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Aliases for SYT7 Gene

Aliases for SYT7 Gene

  • Synaptotagmin 7 2 3 5
  • Synaptotagmin VII 2 3 4
  • Prostate Cancer-Associated Protein 7 3 4
  • PCANAP7 3 4
  • SYTVII 3 4
  • IPCA-7 3 4
  • Prostate Cancer Associated Protein 7 2
  • SYT-VII 3
  • IPCA7 3

External Ids for SYT7 Gene

Previous HGNC Symbols for SYT7 Gene

  • PCANAP7

Previous GeneCards Identifiers for SYT7 Gene

  • GC11U990180
  • GC11M062798
  • GC11M061536
  • GC11M061060
  • GC11M061058
  • GC11M061039
  • GC11M061282
  • GC11M057610

Summaries for SYT7 Gene

Entrez Gene Summary for SYT7 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SYT7 Gene

SYT7 (Synaptotagmin 7) is a Protein Coding gene. Diseases associated with SYT7 include Prostate Cancer. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT7 Gene

  • Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).

Gene Wiki entry for SYT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT7 Gene

Genomics for SYT7 Gene

Regulatory Elements for SYT7 Gene


Promoters for SYT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT7 Gene

Chromosome:
11
Start:
61,513,716 bp from pter
End:
61,588,396 bp from pter
Size:
74,681 bases
Orientation:
Minus strand

Genomic View for SYT7 Gene

Genes around SYT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT7 Gene

Proteins for SYT7 Gene

  • Protein details for SYT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43581-SYT7_HUMAN
    Recommended name:
    Synaptotagmin-7
    Protein Accession:
    O43581
    Secondary Accessions:
    • F5GZC2
    • F5GZU9
    • F5H126
    • F5H1N2
    • F5H6C1
    • Q08AH6

    Protein attributes for SYT7 Gene

    Size:
    403 amino acids
    Molecular mass:
    45501 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer. Can also form heterodimers with SYT6, SYT9 and SYT10. Interacts with calmodulin (CALM1, CALM2 or CALM3). Interacts with CD63; required for localization to lysosomes.
    SequenceCaution:
    • Sequence=AAB92667.1; Type=Frameshift; Positions=6, 10, 15; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYT7 Gene

    Alternative splice isoforms for SYT7 Gene

neXtProt entry for SYT7 Gene

Proteomics data for SYT7 Gene at MOPED

Post-translational modifications for SYT7 Gene

  • Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYT7 Gene

Domains & Families for SYT7 Gene

Gene Families for SYT7 Gene

Protein Domains for SYT7 Gene

Suggested Antigen Peptide Sequences for SYT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43581

UniProtKB/Swiss-Prot:

SYT7_HUMAN :
  • The C2 domains bind Ca(2+) and membranes. Binding to membranes involves Ca(2+)-dependent phospholipid binding. Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca(2+) concentrations that are lower than those required for other synaptotagmins (PubMed:22966849). The two C2 domains bind independently to planar membranes, without interdomain cooperativity (PubMed:25437758). Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (PubMed:26322740, PubMed:26333120).
  • Belongs to the synaptotagmin family.
Domain:
  • The C2 domains bind Ca(2+) and membranes. Binding to membranes involves Ca(2+)-dependent phospholipid binding. Compared to other members of the family, the C2 domains of SYT7 dock and insert into cellular membranes in response to intracellular Ca(2+) concentrations that are lower than those required for other synaptotagmins (PubMed:22966849). The two C2 domains bind independently to planar membranes, without interdomain cooperativity (PubMed:25437758). Moreover, SYT7 C2 domains insert more deeply into membranes compared to other synaptotagmins (PubMed:26322740, PubMed:26333120).
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT7: view

Function for SYT7 Gene

Molecular function for SYT7 Gene

GENATLAS Biochemistry:
synaptotagmin 7,multifunctional intrinsic membrane protein of synaptic vesicles and chromaffin granules,involved in exocytosis and endocytosis
UniProtKB/Swiss-Prot Function:
Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).
genes like me logo Genes that share phenotypes with SYT7: view

Animal Models for SYT7 Gene

MGI Knock Outs for SYT7:

Animal Model Products

miRNA for SYT7 Gene

miRTarBase miRNAs that target SYT7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYT7 Gene

