Aliases for LACRT Gene
External Ids for LACRT Gene
- HGNC: 16430
- Entrez Gene: 90070
- Ensembl: ENSG00000135413
- OMIM: 607360
- UniProtKB: Q9GZZ8
Previous GeneCards Identifiers for LACRT Gene
- GC12P049944
- GC12M055138
- GC12M054741
- GC12M053310
- GC12M055024
- GC12M052063
Summaries for LACRT Gene
-
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signaling through tyrosine phosphorylation and release of calcium. [provided by RefSeq, Jul 2008]
GeneCards Summary for LACRT Gene
LACRT (Lacritin) is a Protein Coding gene. Diseases associated with LACRT include Blepharitis and Dry Eye Syndrome. Gene Ontology (GO) annotations related to this gene include growth factor activity and collagen binding.
UniProtKB/Swiss-Prot for LACRT Gene
-
Modulates secretion by lacrimal acinar cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACRT Gene
Genomics for LACRT Gene
GeneHancer (GH) Regulatory Elements for LACRT Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12I054634 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -20 | 0.1 | LACRT DCD |
Regulatory Element Products
Genomic Locations for LACRT Gene
- chr12:54,630,811-54,634,895
- (GRCh38/hg38)
- Size:
- 4,085 bases
- Orientation:
- Minus strand
- chr12:55,024,595-55,028,679
- (GRCh37/hg19)
Genomic View for LACRT Gene
- Cytogenetic band:
-
- 12q13.2 by Ensembl
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC


RefSeq DNA sequence for LACRT Gene
Proteins for LACRT Gene
-
Protein details for LACRT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZZ8-LACRT_HUMAN
- Recommended name:
- Extracellular glycoprotein lacritin
- Protein Accession:
- Q9GZZ8
Protein attributes for LACRT Gene
- Size:
- 138 amino acids
- Molecular mass:
- 14246 Da
- Quaternary structure:
- No Data Available
Protein Expression for LACRT Gene
Post-translational modifications for LACRT Gene
- Glycosylation at posLast=7676 and posLast=119119
Other Protein References for LACRT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
-
OriGene Purified Proteins for LACRT
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-
Cloud-Clone Corp. Proteins for LACRT
- Search GeneTex for Proteins for LACRT
-
ProSci Proteins for LACRT
Assay Products
-
Cloud-Clone Corp. Assay Kits for LACRT
No data available for DME Specific Peptides for LACRT Gene
Domains & Families for LACRT Gene
Gene Families for LACRT Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for LACRT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for LACRT Gene
Function for LACRT Gene
Molecular function for LACRT Gene
- UniProtKB/Swiss-Prot Function:
- Modulates secretion by lacrimal acinar cells.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001968 | fibronectin binding | IDA | 11419941 |
GO:0005515 | protein binding | IDA | -- |
GO:0005518 | collagen binding | IDA | 11419941 |
GO:0008083 | growth factor activity | IDA | 16982797 |
GO:0043237 | laminin-1 binding | IDA | 11419941 |
Phenotypes for LACRT Gene
- GenomeRNAi human phenotypes for LACRT:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for LACRT
-
-
ViGene Biosciences lentiviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
- Search ViGene Biosciences for LACRT
CRISPR Products
-
OriGene CRISPR knockouts for LACRT
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LACRT
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miRNA for LACRT Gene
- miRTarBase miRNAs that target LACRT
miRNA Products
- Search ViGene Biosciences for LACRT
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
Clone Products
- Sino Biological Human cDNA Clone for LACRT
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LACRT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LACRT
- genomics-online: cdna clones - Search results for available LACRT gene related products
- orf clones - Search results for available LACRT gene related products
- Applied Biological Materials Clones for LACRT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for LACRT
-
ViGene Biosciences adenoviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for LACRT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACRT Gene
Localization for LACRT Gene
Subcellular locations from UniProtKB/Swiss-Prot for LACRT Gene
- Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA,IEA | 17850790 |
GO:0005615 | extracellular space | IDA,HDA | 22664934 |
GO:0030141 | secretory granule | IDA | 11419941 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for LACRT Gene
Pathways & Interactions for LACRT Gene
Interacting Proteins for LACRT Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006473 | protein acetylation | IMP | 23640897 |
GO:0008284 | positive regulation of cell proliferation | IDA | 11419941 |
GO:0010469 | regulation of receptor activity | IEA | -- |
GO:0010669 | epithelial structure maintenance | IDA | 25034600 |
GO:0016239 | positive regulation of macroautophagy | IDA | 23640897 |
No data available for Pathways by source and SIGNOR curated interactions for LACRT Gene
Transcripts for LACRT Gene
mRNA/cDNA for LACRT Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for LACRT
