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Aliases for TRPA1 Gene

Aliases for TRPA1 Gene

  • Transient Receptor Potential Cation Channel Subfamily A Member 1 2 3
  • Transient Receptor Potential Cation Channel, Subfamily A, Member 1 2 3 5
  • Ankyrin-Like With Transmembrane Domains 1 2 3
  • Transformation-Sensitive Protein P120 3 4
  • ANKTM1 3 4
  • Ankyrin-Like With Transmembrane Domains Protein 1 4
  • FEPS 3

External Ids for TRPA1 Gene

Previous HGNC Symbols for TRPA1 Gene

  • ANKTM1

Previous GeneCards Identifiers for TRPA1 Gene

  • GC08M072983
  • GC08M073096
  • GC08M068428
  • GC08M072932

Summaries for TRPA1 Gene

Entrez Gene Summary for TRPA1 Gene

  • The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPA1 Gene

TRPA1 (Transient Receptor Potential Cation Channel Subfamily A Member 1) is a Protein Coding gene. Diseases associated with TRPA1 include episodic pain syndrome, familial and familial episodic pain syndrome with predominantly upper body involvement. Among its related pathways are Development Endothelin-1/EDNRA signaling and Ion channel transport. GO annotations related to this gene include ion channel activity and channel activity. An important paralog of this gene is ANKRD55.

UniProtKB/Swiss-Prot for TRPA1 Gene

  • Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Tocris Summary for TRPA1 Gene

  • The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.

Gene Wiki entry for TRPA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPA1 Gene

Genomics for TRPA1 Gene

Regulatory Elements for TRPA1 Gene

Enhancers for TRPA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPA1 Gene

Chromosome:
8
Start:
72,019,917 bp from pter
End:
72,090,009 bp from pter
Size:
70,093 bases
Orientation:
Minus strand

Genomic View for TRPA1 Gene

Genes around TRPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPA1 Gene

Proteins for TRPA1 Gene

  • Protein details for TRPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75762-TRPA1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily A member 1
    Protein Accession:
    O75762
    Secondary Accessions:
    • A6NIN6

    Protein attributes for TRPA1 Gene

    Size:
    1119 amino acids
    Molecular mass:
    127501 Da
    Quaternary structure:
    • Homotetramer (PubMed:25389312, PubMed:25855297). Interacts with TMEM100 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRPA1 Gene

neXtProt entry for TRPA1 Gene

Proteomics data for TRPA1 Gene at MOPED

Post-translational modifications for TRPA1 Gene

  • TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain.
  • Glycosylation at Asn 747 and Asn 753
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRPA1 Gene

Domains & Families for TRPA1 Gene

Protein Domains for TRPA1 Gene

Suggested Antigen Peptide Sequences for TRPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75762

UniProtKB/Swiss-Prot:

TRPA1_HUMAN :
  • C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro).
  • Belongs to the transient receptor (TC 1.A.4) family.
  • Contains 16 ANK repeats.
Domain:
  • C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro).
  • The ANK repeat domain consists of a convex stem structure formed by five ANK repeats and 11 additional ANK repeats that form a crescent-shaped structure that surrounds the protein core.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family.
Similarity:
  • Contains 16 ANK repeats.
genes like me logo Genes that share domains with TRPA1: view

Function for TRPA1 Gene

Molecular function for TRPA1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by ruthenium red, a potent blocker of TRPV channels.
UniProtKB/Swiss-Prot Function:
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
genes like me logo Genes that share phenotypes with TRPA1: view

Human Phenotype Ontology for TRPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRPA1 Gene

MGI Knock Outs for TRPA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPA1

miRNA for TRPA1 Gene

miRTarBase miRNAs that target TRPA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TRPA1 Gene

Localization for TRPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPA1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRPA1 Gene COMPARTMENTS Subcellular localization image for TRPA1 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TRPA1: view

Pathways & Interactions for TRPA1 Gene

genes like me logo Genes that share pathways with TRPA1: view

Pathways by source for TRPA1 Gene

Gene Ontology (GO) - Biological Process for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
GO:0019233 sensory perception of pain IMP 20547126
GO:0042493 response to drug IEA --
GO:0042542 response to hydrogen peroxide IEA --
GO:0050955 thermoception IEA --
genes like me logo Genes that share ontologies with TRPA1: view

No data available for SIGNOR curated interactions for TRPA1 Gene

Drugs & Compounds for TRPA1 Gene

(50) Drugs for TRPA1 Gene - From: DrugBank, ClinicalTrials, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Partial agonist, Activator, activator, Target, inducer 2080
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist 34
Auranofin Approved Pharma Activation, Activator, inhibitor Thioredoxin reductase inhibitor; induces MPT 9
Nicotine Approved Pharma Antagonist, antagonist 990
Thymol Experimental Pharma Activation, Activator 4

(10) Additional Compounds for TRPA1 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
icilin
Activation, Activator 36945-98-9
1-acetoxychavicol acetate
Activation, Activator
2-pentenal
  • FEMA 3218
Agonist, Activator 764-39-6
chembridge-5861528
Inhibition, Gating inhibitor
cinnamaldehyde
  • (2E)-3-Phenyl-2-propenal
  • (2E)-3-phenylacrylaldehyde
  • (E)-3-Phenyl-2-propenal
  • (E)-3-Phenylpropenal
  • (E)-Cinnamaldehyde
Activation, Activator 104-55-2

(5) Tocris Compounds for TRPA1 Gene

Compound Action Cas Number
ASP 7663 Selective TRPA1 activator 1190217-35-6
HC 030031 Selective TRPA1 blocker 349085-38-7
Icilin Activates a novel cold receptor. Cooling agent 36945-98-9
Optovin Reversible photoactive TRPA1 activator 348575-88-2
Polygodial TRPA1 channel activator; analgesic and antifungal 6754-20-7
genes like me logo Genes that share compounds with TRPA1: view

Transcripts for TRPA1 Gene

mRNA/cDNA for TRPA1 Gene

Unigene Clusters for TRPA1 Gene

Transient receptor potential cation channel, subfamily A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRPA1 Gene

No ASD Table

Relevant External Links for TRPA1 Gene

GeneLoc Exon Structure for
TRPA1
ECgene alternative splicing isoforms for
TRPA1

Expression for TRPA1 Gene

mRNA expression in normal human tissues for TRPA1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPA1 Gene

This gene is overexpressed in Bladder (x15.7), Colon - Transverse (x8.8), Small Intestine - Terminal Ileum (x7.4), and Stomach (x5.3).

Protein differential expression in normal tissues from HIPED for TRPA1 Gene

This gene is overexpressed in Urine (50.9) and Platelet (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPA1 Gene



SOURCE GeneReport for Unigene cluster for TRPA1 Gene Hs.716816

mRNA Expression by UniProt/SwissProt for TRPA1 Gene

O75762-TRPA1_HUMAN
Tissue specificity: Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells.
genes like me logo Genes that share expression patterns with TRPA1: view

Protein tissue co-expression partners for TRPA1 Gene

Primer Products

In Situ Assay Products

Orthologs for TRPA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRPA1 35
  • 84.04 (n)
  • 81.28 (a)
TRPA1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRPA1 35
  • 85.94 (n)
  • 83.3 (a)
TRPA1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trpa1 35
  • 81.06 (n)
  • 80.43 (a)
Trpa1 16
Trpa1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRPA1 35
  • 99.49 (n)
  • 99.64 (a)
TRPA1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trpa1 35
  • 80.28 (n)
  • 80.34 (a)
oppossum
(Monodelphis domestica)
Mammalia TRPA1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPA1 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPA1 35
  • 67.99 (n)
  • 63.06 (a)
TRPA1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRPA1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpa1 35
  • 60.98 (n)
  • 55.23 (a)
zebrafish
(Danio rerio)
Actinopterygii trpa1a 35
  • 55.3 (n)
  • 50.05 (a)
trpa1a 36
  • 48 (a)
OneToMany
trpa1b 36
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004863 35
  • 47.85 (n)
  • 39.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta TrpA1 35
  • 47.01 (n)
  • 38.57 (a)
TrpA1 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpa-1 35
  • 43.78 (n)
  • 30.12 (a)
trpa-1 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
Species with no ortholog for TRPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPA1 Gene

ENSEMBL:
Gene Tree for TRPA1 (if available)
TreeFam:
Gene Tree for TRPA1 (if available)

Paralogs for TRPA1 Gene

Paralogs for TRPA1 Gene

(6) SIMAP similar genes for TRPA1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRPA1 Gene

genes like me logo Genes that share paralogs with TRPA1: view

Variants for TRPA1 Gene

Sequence variations from dbSNP and Humsavar for TRPA1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs13268757 - 72,075,403(+) GCTGC(A/G)CTTCA reference, missense
rs920829 - 72,065,468(-) ATAGC(A/G)AAGCA reference, missense
rs7819749 - 72,063,566(+) CCTTT(A/G/T)TTAAG reference, missense
VAR_020663 -
rs16937976 - 72,071,806(+) CACAT(C/G)TTTTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRPA1 Gene

Variant ID Type Subtype PubMed ID
esv2737154 CNV Deletion 23290073
nsv831353 CNV Loss 17160897
esv1942504 CNV Deletion 18987734
esv2737155 CNV Deletion 23290073
esv6851 CNV Gain 19470904
esv2737156 CNV Deletion 23290073

Variation tolerance for TRPA1 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.53; 91.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPA1 Gene

HapMap Linkage Disequilibrium report
TRPA1
Human Gene Mutation Database (HGMD)
TRPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPA1 Gene

Disorders for TRPA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TRPA1 Gene - From: OMIM, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
episodic pain syndrome, familial
  • familial episodic pain syndrome
familial episodic pain syndrome with predominantly upper body involvement
somatoform disorder
  • physiological malfunction arising from mental factor
dentin sensitivity
  • sensitive dentin
pain disorder
  • paine syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TRPA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRPA1_HUMAN
  • Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. {ECO:0000269 PubMed:20547126}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRPA1

Genetic Association Database (GAD)
TRPA1
Human Genome Epidemiology (HuGE) Navigator
TRPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPA1
genes like me logo Genes that share disorders with TRPA1: view

No data available for Genatlas for TRPA1 Gene

Publications for TRPA1 Gene

  1. Structure of the TRPA1 ion channel suggests regulatory mechanisms. (PMID: 25855297) Paulsen C.E. … Julius D. (Nature 2015) 3 4 67
  2. TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. (PMID: 15931068) Namer B. … MaihAPfner C. (Neuroreport 2005) 23 25 26
  3. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. (PMID: 19507004) Doihara H. … Ito H. (Mol. Cell. Biochem. 2009) 3 23
  4. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. (PMID: 19507192) Louhivuori L.M. … Akerman K.E. (J. Cell. Physiol. 2009) 3 23
  5. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (PMID: 19074743) Bessac B.F. … Jordt S.E. (Physiology (Bethesda) 2008) 3 23

Products for TRPA1 Gene

Sources for TRPA1 Gene

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