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Aliases for SLC25A14 Gene

Aliases for SLC25A14 Gene

  • Solute Carrier Family 25 (Mitochondrial Carrier, Brain), Member 14 2 3
  • BMCP1 3 4 6
  • Mitochondrial Uncoupling Protein 5 3 4
  • UCP5 3 4
  • Brain Mitochondrial Carrier Protein 1 3
  • Solute Carrier Family 25 Member 14 4
  • BMCP-1 4
  • UCP 5 4

External Ids for SLC25A14 Gene

Previous GeneCards Identifiers for SLC25A14 Gene

  • GC0XP124119
  • GC0XP126319
  • GC0XP127418
  • GC0XP128179
  • GC0XP129199
  • GC0XP129301
  • GC0XP129473
  • GC0XP118868

Summaries for SLC25A14 Gene

Entrez Gene Summary for SLC25A14 Gene

  • Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]

GeneCards Summary for SLC25A14 Gene

SLC25A14 (Solute Carrier Family 25 (Mitochondrial Carrier, Brain), Member 14) is a Protein Coding gene. Diseases associated with SLC25A14 include congenital nystagmus. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is SLC25A30.

UniProtKB/Swiss-Prot for SLC25A14 Gene

  • Participates in the mitochondrial proton leak measured in brain mitochondria

Gene Wiki entry for SLC25A14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A14 Gene

Genomics for SLC25A14 Gene

Regulatory Elements for SLC25A14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A14 Gene

Start:
130,338,715 bp from pter
End:
130,373,361 bp from pter
Size:
34,647 bases
Orientation:
Plus strand

Genomic View for SLC25A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A14 Gene

Proteins for SLC25A14 Gene

  • Protein details for SLC25A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95258-UCP5_HUMAN
    Recommended name:
    Brain mitochondrial carrier protein 1
    Protein Accession:
    O95258
    Secondary Accessions:
    • D3DTG2
    • Q0VDH7
    • Q9HC60
    • Q9HC61

    Protein attributes for SLC25A14 Gene

    Size:
    325 amino acids
    Molecular mass:
    36202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC25A14 Gene

Proteomics data for SLC25A14 Gene at MOPED

Post-translational modifications for SLC25A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLC25A14 Gene

Domains for SLC25A14 Gene

Gene Families for SLC25A14 Gene

Graphical View of Domain Structure for InterPro Entry

O95258

UniProtKB/Swiss-Prot:

UCP5_HUMAN :
  • O95258
Family:
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
Similarity:
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A14: view

Function for SLC25A14 Gene

Molecular function for SLC25A14 Gene

GENATLAS Biochemistry:
solute carrier family 25,mitochondrial,predominantly expressed in the brain,particularily in cortex,hippocampus,thalamus,amygdala,hyppothalamus
UniProtKB/Swiss-Prot Function:
Participates in the mitochondrial proton leak measured in brain mitochondria

Phenotypes for SLC25A14 Gene

GenomeRNAi human phenotypes for SLC25A14:
genes like me logo Genes that share phenotypes with SLC25A14: view

Animal Model Products

miRNA for SLC25A14 Gene

miRTarBase miRNAs that target SLC25A14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A14 Gene

Localization for SLC25A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A14 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC25A14 Gene COMPARTMENTS Subcellular localization image for SLC25A14 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
extracellular 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9852133
GO:0005740 mitochondrial envelope --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9852133
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC25A14: view

Pathways for SLC25A14 Gene

genes like me logo Genes that share pathways with SLC25A14: view

Pathways by source for SLC25A14 Gene

1 BioSystems pathway for SLC25A14 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC25A14 Gene

Gene Ontology (GO) - Biological Process for SLC25A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9852133
GO:0006839 mitochondrial transport IEA --
GO:0009060 aerobic respiration TAS 9852133
GO:0015992 proton transport TAS --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with SLC25A14: view

Compounds for SLC25A14 Gene

(1) Novoseek inferred chemical compound relationships for SLC25A14 Gene

Compound -log(P) Hits PubMed IDs
hydrogen 7.01 2
genes like me logo Genes that share compounds with SLC25A14: view

