Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC7A6 Gene

Aliases for SLC7A6 Gene

  • Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 6 2 3
  • Cationic Amino Acid Transporter, Y+ System 3 4
  • Y(+)L-Type Amino Acid Transporter 2 3 4
  • Solute Carrier Family 7 Member 6 3 4
  • Y+LAT-2 3 4
  • Y+LAT2 3 4
  • Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 6 3
  • Y+L Amino Acid Transporter 2 3
  • Amino Acid Permease 3
  • KIAA0245 4
  • LAT-2 3
  • LAT3 3

External Ids for SLC7A6 Gene

Summaries for SLC7A6 Gene

GeneCards Summary for SLC7A6 Gene

SLC7A6 (Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 6) is a Protein Coding gene. Diseases associated with SLC7A6 include lysinuric protein intolerance. Among its related pathways are Hemostasis and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include amino acid transmembrane transporter activity and antiporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot for SLC7A6 Gene

  • Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

Gene Wiki entry for SLC7A6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A6 Gene

Genomics for SLC7A6 Gene

Genomic Location for SLC7A6 Gene

Start:
68,264,516 bp from pter
End:
68,301,823 bp from pter
Size:
37,308 bases
Orientation:
Plus strand

Genomic View for SLC7A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A6 Gene

Regulatory Elements for SLC7A6 Gene

Proteins for SLC7A6 Gene

  • Protein details for SLC7A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92536-YLAT2_HUMAN
    Recommended name:
    Y+L amino acid transporter 2
    Protein Accession:
    Q92536
    Secondary Accessions:
    • Q68DS4
    • Q7L1N3

    Protein attributes for SLC7A6 Gene

    Size:
    515 amino acids
    Molecular mass:
    56828 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.
    SequenceCaution:
    • Sequence=BAA13376.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC7A6 Gene

Proteomics data for SLC7A6 Gene at MOPED

Post-translational modifications for SLC7A6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC7A6 Gene

Domains for SLC7A6 Gene

Gene Families for SLC7A6 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC7A6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

YLAT2_HUMAN
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.:
    • Q92536
genes like me logo Genes that share domains with SLC7A6: view

Function for SLC7A6 Gene

Molecular function for SLC7A6 Gene

GENATLAS Biochemistry: solute carrier family 7,member A6,heterodimerizing with the cell surface glycoprotein to form a complex mediating y+L -type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium,glycoprotein associated aminoacid transporter family
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=295 uM for glutamine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=236 uM for leucine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=120 uM for arginine (in the presence of NaCl) {ECO:0000269 PubMed:10903140}; KM=138 uM for arginine (in the absence of NaCl) {ECO:0000269 PubMed:10903140};
UniProtKB/Swiss-Prot EnzymeRegulation: Arginine transport is strongly inhibited by lysine, glutamate, leucine, glutamine, methionine and histidine, in the presence of Na(+). Also inhibited by protein kinase C (PKC) and treatment with phorbol-12-myristate-13-acetate (PMA). Mutual inhibition is observed when leucine or glutamine is used as substrate. Inhibition of arginine and leucine uptake also occurs when SLC3A2/4F2hc is either truncated at its C-terminus or mutated at critical residues within the terminal 15 amino acids
UniProtKB/Swiss-Prot Function: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.

Gene Ontology (GO) - Molecular Function for SLC7A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity TAS 9829974
GO:0015179 L-amino acid transmembrane transporter activity IBA --
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A6: view

Phenotypes for SLC7A6 Gene

genes like me logo Genes that share phenotypes with SLC7A6: view

miRNA for SLC7A6 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC7A6 Gene

Localization for SLC7A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A6 Gene

Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A6 Gene COMPARTMENTS Subcellular localization image for SLC7A6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC7A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9829974
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC7A6: view

Pathways for SLC7A6 Gene

genes like me logo Genes that share pathways with SLC7A6: view

Gene Ontology (GO) - Biological Process for SLC7A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006461 protein complex assembly TAS 9829974
GO:0006520 cellular amino acid metabolic process TAS 9829974
GO:0006810 transport TAS 9829974
GO:0006811 ion transport TAS --
genes like me logo Genes that share ontologies with SLC7A6: view

Compounds for SLC7A6 Gene

(3) HMDB Compounds for SLC7A6 Gene

Compound Synonyms Cas Number PubMed IDs
L-Arginine
  • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
74-79-3
Ornithine
  • (+)-S-Ornithine
70-26-8
Sodium
  • Sodium
7440-23-5

(3) Novoseek inferred chemical compound relationships for SLC7A6 Gene

Compound -log(P) Hits PubMed IDs
leucine 35.9 1
arginine 33.5 2
glucose 0 1
genes like me logo Genes that share compounds with SLC7A6: view

Transcripts for SLC7A6 Gene

mRNA/cDNA for SLC7A6 Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC7A6 Gene

Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^
SP1:
SP2: -
SP3: - - - -
SP4:
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9:
SP10: - - -
SP11: - - -
SP12: - -
SP13: - - - -

