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Aliases for SLC25A21 Gene

Aliases for SLC25A21 Gene

  • Solute Carrier Family 25 (Mitochondrial Oxoadipate Carrier), Member 21 2 3
  • ODC 3 4 6
  • Solute Carrier Family 25 (Mitochondrial Oxodicarboxylate Carrier), Member 21 2 3
  • Solute Carrier Family 25 Member 21 3 4
  • Mitochondrial 2-Oxodicarboxylate Carrier 3
  • Oxodicarboxylate Carrier 3
  • ODC1 3

External Ids for SLC25A21 Gene

Previous GeneCards Identifiers for SLC25A21 Gene

  • GC14M034529
  • GC14M031006
  • GC14M035139
  • GC14M036218
  • GC14M037148
  • GC14M017261

Summaries for SLC25A21 Gene

Entrez Gene Summary for SLC25A21 Gene

  • SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC25A21 Gene

SLC25A21 (Solute Carrier Family 25 (Mitochondrial Oxoadipate Carrier), Member 21) is a Protein Coding gene. Among its related pathways are Metabolism and Arginine and proline metabolism.

UniProtKB/Swiss-Prot for SLC25A21 Gene

  • Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate

Gene Wiki entry for SLC25A21 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC25A21 Gene

Genomics for SLC25A21 Gene

Regulatory Elements for SLC25A21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC25A21 Gene

36,677,921 bp from pter
37,172,866 bp from pter
494,946 bases
Minus strand

Genomic View for SLC25A21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC25A21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC25A21 Gene

Proteins for SLC25A21 Gene

  • Protein details for SLC25A21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial 2-oxodicarboxylate carrier
    Protein Accession:
    Secondary Accessions:
    • A8K0L0
    • G3V4L5
    • Q3MJ99

    Protein attributes for SLC25A21 Gene

    299 amino acids
    Molecular mass:
    33303 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC25A21 Gene


neXtProt entry for SLC25A21 Gene

Proteomics data for SLC25A21 Gene at MOPED

Post-translational modifications for SLC25A21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC25A21 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC25A21 Gene

Domains for SLC25A21 Gene

Gene Families for SLC25A21 Gene

Protein Domains for SLC25A21 Gene

Suggested Antigen Peptide Sequences for SLC25A21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BQT8
  • Belongs to the mitochondrial carrier (TC 2.A.29) family.
  • Contains 3 Solcar repeats.
genes like me logo Genes that share domains with SLC25A21: view

Function for SLC25A21 Gene

Molecular function for SLC25A21 Gene

UniProtKB/Swiss-Prot Function: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate
genes like me logo Genes that share phenotypes with SLC25A21: view

Animal Model Products

CRISPR Products

miRNA for SLC25A21 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC25A21 Gene

Localization for SLC25A21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC25A21 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC25A21 Gene COMPARTMENTS Subcellular localization image for SLC25A21 gene
Compartment Confidence
mitochondrion 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC25A21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC25A21: view

Pathways for SLC25A21 Gene

genes like me logo Genes that share pathways with SLC25A21: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC25A21 Gene

Gene Ontology (GO) - Biological Process for SLC25A21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC25A21: view

Compounds for SLC25A21 Gene

(1) Novoseek inferred chemical compound relationships for SLC25A21 Gene

Compound -log(P) Hits PubMed IDs
alpha-ketoglutarate 67.9 1
genes like me logo Genes that share compounds with SLC25A21: view

Transcripts for SLC25A21 Gene

mRNA/cDNA for SLC25A21 Gene

Unigene Clusters for SLC25A21 Gene

Solute carrier family 25 (mitochondrial oxoadipate carrier), member 21:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC25A21

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC25A21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC25A21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -

Relevant External Links for SLC25A21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC25A21 Gene

mRNA expression in normal human tissues for SLC25A21 Gene

mRNA differential expression in normal tissues according to GTEx for SLC25A21 Gene

This gene is overexpressed in Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC25A21 Gene

SOURCE GeneReport for Unigene cluster for SLC25A21 Gene Hs.730857

mRNA Expression by UniProt/SwissProt for SLC25A21 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SLC25A21: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC25A21 Gene

