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Aliases for RPL14 Gene

Aliases for RPL14 Gene

  • Ribosomal Protein L14 2 3 5
  • CAG-ISL 7 2 4
  • 60S Ribosomal Protein L14 2
  • CAG-ISL-7 3
  • CTG-B33 3
  • HRL14 3
  • RL14 3
  • L14 3

External Ids for RPL14 Gene

Previous GeneCards Identifiers for RPL14 Gene

  • GC03P039807
  • GC03P039727
  • GC03P040312
  • GC03P040459
  • GC03P040473

Summaries for RPL14 Gene

Entrez Gene Summary for RPL14 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPL14 Gene

RPL14 (Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPL14 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPL14 Gene

Genomics for RPL14 Gene

Regulatory Elements for RPL14 Gene

Enhancers for RPL14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPL14 on UCSC Golden Path with GeneCards custom track

Promoters for RPL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPL14 Gene

Chromosome:
3
Start:
40,457,292 bp from pter
End:
40,468,587 bp from pter
Size:
11,296 bases
Orientation:
Plus strand

Genomic View for RPL14 Gene

Genes around RPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPL14 Gene

Proteins for RPL14 Gene

  • Protein details for RPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50914-RL14_HUMAN
    Recommended name:
    60S ribosomal protein L14
    Protein Accession:
    P50914
    Secondary Accessions:
    • Q45RF0
    • Q53G20
    • Q8TBD5
    • Q8WUT0
    • Q92579
    • Q96GR0
    • Q9BSB8
    • Q9BW65
    • Q9BYF6

    Protein attributes for RPL14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23432 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPL14 Gene

neXtProt entry for RPL14 Gene

Proteomics data for RPL14 Gene at MOPED

Post-translational modifications for RPL14 Gene

  • Ubiquitination at Lys 53 and Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for RPL14 Gene

No data available for DME Specific Peptides for RPL14 Gene

Domains & Families for RPL14 Gene

Gene Families for RPL14 Gene

Protein Domains for RPL14 Gene

Graphical View of Domain Structure for InterPro Entry

P50914

UniProtKB/Swiss-Prot:

RL14_HUMAN :
  • Belongs to the ribosomal protein L14e family.
Family:
  • Belongs to the ribosomal protein L14e family.
genes like me logo Genes that share domains with RPL14: view

Function for RPL14 Gene

Gene Ontology (GO) - Molecular Function for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11369516
genes like me logo Genes that share ontologies with RPL14: view
genes like me logo Genes that share phenotypes with RPL14: view

Animal Model Products

miRNA for RPL14 Gene

miRTarBase miRNAs that target RPL14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPL14 Gene

Localization for RPL14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPL14 Gene COMPARTMENTS Subcellular localization image for RPL14 gene
Compartment Confidence
cytosol 5
extracellular 5
chloroplast 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPL14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPL14 Gene

Pathways & Interactions for RPL14 Gene

genes like me logo Genes that share pathways with RPL14: view

Pathways by source for RPL14 Gene

1 KEGG pathway for RPL14 Gene
1 GeneGo (Thomson Reuters) pathway for RPL14 Gene

Gene Ontology (GO) - Biological Process for RPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP,TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with RPL14: view

No data available for SIGNOR curated interactions for RPL14 Gene

Drugs & Compounds for RPL14 Gene

(1) Drugs for RPL14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPL14: view

Transcripts for RPL14 Gene

Unigene Clusters for RPL14 Gene

Ribosomal protein L14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPL14 Gene

No ASD Table

Relevant External Links for RPL14 Gene

GeneLoc Exon Structure for
RPL14
ECgene alternative splicing isoforms for
RPL14

Expression for RPL14 Gene

mRNA expression in normal human tissues for RPL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPL14 Gene

This gene is overexpressed in Tlymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPL14 Gene



SOURCE GeneReport for Unigene cluster for RPL14 Gene Hs.446522

genes like me logo Genes that share expression patterns with RPL14: view

Protein tissue co-expression partners for RPL14 Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPL14 Gene

Orthologs for RPL14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPL14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPL14 35
  • 88.47 (n)
  • 87.85 (a)
RPL14 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPL14 35
  • 89.52 (n)
  • 92.38 (a)
RPL14 36
  • 94 (a)
OneToMany
RPL14 36
  • 94 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rpl14 35
  • 85.58 (n)
  • 86.51 (a)
Rpl14 16
Rpl14 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPL14 35
  • 99.84 (n)
  • 99.53 (a)
RPL14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rpl14 35
  • 84.74 (n)
  • 86.92 (a)
oppossum
(Monodelphis domestica)
Mammalia RPL14 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPL14 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPL14 35
  • 79.04 (n)
  • 85.61 (a)
RPL14 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPL14 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rpl14 35
  • 76.09 (n)
  • 80.43 (a)
zebrafish
(Danio rerio)
Actinopterygii rpl14 35
  • 72.39 (n)
  • 72.39 (a)
rpl14 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005991 35
  • 51.75 (n)
  • 46.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpL14 35
  • 51.3 (n)
  • 42.55 (a)
RpL14 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rpl-14 35
  • 54.89 (n)
  • 48.12 (a)
rpl-14 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR005C 35
  • 49.23 (n)
  • 50.77 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13409g 35
  • 52 (n)
  • 46.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL14A 36
  • 40 (a)
OneToMany
RPL14B 36
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20450 35
  • 54.62 (n)
  • 46.15 (a)
rice
(Oryza sativa)
Liliopsida Os04g0515300 35
  • 54.8 (n)
  • 47.73 (a)
Species with no ortholog for RPL14:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPL14 Gene

ENSEMBL:
Gene Tree for RPL14 (if available)
TreeFam:
Gene Tree for RPL14 (if available)

Paralogs for RPL14 Gene

genes like me logo Genes that share paralogs with RPL14: view

No data available for Paralogs for RPL14 Gene

Variants for RPL14 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for RPL14 Gene

RL14_HUMAN-P50914
The poly-Ala stretch is highly polymorphic.

Sequence variations from dbSNP and Humsavar for RPL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_013633 -
rs8127 -- 40,462,262(+) GGTTC(C/T)TTTTG utr-variant-3-prime
rs8701 -- 40,462,169(+) GCTCA(A/G)AAGGG reference, synonymous-codon
rs10731 -- 40,462,256(+) AATAA(A/G)GGTTC utr-variant-3-prime
rs15369 -- 40,462,260(+) AAGGT(C/T)CTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPL14 Gene

Variant ID Type Subtype PubMed ID
nsv876716 CNV Gain 21882294
nsv818137 CNV Loss 17921354

Variation tolerance for RPL14 Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for RPL14 Gene

Disorders for RPL14 Gene

Relevant External Links for RPL14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPL14

No disorders were found for RPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPL14 Gene

Publications for RPL14 Gene

  1. Triplet repeat-containing ribosomal protein L14 gene in immortalized human endothelial cell line (t-HUE4). (PMID: 9480843) Tanaka M. … Mitsui Y. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PMID: 12962325) Odintsova T.I. … Karpova G.G. (J. Protein Chem. 2003) 3 23
  3. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  4. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for RPL14 Gene

Sources for RPL14 Gene

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