Localization for SYT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT7 Gene

Cell membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Note=Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. {ECO:0000250 UniProtKB:Q9R0N7}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT7 Gene COMPARTMENTS Subcellular localization image for SYT7 gene
Compartment Confidence
extracellular 5
cytosol 3
lysosome 3
plasma membrane 3
vacuole 3
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005777 peroxisome ISS --
GO:0005829 cytosol ISS --
GO:0031045 dense core granule IEA --
GO:0042734 presynaptic membrane IEA --
genes like me logo Genes that share ontologies with SYT7: view

Pathways & Interactions for SYT7 Gene

SuperPathways for SYT7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001778 plasma membrane repair ISS --
GO:0006887 exocytosis IEA --
GO:0046850 regulation of bone remodeling ISS --
GO:0050764 regulation of phagocytosis ISS --
genes like me logo Genes that share ontologies with SYT7: view

No data available for Pathways by source and SIGNOR curated interactions for SYT7 Gene

Drugs & Compounds for SYT7 Gene

(1) Drugs for SYT7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SYT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYT7: view

Transcripts for SYT7 Gene

mRNA/cDNA for SYT7 Gene

(18) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SYT7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: -
SP6:

Relevant External Links for SYT7 Gene

GeneLoc Exon Structure for
SYT7
ECgene alternative splicing isoforms for
SYT7

Expression for SYT7 Gene

mRNA expression in normal human tissues for SYT7 Gene

mRNA differential expression in normal tissues according to GTEx for SYT7 Gene

This gene is overexpressed in Brain - Cortex (x5.5), Brain - Frontal Cortex (BA9) (x4.7), Liver (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for SYT7 Gene

This gene is overexpressed in Frontal cortex (29.5) and Fetal Brain (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT7 Gene



SOURCE GeneReport for Unigene cluster for SYT7 Gene Hs.131188

mRNA Expression by UniProt/SwissProt for SYT7 Gene

O43581-SYT7_HUMAN
Tissue specificity: Expressed in a variety of adult and fetal tissues.
genes like me logo Genes that share expression patterns with SYT7: view

Protein tissue co-expression partners for SYT7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SYT7 Gene

Orthologs for SYT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYT7 35
  • 94.36 (n)
  • 97.38 (a)
SYT7 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483796 35
  • 94.65 (n)
  • 97.92 (a)
SYT7 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt7 35
  • 92.74 (n)
  • 98.02 (a)
Syt7 16
Syt7 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYT7 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYT7 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT7 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT7 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syt7 35
  • 73.48 (n)
  • 79.79 (a)
zebrafish
(Danio rerio)
Actinopterygii syt7b 35
  • 67.61 (n)
  • 70 (a)
SYT7 (1 of 2) 36
  • 50 (a)
OneToMany
syt7b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syt7 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea snt-5 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for SYT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYT7 Gene

ENSEMBL:
Gene Tree for SYT7 (if available)
TreeFam:
Gene Tree for SYT7 (if available)

Paralogs for SYT7 Gene

Paralogs for SYT7 Gene

genes like me logo Genes that share paralogs with SYT7: view

Variants for SYT7 Gene

Sequence variations from dbSNP and Humsavar for SYT7 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs407740 - 61,523,187(-) CCCCA(A/C/T)CTTCA reference, missense
rs887646 -- 61,575,224(-) CTGAA(A/G)GAGAA intron-variant
rs887647 -- 61,575,185(-) GAGAC(A/G)GGAGG intron-variant
rs1023424 -- 61,539,530(-) GCTTT(C/T)CTGCC intron-variant, utr-variant-3-prime
rs1023425 -- 61,539,516(-) CCTGT(C/T)CAAGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYT7 Gene

Variant ID Type Subtype PubMed ID
nsv832178 CNV Gain+Loss 17160897
nsv897603 CNV Loss 21882294
nsv468582 CNV Loss 19166990
nsv825938 CNV Gain 20364138
nsv897604 CNV Loss 21882294
nsv342 CNV Insertion 18451855

Variation tolerance for SYT7 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYT7 Gene

Disorders for SYT7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SYT7 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search SYT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYT7

Genetic Association Database (GAD)
SYT7
Human Genome Epidemiology (HuGE) Navigator
SYT7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT7
genes like me logo Genes that share disorders with SYT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYT7 Gene

Publications for SYT7 Gene

  1. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. (PMID: 9615227) Cooper P.R. … Shows T.B. (Genomics 1998) 2 3 4 67
  2. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains. (PMID: 25437758) Vasquez J.K. … Knight J.D. (Biochemistry 2014) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for SYT7 Gene

Sources for SYT7 Gene

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