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Aliases for RPL14 Gene

Aliases for RPL14 Gene

  • Ribosomal Protein L14 2 3 5
  • Large Ribosomal Subunit Protein EL14 3 4
  • 60S Ribosomal Protein L14 2 3
  • CAG-ISL 7 2 4
  • CAG-ISL-7 3
  • CTG-B33 3
  • HRL14 3
  • RL14 3
  • L14 3

External Ids for RPL14 Gene

Previous GeneCards Identifiers for RPL14 Gene

  • GC03P039807
  • GC03P039727
  • GC03P040312
  • GC03P040459
  • GC03P040473

Summaries for RPL14 Gene

Entrez Gene Summary for RPL14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL14 Gene

RPL14 (Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL14 Gene

Genomics for RPL14 Gene

Regulatory Elements for RPL14 Gene

Enhancers for RPL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G040503 1.1 ENCODE 10.6 +48.1 48138 3.0 PKNOX1 FOXA2 CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF619 RPL14 ENTPD3-AS1 ZNF620 ZNF621
GH03G040417 0.9 ENCODE 10.8 -39.2 -39234 0.8 HDAC1 PKNOX1 ATF1 NFXL1 CHAMP1 TCF12 ZNF766 GATA2 FOS ZBTB2 ENTPD3-AS1 RPL14 GC03P040390
GH03G040452 1.4 ENCODE dbSUPER 5.7 -4.1 -4117 2.3 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENTPD3-AS1 RNU5B-2P RPL14 MOBP GC03P040390
GH03G040430 0.5 ENCODE 12.3 -27.1 -27128 0.2 HDGF BCOR TEAD4 MAX ENTPD3-AS1 RPL14 RNU5B-2P GC03P040390
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPL14 on UCSC Golden Path with GeneCards custom track

Promoters for RPL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RPL14 Gene

40,457,292 bp from pter
40,468,587 bp from pter
11,296 bases
Plus strand

Genomic View for RPL14 Gene

Genes around RPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL14 Gene

Proteins for RPL14 Gene

  • Protein details for RPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    60S ribosomal protein L14
    Protein Accession:
    Secondary Accessions:
    • Q45RF0
    • Q53G20
    • Q8TBD5
    • Q8WUT0
    • Q92579
    • Q96GR0
    • Q9BSB8
    • Q9BW65
    • Q9BYF6

    Protein attributes for RPL14 Gene

    215 amino acids
    Molecular mass:
    23432 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL14 Gene

neXtProt entry for RPL14 Gene

Post-translational modifications for RPL14 Gene

  • Ubiquitination at Lys53 and isoforms=71
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL14 Gene

No data available for DME Specific Peptides for RPL14 Gene

Domains & Families for RPL14 Gene

Gene Families for RPL14 Gene

Protein Domains for RPL14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the eukaryotic ribosomal protein eL14 family.
  • Belongs to the eukaryotic ribosomal protein eL14 family.
genes like me logo Genes that share domains with RPL14: view

Function for RPL14 Gene

Gene Ontology (GO) - Molecular Function for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 12962325
GO:0005515 protein binding IPI 11369516
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RPL14: view
genes like me logo Genes that share phenotypes with RPL14: view

Animal Model Products

miRNA for RPL14 Gene

miRTarBase miRNAs that target RPL14

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL14 Gene

Localization for RPL14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPL14 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit TAS,IDA 12962325
genes like me logo Genes that share ontologies with RPL14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL14 Gene

Pathways & Interactions for RPL14 Gene

genes like me logo Genes that share pathways with RPL14: view

Pathways by source for RPL14 Gene

1 KEGG pathway for RPL14 Gene
1 GeneGo (Thomson Reuters) pathway for RPL14 Gene

Gene Ontology (GO) - Biological Process for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation IEA,NAS 12962325
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPL14: view

No data available for SIGNOR curated interactions for RPL14 Gene

Drugs & Compounds for RPL14 Gene

(1) Drugs for RPL14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL14: view

Transcripts for RPL14 Gene

Unigene Clusters for RPL14 Gene

Ribosomal protein L14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RPL14 Gene

No ASD Table

Relevant External Links for RPL14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL14 Gene

This gene is overexpressed in Tlymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPL14 Gene

Protein tissue co-expression partners for RPL14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPL14 Gene:


SOURCE GeneReport for Unigene cluster for RPL14 Gene:


Evidence on tissue expression from TISSUES for RPL14 Gene

  • Kidney(4.9)
  • Skin(4.9)
  • Nervous system(4.9)
  • Lung(4.7)
  • Pancreas(4.7)
  • Muscle(4.6)
  • Intestine(4.3)
  • Thyroid gland(4.1)
  • Eye(3.6)
  • Liver(3.4)
  • Blood(3.3)
  • Heart(3)
  • Spleen(2.7)
  • Bone(2.4)
  • Stomach(2.2)
  • Lymph node(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with RPL14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPL14 Gene

Orthologs for RPL14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RPL14 34 35
  • 99.84 (n)
(Canis familiaris)
Mammalia RPL14 34 35 35
  • 89.52 (n)
(Bos Taurus)
Mammalia RPL14 34 35
  • 88.47 (n)
(Mus musculus)
Mammalia Rpl14 34 16 35
  • 85.58 (n)
(Rattus norvegicus)
Mammalia Rpl14 34
  • 84.74 (n)
(Ornithorhynchus anatinus)
Mammalia RPL14 35
  • 72 (a)
(Monodelphis domestica)
Mammalia RPL14 35
  • 70 (a)
(Gallus gallus)
Aves RPL14 34 35
  • 79.04 (n)
(Anolis carolinensis)
Reptilia RPL14 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl14 34
  • 76.09 (n)
(Danio rerio)
Actinopterygii rpl14 34 35
  • 72.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005991 34
  • 51.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpL14 34 35
  • 51.3 (n)
(Caenorhabditis elegans)
Secernentea rpl-14 34 35
  • 54.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13409g 34
  • 52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR005C 34
  • 49.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL14A 35
  • 40 (a)
RPL14B 35
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20450 34
  • 54.62 (n)
(Oryza sativa)
Liliopsida Os04g0515300 34
  • 54.8 (n)
Species where no ortholog for RPL14 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL14 Gene

Gene Tree for RPL14 (if available)
Gene Tree for RPL14 (if available)

Paralogs for RPL14 Gene

genes like me logo Genes that share paralogs with RPL14: view

No data available for Paralogs for RPL14 Gene

Variants for RPL14 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for RPL14 Gene

The poly-Ala stretch is highly polymorphic.

Sequence variations from dbSNP and Humsavar for RPL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000744247 -- 40,455,376(+) CTAAA(G/T)AATAA upstream-variant-2KB
rs1002162982 -- 40,457,517(+) CCCTT(C/T)CCGGA intron-variant
rs1002236411 -- 40,457,401(+) CGACC(A/G)TGCCG intron-variant, utr-variant-5-prime
rs1002314769 -- 40,462,526(+) TGCCC(A/G)CCACC downstream-variant-500B
rs1002706607 -- 40,457,411(+) CTCGA(-/CCT)CCTCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL14 Gene

Variant ID Type Subtype PubMed ID
nsv818137 CNV loss 17921354

Variation tolerance for RPL14 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for RPL14 Gene

Relevant External Links for RPL14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL14 Gene

Publications for RPL14 Gene

  1. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). (PMID: 9480843) Tanaka M. … Mitsui Y. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 4 22 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M. … Kenmochi N. (Genome Res. 2002) 3 4 64

Products for RPL14 Gene

Sources for RPL14 Gene

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