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Aliases for NAT1 Gene

Aliases for NAT1 Gene

  • N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) 2 3
  • AAC1 3 4 6
  • Monomorphic Arylamine N-Acetyltransferase 3 4
  • N-Acetyltransferase Type 1 3 4
  • Arylamide Acetylase 1 3 4
  • EC 2.3.1.5 4 64
  • NAT-1 3 4
  • MNAT 3 4
  • Arylamine N-Acetyltransferase 1 3
  • NATI 3

External Ids for NAT1 Gene

Previous Symbols for NAT1 Gene

  • AAC1

Summaries for NAT1 Gene

Entrez Gene Summary for NAT1 Gene

  • This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for NAT1 Gene

NAT1 (N-Acetyltransferase 1 (Arylamine N-Acetyltransferase)) is a Protein Coding gene. Diseases associated with NAT1 include multiple chemical sensitivity and orthostatic intolerance. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include arylamine N-acetyltransferase activity. An important paralog of this gene is NAT2.

UniProtKB/Swiss-Prot for NAT1 Gene

  • Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens

Gene Wiki entry for NAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT1 Gene

Genomics for NAT1 Gene

Genomic Location for NAT1 Gene

Start:
18,170,462 bp from pter
End:
18,223,689 bp from pter
Size:
53,228 bases
Orientation:
Plus strand

Genomic View for NAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT1 Gene

Regulatory Elements for NAT1 Gene

Proteins for NAT1 Gene

  • Protein details for NAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18440-ARY1_HUMAN
    Recommended name:
    Arylamine N-acetyltransferase 1
    Protein Accession:
    P18440
    Secondary Accessions:
    • A8K4E7
    • O15159
    • O15300
    • Q546N1
    • Q96TE9

    Protein attributes for NAT1 Gene

    Size:
    290 amino acids
    Molecular mass:
    33899 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme

    Three dimensional structures from OCA and Proteopedia for NAT1 Gene

neXtProt entry for NAT1 Gene

Proteomics data for NAT1 Gene at MOPED

Post-translational modifications for NAT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18

Domains for NAT1 Gene

Protein Domains for NAT1 Gene

UniProtKB/Swiss-Prot:

ARY1_HUMAN
Family:
  • Belongs to the arylamine N-acetyltransferase family.:
    • P18440
genes like me logo Genes that share domains with NAT1: view

No data available for Gene Families for NAT1 Gene

Function for NAT1 Gene

Molecular function for NAT1 Gene

GENATLAS Biochemistry: arylamine N-acetyltransferase 1,widely expressed,monomorphic,also involved in bladder carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
UniProtKB/Swiss-Prot Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens

Enzyme Numbers (IUBMB) for NAT1 Gene

Gene Ontology (GO) - Molecular Function for NAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004060 arylamine N-acetyltransferase activity IEA --
GO:0016407 acetyltransferase activity --
genes like me logo Genes that share ontologies with NAT1: view
genes like me logo Genes that share phenotypes with NAT1: view

Animal Models for NAT1 Gene

MGI Knock Outs for NAT1:

miRNA for NAT1 Gene

miRTarBase miRNAs that target NAT1

No data available for Transcription Factor Targeting and HOMER Transcription for NAT1 Gene

Localization for NAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT1 Gene COMPARTMENTS Subcellular localization image for NAT1 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NAT1: view

Pathways for NAT1 Gene

genes like me logo Genes that share pathways with NAT1: view

Pathways by source for NAT1 Gene

Gene Ontology (GO) - Biological Process for NAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NAT1: view

Compounds for NAT1 Gene

(6) HMDB Compounds for NAT1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Aminosalicylic acid
  • 3-Amino Salicylate
570-23-0
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Aniline
  • Aminobenzene
62-53-3
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
N-Acetylarylamine
  • N-Acetylarylamine
55576-55-1

(1) Drugbank Compounds for NAT1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sulfamethoxazole
723-46-6 enzyme substrate

(51) Novoseek inferred chemical compound relationships for NAT1 Gene

Compound -log(P) Hits PubMed IDs
arylamine 97.6 120
2-aminofluorene 89.7 9
paba 88.8 25
para aminosalicylic acid 80.6 12
n-hydroxy-2-aminofluorene 80.5 4
genes like me logo Genes that share compounds with NAT1: view

Transcripts for NAT1 Gene

Unigene Clusters for NAT1 Gene

N-acetyltransferase 1 (arylamine N-acetyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - -
SP8: - - - - - - -
SP9: - - - - -

Relevant External Links for NAT1 Gene

GeneLoc Exon Structure for
NAT1
ECgene alternative splicing isoforms for
NAT1

Expression for NAT1 Gene

mRNA expression in normal human tissues for NAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAT1 Gene

