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Aliases for UBE2M Gene

Aliases for UBE2M Gene

  • Ubiquitin-Conjugating Enzyme E2M 2 3
  • UBC12 3 4 6
  • Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog, Yeast) 2 3
  • NEDD8 Carrier Protein 3 4
  • NEDD8 Protein Ligase 3 4
  • Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12) 2
  • Ubiquitin-Conjugating Enzyme E2 M 4
  • NEDD8-Conjugating Enzyme Ubc12 3
  • Ubiquitin Carrier Protein M 3
  • Ubiquitin-Protein Ligase M 3
  • Yeast UBC12 Homolog 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • UBC-RS2 3
  • HUbc12 3

External Ids for UBE2M Gene

Previous GeneCards Identifiers for UBE2M Gene

  • GC19M059965
  • GC19M059521
  • GC19M063742
  • GC19M063758
  • GC19M059067

Summaries for UBE2M Gene

Entrez Gene Summary for UBE2M Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2M Gene

UBE2M (Ubiquitin-Conjugating Enzyme E2M) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity and ribosomal S6-glutamic acid ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot for UBE2M Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Gene Wiki entry for UBE2M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2M Gene

Genomics for UBE2M Gene

Regulatory Elements for UBE2M Gene

Transcription factor binding sites by QIAGEN in the UBE2M gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2M Gene

58,555,712 bp from pter
58,558,976 bp from pter
3,265 bases
Minus strand

Genomic View for UBE2M Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2M Gene

Proteins for UBE2M Gene

  • Protein details for UBE2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD8-conjugating enzyme Ubc12
    Protein Accession:
    Secondary Accessions:
    • O76069
    • Q8VC50

    Protein attributes for UBE2M Gene

    183 amino acids
    Molecular mass:
    20900 Da
    Quaternary structure:
    • Interacts with UBA3, DCUN1D1 and RBX1.

    Three dimensional structures from OCA and Proteopedia for UBE2M Gene

neXtProt entry for UBE2M Gene

Proteomics data for UBE2M Gene at MOPED

Selected DME Specific Peptides for UBE2M Gene

Post-translational modifications for UBE2M Gene

  • The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Ubiquitination at Lys8, Lys36, Lys75, and Lys81
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2M Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2M (UBE2M)

Domains for UBE2M Gene

Gene Families for UBE2M Gene

  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2M Gene

Suggested Antigen Peptide Sequences for UBE2M Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P61081
  • Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8
  • Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
genes like me logo Genes that share domains with UBE2M: view

Function for UBE2M Gene

Molecular function for UBE2M Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Enzyme Numbers (IUBMB) for UBE2M Gene

Gene Ontology (GO) - Molecular Function for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9694792
GO:0005515 protein binding IPI 15361859
GO:0005524 ATP binding IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0018169 ribosomal S6-glutamic acid ligase activity IDA 15361859
genes like me logo Genes that share ontologies with UBE2M: view
genes like me logo Genes that share phenotypes with UBE2M: view

Animal Model Products

miRNA for UBE2M Gene

miRTarBase miRNAs that target UBE2M

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2M Gene

Localization for UBE2M Gene

Subcellular locations from

Jensen Localization Image for UBE2M Gene COMPARTMENTS Subcellular localization image for UBE2M gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UBE2M: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2M Gene

Pathways for UBE2M Gene

genes like me logo Genes that share pathways with UBE2M: view

Pathways by source for UBE2M Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P61081-UBC12_HUMAN

  • Pathway: Protein modification; protein neddylation

Gene Ontology (GO) - Biological Process for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006464 cellular protein modification process TAS 9694792
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0008152 metabolic process --
GO:0016567 protein ubiquitination TAS 9694792
genes like me logo Genes that share ontologies with UBE2M: view

Compounds for UBE2M Gene

(4) HMDB Compounds for UBE2M Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE2M: view

Transcripts for UBE2M Gene

mRNA/cDNA for UBE2M Gene

Unigene Clusters for UBE2M Gene

Ubiquitin-conjugating enzyme E2M:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2M

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2M Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -

Relevant External Links for UBE2M Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2M Gene

mRNA expression in normal human tissues for UBE2M Gene

Protein differential expression in normal tissues for UBE2M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2M Gene

