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Aliases for LACRT Gene

Aliases for LACRT Gene

  • Lacritin 2 3

External Ids for LACRT Gene

Previous GeneCards Identifiers for LACRT Gene

  • GC12P049944
  • GC12M055138
  • GC12M054741
  • GC12M053310
  • GC12M055024
  • GC12M052063

Summaries for LACRT Gene

Entrez Gene Summary for LACRT Gene

  • The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for LACRT Gene

LACRT (Lacritin) is a Protein Coding gene. Diseases associated with LACRT include blepharitis. GO annotations related to this gene include growth factor activity and collagen binding.

UniProtKB/Swiss-Prot for LACRT Gene

  • Modulates secretion by lacrimal acinar cells

Gene Wiki entry for LACRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACRT Gene

Genomics for LACRT Gene

Regulatory Elements for LACRT Gene

Genomic Location for LACRT Gene

Start:
54,630,811 bp from pter
End:
54,634,895 bp from pter
Size:
4,085 bases
Orientation:
Minus strand

Genomic View for LACRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LACRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACRT Gene

Proteins for LACRT Gene

  • Protein details for LACRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ8-LACRT_HUMAN
    Recommended name:
    Extracellular glycoprotein lacritin
    Protein Accession:
    Q9GZZ8
    Secondary Accessions:

    Protein attributes for LACRT Gene

    Size:
    138 amino acids
    Molecular mass:
    14246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LACRT Gene

Proteomics data for LACRT Gene at MOPED

Post-translational modifications for LACRT Gene

  • Glycosylation at Thr75, Ser76, Ser77, and Asn119
  • Modification sites at PhosphoSitePlus

Other Protein References for LACRT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LACRT Gene

Domains for LACRT Gene

Protein Domains for LACRT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LACRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LACRT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LACRT Gene

Function for LACRT Gene

Molecular function for LACRT Gene

UniProtKB/Swiss-Prot Function: Modulates secretion by lacrimal acinar cells

Gene Ontology (GO) - Molecular Function for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IDA 11419941
GO:0001968 fibronectin binding IDA 11419941
GO:0005518 collagen binding IDA 11419941
GO:0008083 growth factor activity IDA 16982797
GO:0043237 laminin-1 binding IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view

Animal Model Products

CRISPR Products

miRNA for LACRT Gene

miRTarBase miRNAs that target LACRT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LACRT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LACRT Gene

Localization for LACRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACRT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LACRT Gene COMPARTMENTS Subcellular localization image for LACRT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 17850790
GO:0005615 extracellular space IDA 22664934
GO:0030141 secretory granule IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view

Pathways for LACRT Gene

SuperPathways for LACRT Gene

No Data Available

Gene Ontology (GO) - Biological Process for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 11419941
GO:0019722 calcium-mediated signaling IDA 11419941
GO:0033173 calcineurin-NFAT signaling cascade IDA 16923831
GO:0034067 protein localization to Golgi apparatus IDA 16923831
GO:0050679 positive regulation of epithelial cell proliferation IDA 16923831
genes like me logo Genes that share ontologies with LACRT: view

No data available for Pathways by source for LACRT Gene

Compounds for LACRT Gene

(1) Novoseek inferred chemical compound relationships for LACRT Gene

Compound -log(P) Hits PubMed IDs
tyrosine 6.03 2
genes like me logo Genes that share compounds with LACRT: view

Transcripts for LACRT Gene

mRNA/cDNA for LACRT Gene

Unigene Clusters for LACRT Gene

Lacritin:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LACRT

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LACRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for LACRT Gene

GeneLoc Exon Structure for
LACRT
ECgene alternative splicing isoforms for
LACRT

Expression for LACRT Gene

mRNA expression in normal human tissues for LACRT Gene

mRNA differential expression in normal tissues according to GTEx for LACRT Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (30.8), Skin - Not Sun Exposed (Suprapubic) (12.0), and Minor Salivary Gland (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LACRT Gene

SOURCE GeneReport for Unigene cluster for LACRT Gene Hs.307096

mRNA Expression by UniProt/SwissProt for LACRT Gene

Q9GZZ8-LACRT_HUMAN
Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands
genes like me logo Genes that share expressions with LACRT: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LACRT Gene

Orthologs for LACRT Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LACRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACRT 35
  • 99.27 (n)
  • 99.27 (a)
LACRT 36
  • 99 (a)
OneToOne
Species with no ortholog for LACRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LACRT Gene

ENSEMBL:
Gene Tree for LACRT (if available)
TreeFam:
Gene Tree for LACRT (if available)

Paralogs for LACRT Gene

No data available for Paralogs for LACRT Gene

Variants for LACRT Gene

Sequence variations from dbSNP and Humsavar for LACRT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1495930 -- 54,635,822(-) AACTC(C/T)TAGAC upstream-variant-2KB
rs2706226 -- 54,632,759(+) TGATG(G/T)GGGTG intron-variant
rs3809160 -- 54,635,559(-) GGGTC(C/T)CATTG upstream-variant-2KB
rs4505153 -- 54,636,004(-) GACTC(C/T)TGCTC upstream-variant-2KB
rs4505154 -- 54,635,947(-) AAAAC(C/T)TACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LACRT Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV Gain 17160897

Relevant External Links for LACRT Gene

HapMap Linkage Disequilibrium report
LACRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACRT Gene

Disorders for LACRT Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for LACRT Gene including...

Search for LACRT Gene in MalaCards »

(1) University of Copenhagen DISEASES for LACRT Gene

genes like me logo Genes that share disorders with LACRT: view

No data available for UniProtKB/Swiss-Prot for LACRT Gene

Publications for LACRT Gene

  1. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PMID: 11419941) Sanghi S. … Laurie G.W. (J. Mol. Biol. 2001) 2 3 4 23
  2. Expression of a novel lacrimal gland gene lacritin in human breast tissues. (PMID: 14574570) Weigelt B. … van 't Veer L.J. (J. Cancer Res. Clin. Oncol. 2003) 3 23
  3. Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. (PMID: 15952718) Koo B.S. … Kim C.W. (J. Proteome Res. 2005) 3 23
  4. Proteomic analysis of human meibomian gland secretions. (PMID: 16488965) Tsai P.S. … Sullivan D.A. (Br J Ophthalmol 2006) 3 23
  5. Characterisation of human tear proteins using high-resolution mass spectrometry. (PMID: 16865190) Zhou L. … Tan D.T. (Ann. Acad. Med. Singap. 2006) 3 23

Products for LACRT Gene

Sources for LACRT Gene

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