Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LACRT Gene

Aliases for LACRT Gene

  • Lacritin 2 3

External Ids for LACRT Gene

Previous GeneCards Identifiers for LACRT Gene

  • GC12P049944
  • GC12M055138
  • GC12M054741
  • GC12M053310
  • GC12M055024
  • GC12M052063

Summaries for LACRT Gene

Entrez Gene Summary for LACRT Gene

  • The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for LACRT Gene

LACRT (Lacritin) is a Protein Coding gene. Diseases associated with LACRT include dry eye syndrome and lacrimal apparatus disease. GO annotations related to this gene include growth factor activity and collagen binding.

UniProtKB/Swiss-Prot for LACRT Gene

  • Modulates secretion by lacrimal acinar cells

Gene Wiki entry for LACRT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACRT Gene

Genomics for LACRT Gene

Regulatory Elements for LACRT Gene

Genomic Location for LACRT Gene

Chromosome:
12
Start:
54,630,811 bp from pter
End:
54,634,895 bp from pter
Size:
4,085 bases
Orientation:
Minus strand

Genomic View for LACRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LACRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACRT Gene

Proteins for LACRT Gene

  • Protein details for LACRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZZ8-LACRT_HUMAN
    Recommended name:
    Extracellular glycoprotein lacritin
    Protein Accession:
    Q9GZZ8

    Protein attributes for LACRT Gene

    Size:
    138 amino acids
    Molecular mass:
    14246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LACRT Gene

Proteomics data for LACRT Gene at MOPED

Post-translational modifications for LACRT Gene

  • Glycosylation at Ser 76 and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for LACRT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LACRT Gene

Domains & Families for LACRT Gene

Protein Domains for LACRT Gene

ProtoNet:

Suggested Antigen Peptide Sequences for LACRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LACRT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LACRT Gene

Function for LACRT Gene

Molecular function for LACRT Gene

UniProtKB/Swiss-Prot Function:
Modulates secretion by lacrimal acinar cells

Gene Ontology (GO) - Molecular Function for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IDA 11419941
GO:0001968 fibronectin binding IDA 11419941
GO:0005518 collagen binding IDA 11419941
GO:0008083 growth factor activity IDA 16982797
GO:0043237 laminin-1 binding IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view

Phenotypes for LACRT Gene

GenomeRNAi human phenotypes for LACRT:
genes like me logo Genes that share phenotypes with LACRT: view

Animal Model Products

miRNA for LACRT Gene

miRTarBase miRNAs that target LACRT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LACRT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LACRT Gene

Localization for LACRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACRT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LACRT Gene COMPARTMENTS Subcellular localization image for LACRT gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 17850790
GO:0005615 extracellular space IDA 22664934
GO:0030141 secretory granule IDA 11419941
genes like me logo Genes that share ontologies with LACRT: view

Pathways & Interactions for LACRT Gene

SuperPathways for LACRT Gene

No Data Available

Gene Ontology (GO) - Biological Process for LACRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 11419941
GO:0019722 calcium-mediated signaling IDA 11419941
GO:0033173 calcineurin-NFAT signaling cascade IDA 16923831
GO:0034067 protein localization to Golgi apparatus IDA 16923831
GO:0050679 positive regulation of epithelial cell proliferation IDA 16923831
genes like me logo Genes that share ontologies with LACRT: view

No data available for Pathways by source and SIGNOR curated interactions for LACRT Gene

Drugs & Compounds for LACRT Gene

(1) Drugs for LACRT Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547
genes like me logo Genes that share compounds with LACRT: view

Transcripts for LACRT Gene

mRNA/cDNA for LACRT Gene

Unigene Clusters for LACRT Gene

Lacritin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LACRT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LACRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1: - -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for LACRT Gene

GeneLoc Exon Structure for
LACRT
ECgene alternative splicing isoforms for
LACRT

Expression for LACRT Gene

mRNA expression in normal human tissues for LACRT Gene

mRNA differential expression in normal tissues according to GTEx for LACRT Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x30.8), Skin - Not Sun Exposed (Suprapubic) (x12.0), and Minor Salivary Gland (x5.6).

Protein differential expression in normal tissues from HIPED for LACRT Gene

This gene is overexpressed in Platelet (38.0) and Heart (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LACRT Gene



SOURCE GeneReport for Unigene cluster for LACRT Gene Hs.307096

mRNA Expression by UniProt/SwissProt for LACRT Gene

Q9GZZ8-LACRT_HUMAN
Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands
genes like me logo Genes that share expression patterns with LACRT: view

Protein tissue co-expression partners for LACRT Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for LACRT Gene

Orthologs for LACRT Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for LACRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LACRT 35
  • 99.27 (n)
  • 99.27 (a)
LACRT 36
  • 99 (a)
OneToOne
Species with no ortholog for LACRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LACRT Gene

ENSEMBL:
Gene Tree for LACRT (if available)
TreeFam:
Gene Tree for LACRT (if available)

Paralogs for LACRT Gene

No data available for Paralogs for LACRT Gene

Variants for LACRT Gene

Sequence variations from dbSNP and Humsavar for LACRT Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2706226 -- 54,632,759(+) TGATG(G/T)GGGTG intron-variant
rs3809160 -- 54,635,559(-) GGGTC(C/T)CATTG upstream-variant-2KB
rs7138121 -- 54,634,262(+) CAAGA(G/T)AATCG intron-variant
rs10561513 -- 54,634,371(+) AAAAA(-/A)GGCAT intron-variant
rs11832807 -- 54,635,024(+) AAGGG(A/C)TAGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LACRT Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV Gain 17160897

Variation tolerance for LACRT Gene

Residual Variation Intolerance Score: 44.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LACRT Gene

HapMap Linkage Disequilibrium report
LACRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACRT Gene

Disorders for LACRT Gene

MalaCards: The human disease database

(2) MalaCards diseases for LACRT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dry eye syndrome
  • tear film insufficiency
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association
Search LACRT in MalaCards View complete list of genes associated with diseases

Relevant External Links for LACRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LACRT
genes like me logo Genes that share disorders with LACRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LACRT Gene

Publications for LACRT Gene

  1. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PMID: 11419941) Sanghi S. … Laurie G.W. (J. Mol. Biol. 2001) 2 23 67
  2. Lacritin and other new proteins of the lacrimal functional unit. (PMID: 18840430) McKown R.L. … Laurie G.W. (Exp. Eye Res. 2009) 23 67
  3. Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PMID: 19714880) Lei Z. … Serra H.M. (J. Proteome Res. 2009) 23 67
  4. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PMID: 19770725) Nichols J.J. … Green-Church K.B. (Cornea 2009) 23 67
  5. Mass spectrometry-based proteomic analyses of contact lens deposition. (PMID: 18334948) Green-Church K.B. … Nichols J.J. (Mol. Vis. 2008) 23 67

Products for LACRT Gene

Sources for LACRT Gene

Back to Top

Content