SOURCE GeneReport for Unigene cluster for UBE2M Gene Hs.406068

genes like me logo Genes that share expressions with UBE2M: view

Expression partners for UBE2M Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2M Gene

Orthologs for UBE2M Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2M Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBE2M 35
  • 96.54 (n)
  • 100 (a)
UBE2M 36
  • 100 (a)
(Canis familiaris)
Mammalia UBE2M 35
  • 97.27 (n)
  • 100 (a)
UBE2M 36
  • 99 (a)
(Mus musculus)
Mammalia Ube2m 35
  • 94.35 (n)
  • 100 (a)
Ube2m 16
Ube2m 36
  • 100 (a)
(Pan troglodytes)
Mammalia UBE2M 35
  • 99.77 (n)
  • 100 (a)
UBE2M 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Ube2m 35
  • 94.9 (n)
  • 100 (a)
(Gallus gallus)
Aves UBE2M 36
  • 47 (a)
(Anolis carolinensis)
Reptilia UBE2M 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75750 35
ube2m 35
  • 81.42 (n)
  • 97.81 (a)
(Danio rerio)
Actinopterygii wu:fb58e05 35
  • 81.24 (n)
  • 91.26 (a)
wufb58e05 35
fruit fly
(Drosophila melanogaster)
Insecta CG7375 37
  • 75 (a)
Ubc12 35
  • 73.56 (n)
  • 76.54 (a)
Ubc12 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005916 35
  • 70.13 (n)
  • 80.87 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL035C 35
  • 55.49 (n)
  • 41.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17248g 35
  • 47.25 (n)
  • 38.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 35
  • 50.93 (n)
  • 43.33 (a)
UBC12 36
  • 37 (a)
UBC12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18600 35
  • 59.89 (n)
  • 63.19 (a)
(Glycine max)
eudicotyledons Gma.17973 35
(Hordeum vulgare)
Liliopsida Hv.3803 35
(Oryza sativa)
Liliopsida Os.14656 35
Os08g0374100 35
  • 59.52 (n)
  • 61.54 (a)
(Triticum aestivum)
Liliopsida Ta.3716 35
(Zea mays)
Liliopsida Zm.4335 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1924 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03610 35
  • 62.3 (n)
  • 56.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc12 35
  • 54.17 (n)
  • 51.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4912 36
  • 62 (a)
Species with no ortholog for UBE2M:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for UBE2M Gene

Gene Tree for UBE2M (if available)
Gene Tree for UBE2M (if available)

Paralogs for UBE2M Gene

Paralogs for UBE2M Gene

Selected SIMAP similar genes for UBE2M Gene using alignment to 3 proteins: Pseudogenes for UBE2M Gene

genes like me logo Genes that share paralogs with UBE2M: view

Variants for UBE2M Gene

Sequence variations from dbSNP and Humsavar for UBE2M Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs200667382 -- 58,557,161(+) GTCTG(G/T)GTTTG intron-variant
rs201857688 -- 58,557,152(+) CTCGT(C/T)TATGT reference, missense
rs370510222 -- 58,557,140(+) GGGCA(A/G)GTTCA reference, synonymous-codon
rs539036249 -- 58,557,169(+) TTGGG(C/T)AGCAG intron-variant
rs566710013 -- 58,557,165(+) GGGTT(C/T)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2M Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
nsv912546 CNV Loss 21882294
dgv4032n71 CNV Loss 21882294

Relevant External Links for UBE2M Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2M Gene

Disorders for UBE2M Gene

No disorders were found for UBE2M Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UBE2M Gene

Publications for UBE2M Gene

  1. A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. (PMID: 10828074) Wada H. … Kamitani T. (J. Biol. Chem. 2000) 3 4 23
  2. A new NEDD8-ligating system for cullin-4A. (PMID: 9694792) Osaka F. … Kato S. (Genes Dev. 1998) 2 3 4
  3. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. (PMID: 10207026) Gong L. … Yeh E.T.H. (J. Biol. Chem. 1999) 3 4
  4. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PMID: 15361859) Huang D.T. … Schulman B.A. (Nat. Struct. Mol. Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UBE2M Gene

  • Addgene plasmids for UBE2M

Sources for UBE2M Gene

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