Aliases for LACRT Gene
External Ids for LACRT Gene
- HGNC: 16430
- Entrez Gene: 90070
- Ensembl: ENSG00000135413
- OMIM: 607360
- UniProtKB: Q9GZZ8
Previous GeneCards Identifiers for LACRT Gene
- GC12P049944
- GC12M055138
- GC12M054741
- GC12M053310
- GC12M055024
- GC12M052063
Summaries for LACRT Gene
-
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
GeneCards Summary for LACRT Gene
LACRT (Lacritin) is a Protein Coding gene. Diseases associated with LACRT include Dry Eye Syndrome and Lacrimal Apparatus Disease. GO annotations related to this gene include growth factor activity and collagen binding.
UniProtKB/Swiss-Prot for LACRT Gene
-
Modulates secretion by lacrimal acinar cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACRT Gene
Genomics for LACRT Gene
Regulatory Elements for LACRT Gene
Regulatory Element Products
Genomic Location for LACRT Gene
- Chromosome:
- 12
- Start:
- 54,630,811 bp from pter
- End:
- 54,634,895 bp from pter
- Size:
- 4,085 bases
- Orientation:
- Minus strand
Genomic View for LACRT Gene
Genes around LACRT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Ensembl
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC
LACRT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for LACRT Gene
Proteins for LACRT Gene
-
Protein details for LACRT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZZ8-LACRT_HUMAN
- Recommended name:
- Extracellular glycoprotein lacritin
- Protein Accession:
- Q9GZZ8
Protein attributes for LACRT Gene
- Size:
- 138 amino acids
- Molecular mass:
- 14246 Da
- Quaternary structure:
- No Data Available
Protein Expression for LACRT Gene
Post-translational modifications for LACRT Gene
Other Protein References for LACRT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
-
OriGene Purified Proteins for LACRT
- Search Origene for MassSpec and Protein Over-expression Lysates for LACRT
- Origene Custom Protein Services for LACRT
- Novus Biologicals lysates for LACRT
-
Cloud-Clone Corp. Proteins for LACRT
- Search GeneTex for Proteins for LACRT
-
ProSci Proteins for LACRT
-
Abcam proteins for LACRT
Assay Products
-
Cloud-Clone Corp Assay Kits for LACRT
No data available for DME Specific Peptides for LACRT Gene
Domains & Families for LACRT Gene
Suggested Antigen Peptide Sequences for LACRT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for LACRT Gene
Function for LACRT Gene
Molecular function for LACRT Gene
- UniProtKB/Swiss-Prot Function:
- Modulates secretion by lacrimal acinar cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001948 | glycoprotein binding | IDA | 11419941 |
| GO:0001968 | fibronectin binding | IDA | 11419941 |
| GO:0005518 | collagen binding | IDA | 11419941 |
| GO:0008083 | growth factor activity | IDA | 16982797 |
| GO:0043237 | laminin-1 binding | IDA | 11419941 |
Phenotypes for LACRT Gene
- GenomeRNAi human phenotypes for LACRT:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
- Search ViGene Biosciences for LACRT
CRISPR Products
-
OriGene CRISPR knockouts for LACRT
-
Santa Cruz Biotechnology (SCBT) CRISPR for LACRT
- GenScript: Design CRISPR guide RNA sequences for LACRT
miRNA for LACRT Gene
- miRTarBase miRNAs that target LACRT
miRNA Products
- Search ViGene Biosciences for LACRT
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for LACRT
- Browse OriGene Inhibitory RNA Products For LACRT
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
Clone Products
-
OriGene ORF clones in human for LACRT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for LACRT
Cell Line Products
-
Horizon Cell Lines for LACRT
-
ViGene Biosciences adenoviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACRT Gene
Localization for LACRT Gene
Subcellular locations from UniProtKB/Swiss-Prot for LACRT Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA,IEA | 17850790 |
| GO:0005615 | extracellular space | IDA | 22664934 |
| GO:0030141 | secretory granule | IDA | 11419941 |
Pathways & Interactions for LACRT Gene
No Data Available
Interacting Proteins for LACRT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006473 | protein acetylation | IMP | 23640897 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 11419941 |
| GO:0010669 | epithelial structure maintenance | IDA | 25034600 |
| GO:0016239 | positive regulation of macroautophagy | IDA | 23640897 |
| GO:0019722 | calcium-mediated signaling | IDA | 11419941 |
No data available for Pathways by source and SIGNOR curated interactions for LACRT Gene
Transcripts for LACRT Gene
mRNA/cDNA for LACRT Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LACRT
-
Santa Cruz Biotechnology (SCBT) CRISPR for LACRT
- GenScript: Design CRISPR guide RNA sequences for LACRT
miRNA Products
- Search ViGene Biosciences for LACRT
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for LACRT
- Browse OriGene Inhibitory RNA Products For LACRT
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
Clone Products
-
OriGene ORF clones in human for LACRT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for LACRT
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | - | - |
Expression for LACRT Gene
mRNA differential expression in normal tissues according to GTEx for LACRT Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x30.8), Skin - Not Sun Exposed (Suprapubic) (x12.0), and Minor Salivary Gland (x5.6).