- genomics-online: gRNA clones - Search results for available LACRT gene related products
- Applied Biological Materials CRISPR for LACRT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for LACRT
- GenScript: Design CRISPR guide RNA sequences for LACRT
miRNA Products
- Search ViGene Biosciences for LACRT
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for LACRT
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- genomics-online: shRNA clones - Search results for available LACRT gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for LACRT gene
Clone Products
- Sino Biological Human cDNA Clone for LACRT
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for LACRT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LACRT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LACRT
- genomics-online: cdna clones - Search results for available LACRT gene related products
- orf clones - Search results for available LACRT gene related products
- Applied Biological Materials Clones for LACRT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | - | - | ||||||||||||||||
SP3: | |||||||||||||||||||
SP4: | - | - |
Expression for LACRT Gene
mRNA differential expression in normal tissues according to GTEx for LACRT Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LACRT Gene
NURSA nuclear receptor signaling pathways regulating expression of LACRT Gene:
LACRTSOURCE GeneReport for Unigene cluster for LACRT Gene:
Hs.307096mRNA Expression by UniProt/SwissProt for LACRT Gene:
Q9GZZ8-LACRT_HUMANEvidence on tissue expression from TISSUES for LACRT Gene
- Eye(4.9)
- Saliva(4.2)
- Thyroid gland(4)
Primer Products
-
OriGene qPCR primer pairs for LACRT
-
OriGene qPCR primer pairs and template standards for LACRT
- genomics-online: primer clones - Search results for available LACRT gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for LACRT Gene
Orthologs for LACRT Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LACRT 33 34 |
|
- Species where no ortholog for LACRT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for LACRT Gene
No data available for Paralogs for LACRT Gene
Variants for LACRT Gene
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000594022 | -- | 54,633,766(-) | G/A | intron_variant | |
rs1000951181 | -- | 54,632,674(-) | A/G | intron_variant | |
rs1001132320 | -- | 54,633,987(-) | A/T | intron_variant | |
rs1001278679 | -- | 54,636,514(-) | T/C | upstream_transcript_variant | |
rs1001429595 | -- | 54,630,774(-) | C/T | downstream_transcript_variant |
Additional Variant Information for LACRT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- LACRT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACRT Gene
Disorders for LACRT Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
blepharitis |
|
|
dry eye syndrome |
|
|
lacrimal apparatus disease |
|
|
Additional Disease Information for LACRT
No data available for UniProtKB/Swiss-Prot and Genatlas for LACRT Gene
Publications for LACRT Gene
- cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PMID: 11419941) Sanghi S … Laurie GW (Journal of molecular biology 2001) 2 3 4 22 58
- Lacritin and other new proteins of the lacrimal functional unit. (PMID: 18840430) McKown RL … Laurie GW (Experimental eye research 2009) 3 22 58
- Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PMID: 19714880) Lei Z … Serra HM (Journal of proteome research 2009) 3 22 58
- Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PMID: 19770725) Nichols JJ … Green-Church KB (Cornea 2009) 3 22 58
- Mass spectrometry-based proteomic analyses of contact lens deposition. (PMID: 18334948) Green-Church KB … Nichols JJ (Molecular vision 2008) 3 22 58
Products for LACRT Gene
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- Browse ELISAs
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- VectorBuilder custom plasmid, inducible vectors for LACRT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for LACRT
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for LACRT
- antibodies-online: Search results for available LACRT related products ranked by validation data
- antibodies-online: Search results for available LACRT related products ranked by validation data
- antibodies-online: Search results for available LACRT related products ranked by validation data
- Search GeneTex for Antibodies for LACRT
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- ViGene Biosciences adenoviral particle packaged cDNA for LACRT gene
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- Search ViGene Biosciences for LACRT
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- ProSci Proteins for LACRT
- Horizon Cell Lines for LACRT
- genomics-online: cdna clones - Search results for available LACRT gene related products
- orf clones - Search results for available LACRT gene related products
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- genomics-online: primer clones - Search results for available LACRT gene related products
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Sources for LACRT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew