reference, missense
rs61758741 -- 154,959,219(+) GGGCT(C/T)CCCCC reference, missense
rs116588813 -- 154,958,782(+) CGTCA(C/T)CCATC synonymous-codon, reference
rs139289929 -- 154,959,316(+) GGTCT(C/T)TGGAG synonymous-codon, reference
rs139768764 -- 154,958,243(+) AAGGA(A/G)TGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PYGO2 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294

Relevant External Links for PYGO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PYGO2 Gene

Disorders for PYGO2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PYGO2 Gene including...

Search for PYGO2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PYGO2 Gene

genes like me logo Genes that share disorders with PYGO2: view

No data available for UniProtKB/Swiss-Prot for PYGO2 Gene

Publications for PYGO2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. (PMID: 11955446) Kramps T. … Basler K. (Cell 2002) 3 4
  4. A new nuclear component of the Wnt signalling pathway. (PMID: 11988739) Thompson B. … Bienz M. (Nat. Cell Biol. 2002) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PYGO2 Gene

Sources for PYGO2 Gene

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