This gene is overexpressed in Colon - Transverse (5.2) and Liver (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAT1 Gene

SOURCE GeneReport for Unigene cluster for NAT1 Gene Hs.591847

genes like me logo Genes that share expressions with NAT1: view

Orthologs for NAT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT1 36
  • 97.43 (n)
  • 96.64 (a)
NAT1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAT1 36
  • 84.48 (n)
  • 82.76 (a)
NAT1 37
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nat1 37
  • 75 (a)
ManyToMany
Nat2 36
  • 83.22 (n)
  • 82.07 (a)
Nat2 16
Nat2 37
  • 82 (a)
ManyToMany
Nat3 37
  • 68 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nat2 36
  • 83.91 (n)
  • 81.38 (a)
chicken
(Gallus gallus)
Aves NAT 37
  • 46 (a)
ManyToMany
PNAT10 36
  • 64.02 (n)
  • 57.93 (a)
PNAT10 37
  • 58 (a)
ManyToMany
PNAT3 37
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC794381 36
  • 52.28 (n)
  • 43.15 (a)
si:dkey-78a14.4 37
  • 44 (a)
ManyToMany
si:dkey-78a14.5 37
  • 42 (a)
ManyToMany
si:rp71-1f1.4 37
  • 32 (a)
ManyToMany
si:rp71-1f1.5 37
  • 34 (a)
ManyToMany
si:rp71-1f1.6 37
  • 33 (a)
ManyToMany
zgc:101040 37
  • 40 (a)
ManyToMany
zgc:103601 37
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 20 (a)
ManyToMany
CSA.3273 37
  • 21 (a)
ManyToMany
Species with no ortholog for NAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT1 Gene

ENSEMBL:
Gene Tree for NAT1 (if available)
TreeFam:
Gene Tree for NAT1 (if available)

Paralogs for NAT1 Gene

Paralogs for NAT1 Gene

Selected SIMAP similar genes for NAT1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for NAT1 Gene

genes like me logo Genes that share paralogs with NAT1: view

Variants for NAT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NAT1 Gene

P18440-ARY1_HUMAN
N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder

Sequence variations from dbSNP and Humsavar for NAT1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15561 -- 18,223,142(+) AATGT(A/C)TTTTA utr-variant-3-prime
rs971644 -- 18,173,315(+) TCATA(C/G)TATCT intron-variant
rs971645 -- 18,173,366(+) CTCTT(G/T)TTTTC intron-variant
rs971646 -- 18,173,386(+) GAATG(A/C)ATGTT intron-variant
rs971652 -- 18,177,550(+) ATTAC(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAT1 Gene

Variant ID Type Subtype PubMed ID
nsv522647 CNV Loss 19592680
nsv890597 CNV Gain 21882294
esv2666024 CNV Deletion 23128226
nsv890598 CNV Loss 21882294
nsv890599 CNV Gain 21882294
nsv831251 CNV Loss 17160897
nsv428196 CNV Gain 18775914

Relevant External Links for NAT1 Gene

HapMap Linkage Disequilibrium report
NAT1
Human Gene Mutation Database (HGMD)
NAT1
Locus Specific Mutation Databases (LSDB)
NAT1

Disorders for NAT1 Gene

(1) University of Copenhagen DISEASES for NAT1 Gene

(36) Novoseek inferred disease relationships for NAT1 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 70.9 30
colorectal cancer 54 29
genetic susceptibility 51 3
cancer 50.9 60
breast cancer 27.7 37

Relevant External Links for NAT1

Genetic Association Database (GAD)
NAT1
Human Genome Epidemiology (HuGE) Navigator
NAT1
genes like me logo Genes that share disorders with NAT1: view

No data available for UniProtKB/Swiss-Prot for NAT1 Gene

Publications for NAT1 Gene

  1. Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. (PMID: 8442668) Vatsis K.P. … Weber W.W. (Arch. Biochem. Biophys. 1993) 3 4 23
  2. Identification of a novel allele at the human NAT1 acetyltransferase locus. (PMID: 9168895) Doll M.A. … Hein D.W. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis. (PMID: 9173883) Delomenie C. … Dupret J.-M. (Biochem. J. 1997) 3 4 23
  4. Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe. (PMID: 9511182) Hughes N.C. … Grant D.M. (Pharmacogenetics 1998) 3 4 23
  5. Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations. (PMID: 9511183) Butcher N.J. … Minchin R.F. (Pharmacogenetics 1998) 3 4 23

Products for NAT1 Gene

  • Addgene plasmids for NAT1

Sources for NAT1 Gene

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