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Aliases for CCNE1 Gene

Aliases for CCNE1 Gene

  • Cyclin E1 2 3 5
  • CCNE 3 4
  • Cyclin Es 2
  • Cyclin Et 2
  • PCCNE1 3

External Ids for CCNE1 Gene

Previous HGNC Symbols for CCNE1 Gene

  • CCNE

Previous GeneCards Identifiers for CCNE1 Gene

  • GC19P030925
  • GC19P030751
  • GC19P034978
  • GC19P034994
  • GC19P030302
  • GC19P026814

Summaries for CCNE1 Gene

Entrez Gene Summary for CCNE1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

GeneCards Summary for CCNE1 Gene

CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Senile Angioma. Among its related pathways are Packaging Of Telomere Ends and p53 Pathway (RnD). GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNE1 Gene

  • Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Wiki entry for CCNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene

Genomics for CCNE1 Gene

Regulatory Elements for CCNE1 Gene

Enhancers for CCNE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCNE1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCNE1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:

Genomic Location for CCNE1 Gene

Chromosome:
19
Start:
29,811,898 bp from pter
End:
29,824,312 bp from pter
Size:
12,415 bases
Orientation:
Plus strand

Genomic View for CCNE1 Gene

Genes around CCNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE1 Gene

Proteins for CCNE1 Gene

  • Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24864-CCNE1_HUMAN
    Recommended name:
    G1/S-specific cyclin-E1
    Protein Accession:
    P24864
    Secondary Accessions:
    • A8K684
    • Q14091
    • Q8NFG1
    • Q92501
    • Q9UD21

    Protein attributes for CCNE1 Gene

    Size:
    410 amino acids
    Molecular mass:
    47077 Da
    Quaternary structure:
    • Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CCNE1 Gene

    Alternative splice isoforms for CCNE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE1 Gene

Proteomics data for CCNE1 Gene at MOPED

Post-translational modifications for CCNE1 Gene

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNE1 Gene

Domains & Families for CCNE1 Gene

Gene Families for CCNE1 Gene

Protein Domains for CCNE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24864

UniProtKB/Swiss-Prot:

CCNE1_HUMAN :
  • Belongs to the cyclin family. Cyclin E subfamily.
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE1: view

Function for CCNE1 Gene

Molecular function for CCNE1 Gene

GENATLAS Biochemistry:
cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Ontology (GO) - Molecular Function for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050681 androgen receptor binding NAS 15572661
genes like me logo Genes that share ontologies with CCNE1: view
genes like me logo Genes that share phenotypes with CCNE1: view

Animal Models for CCNE1 Gene

MGI Knock Outs for CCNE1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene

Localization for CCNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNE1 Gene COMPARTMENTS Subcellular localization image for CCNE1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16109376
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Pathways & Interactions for CCNE1 Gene

genes like me logo Genes that share pathways with CCNE1: view

SIGNOR curated interactions for CCNE1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0001889 liver development IEA --
GO:0006270 DNA replication initiation IEA --
GO:0006468 protein phosphorylation IMP 10500095
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Drugs & Compounds for CCNE1 Gene

(8) Drugs for CCNE1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alisertib Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
BAY1000394 Pharma Inhibition, Biomarker CDK4 Inhibitors, CDK2 Inhibitors 0
SCH727965 Pharma inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0
genes like me logo Genes that share compounds with CCNE1: view

Transcripts for CCNE1 Gene

Unigene Clusters for CCNE1 Gene

Cyclin E1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CCNE1 Gene

GeneLoc Exon Structure for
CCNE1
ECgene alternative splicing isoforms for
CCNE1

Expression for CCNE1 Gene

mRNA expression in normal human tissues for CCNE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for CCNE1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNE1 Gene



SOURCE GeneReport for Unigene cluster for CCNE1 Gene Hs.244723

mRNA Expression by UniProt/SwissProt for CCNE1 Gene

P24864-CCNE1_HUMAN
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
genes like me logo Genes that share expression patterns with CCNE1: view

