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Aliases for SLC25A14 Gene

Aliases for SLC25A14 Gene

  • Solute Carrier Family 25 Member 14 2 3 4 5
  • Mitochondrial Uncoupling Protein 5 3 4
  • BMCP1 3 4
  • UCP5 3 4
  • Solute Carrier Family 25 (Mitochondrial Carrier, Brain), Member 14 2
  • Brain Mitochondrial Carrier Protein 1 3
  • BMCP-1 4
  • UCP 5 4

External Ids for SLC25A14 Gene

Previous GeneCards Identifiers for SLC25A14 Gene

  • GC0XP124119
  • GC0XP126319
  • GC0XP127418
  • GC0XP128179
  • GC0XP129199
  • GC0XP129301
  • GC0XP129473
  • GC0XP118868

Summaries for SLC25A14 Gene

Entrez Gene Summary for SLC25A14 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC25A14 Gene

SLC25A14 (Solute Carrier Family 25 Member 14) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial Uncoupling Proteins. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A14 Gene

  • Participates in the mitochondrial proton leak measured in brain mitochondria.

Gene Wiki entry for SLC25A14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A14 Gene

Genomics for SLC25A14 Gene

Regulatory Elements for SLC25A14 Gene

Enhancers for SLC25A14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG130280 0.4 ENCODE 12.4 -58.9 -58934 1.0 PRDM1 RNU6-1130P ENSG00000225046 SLC25A14 ZNF280C GC0XM130311
GH0XG130287 0.4 ENCODE 11.6 -52.5 -52480 0.6 HNF4A ENSG00000225046 SLC25A14 ZNF280C GC0XM130311 RNU6-1130P
GH0XG130339 1 ENCODE 0.7 +0.1 89 1.4 ATF1 CREB3L1 ARID4B E2F7 SIN3A DMAP1 GLI4 ZNF2 YY1 GLIS2 SLC25A14 GC0XM130346
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC25A14 on UCSC Golden Path with GeneCards custom track

Promoters for SLC25A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248720 113 1599 ATF1 CREB3L1 ARID4B E2F7 SIN3A DMAP1 GLI4 ZNF2 YY1 GLIS2

Genomic Location for SLC25A14 Gene

130,339,888 bp from pter
130,373,361 bp from pter
33,474 bases
Plus strand

Genomic View for SLC25A14 Gene

Genes around SLC25A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC25A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC25A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A14 Gene

Proteins for SLC25A14 Gene

  • Protein details for SLC25A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain mitochondrial carrier protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DTG2
    • Q0VDH7
    • Q9HC60
    • Q9HC61

    Protein attributes for SLC25A14 Gene

    325 amino acids
    Molecular mass:
    36202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A14 Gene


neXtProt entry for SLC25A14 Gene

Post-translational modifications for SLC25A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC25A14 Gene

Domains & Families for SLC25A14 Gene

Gene Families for SLC25A14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
genes like me logo Genes that share domains with SLC25A14: view

Function for SLC25A14 Gene

Molecular function for SLC25A14 Gene

GENATLAS Biochemistry:
solute carrier family 25,mitochondrial,predominantly expressed in the brain,particularily in cortex,hippocampus,thalamus,amygdala,hyppothalamus
UniProtKB/Swiss-Prot Function:
Participates in the mitochondrial proton leak measured in brain mitochondria.

Gene Ontology (GO) - Molecular Function for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC25A14: view
genes like me logo Genes that share phenotypes with SLC25A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC25A14

miRNA for SLC25A14 Gene

miRTarBase miRNAs that target SLC25A14

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC25A14 Gene

Localization for SLC25A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A14 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC25A14 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
extracellular 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9852133
GO:0005740 mitochondrial envelope IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9852133
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC25A14: view

Pathways & Interactions for SLC25A14 Gene

genes like me logo Genes that share pathways with SLC25A14: view

Interacting Proteins for SLC25A14 Gene

Gene Ontology (GO) - Biological Process for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9852133
GO:0006839 mitochondrial transport IBA --
GO:0009060 aerobic respiration TAS 9852133
GO:0015992 proton transport TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A14: view

