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Aliases for CCNG1 Gene

Aliases for CCNG1 Gene

  • Cyclin G1 2 3
  • Cyclin-G 3 4
  • CCNG 3 4
  • Cyclin-G1 3
  • CYCG1 4

External Ids for CCNG1 Gene

Previous HGNC Symbols for CCNG1 Gene

  • CCNG

Previous GeneCards Identifiers for CCNG1 Gene

  • GC05P163067
  • GC05P162800
  • GC05P162845
  • GC05P162797
  • GC05P162864
  • GC05P157964

Summaries for CCNG1 Gene

Entrez Gene Summary for CCNG1 Gene

  • The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNG1 Gene

CCNG1 (Cyclin G1) is a Protein Coding gene. Diseases associated with CCNG1 include mantle cell lymphoma and pancreatic cancer. Among its related pathways are GPCR Pathway and GPCR Pathway. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is CCNI.

UniProtKB/Swiss-Prot for CCNG1 Gene

  • May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).

Gene Wiki entry for CCNG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNG1 Gene

Genomics for CCNG1 Gene

Regulatory Elements for CCNG1 Gene

Genomic Location for CCNG1 Gene

Start:
163,437,569 bp from pter
End:
163,446,151 bp from pter
Size:
8,583 bases
Orientation:
Plus strand

Genomic View for CCNG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNG1 Gene

Proteins for CCNG1 Gene

  • Protein details for CCNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51959-CCNG1_HUMAN
    Recommended name:
    Cyclin-G1
    Protein Accession:
    P51959
    Secondary Accessions:
    • B2R7B2
    • B4DLW7
    • D3DQK7
    • Q15757
    • Q96L32

    Protein attributes for CCNG1 Gene

    Size:
    295 amino acids
    Molecular mass:
    34074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB03903.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA54821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCNG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNG1 Gene

Proteomics data for CCNG1 Gene at MOPED

Post-translational modifications for CCNG1 Gene

  • Ubiquitination at Lys247
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNG1 Gene

No data available for DME Specific Peptides for CCNG1 Gene

Domains for CCNG1 Gene

Protein Domains for CCNG1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNG1 Gene

Graphical View of Domain Structure for InterPro Entry

P51959

UniProtKB/Swiss-Prot:

CCNG1_HUMAN :
  • P51959
Family:
  • Belongs to the cyclin family. Cyclin G subfamily.
genes like me logo Genes that share domains with CCNG1: view

No data available for Gene Families for CCNG1 Gene

Function for CCNG1 Gene

Molecular function for CCNG1 Gene

GENATLAS Biochemistry: cyclin G,modulator of the cell cycle and apoptosis,transcriptional target of p53 tumor suppressor gene
UniProtKB/Swiss-Prot Function: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
UniProtKB/Swiss-Prot Induction: Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage

Gene Ontology (GO) - Molecular Function for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with CCNG1: view
genes like me logo Genes that share phenotypes with CCNG1: view

Animal Models for CCNG1 Gene

MGI Knock Outs for CCNG1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCNG1 Gene

Localization for CCNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNG1 Gene

Nucleus. Note=DNA replication foci after DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNG1 Gene COMPARTMENTS Subcellular localization image for CCNG1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNG1: view

Pathways for CCNG1 Gene

genes like me logo Genes that share pathways with CCNG1: view

Pathways by source for CCNG1 Gene

2 KEGG pathways for CCNG1 Gene

Gene Ontology (GO) - Biological Process for CCNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8626390
GO:0006949 syncytium formation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with CCNG1: view

Compounds for CCNG1 Gene

(16) Novoseek inferred chemical compound relationships for CCNG1 Gene

Compound -log(P) Hits PubMed IDs
mimosine 43.9 1
retinoid 11 1
rapamycin 9.68 1
calcium 2.06 1
glucose 1.49 1
genes like me logo Genes that share compounds with CCNG1: view

Transcripts for CCNG1 Gene

Unigene Clusters for CCNG1 Gene

Cyclin G1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNG1 Gene

No ASD Table

Relevant External Links for CCNG1 Gene

GeneLoc Exon Structure for
CCNG1
ECgene alternative splicing isoforms for
CCNG1

Expression for CCNG1 Gene

mRNA expression in normal human tissues for CCNG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCNG1 Gene

