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Aliases for SLC13A2 Gene

Aliases for SLC13A2 Gene

  • Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 2 2 3
  • NADC1 3 4 6
  • Renal Sodium/Dicarboxylate Cotransporter 3 4
  • Na(+)/Dicarboxylate Cotransporter 1 3 4
  • NaDC-1 3 4
  • SDCT1 3 4
  • Na(+)-Coupled Citrate Transporter 3
  • Solute Carrier Family 13 Member 2 3
  • NaCT 3

External Ids for SLC13A2 Gene

Previous GeneCards Identifiers for SLC13A2 Gene

  • GC17P026645
  • GC17P028700
  • GC17P026652
  • GC17P026946
  • GC17P023824
  • GC17P026800
  • GC17P023009

Summaries for SLC13A2 Gene

GeneCards Summary for SLC13A2 Gene

SLC13A2 (Solute Carrier Family 13 (Sodium-Dependent Dicarboxylate Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC13A2 include metabolic acidosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include low-affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A2 Gene

  • Cotransport of sodium ions and dicarboxylates such as succinate and citrate

Gene Wiki entry for SLC13A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A2 Gene

Genomics for SLC13A2 Gene

Regulatory Elements for SLC13A2 Gene

Genomic Location for SLC13A2 Gene

28,473,293 bp from pter
28,497,781 bp from pter
24,489 bases
Plus strand

Genomic View for SLC13A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A2 Gene

Proteins for SLC13A2 Gene

  • Protein details for SLC13A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 13 member 2
    Protein Accession:
    Secondary Accessions:
    • B2RBI9
    • B4DPL1
    • E7ETH5
    • Q4VAR7

    Protein attributes for SLC13A2 Gene

    592 amino acids
    Molecular mass:
    64410 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC13A2 Gene


neXtProt entry for SLC13A2 Gene

Proteomics data for SLC13A2 Gene at MOPED

Post-translational modifications for SLC13A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC13A2 Gene

No data available for DME Specific Peptides for SLC13A2 Gene

Domains for SLC13A2 Gene

Protein Domains for SLC13A2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q13183
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A2: view

Function for SLC13A2 Gene

Molecular function for SLC13A2 Gene

GENATLAS Biochemistry: solute carrier family 13,member A2,sodium dependent dicarboxylate transporter,located in proximal tubule,kidney
UniProtKB/Swiss-Prot Function: Cotransport of sodium ions and dicarboxylates such as succinate and citrate

Gene Ontology (GO) - Molecular Function for SLC13A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015361 low-affinity sodium:dicarboxylate symporter activity TAS 8967342
genes like me logo Genes that share ontologies with SLC13A2: view

Phenotypes for SLC13A2 Gene

genes like me logo Genes that share phenotypes with SLC13A2: view

Animal Models for SLC13A2 Gene

MGI Knock Outs for SLC13A2:

Animal Model Products

CRISPR Products

miRNA for SLC13A2 Gene

miRTarBase miRNAs that target SLC13A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC13A2 Gene

Localization for SLC13A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC13A2 Gene COMPARTMENTS Subcellular localization image for SLC13A2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC13A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8967342
GO:0016020 membrane TAS 8967342
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC13A2: view

Pathways for SLC13A2 Gene

genes like me logo Genes that share pathways with SLC13A2: view

Interacting Proteins for SLC13A2 Gene

Gene Ontology (GO) - Biological Process for SLC13A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8967342
GO:0006814 sodium ion transport IEA --
GO:0006835 dicarboxylic acid transport TAS 8967342
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC13A2: view

Compounds for SLC13A2 Gene

(1) HMDB Compounds for SLC13A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Sodium

(1) Drugbank Compounds for SLC13A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Succinic acid
  • 1,2-Ethanedicarboxylic acid
110-15-6 target

(9) Novoseek inferred chemical compound relationships for SLC13A2 Gene

Compound -log(P) Hits PubMed IDs
dicarboxylate 93.1 18
flufenamate 84.7 1
succinate 82.6 12
citrate 76.9 12
glutaric acid 70.5 1
genes like me logo Genes that share compounds with SLC13A2: view

Transcripts for SLC13A2 Gene

Unigene Clusters for SLC13A2 Gene

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC13A2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC13A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for SLC13A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC13A2 Gene

mRNA expression in normal human tissues for SLC13A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A2 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (24.4), Kidney - Cortex (12.4), Minor Salivary Gland (6.3), and Colon - Transverse (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC13A2 Gene