No data available for SIGNOR curated interactions for SLC25A14 Gene

Drugs & Compounds for SLC25A14 Gene

(1) Additional Compounds for SLC25A14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC25A14: view

Transcripts for SLC25A14 Gene

Unigene Clusters for SLC25A14 Gene

Solute carrier family 25 (mitochondrial carrier, brain), member 14:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A14 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - - -

Relevant External Links for SLC25A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC25A14 Gene

Protein differential expression in normal tissues from HIPED for SLC25A14 Gene

This gene is overexpressed in Testis (17.1), Retina (16.4), Frontal cortex (14.6), Fetal Brain (10.4), and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC25A14 Gene

Protein tissue co-expression partners for SLC25A14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC25A14 Gene:


SOURCE GeneReport for Unigene cluster for SLC25A14 Gene:


mRNA Expression by UniProt/SwissProt for SLC25A14 Gene:

Tissue specificity: Mainly expressed in brain. Some expression in testis and pituitary.

Evidence on tissue expression from TISSUES for SLC25A14 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC25A14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC25A14 Gene

Orthologs for SLC25A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A14 34 35
  • 99.81 (n)
(Monodelphis domestica)
Mammalia SLC25A14 35
  • 94 (a)
(Bos Taurus)
Mammalia SLC25A14 34 35
  • 92.44 (n)
(Canis familiaris)
Mammalia SLC25A14 34 35
  • 92.13 (n)
(Mus musculus)
Mammalia Slc25a14 34 16 35
  • 89.44 (n)
(Rattus norvegicus)
Mammalia Slc25a14 34
  • 88.92 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
(Gallus gallus)
Aves SLC25A14 34 35
  • 77.18 (n)
(Anolis carolinensis)
Reptilia SLC25A14 35
  • 85 (a)
(Danio rerio)
Actinopterygii slc25a14 34 35
  • 71.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bmcp 36 35
  • 55 (a)
Species where no ortholog for SLC25A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A14 Gene

Gene Tree for SLC25A14 (if available)
Gene Tree for SLC25A14 (if available)

Paralogs for SLC25A14 Gene

(10) SIMAP similar genes for SLC25A14 Gene using alignment to 4 proteins: Pseudogenes for SLC25A14 Gene

genes like me logo Genes that share paralogs with SLC25A14: view

Variants for SLC25A14 Gene

Sequence variations from dbSNP and Humsavar for SLC25A14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000082474 -- 130,359,528(+) TGTCA(C/T)ATTAT intron-variant, utr-variant-3-prime
rs1000198001 -- 130,354,654(+) AAACT(A/G)CTGTC intron-variant
rs1000220450 -- 130,360,989(+) CTATC(A/G)ATTTG intron-variant
rs1000275855 -- 130,343,481(+) TATCT(A/G)TCCCA intron-variant, upstream-variant-2KB
rs1000352631 -- 130,365,443(+) TGATG(G/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A14 Gene

Variant ID Type Subtype PubMed ID
nsv510559 OTHER sequence alteration 20534489
nsv528290 CNV gain 19592680

Variation tolerance for SLC25A14 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC25A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A14 Gene

Disorders for SLC25A14 Gene

Relevant External Links for SLC25A14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC25A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC25A14 Gene

Publications for SLC25A14 Gene

  1. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. (PMID: 9852133) Sanchis D. … Ricquier D. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. (PMID: 10928996) Yu X.X. … Pan G. (FASEB J. 2000) 3 4 22 64
  3. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. (PMID: 17066476) Yasuno K. … Tamiya G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 46 64
  4. Amplified expression of uncoupling proteins in human brain ischemic lesions. (PMID: 18018477) Nakase T. … Nagata K. (Neuropathology 2007) 3 22 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64

Products for SLC25A14 Gene

Sources for SLC25A14 Gene

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