Transcripts for SLC25A14 Gene

Unigene Clusters for SLC25A14 Gene

Solute carrier family 25 (mitochondrial carrier, brain), member 14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A14 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: - - -

Relevant External Links for SLC25A14 Gene

GeneLoc Exon Structure for
SLC25A14
ECgene alternative splicing isoforms for
SLC25A14

Expression for SLC25A14 Gene

mRNA expression in normal human tissues for SLC25A14 Gene

Protein differential expression in normal tissues for SLC25A14 Gene

This gene is overexpressed in Testis (17.1), Retina (16.4), Frontal cortex (14.6), Fetal Brain (10.4), and Fetal ovary (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC25A14 Gene

SOURCE GeneReport for Unigene cluster for SLC25A14 Gene Hs.194686

mRNA Expression by UniProt/SwissProt for SLC25A14 Gene

O95258-UCP5_HUMAN
Tissue specificity: Mainly expressed in brain. Some expression in testis and pituitary.
genes like me logo Genes that share expressions with SLC25A14: view

Expression partners for SLC25A14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC25A14 Gene

Orthologs for SLC25A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC25A14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC25A14 35
  • 92.44 (n)
  • 98.14 (a)
SLC25A14 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC25A14 35
  • 92.13 (n)
  • 98.14 (a)
SLC25A14 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc25a14 35
  • 89.44 (n)
  • 97.52 (a)
Slc25a14 16
Slc25a14 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC25A14 35
  • 99.81 (n)
  • 99.72 (a)
SLC25A14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc25a14 35
  • 88.92 (n)
  • 96.89 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC25A14 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC25A14 35
  • 77.18 (n)
  • 91.04 (a)
SLC25A14 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC25A14 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc25a14 35
  • 71.21 (n)
  • 79.37 (a)
slc25a14 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bmcp 37
  • 55 (a)
Bmcp 36
  • 54 (a)
OneToMany
Species with no ortholog for SLC25A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC25A14 Gene

ENSEMBL:
Gene Tree for SLC25A14 (if available)
TreeFam:
Gene Tree for SLC25A14 (if available)

Paralogs for SLC25A14 Gene

Selected SIMAP similar genes for SLC25A14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC25A14 Gene

genes like me logo Genes that share paralogs with SLC25A14: view

Variants for SLC25A14 Gene

Sequence variations from dbSNP and Humsavar for SLC25A14 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs734684 -- 130,342,433(+) AGCTC(A/G)AGAAA intron-variant
rs1010977 -- 130,345,348(+) TTTGG(C/T)GAAAG intron-variant
rs1010978 -- 130,345,486(+) TTTGG(C/T)AGTTT intron-variant
rs2143598 - 130,345,270(+) GGCTG(A/C)GTTTG reference, missense, nc-transcript-variant, intron-variant, utr-variant-5-prime
rs2179671 -- 130,353,151(+) CAGTA(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A14 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV Gain 19592680
nsv510559 CNV Loss 20534489

Relevant External Links for SLC25A14 Gene

HapMap Linkage Disequilibrium report
SLC25A14
Locus Specific Mutation Databases (LSDB)
SLC25A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A14 Gene

Disorders for SLC25A14 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC25A14 Gene in MalaCards »

(1) Diseases for SLC25A14 Gene including...

(1) University of Copenhagen DISEASES for SLC25A14 Gene

Relevant External Links for SLC25A14

Genetic Association Database (GAD)
SLC25A14
Human Genome Epidemiology (HuGE) Navigator
SLC25A14
genes like me logo Genes that share disorders with SLC25A14: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SLC25A14 Gene

Publications for SLC25A14 Gene

  1. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. (PMID: 9852133) Sanchis D. … Ricquier D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. (PMID: 10928996) Yu X.X. … Pan G. (FASEB J. 2000) 3 4 23
  3. Amplified expression of uncoupling proteins in human brain ischemic lesions. (PMID: 18018477) Nakase T. … Nagata K. (Neuropathology 2007) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC25A14 Gene

Sources for SLC25A14 Gene

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