Protein tissue co-expression partners for CCNE1 Gene

- Elite partner

Primer Products

Orthologs for CCNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNE1 35
  • 88.4 (n)
  • 85.93 (a)
CCNE1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNE1 35
  • 86.6 (n)
  • 86.6 (a)
CCNE1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccne1 35
  • 79.32 (n)
  • 79.65 (a)
Ccne1 16
Ccne1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNE1 35
  • 99.92 (n)
  • 99.76 (a)
CCNE1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccne1 35
  • 79.41 (n)
  • 80.15 (a)
oppossum
(Monodelphis domestica)
Mammalia CCNE1 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNE1 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNE1 35
  • 74.42 (n)
  • 73.75 (a)
CCNE1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNE1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne1 35
  • 66.16 (n)
  • 62.24 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccne1 35
  • 63.68 (n)
  • 62.01 (a)
ccne1 36
  • 58 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3561 35
fruit fly
(Drosophila melanogaster)
Insecta CycE 37
  • 43 (a)
CycE 35
  • 52.43 (n)
  • 49.34 (a)
CycE 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cye-1 37
  • 31 (a)
cye-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 17 (a)
ManyToMany
CLB2 36
  • 17 (a)
ManyToMany
CLB3 36
  • 17 (a)
ManyToMany
CLB4 36
  • 13 (a)
ManyToMany
CLB5 36
  • 16 (a)
ManyToMany
CLB6 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14750 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for CCNE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE1 Gene

ENSEMBL:
Gene Tree for CCNE1 (if available)
TreeFam:
Gene Tree for CCNE1 (if available)

Paralogs for CCNE1 Gene

Paralogs for CCNE1 Gene

(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE1: view

Variants for CCNE1 Gene

Sequence variations from dbSNP and Humsavar for CCNE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7257330 -- 29,810,916(+) GGGTG(A/G)GGGAT upstream-variant-2KB
rs7257694 -- 29,823,759(+) AGCAG(C/T)GGGCC reference, synonymous-codon
rs12980505 -- 29,824,415(+) TCAAG(C/G/T)CTTTC downstream-variant-500B
rs67237737 -- 29,811,332(+) CCGGC(C/T)CCCAG upstream-variant-2KB
rs67602822 -- 29,822,617(+) TGCTC(-/CTT)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE1 Gene

Variant ID Type Subtype PubMed ID
nsv833800 CNV Loss 17160897
nsv828517 CNV Gain 20364138
nsv2456 CNV Loss 18451855
nsv828518 CNV Loss 20364138
esv274862 CNV Loss 21479260

Variation tolerance for CCNE1 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNE1 Gene

Human Gene Mutation Database (HGMD)
CCNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene

Disorders for CCNE1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for CCNE1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic endophthalmitis
senile angioma
  • senile hemangioma
lung adenoma
  • adenoma of lung
facial dermatosis
  • facial dermatoses
phlyctenulosis
  • phlyctenular keratoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search CCNE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNE1

Genetic Association Database (GAD)
CCNE1
Human Genome Epidemiology (HuGE) Navigator
CCNE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNE1
genes like me logo Genes that share disorders with CCNE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene

Publications for CCNE1 Gene

  1. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. (PMID: 1833066) Lew D.J. … Reed S.I. (Cell 1991) 2 3 4 67
  2. Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer. (PMID: 20336784) Nakayama N. … Miyazaki K. (Cancer 2010) 3 23
  3. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PMID: 19258477) Goode E.L. … Sellers T.A. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 23
  4. Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma. (PMID: 19454496) Nagel I. … Siebert R. (Haematologica 2009) 3 23
  5. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. (PMID: 19470724) Agarwal R. … Hennessy B.T. (Clin. Cancer Res. 2009) 3 23

Products for CCNE1 Gene

Sources for CCNE1 Gene

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