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Aliases for PIAS2 Gene

Aliases for PIAS2 Gene

  • Protein Inhibitor Of Activated STAT, 2 2 3
  • Androgen Receptor-Interacting Protein 3 3 4
  • Protein Inhibitor Of Activated STAT X 3 4
  • Msx-Interacting Zinc Finger Protein 3 4
  • DAB2-Interacting Protein 3 4
  • ARIP3 3 4
  • PIASX 3 4
  • MIZ1 3 4
  • DIP 3 4
  • Protein Inhibitor Of Activated STAT2 4
  • Zinc Finger, MIZ-Type Containing 4 3
  • E3 SUMO-Protein Ligase PIAS2 3
  • MIZ-Type Containing 4 2
  • PIAS-NY Protein 4
  • Zinc Finger 2
  • PIASX-ALPHA 3
  • PIASX-BETA 3
  • EC 6.3.2.- 4
  • ZMIZ4 3
  • SIZ2 3
  • MIZ 3

External Ids for PIAS2 Gene

Previous GeneCards Identifiers for PIAS2 Gene

  • GC18M042645
  • GC18M042646
  • GC18M044392
  • GC18M041249

Summaries for PIAS2 Gene

Entrez Gene Summary for PIAS2 Gene

  • This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

GeneCards Summary for PIAS2 Gene

PIAS2 (Protein Inhibitor Of Activated STAT, 2) is a Protein Coding gene. Diseases associated with PIAS2 include tinea capitis. Among its related pathways are Pathways in cancer and ERK Signaling. GO annotations related to this gene include transcription coactivator activity and androgen receptor binding. An important paralog of this gene is ZMIZ1.

UniProtKB/Swiss-Prot for PIAS2 Gene

  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML atLys-65 and Lys-160.

Gene Wiki entry for PIAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS2 Gene

Genomics for PIAS2 Gene

Regulatory Elements for PIAS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIAS2 Gene

Start:
46,808,390 bp from pter
End:
46,920,167 bp from pter
Size:
111,778 bases
Orientation:
Minus strand

Genomic View for PIAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIAS2 Gene

Proteins for PIAS2 Gene

  • Protein details for PIAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75928-PIAS2_HUMAN
    Recommended name:
    E3 SUMO-protein ligase PIAS2
    Protein Accession:
    O75928
    Secondary Accessions:
    • O75927
    • Q96BT5
    • Q96KE3

    Protein attributes for PIAS2 Gene

    Size:
    621 amino acids
    Molecular mass:
    68240 Da
    Quaternary structure:
    • Binds SUMO1 and UBE2I. Interacts with AXIN1, JUN, MDM2, PARK7, TP53 and TP73 isoform alpha, but not TP73 isoform beta. Interacts with STAT4 following IL12 and IFN-alpha stimulation of T-cells. Interacts also with GTF2I, GTF2IRD1, IKFZ1, DAB2 and MSX2, as well as with several steroid receptors, including ESR1, ESR2, NR3C1, PGR, AR, and with NCOA2 (By similarity). Sumoylation of a target protein seems to enhance the interaction. Binds to sumoylated ELK1. Binds DNA, such as CDKN1A promoter, in a sequence-specific manner. Interacts with PLAG1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. PIAS2-beta interacts with IFIH1/MDA5. Isoform PIAS2-alpha interacts with PML (isoform PML-12).

    Three dimensional structures from OCA and Proteopedia for PIAS2 Gene

    Alternative splice isoforms for PIAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIAS2 Gene

Proteomics data for PIAS2 Gene at MOPED

Post-translational modifications for PIAS2 Gene

No data available for DME Specific Peptides for PIAS2 Gene

Domains for PIAS2 Gene

Gene Families for PIAS2 Gene

HGNC:
  • ZMIZ :Zinc fingers, MIZ-type

Protein Domains for PIAS2 Gene

Graphical View of Domain Structure for InterPro Entry

O75928

UniProtKB/Swiss-Prot:

PIAS2_HUMAN :
  • O75928
Domain:
  • The LXXLL motif is a transcriptional coregulator signature
  • Contains 1 PINIT domain.
  • Contains 1 SAP domain.
Family:
  • Belongs to the PIAS family.
Similarity:
  • Contains 1 SP-RING-type zinc finger.
genes like me logo Genes that share domains with PIAS2: view

Function for PIAS2 Gene

Molecular function for PIAS2 Gene

UniProtKB/Swiss-Prot Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML atLys-65 and Lys-160.
UniProtKB/Swiss-Prot Induction: Up-regulated transiently during myeloid differentiation in various cells lines, such as HL-60, U-937, K-562, induced by either phorbol ester (TPA) or retinoic acid

Enzyme Numbers (IUBMB) for PIAS2 Gene

Gene Ontology (GO) - Molecular Function for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 11477070
GO:0008134 transcription factor binding IDA 20408817
genes like me logo Genes that share ontologies with PIAS2: view

Phenotypes for PIAS2 Gene

MGI mutant phenotypes for PIAS2:
inferred from 2 alleles
GenomeRNAi human phenotypes for PIAS2:
genes like me logo Genes that share phenotypes with PIAS2: view

Animal Model Products

CRISPR Products

miRNA for PIAS2 Gene

miRTarBase miRNAs that target PIAS2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PIAS2 Gene

Localization for PIAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIAS2 Gene

