Aliases for SLC7A6 Gene
Aliases for SLC7A6 Gene
- Solute Carrier Family 7 Member 6 2 3 4 5
- Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 6 2 3
- Cationic Amino Acid Transporter, Y+ System 3 4
- Y(+)L-Type Amino Acid Transporter 2 3 4
- Y+LAT-2 3 4
- Y+LAT2 3 4
- Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 6 3
External Ids for SLC7A6 Gene
- HGNC: 11064
- Entrez Gene: 9057
- Ensembl: ENSG00000103064
- OMIM: 605641
- UniProtKB: Q92536
Previous GeneCards Identifiers for SLC7A6 Gene
- GC16P058995
- GC16P068678
- GC16P068033
- GC16P068076
- GC16P068074
- GC16P066855
- GC16U900049
- GC16P054171
Summaries for SLC7A6 Gene
GeneCards Summary for SLC7A6 Gene
SLC7A6 (Solute Carrier Family 7 Member 6) is a Protein Coding gene. Diseases associated with SLC7A6 include Lysinuric Protein Intolerance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Basigin interactions. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A7.
UniProtKB/Swiss-Prot for SLC7A6 Gene
-
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Additional gene information for SLC7A6 Gene
- Monarch Initiative
- Search for SLC7A6 at DataMed
- Search for SLC7A6 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A6 Gene
Genomics for SLC7A6 Gene
GeneHancer (GH) Regulatory Elements for SLC7A6 Gene
Promoters and enhancers for SLC7A6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SLC7A6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC7A6 gene promoter:
Regulatory Element Products
Genomic Locations for SLC7A6 Gene
Genomic Locations for SLC7A6 Gene
- chr16:68,263,830-68,301,823
- (GRCh38/hg38)
- Size:
- 37,994 bases
- Orientation:
- Plus strand
- chr16:68,298,423-68,335,722
- (GRCh37/hg19)
Genomic View for SLC7A6 Gene
Genes around SLC7A6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
SLC7A6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC7A6 Gene
Proteins for SLC7A6 Gene
-
Protein details for SLC7A6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92536-YLAT2_HUMAN
- Recommended name:
- Y+L amino acid transporter 2
- Protein Accession:
- Q92536
- Q68DS4
- Q7L1N3
Protein attributes for SLC7A6 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 56828 Da
- Quaternary structure:
-
- Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
- SequenceCaution:
-
- Sequence=BAA13376.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SLC7A6 Gene
Post-translational modifications for SLC7A6 Gene
No Post-translational modifications
Other Protein References for SLC7A6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLC7A6
-
Abcam antibodies for SLC7A6
- Invitrogen Antibodies for SLC7A6
- Search GeneTex for Antibodies for SLC7A6
Protein Products
-
OriGene Purified Proteins for SLC7A6
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC7A6
- Origene Custom Protein Services for SLC7A6
- antibodies-online: Search results for 4 available SLC7A6 Proteins ranked by validation data
- Compare Top SLC7A6 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SLC7A6
Assay Products
No data available for DME Specific Peptides for SLC7A6 Gene
Domains & Families for SLC7A6 Gene
Gene Families for SLC7A6 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Protein Domains for SLC7A6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC7A6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92536UniProtKB/Swiss-Prot:
YLAT2_HUMAN :- Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
- Family:
-
- Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Function for SLC7A6 Gene
Molecular function for SLC7A6 Gene
- GENATLAS Biochemistry:
- solute carrier family 7,member A6,heterodimerizing with the cell surface glycoprotein to form a complex mediating y+L -type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium,glycoprotein associated aminoacid transporter family
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=295 uM for glutamine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=236 uM for leucine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=120 uM for arginine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=138 uM for arginine (in the absence of NaCl) {ECO:0000269 PubMed:10903140};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids.
- UniProtKB/Swiss-Prot Function:
- Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Phenotypes From GWAS Catalog for SLC7A6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015171 | amino acid transmembrane transporter activity | TAS,IEA | 9829974 |
| GO:0015179 | L-amino acid transmembrane transporter activity | IBA | -- |
| GO:0015297 | antiporter activity | IBA | -- |
Phenotypes for SLC7A6 Gene
- GenomeRNAi human phenotypes for SLC7A6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC7A6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC7A6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC7A6 gene
- Search ViGene Biosciences for SLC7A6
CRISPR Products
-
OriGene CRISPR knockouts for SLC7A6
- genomics-online: gRNA clones - Search results for available LAT3 gene related products
- Applied Biological Materials CRISPR for SLC7A6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC7A6
- GenScript: Design CRISPR guide RNA sequences for SLC7A6
miRNA for SLC7A6 Gene
- miRTarBase miRNAs that target SLC7A6
miRNA Products
- Search ViGene Biosciences for SLC7A6
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for SLC7A6
- Browse OriGene Inhibitory RNA Products For SLC7A6
- genomics-online: shRNA clones - Search results for available LAT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC7A6 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC7A6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC7A6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC7A6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SLC7A6 gene related products
- orf clones - Search results for available LAT3 gene related products
- Applied Biological Materials Clones for SLC7A6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLC7A6
Cell Line Products
-
Horizon Cell Lines for SLC7A6
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC7A6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC7A6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC7A6 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC7A6 Gene
Localization for SLC7A6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6 Gene
- Basolateral cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,IDA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9829974 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for SLC7A6 Gene
Pathways by source for SLC7A6 Gene
7 Reactome pathways for SLC7A6 Gene
Interacting Proteins for SLC7A6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006461 | protein complex assembly | TAS | 9829974 |
| GO:0006520 | cellular amino acid metabolic process | TAS | 9829974 |
| GO:0006810 | transport | TAS | 9829974 |
| GO:0006865 | amino acid transport | TAS | -- |
| GO:0050900 | leukocyte migration | TAS | -- |
No data available for SIGNOR curated interactions for SLC7A6 Gene
Transcripts for SLC7A6 Gene
mRNA/cDNA for SLC7A6 Gene
- (7) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC7A6 Gene
- Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SLC7A6
- genomics-online: gRNA clones - Search results for available LAT3 gene related products
- Applied Biological Materials CRISPR for SLC7A6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC7A6
- GenScript: Design CRISPR guide RNA sequences for SLC7A6
miRNA Products
- Search ViGene Biosciences for SLC7A6
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for SLC7A6
- Browse OriGene Inhibitory RNA Products For SLC7A6
- genomics-online: shRNA clones - Search results for available LAT3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC7A6 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC7A6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC7A6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC7A6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SLC7A6 gene related products
- orf clones - Search results for available LAT3 gene related products
- Applied Biological Materials Clones for SLC7A6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLC7A6
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - |
| ExUns: | 15 | ^ | 16 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: |
Expression for SLC7A6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for SLC7A6 Gene
This gene is overexpressed in Muscle - Skeletal (x9.2).
This gene is overexpressed in Placenta (57.2) and Bone (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC7A6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SLC7A6 Gene:
SLC7A6SOURCE GeneReport for Unigene cluster for SLC7A6 Gene:
Hs.679580mRNA Expression by UniProt/SwissProt for SLC7A6 Gene:
Q92536-YLAT2_HUMAN
Tissue specificity:
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
Evidence on tissue expression from TISSUES for SLC7A6 Gene
- Nervous system(3.1)
- Lung(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for SLC7A6
-
OriGene qPCR primer pairs and template standards for SLC7A6
- genomics-online: primer clones - Search results for available LAT3 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A6 Gene
Orthologs for SLC7A6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC7A6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC7A6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC7A6 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc7a6 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc7a6 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC7A6 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC7A6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC7A6 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLC7A6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc7a6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | slc7a6 33 34 |
|
||
| Dr.18441 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG1607 33 |
|
||
| mnd 35 34 |
|
||||
| JhI-21 35 34 |
|
||||
| CG6070 35 |
|
|
|||
| gb 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001627 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | aat-1 33 |
|
||
| F52H2.2 35 |
|
|
|||
| F27C8.1 35 |
|
|
|||
| aat-2 34 |
|
OneToMany | |||
| F07C3.7 35 |
|
|
|||
| T13A10.10 35 |
|
|
|||
| Y53H1C.1 35 |
|
|
|||
| C55C2.5a 35 |
|
|
|||
| C55C2.5b 35 |
|
|
|||
| T11F9.4 35 |
|
|
|||
| F54D12.3 35 |
|
|
|||
| F28F9.4 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03815 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4067 33 |
|
- Species where no ortholog for SLC7A6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SLC7A6 Gene
(14) SIMAP similar genes for SLC7A6 Gene using alignment to 12 proteins:
Pseudogenes.org Pseudogenes for SLC7A6 Gene
Variants for SLC7A6 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000080359 | -- | 68,280,142(+) | T/C | intron_variant | |
| rs1000109266 | -- | 68,289,560(+) | T/C | intron_variant | |
| rs1000161981 | -- | 68,284,705(+) | A/G | intron_variant | |
| rs1000264895 | -- | 68,263,384(+) | C/A | upstream_transcript_variant | |
| rs1000397244 | -- | 68,288,283(+) | G/A/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2675923 | CNV | deletion | 23128226 |
| esv3638904 | CNV | loss | 21293372 |
| nsv510691 | CNV | deletion | 20534489 |
Residual Variation Intolerance Score:
46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.65;
56.87% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC7A6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A6 Gene
Disorders for SLC7A6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lysinuric protein intolerance |
|
Search SLC7A6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC7A6
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A6 Gene
Publications for SLC7A6 Gene
- Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 44 58
- Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PMID: 17329401) Rotmann A … Closs EI (American journal of physiology. Cell physiology 2007) 4 22 58
- A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance. (PMID: 15756301) Sperandeo MP … Sebastio G (European journal of human genetics : EJHG 2005) 4 22 58
- The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine. (PMID: 10903140) Bröer A … Bröer S (The Biochemical journal 2000) 3 4 58
- Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. (PMID: 11078698) Dall'Asta V … Gazzola GC (American journal of physiology. Cell physiology 2000) 4 22 58
Products for SLC7A6 Gene
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- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for SLC7A6
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- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- OriGene Purified Proteins for SLC7A6
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC7A6
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- Origene shrna and RNAi products in human, mouse, rat for SLC7A6
- Browse OriGene Inhibitory RNA Products For SLC7A6
- OriGene qPCR primer pairs and template standards for SLC7A6
- OriGene qPCR primer pairs for SLC7A6
- OriGene CRISPR knockouts for SLC7A6
- OriGene ORF clones in human for SLC7A6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC7A6
- GenScript: Next-day shipping of latest version cDNA ORF clones for SLC7A6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SLC7A6
- GenScript Custom Assay Services for SLC7A6
- GenScript Custom overexpressing Cell Line Services for SLC7A6
- GenScript: Design CRISPR guide RNA sequences for SLC7A6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SLC7A6
- Sino Biological Human cDNA Clone for SLC7A6
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SLC7A6
- Novus Biologicals lysates and proteins for SLC7A6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for SLC7A6
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SLC7A6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC7A6
- VectorBuilder custom plasmid, inducible vectors for SLC7A6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC7A6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 7 available SLC7A6 Antibodies ranked by validation data
- Compare Top SLC7A6 Antibodies
- antibodies-online: Search results for available SLC7A6 related products ranked by validation data
- antibodies-online: Search results for 4 available SLC7A6 Proteins ranked by validation data
- Compare Top SLC7A6 Proteins
- Quality Products:
- Search GeneTex for Antibodies for SLC7A6
- Search GeneTex for Proteins for SLC7A6
- ViGene Biosciences adenoviral particle packaged cDNA for SLC7A6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC7A6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC7A6 gene
- Search ViGene Biosciences for SLC7A6
- Horizon Cell Lines for SLC7A6
- genomics-online: cdna clones - Search results for available SLC7A6 gene related products
- orf clones - Search results for available SLC7A6 gene related products
- genomics-online: gRNA clones - Search results for available SLC7A6 gene related products
- genomics-online: primer clones - Search results for available SLC7A6 gene related products
- genomics-online: shRNA clones - Search results for available SLC7A6 gene related products
Sources for SLC7A6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew