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Aliases for MED30 Gene

Aliases for MED30 Gene

  • Mediator Complex Subunit 30 2 3 4 5
  • Thyroid Hormone Receptor-Associated Protein Complex 25 KDa Component 3 4
  • Thyroid Hormone Receptor-Associated Protein 6 3 4
  • TRAP/Mediator Complex Component TRAP25 3 4
  • THRAP6 3 4
  • TRAP25 3 4
  • Putative Mediator Of RNA Polymerase II Transcription Subunit 30 3
  • Mediator Of RNA Polymerase II Transcription Subunit 30 3
  • Thyroid Hormone Receptor Associated Protein 6 2
  • MED30S 3

External Ids for MED30 Gene

Previous HGNC Symbols for MED30 Gene

  • THRAP6

Previous GeneCards Identifiers for MED30 Gene

  • GC08P118603
  • GC08P113859

Summaries for MED30 Gene

Entrez Gene Summary for MED30 Gene

  • The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]

GeneCards Summary for MED30 Gene

MED30 (Mediator Complex Subunit 30) is a Protein Coding gene. Among its related pathways are Thyroid hormone signaling pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include receptor activity and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for MED30 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED30 Gene

Additional gene information for MED30 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED30 Gene

Genomics for MED30 Gene

GeneHancer (GH) Regulatory Elements for MED30 Gene

Promoters and enhancers for MED30 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I117519 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 558 +0.3 266 2.4 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF213 E2F8 ZNF143 MED30 LOC105375716 UTP23 EIF3H EXT1 RPS10P16
GH08I118126 Enhancer 1.2 Ensembl ENCODE dbSUPER 51.4 +606.2 606166 1.2 ZFP64 ZNF213 ZNF354C KLF7 ZNF202 ZNF680 ZBTB11 ZC3H11A REST ZNF518A MED30 LOC105375724 EXT1 ENSG00000279535
GH08I116754 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 26.7 -765.1 -765148 2.1 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B EIF3H MED30 UTP23 LOC105375713
GH08I118065 Enhancer 0.8 dbSUPER 51.4 +545.0 544976 1.3 ZNF529 ZFP64 ZNF121 ZNF213 ZNF354C ZNF138 FOS ZNF202 ZNF680 ZNF654 MED30 EXT1 GC08M118085 GC08M118034
GH08I118066 Enhancer 0.8 dbSUPER 43.4 +547.7 547668 3.8 PKNOX1 ZBTB21 ZNF529 ZSCAN4 ZNF140 ZNF266 ZNF697 ZNF664 ZNF791 ZNF213 MED30 EXT1 GC08M118085 GC08M118034
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED30 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED30 gene promoter:

Genomic Locations for MED30 Gene

Genomic Locations for MED30 Gene
chr8:117,520,713-117,540,262
(GRCh38/hg38)
Size:
19,550 bases
Orientation:
Plus strand
chr8:118,532,952-118,552,501
(GRCh37/hg19)

Genomic View for MED30 Gene

Genes around MED30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED30 Gene

Proteins for MED30 Gene

  • Protein details for MED30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HR3-MED30_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 30
    Protein Accession:
    Q96HR3
    Secondary Accessions:
    • C6GKU9

    Protein attributes for MED30 Gene

    Size:
    178 amino acids
    Molecular mass:
    20277 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

    Alternative splice isoforms for MED30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MED30 Gene

Post-translational modifications for MED30 Gene

Other Protein References for MED30 Gene

No data available for DME Specific Peptides for MED30 Gene

Domains & Families for MED30 Gene

Gene Families for MED30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED30 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MED30 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HR3

UniProtKB/Swiss-Prot:

MED30_HUMAN :
  • Belongs to the Mediator complex subunit 30 family.
Family:
  • Belongs to the Mediator complex subunit 30 family.
genes like me logo Genes that share domains with MED30: view

Function for MED30 Gene

Molecular function for MED30 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED30 Gene