Orthologs for SLC25A21 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC25A21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC25A21 35
  • 99.55 (n)
  • 99.33 (a)
SLC25A21 36
  • 99 (a)
(Bos Taurus)
Mammalia SLC25A21 35
  • 89.89 (n)
  • 90.98 (a)
SLC25A21 36
  • 92 (a)
(Canis familiaris)
Mammalia SLC25A21 35
  • 92.42 (n)
  • 91.3 (a)
SLC25A21 36
  • 93 (a)
(Mus musculus)
Mammalia Slc25a21 35
  • 83.67 (n)
  • 81.54 (a)
Slc25a21 16
Slc25a21 36
  • 76 (a)
(Monodelphis domestica)
Mammalia SLC25A21 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SLC25A21 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Slc25a21 35
  • 84.45 (n)
  • 82.55 (a)
(Gallus gallus)
Aves SLC25A21 35
  • 80.05 (n)
  • 84.59 (a)
SLC25A21 36
  • 79 (a)
(Anolis carolinensis)
Reptilia SLC25A21 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc25a21 35
  • 71.79 (n)
  • 78.26 (a)
Str.17900 35
(Danio rerio)
Actinopterygii slc25a21 35
  • 70.02 (n)
  • 76.85 (a)
slc25a21 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002939 35
  • 61.01 (n)
  • 61.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5254 35
  • 59.11 (n)
  • 59.45 (a)
CG5254 36
  • 56 (a)
CG9582 36
  • 41 (a)
CG9582 37
  • 41 (a)
EG:BACR19J1.2 37
  • 57 (a)
(Caenorhabditis elegans)
Secernentea R11.1 35
  • 60.19 (n)
  • 59.36 (a)
R11.1 36
  • 58 (a)
R11.1 37
  • 52 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR109W 35
  • 47.57 (n)
  • 41.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ODC1 36
  • 33 (a)
ODC2 35
  • 50.88 (n)
  • 40.6 (a)
ODC2 36
  • 34 (a)
ODC2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07073g 35
  • 50.44 (n)
  • 40.82 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04837 35
  • 47.48 (n)
  • 37.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC328.09 35
  • 49.75 (n)
  • 41.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7287 35
Species with no ortholog for SLC25A21:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC25A21 Gene

Gene Tree for SLC25A21 (if available)
Gene Tree for SLC25A21 (if available)

Paralogs for SLC25A21 Gene

Selected SIMAP similar genes for SLC25A21 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC25A21: view

No data available for Paralogs for SLC25A21 Gene

Variants for SLC25A21 Gene

Sequence variations from dbSNP and Humsavar for SLC25A21 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1684 -- 36,679,181(-) AAAAA(A/G)AGAAA intron-variant, utr-variant-3-prime
rs17191 -- 36,828,827(+) GACCA(C/T)CACTT intron-variant
rs367127 -- 36,855,275(+) AGCAA(A/T)CAGCC intron-variant
rs382321 -- 36,851,009(-) AAACA(A/G)GCAGA intron-variant
rs396986 -- 36,864,988(+) CTTGT(A/T)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC25A21 Gene

Variant ID Type Subtype PubMed ID
esv2748604 CNV Deletion 23290073
nsv523551 CNV Loss 19592680
esv259653 OTHER Complex 20981092
esv2748605 CNV Deletion 23290073
nsv1244 CNV Insertion 18451855
esv28302 CNV Loss 19812545
nsv526786 CNV Loss 19592680
esv275403 CNV Loss 21479260
esv2748606 CNV Deletion 23290073
nsv507743 CNV Insertion 20534489
nsv511032 CNV Complex 20534489
nsv901635 CNV Gain 21882294
nsv507744 CNV Insertion 20534489
esv2670122 CNV Deletion 23128226
esv2669967 CNV Deletion 23128226

Relevant External Links for SLC25A21 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC25A21 Gene

Disorders for SLC25A21 Gene

Relevant External Links for SLC25A21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC25A21: view

No data available for UniProtKB/Swiss-Prot for SLC25A21 Gene

Publications for SLC25A21 Gene

  1. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location. (PMID: 11083877) Fiermonte G. … Walker J.E. (J. Biol. Chem. 2001) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for SLC25A21 Gene

Sources for SLC25A21 Gene

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