SOURCE GeneReport for Unigene cluster for SLC13A2 Gene Hs.102307

genes like me logo Genes that share expressions with SLC13A2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC13A2 Gene

Orthologs for SLC13A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC13A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC13A2 35
  • 99.04 (n)
  • 98.65 (a)
SLC13A2 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC13A2 35
  • 80.57 (n)
  • 73.82 (a)
SLC13A2 36
  • 75 (a)
(Canis familiaris)
Mammalia SLC13A2 35
  • 84.41 (n)
  • 81.19 (a)
SLC13A2 36
  • 81 (a)
(Mus musculus)
Mammalia Slc13a2 35
  • 80.54 (n)
  • 77.74 (a)
Slc13a2 16
Slc13a2 36
  • 77 (a)
(Monodelphis domestica)
Mammalia SLC13A2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SLC13A2 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Slc13a2 35
  • 80.99 (n)
  • 77.74 (a)
(Gallus gallus)
Aves SLC13A2 35
  • 65.44 (n)
  • 65.21 (a)
SLC13A2 36
  • 63 (a)
(Anolis carolinensis)
Reptilia SLC13A2 36
  • 60 (a)
African clawed frog
(Xenopus laevis)
Amphibia nadc2-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a2 35
  • 65.91 (n)
  • 65.97 (a)
(Danio rerio)
Actinopterygii Dr.4271 35
slc13a2 35
  • 65.11 (n)
  • 63.08 (a)
slc13a2 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007054 35
  • 53.41 (n)
  • 43.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Indy 35
  • 53.51 (n)
  • 40.98 (a)
Indy 36
  • 35 (a)
Indy-2 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea B0285.6 36
  • 34 (a)
nac-1 35
  • 48.95 (n)
  • 44.07 (a)
nac-1 36
  • 39 (a)
nac-2 36
  • 31 (a)
nac-3 36
  • 38 (a)
R107.1 37
  • 32 (a)
B0285.6 37
  • 35 (a)
F31F6.6 37
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TDT 35
  • 49.23 (n)
  • 40.62 (a)
(Oryza sativa)
Liliopsida Os09g0484900 35
  • 51.79 (n)
  • 39.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
Species with no ortholog for SLC13A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A2 Gene

Gene Tree for SLC13A2 (if available)
Gene Tree for SLC13A2 (if available)

Paralogs for SLC13A2 Gene

Paralogs for SLC13A2 Gene

Selected SIMAP similar genes for SLC13A2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC13A2: view

Variants for SLC13A2 Gene

Sequence variations from dbSNP and Humsavar for SLC13A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1558220 -- 28,481,950(-) GAAAA(G/T)GTGCT intron-variant
rs1974589 -- 28,481,999(-) CTTAA(C/T)TTTTA intron-variant
rs1990287 -- 28,492,047(-) TTGCG(C/T)ATCTG intron-variant
rs1990288 -- 28,488,310(-) TTGGA(C/T)AATGG intron-variant
rs2017745 -- 28,479,214(-) atttt(C/T)gagat intron-variant

Relevant External Links for SLC13A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC13A2 Gene

Disorders for SLC13A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC13A2 Gene including...

Search for SLC13A2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SLC13A2 Gene

(1) Novoseek inferred disease relationships for SLC13A2 Gene

Disease -log(P) Hits PubMed IDs
metabolic acidosis 40.1 1

Relevant External Links for SLC13A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC13A2: view

No data available for UniProtKB/Swiss-Prot for SLC13A2 Gene

Publications for SLC13A2 Gene

  1. Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. (PMID: 8967342) Pajor A.M. (Am. J. Physiol. 1996) 2 3 4 23
  2. Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls. (PMID: 17470169) Okamoto N. … Kitamura T. (Int. J. Urol. 2007) 3 4 23 48
  3. Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1-->q11.1 by radiation hybrid mapping and fluorescence in situ hybridization. (PMID: 10343111) Mann S.S. … Holmes R.P. (Cytogenet. Cell Genet. 1999) 2 3 23
  4. Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter. (PMID: 18161988) Weerachayaphorn J. … Pajor A.M. (Biochemistry 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SLC13A2 Gene

Sources for SLC13A2 Gene

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