Gene Ontology (GO) - Molecular Function for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0004872 receptor activity IDA 12218053
GO:0005515 protein binding IPI 21784977
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity NAS 10235266
genes like me logo Genes that share ontologies with MED30: view
genes like me logo Genes that share phenotypes with MED30: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED30 Gene

Localization for MED30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED30 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA,IDA 10235267
GO:0005654 nucleoplasm TAS --
GO:0016592 mediator complex IDA 10198638
genes like me logo Genes that share ontologies with MED30: view

Pathways & Interactions for MED30 Gene

genes like me logo Genes that share pathways with MED30: view

Pathways by source for MED30 Gene

Gene Ontology (GO) - Biological Process for MED30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED30: view

No data available for SIGNOR curated interactions for MED30 Gene

Drugs & Compounds for MED30 Gene

No Compound Related Data Available

Transcripts for MED30 Gene

Unigene Clusters for MED30 Gene

Mediator complex subunit 30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED30 Gene

No ASD Table

Relevant External Links for MED30 Gene

GeneLoc Exon Structure for
MED30
ECgene alternative splicing isoforms for
MED30

Expression for MED30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED30 Gene

Protein differential expression in normal tissues from HIPED for MED30 Gene

This gene is overexpressed in Colon muscle (46.8) and Plasma (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED30 Gene



Protein tissue co-expression partners for MED30 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED30 Gene:

MED30

SOURCE GeneReport for Unigene cluster for MED30 Gene:

Hs.492612

mRNA Expression by UniProt/SwissProt for MED30 Gene:

Q96HR3-MED30_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.

Evidence on tissue expression from TISSUES for MED30 Gene

  • Bone marrow(4.3)
  • Blood(4.1)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MED30: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED30 Gene

Orthologs for MED30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED30 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia MED30 33 34
  • 94.01 (n)
cow
(Bos Taurus)
Mammalia MED30 33 34
  • 92.92 (n)
oppossum
(Monodelphis domestica)
Mammalia MED30 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med30 33 16 34
  • 90.07 (n)
rat
(Rattus norvegicus)
Mammalia Med30 33
  • 89.28 (n)
chicken
(Gallus gallus)
Aves MED30 33 34
  • 80.79 (n)
lizard
(Anolis carolinensis)
Reptilia MED30 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med30 33
  • 74.91 (n)
Str.16066 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.29036 33
zebrafish
(Danio rerio)
Actinopterygii med30 33 34
  • 72.12 (n)
zgc73113 33
fruit fly
(Drosophila melanogaster)
Insecta MED30 33 34
  • 55.41 (n)
Species where no ortholog for MED30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MED30 Gene

ENSEMBL:
Gene Tree for MED30 (if available)
TreeFam:
Gene Tree for MED30 (if available)

Paralogs for MED30 Gene

No data available for Paralogs for MED30 Gene

Variants for MED30 Gene

Sequence variations from dbSNP and Humsavar for MED30 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000079450 -- 117,519,922(+) G/A upstream_transcript_variant
rs1000452794 -- 117,519,603(+) A/C upstream_transcript_variant
rs1000496949 -- 117,522,043(+) T/C intron_variant
rs1000581564 -- 117,539,940(+) A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000681794 -- 117,526,944(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED30 Gene

Variant ID Type Subtype PubMed ID
nsv831436 CNV loss 17160897
nsv981976 CNV duplication 23825009

Variation tolerance for MED30 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED30 Gene

Disorders for MED30 Gene

Additional Disease Information for MED30

No disorders were found for MED30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED30 Gene

Publications for MED30 Gene

  1. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PMID: 22446961) Lee YC … Wu JY (Nature genetics 2012) 3 44 58
  2. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  3. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. (PMID: 12584197) Sato S … Conaway JW (The Journal of biological chemistry 2003) 3 4 58

Products for MED30 Gene

Sources for MED30 Gene

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