Nucleus speckle. Nucleus, PML body. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIAS2 Gene COMPARTMENTS Subcellular localization image for PIAS2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11477070
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body --
GO:0016605 colocalizes_with PML body IDA 22406621
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PIAS2: view

Pathways for PIAS2 Gene

genes like me logo Genes that share pathways with PIAS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O75928-PIAS2_HUMAN

  • Pathway: Protein modification; protein sumoylation

Gene Ontology (GO) - Biological Process for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0008152 metabolic process --
GO:0016925 protein sumoylation TAS --
GO:0030521 androgen receptor signaling pathway NAS 15572661
genes like me logo Genes that share ontologies with PIAS2: view

Compounds for PIAS2 Gene

(4) Novoseek inferred chemical compound relationships for PIAS2 Gene

Compound -log(P) Hits PubMed IDs
lysine 47.2 1
arginine 33.1 1
testosterone 29.5 4
steroid 10.2 2
genes like me logo Genes that share compounds with PIAS2: view

Transcripts for PIAS2 Gene

Unigene Clusters for PIAS2 Gene

Protein inhibitor of activated STAT, 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIAS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIAS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: - - -
SP10: - - - -
SP11: - - -

ExUns: 18 ^ 19 ^ 20
SP1:
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PIAS2 Gene

GeneLoc Exon Structure for
PIAS2
ECgene alternative splicing isoforms for
PIAS2

Expression for PIAS2 Gene

mRNA expression in normal human tissues for PIAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIAS2 Gene

This gene is overexpressed in Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIAS2 Gene

SOURCE GeneReport for Unigene cluster for PIAS2 Gene Hs.657844

mRNA Expression by UniProt/SwissProt for PIAS2 Gene

O75928-PIAS2_HUMAN
Tissue specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
genes like me logo Genes that share expressions with PIAS2: view

In Situ Assay Products

Orthologs for PIAS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIAS2 35
  • 99.69 (n)
  • 100 (a)
PIAS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIAS2 35
  • 94.79 (n)
  • 97.23 (a)
PIAS2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIAS2 35
  • 96.41 (n)
  • 98.86 (a)
PIAS2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pias2 35
  • 93.61 (n)
  • 98.07 (a)
Pias2 16
Pias2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIAS2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIAS2 36
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pias2 35
  • 92.55 (n)
  • 97.82 (a)
chicken
(Gallus gallus)
Aves PIAS2 35
  • 81.21 (n)
  • 91.79 (a)
PIAS2 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIAS2 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pias2 35
  • 72.13 (n)
  • 79.27 (a)
zebrafish
(Danio rerio)
Actinopterygii pias2 35
  • 66.67 (n)
  • 72.24 (a)
pias2 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Su(var)2-10 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-17 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 36
  • 14 (a)
ManyToMany
SIZ1 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for PIAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIAS2 Gene

ENSEMBL:
Gene Tree for PIAS2 (if available)
TreeFam:
Gene Tree for PIAS2 (if available)

Paralogs for PIAS2 Gene

Paralogs for PIAS2 Gene

Selected SIMAP similar genes for PIAS2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PIAS2 Gene

genes like me logo Genes that share paralogs with PIAS2: view

Variants for PIAS2 Gene

Sequence variations from dbSNP and Humsavar for PIAS2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs10070 -- 46,808,936(+) CAAAC(A/G)TCAAC downstream-variant-500B
rs17472 -- 46,810,573(+) AGATT(C/T)GGGTT utr-variant-3-prime
rs476313 -- 46,853,292(-) ttttt(A/T)tttaa intron-variant
rs477243 -- 46,853,192(-) tcaag(C/T)gattc intron-variant
rs477826 -- 46,817,686(+) TACCA(A/G)GCATT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIAS2 Gene

Variant ID Type Subtype PubMed ID
nsv428355 CNV Gain 18775914
nsv9629 CNV Gain+Loss 18304495
dgv3412n71 CNV Gain 21882294
dgv3413n71 CNV Gain 21882294
dgv3415n71 CNV Gain 21882294
nsv833639 CNV Loss 17160897
esv2669583 CNV Deletion 23128226
esv2717037 CNV Deletion 23290073
esv999328 CNV Deletion 20482838
nsv522397 CNV Loss 19592680

Relevant External Links for PIAS2 Gene

HapMap Linkage Disequilibrium report
PIAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS2 Gene

Disorders for PIAS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PIAS2 Gene including...

Search for PIAS2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PIAS2 Gene

genes like me logo Genes that share disorders with PIAS2: view

No data available for UniProtKB/Swiss-Prot for PIAS2 Gene

Publications for PIAS2 Gene

  1. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PMID: 11477070) Takahashi K. … Ariga H. (J. Biol. Chem. 2001) 3 4 23
  2. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. (PMID: 12393906) Miyauchi Y. … Yasuda H. (J. Biol. Chem. 2002) 3 4 23
  3. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. (PMID: 11867732) Schmidt D. … Mueller S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  4. Molecular cloning and characterization of a novel splicing variant of PIASx. (PMID: 15301740) Zheng Y. … Sha J.-H. (Acta Pharmacol. Sin. 2004) 3 4 23
  5. Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. (PMID: 16204249) Song J. … Chen Y. (J. Biol. Chem. 2005) 3 4 23

Products for PIAS2 Gene

  • Addgene plasmids for PIAS2

Sources for PIAS2 Gene

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