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Aliases for CDKL2 Gene

Aliases for CDKL2 Gene

  • Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) 2 3
  • Serine/Threonine-Protein Kinase KKIAMRE 3 4
  • Protein Kinase P56 KKIAMRE 3 4
  • EC 4 63
  • KKIAMRE 3 6
  • P56 3 6
  • Serine/Threonine Protein Kinase KKIAMRE 3
  • Cyclin-Dependent Kinase-Like 2 3
  • P56 KKIAMRE Protein Kinase 3
  • CDC2-Related Kinase 3
  • EC 2.7.11 63

External Ids for CDKL2 Gene

Previous GeneCards Identifiers for CDKL2 Gene

  • GC04M076400
  • GC04M076694
  • GC04M076896
  • GC04M076962
  • GC04M076861
  • GC04M076501
  • GC04M072248

Summaries for CDKL2 Gene

Entrez Gene Summary for CDKL2 Gene

  • This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDKL2 Gene

CDKL2 (Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase)) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL3.

Gene Wiki entry for CDKL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDKL2 Gene

Genomics for CDKL2 Gene

Regulatory Elements for CDKL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDKL2 Gene

75,576,494 bp from pter
75,630,716 bp from pter
54,223 bases
Minus strand

Genomic View for CDKL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDKL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDKL2 Gene

Proteins for CDKL2 Gene

  • Protein details for CDKL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase-like 2
    Protein Accession:
    Secondary Accessions:
    • B2R695

    Protein attributes for CDKL2 Gene

    493 amino acids
    Molecular mass:
    56019 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDKL2 Gene

neXtProt entry for CDKL2 Gene

Proteomics data for CDKL2 Gene at MOPED

Post-translational modifications for CDKL2 Gene

  • Glycosylation at Asn310
  • Modification sites at PhosphoSitePlus

Other Protein References for CDKL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for CDKL2 Gene

Suggested Antigen Peptide Sequences for CDKL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The [NKR]KIAxRE motif seems to be a cyclin-binding region
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • The [NKR]KIAxRE motif seems to be a cyclin-binding region
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDKL2: view

Function for CDKL2 Gene

Molecular function for CDKL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for CDKL2 Gene

Gene Ontology (GO) - Molecular Function for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9000130
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDKL2: view

Phenotypes for CDKL2 Gene

genes like me logo Genes that share phenotypes with CDKL2: view

Animal Model Products

miRNA for CDKL2 Gene

miRTarBase miRNAs that target CDKL2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CDKL2 Gene

Localization for CDKL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDKL2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CDKL2 Gene COMPARTMENTS Subcellular localization image for CDKL2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CDKL2: view

Pathways for CDKL2 Gene

SuperPathways for CDKL2 Gene

No Data Available

Interacting Proteins for CDKL2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000412365 Q92772-CDKL2_HUMAN for CDKL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CDKL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 9000130
GO:0007548 sex differentiation TAS 9000130
GO:0051726 regulation of cell cycle IEA --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with CDKL2: view

No data available for Pathways by source for CDKL2 Gene

Drugs for CDKL2 Gene

(2) HMDB Compounds for CDKL2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
genes like me logo Genes that share compounds with CDKL2: view

Transcripts for CDKL2 Gene

Unigene Clusters for CDKL2 Gene

Cyclin-dependent kinase-like 2 (CDC2-related kinase):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDKL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDKL2 Gene

No ASD Table

Relevant External Links for CDKL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDKL2 Gene

mRNA expression in normal human tissues for CDKL2 Gene

mRNA differential expression in normal tissues according to GTEx for CDKL2 Gene

This gene is overexpressed in Testis (4.5) and Brain - Frontal Cortex (BA9) (4.1).

SOURCE GeneReport for Unigene cluster for CDKL2 Gene Hs.591698

mRNA Expression by UniProt/SwissProt for CDKL2 Gene

Tissue specificity: Expressed in testis and kidney, and at lower level in brain and lung.
genes like me logo Genes that share expressions with CDKL2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for CDKL2 Gene

Orthologs for CDKL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDKL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDKL2 35
  • 89.8 (n)
  • 89.24 (a)
CDKL2 36
  • 77 (a)
(Canis familiaris)
Mammalia CDKL2 35
  • 92.32 (n)
  • 90.7 (a)
CDKL2 36
  • 78 (a)
(Mus musculus)
Mammalia Cdkl2 35
  • 87.16 (n)
  • 87.87 (a)
Cdkl2 16
Cdkl2 36
  • 75 (a)
(Pan troglodytes)
Mammalia CDKL2 35
  • 92.57 (n)
  • 91.82 (a)
CDKL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cdkl2 35
  • 85.06 (n)
  • 85.89 (a)
(Monodelphis domestica)
Mammalia CDKL2 36
  • 56 (a)
(Gallus gallus)
Aves CDKL2 35
  • 69.73 (n)
  • 70.24 (a)
CDKL2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia CDKL2 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdkl2 35
  • 66.05 (n)
  • 65.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7236 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea Y42A5A.4 37
  • 52 (a)
Y42A5A.4 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9638 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for CDKL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CDKL2 Gene

Gene Tree for CDKL2 (if available)
Gene Tree for CDKL2 (if available)

Paralogs for CDKL2 Gene

Paralogs for CDKL2 Gene Pseudogenes for CDKL2 Gene

genes like me logo Genes that share paralogs with CDKL2: view

Variants for CDKL2 Gene

Sequence variations from dbSNP and Humsavar for CDKL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs71203830 -- 75,595,203(+) TTTTT(-/T)GAGAC intron-variant
rs71203827 -- 75,580,390(+) CCAAA(-/T)CATGG intron-variant
rs68155345 -- 75,618,522(+) GTGCT(A/G)GGATT intron-variant
rs68087741 -- 75,627,725(+) CTTTT(C/T)TTTTT intron-variant
rs68011212 -- 75,606,230(+) TTTTT(-/C)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDKL2 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879495 CNV Loss 21882294
dgv5637n71 CNV Loss 21882294

Relevant External Links for CDKL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDKL2 Gene

Disorders for CDKL2 Gene

No disorders were found for CDKL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CDKL2 Gene

Publications for CDKL2 Gene

  1. Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE. (PMID: 9000130) Taglienti C.A. … Davis R.J. (Oncogene 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. (PMID: 15499549) Tao J. … Kalscheuer V.M. (Am. J. Hum. Genet. 2004) 3
  4. Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck). (PMID: 16631599) Marracci G.H. … Bourdette D.N. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for CDKL2 Gene

Sources for CDKL2 Gene

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