This gene is overexpressed in Platelet (38.0) and Heart (26.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LACRT Gene
NURSA nuclear receptor signaling pathways regulating expression of LACRT Gene:
LACRTSOURCE GeneReport for Unigene cluster for LACRT Gene:
Hs.307096mRNA Expression by UniProt/SwissProt for LACRT Gene:
Q9GZZ8-LACRT_HUMAN
Tissue specificity:
Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.
Evidence on tissue expression from TISSUES for LACRT Gene
- Eye(4.9)
- Saliva(4.2)
- Thyroid gland(4)
Primer Products
-
OriGene qPCR primer pairs for LACRT
-
OriGene qPCR primer pairs and template standards for LACRT
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACRT Gene
Orthologs for LACRT Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LACRT 34 35 |
|
- Species where no ortholog for LACRT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for LACRT Gene
No data available for Paralogs for LACRT Gene
Variants for LACRT Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000594022 | -- | 54,633,766(+) | TTTAC(A/G)AAATT | intron-variant | |
| rs1000951181 | -- | 54,632,674(+) | ACCAA(A/G)GGGGC | intron-variant | |
| rs1001132320 | -- | 54,633,987(+) | AAAGG(A/T)CAAGA | intron-variant | |
| rs1001278679 | -- | 54,636,514(+) | AATTA(C/T)GCTAT | upstream-variant-2KB | |
| rs1001429595 | -- | 54,630,774(+) | TTCCT(C/T)CAGGG | downstream-variant-500B |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.17;
3.73% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for LACRT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LACRT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACRT Gene
Disorders for LACRT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dry eye syndrome |
|
|
| lacrimal apparatus disease |
|
|
Search LACRT in MalaCards
View complete list of genes associated with diseases
Relevant External Links for LACRT
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- LACRT
No data available for UniProtKB/Swiss-Prot and Genatlas for LACRT Gene
Publications for LACRT Gene
- cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PMID: 11419941) Sanghi S. … Laurie G.W. (J. Mol. Biol. 2001) 2 3 4 22 64
- Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PMID: 19714880) Lei Z. … Serra H.M. (J. Proteome Res. 2009) 3 22 64
- Lacritin and other new proteins of the lacrimal functional unit. (PMID: 18840430) McKown R.L. … Laurie G.W. (Exp. Eye Res. 2009) 3 22 64
- Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PMID: 19770725) Nichols J.J. … Green-Church K.B. (Cornea 2009) 3 22 64
- Mass spectrometry-based proteomic analyses of contact lens deposition. (PMID: 18334948) Green-Church K.B. … Nichols J.J. (Mol. Vis. 2008) 3 22 64
Products for LACRT Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse ELISAs
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- OriGene Purified Proteins for LACRT
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- OriGene qPCR primer pairs and template standards for LACRT
- OriGene qPCR primer pairs for LACRT
- OriGene CRISPR knockouts for LACRT
- OriGene ORF clones in human for LACRT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals lysates for LACRT
- Novus Biologicals
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- VectorBuilder custom plasmid, inducible vectors for LACRT
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for LACRT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
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- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
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- (82) GeneGo (Thomson Reuters)
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- (100) COMPARTMENTS
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- (155) Gene ORGANizer