SOURCE GeneReport for Unigene cluster for CCNG1 Gene Hs.79101

mRNA Expression by UniProt/SwissProt for CCNG1 Gene

P51959-CCNG1_HUMAN
Tissue specificity: High levels in skeletal muscle, ovary, kidney and colon
genes like me logo Genes that share expressions with CCNG1: view

No data available for mRNA differential expression in normal tissues for CCNG1 Gene

Orthologs for CCNG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCNG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNG1 35
  • 99.44 (n)
  • 100 (a)
CCNG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNG1 35
  • 93.33 (n)
  • 94.24 (a)
CCNG1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNG1 35
  • 95.14 (n)
  • 97.63 (a)
CCNG1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccng1 35
  • 89.65 (n)
  • 92.83 (a)
Ccng1 16
Ccng1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNG1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNG1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccng1 35
  • 88.77 (n)
  • 94.5 (a)
chicken
(Gallus gallus)
Aves CCNG1 35
  • 76.03 (n)
  • 84.93 (a)
CCNG1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNG1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53060 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccng1 35
  • 72.83 (n)
  • 77.05 (a)
Str.1803 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10949 35
zebrafish
(Danio rerio)
Actinopterygii ccng1 35
  • 64.16 (n)
  • 63.7 (a)
ccng1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycG 35
  • 43.85 (n)
  • 34.84 (a)
CycG 36
  • 16 (a)
OneToMany
Species with no ortholog for CCNG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCNG1 Gene

ENSEMBL:
Gene Tree for CCNG1 (if available)
TreeFam:
Gene Tree for CCNG1 (if available)

Paralogs for CCNG1 Gene

Paralogs for CCNG1 Gene

Selected SIMAP similar genes for CCNG1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CCNG1 Gene

genes like me logo Genes that share paralogs with CCNG1: view

Variants for CCNG1 Gene

Sequence variations from dbSNP and Humsavar for CCNG1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs188485 -- 163,437,385(+) GCTTA(A/G)AGGTA upstream-variant-2KB
rs299321 -- 163,443,242(+) gggag(A/G)cggag intron-variant
rs299322 -- 163,439,542(+) ATTTT(C/T)GTAAT intron-variant
rs299323 -- 163,436,683(+) TTTAC(A/T)AATGG upstream-variant-2KB
rs299324 -- 163,436,003(+) ttgta(C/T)tttca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCNG1 Gene

Variant ID Type Subtype PubMed ID
nsv830538 CNV Gain+Loss 17160897

Relevant External Links for CCNG1 Gene

HapMap Linkage Disequilibrium report
CCNG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNG1 Gene

Disorders for CCNG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCNG1 Gene including...

Search for CCNG1 Gene in MalaCards »

(34) Novoseek inferred disease relationships for CCNG1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 79.5 20
lymphoma mantle-cell 48.6 1
tumors 41.3 33
cancer 37 15
osteosarcoma 30.9 6

Relevant External Links for CCNG1

Genetic Association Database (GAD)
CCNG1
Human Genome Epidemiology (HuGE) Navigator
CCNG1
genes like me logo Genes that share disorders with CCNG1: view

No data available for UniProtKB/Swiss-Prot for CCNG1 Gene

Publications for CCNG1 Gene

  1. Characterisation of human cyclin G1 and G2: DNA damage inducible genes. (PMID: 8806701) Bates S.A. … Vousden K.H. (Oncogene 1996) 2 3 4 23
  2. Structure and chromosomal assignment of the human cyclin G gene. (PMID: 8954786) Endo Y. … Nojima H. (Genomics 1996) 2 3 4 23
  3. Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression. (PMID: 8626390) Horne M.C. … Wahl A.F. (J. Biol. Chem. 1996) 3 4 23
  4. Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells. (PMID: 10196184) Reimer C.L. … Lee S.W. (J. Biol. Chem. 1999) 3 4 23
  5. Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. (PMID: 12634633) Baek W.K. … Cho C.H. (Am. J. Obstet. Gynecol. 2003) 3 23

Products for CCNG1 Gene

Sources for CCNG1 Gene

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