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC7A6 Gene

GeneLoc Exon Structure for
SLC7A6
ECgene alternative splicing isoforms for
SLC7A6

Expression for SLC7A6 Gene

mRNA expression in normal human tissues for SLC7A6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A6 Gene

This gene is overexpressed in Muscle - Skeletal (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC7A6 Gene

SOURCE GeneReport for Unigene cluster for SLC7A6 Gene Hs.679580

mRNA Expression by UniProt/SwissProt for SLC7A6 Gene

Q92536-YLAT2_HUMAN
Tissue specificity: Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
genes like me logo Genes that share expressions with SLC7A6: view

Orthologs for SLC7A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC7A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A6 36
  • 99.74 (n)
  • 100 (a)
SLC7A6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC7A6 36
  • 89.97 (n)
  • 89.9 (a)
SLC7A6 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A6 36
  • 91.18 (n)
  • 90.86 (a)
SLC7A6 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a6 36
  • 89.32 (n)
  • 89.13 (a)
Slc7a6 16
Slc7a6 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A6 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A6 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a6 36
  • 89.26 (n)
  • 89.51 (a)
chicken
(Gallus gallus)
Aves SLC7A6 36
  • 72.18 (n)
  • 80.2 (a)
SLC7A6 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A6 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a6 36
  • 68.47 (n)
  • 73.9 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18441 36
slc7a6 36
  • 72.44 (n)
  • 78.63 (a)
slc7a6 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001627 36
  • 55.29 (n)
  • 50.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1607 36
  • 57.19 (n)
  • 48.67 (a)
gb 37
  • 42 (a)
ManyToMany
JhI-21 37
  • 44 (a)
ManyToMany
mnd 37
  • 48 (a)
ManyToMany
mnd 38
  • 54 (a)
JhI-21 38
  • 48 (a)
CG6070 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea aat-1 36
  • 51.95 (n)
  • 46.65 (a)
aat-2 37
  • 45 (a)
OneToMany
C55C2.5a 38
  • 33 (a)
F54D12.3 38
  • 32 (a)
C55C2.5b 38
  • 33 (a)
Y53H1C.1 38
  • 35 (a)
F27C8.1 38
  • 45 (a)
T13A10.10 38
  • 35 (a)
T11F9.4 38
  • 33 (a)
F07C3.7 38
  • 44 (a)
F52H2.2 38
  • 46 (a)
F28F9.4 38
  • 28 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03815 36
  • 49.11 (n)
  • 38.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4067 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for SLC7A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A6 Gene

ENSEMBL:
Gene Tree for SLC7A6 (if available)
TreeFam:
Gene Tree for SLC7A6 (if available)

Paralogs for SLC7A6 Gene

Paralogs for SLC7A6 Gene

Pseudogenes.org Pseudogenes for SLC7A6 Gene

genes like me logo Genes that share paralogs with SLC7A6: view

Variants for SLC7A6 Gene

Sequence variations from dbSNP and Humsavar for SLC7A6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs13645 -- 68,298,504(+) TACAC(C/T)TGGAG utr-variant-3-prime, nc-transcript-variant
rs1075851 -- 68,262,626(-) GCCTC(A/G)AACTC upstream-variant-2KB
rs1127773 -- 68,298,844(+) ATCCT(A/G)GGCCG utr-variant-3-prime, nc-transcript-variant
rs2305810 -- 68,287,975(-) TGCTA(G/T)CATGT intron-variant
rs2305811 -- 68,287,956(-) ACAGC(C/T)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A6 Gene

Variant ID Type Subtype PubMed ID
nsv510691 CNV Loss 20534489
esv2675923 CNV Deletion 23128226

Relevant External Links for SLC7A6 Gene

HapMap Linkage Disequilibrium report
SLC7A6
Human Gene Mutation Database (HGMD)
SLC7A6

Disorders for SLC7A6 Gene

(1) Novoseek inferred disease relationships for SLC7A6 Gene

Disease -log(P) Hits PubMed IDs
lysinuric protein intolerance 86.6 1

Relevant External Links for SLC7A6

Genetic Association Database (GAD)
SLC7A6
genes like me logo Genes that share disorders with SLC7A6: view

No data available for UniProtKB/Swiss-Prot for SLC7A6 Gene

Publications for SLC7A6 Gene

  1. Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects. (PMID: 11078698) Dall'Asta V. … Gazzola G.C. (Am. J. Physiol. 2000) 4 23
  2. A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance. (PMID: 15756301) Sperandeo M.P. … Sebastio G. (Eur. J. Hum. Genet. 2005) 4 23
  3. Activation of classical protein kinase C decreases transport via systems y+ and y+L. (PMID: 17329401) Rotmann A. … Closs E.I. (Am. J. Physiol. 2007) 4 23
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  5. Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance. (PMID: 9829974) Torrents D. … Palacin M. (J. Biol. Chem. 1998) 3 4

Products for SLC7A6 Gene

Sources for SLC7A6 Gene

Back to Top

Content