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Aliases for FATE1 Gene

Aliases for FATE1 Gene

  • Fetal And Adult Testis Expressed 1 2 3
  • Cancer/Testis Antigen 43 2 3 4
  • Tumor Antigen BJ-HCC-2 3 4
  • CT43 3 4
  • FATE 3 4
  • Fetal And Adult Testis Expressed Transcript Protein 3
  • Fetal And Adult Testis-Expressed Transcript Protein 3
  • BJ-HCC-2 Antigen 3

External Ids for FATE1 Gene

Summaries for FATE1 Gene

Entrez Gene Summary for FATE1 Gene

  • This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]

GeneCards Summary for FATE1 Gene

FATE1 (Fetal And Adult Testis Expressed 1) is a Protein Coding gene.

Gene Wiki entry for FATE1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FATE1 Gene

Genomics for FATE1 Gene

Genomic Location for FATE1 Gene

Start:
151,716,035 bp from pter
End:
151,723,194 bp from pter
Size:
7,160 bases
Orientation:
Plus strand

Genomic View for FATE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FATE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FATE1 Gene

Regulatory Elements for FATE1 Gene

Proteins for FATE1 Gene

  • Protein details for FATE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969F0-FATE1_HUMAN
    Recommended name:
    Fetal and adult testis-expressed transcript protein
    Protein Accession:
    Q969F0
    Secondary Accessions:

    Protein attributes for FATE1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FATE1 Gene

Proteomics data for FATE1 Gene at MOPED

Post-translational modifications for FATE1 Gene

No Post-translational modifications

Other Protein References for FATE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FATE1 Gene

Domains for FATE1 Gene

Protein Domains for FATE1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with FATE1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FATE1 Gene

Function for FATE1 Gene

Gene Ontology (GO) - Molecular Function for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with FATE1: view

Phenotypes for FATE1 Gene

GenomeRNAi human phenotypes for FATE1:
genes like me logo Genes that share phenotypes with FATE1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FATE1 Gene

Localization for FATE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FATE1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FATE1 Gene COMPARTMENTS Subcellular localization image for FATE1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 2
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FATE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FATE1: view

Pathways for FATE1 Gene

SuperPathways for FATE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FATE1 Gene

None

No data available for Pathways by source for FATE1 Gene

Transcripts for FATE1 Gene

mRNA/cDNA for FATE1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FATE1 Gene

Fetal and adult testis expressed 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FATE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for FATE1 Gene

GeneLoc Exon Structure for
FATE1
ECgene alternative splicing isoforms for
FATE1

Expression for FATE1 Gene

mRNA expression in normal human tissues for FATE1 Gene

mRNA differential expression in normal tissues according to GTEx for FATE1 Gene

This gene is overexpressed in Testis (51.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FATE1 Gene

SOURCE GeneReport for Unigene cluster for FATE1 Gene Hs.301960

mRNA Expression by UniProt/SwissProt for FATE1 Gene

Q969F0-FATE1_HUMAN
Tissue specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain
genes like me logo Genes that share expressions with FATE1: view

Orthologs for FATE1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FATE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FATE1 36
  • 99.45 (n)
  • 99.45 (a)
FATE1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FATE1 37
  • 49 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FATE1 36
  • 78.87 (n)
  • 66.67 (a)
FATE1 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fate1 16
Fate1 37
  • 48 (a)
OneToOne
Species with no ortholog for FATE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FATE1 Gene

ENSEMBL:
Gene Tree for FATE1 (if available)
TreeFam:
Gene Tree for FATE1 (if available)

Paralogs for FATE1 Gene

No data available for Paralogs for FATE1 Gene

Variants for FATE1 Gene

Sequence variations from dbSNP and Humsavar for FATE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs13047 -- 151,723,027(+) GCCCC(A/C)CAGTA utr-variant-3-prime
rs873157 -- 151,720,388(+) GTCTT(A/G)TGGGT intron-variant
rs873158 -- 151,720,305(+) GCCTA(A/G)TTCCT intron-variant
rs3810714 -- 151,717,104(-) CATCT(A/G)TTCAA intron-variant
rs3810715 - 151,716,148(-) TCTCC(A/G)CCTTG reference, missense

Relevant External Links for FATE1 Gene

HapMap Linkage Disequilibrium report
FATE1
Locus Specific Mutation Databases (LSDB)
FATE1

No data available for Structural Variations from Database of Genomic Variants (DGV) for FATE1 Gene

Disorders for FATE1 Gene

(1) University of Copenhagen DISEASES for FATE1 Gene

genes like me logo Genes that share disorders with FATE1: view

No data available for UniProtKB/Swiss-Prot for FATE1 Gene

Publications for FATE1 Gene

  1. Human FATE is a novel X-linked gene expressed in fetal and adult testis. (PMID: 11694338) Olesen C. … Tommerup N. (Mol. Cell. Endocrinol. 2001) 2 3 4
  2. Mutational analysis of the human FATE gene in 144 infertile men. (PMID: 12811541) Olesen C. … Tommerup N. (Hum. Genet. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for FATE1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate FATE1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FATE1
    • Block miRNA regulation of FATE1 using miScript Target Protectors

    Sources for FATE1 Gene

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