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Aliases for CCNE1 Gene

Aliases for CCNE1 Gene

  • Cyclin E1 2 3 5
  • CCNE 3 4
  • G1/S-Specific Cyclin-E1 3
  • Cyclin Es 2
  • Cyclin Et 2
  • PCCNE1 3

External Ids for CCNE1 Gene

Previous HGNC Symbols for CCNE1 Gene

  • CCNE

Previous GeneCards Identifiers for CCNE1 Gene

  • GC19P030925
  • GC19P030751
  • GC19P034978
  • GC19P034994
  • GC19P030302
  • GC19P026814

Summaries for CCNE1 Gene

Entrez Gene Summary for CCNE1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

CIViC summary for CCNE1 Gene

  • Cyclin E, while currenly not as widely implicated as its cyclin D counterparts, has been implicated in various carcinomas, including breast, gastric, stomach and colorectal. High levels of cyclin E, either by gene amplification or overexpression, have been shown to lead to poorer prognosis in gastic carcinoma, and these measurements are correlated with later stage disease. In lung cancer, neoplastic cells with higher levels of the cyclin E/CDK2 complex are more radiosensitive than their more lowly expressed counterparts.

GeneCards Summary for CCNE1 Gene

CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include Chronic Endophthalmitis and Facial Dermatosis. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Chaperonin-mediated protein folding. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCNE2.

UniProtKB/Swiss-Prot for CCNE1 Gene

  • Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Wiki entry for CCNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene

Genomics for CCNE1 Gene

Regulatory Elements for CCNE1 Gene

Enhancers for CCNE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G029870 1.5 Ensembl ENCODE dbSUPER 18 +61.4 61397 5.3 ATF1 ZNF133 SIN3A ZNF121 GLIS2 GATA2 ELK1 ZNF143 ZNF207 KLF7 CCNE1 URI1 ENSG00000267528 ENSG00000267433
GH19G029836 0.8 ENCODE 30.1 +25.5 25473 1.6 PKNOX1 TBL1XR1 ZNF121 EGR1 ZNF207 RELB ETV6 IKZF2 CREM EGR2 CCNE1 ENSG00000267433
GH19G029804 1.1 Ensembl ENCODE 21.2 -6.0 -6019 3.6 NFIB RARA CHAMP1 YY1 ZNF366 SCRT2 FOS EGR2 ZIK1 NFYC CCNE1 ENSG00000266910 C19orf12
GH19G029759 1.2 Ensembl ENCODE 17.8 -51.6 -51613 0.6 PKNOX1 ARID4B SIN3A GLI4 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF207 CCNE1 C19orf12
GH19G029810 1.1 ENCODE 15.3 -0.7 -719 1.8 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 KLF13 CCNE1 RPL9P32 ENSG00000266910 C19orf12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCNE1 on UCSC Golden Path with GeneCards custom track

Promoters for CCNE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108526 102 2001 HDGF CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 KLF13 ZNF263

Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:

Genomic Location for CCNE1 Gene

Chromosome:
19
Start:
29,811,898 bp from pter
End:
29,824,312 bp from pter
Size:
12,415 bases
Orientation:
Plus strand

Genomic View for CCNE1 Gene

Genes around CCNE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCNE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE1 Gene

Proteins for CCNE1 Gene

  • Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24864-CCNE1_HUMAN
    Recommended name:
    G1/S-specific cyclin-E1
    Protein Accession:
    P24864
    Secondary Accessions:
    • A8K684
    • Q14091
    • Q8NFG1
    • Q92501
    • Q9UD21

    Protein attributes for CCNE1 Gene

    Size:
    410 amino acids
    Molecular mass:
    47077 Da
    Quaternary structure:
    • Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CCNE1 Gene

    Alternative splice isoforms for CCNE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE1 Gene

Post-translational modifications for CCNE1 Gene

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCNE1 Gene

Domains & Families for CCNE1 Gene

Gene Families for CCNE1 Gene

Protein Domains for CCNE1 Gene

Suggested Antigen Peptide Sequences for CCNE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24864

UniProtKB/Swiss-Prot:

CCNE1_HUMAN :
  • Belongs to the cyclin family. Cyclin E subfamily.
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE1: view

Function for CCNE1 Gene

Molecular function for CCNE1 Gene

GENATLAS Biochemistry:
cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Ontology (GO) - Molecular Function for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 8756624
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE1: view
genes like me logo Genes that share phenotypes with CCNE1: view

Animal Models for CCNE1 Gene

MGI Knock Outs for CCNE1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene

Localization for CCNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCNE1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA --
GO:0005634 nucleus IDA,IEA 16109376
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol TAS --
GO:0097134 cyclin E1-CDK2 complex IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Pathways & Interactions for CCNE1 Gene

genes like me logo Genes that share pathways with CCNE1: view

SIGNOR curated interactions for CCNE1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000723 telomere maintenance IEA --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Drugs & Compounds for CCNE1 Gene

(8) Drugs for CCNE1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alisertib Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
BAY1000394 Pharma Inhibition, Biomarker CDK4 Inhibitors, CDK2 Inhibitors 0
SCH727965 Pharma inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0
genes like me logo Genes that share compounds with CCNE1: view

Transcripts for CCNE1 Gene

Unigene Clusters for CCNE1 Gene

Cyclin E1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CCNE1 Gene

GeneLoc Exon Structure for
CCNE1
ECgene alternative splicing isoforms for
CCNE1

Expression for CCNE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCNE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for CCNE1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCNE1 Gene



Protein tissue co-expression partners for CCNE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCNE1 Gene:

CCNE1

SOURCE GeneReport for Unigene cluster for CCNE1 Gene:

Hs.244723

mRNA Expression by UniProt/SwissProt for CCNE1 Gene:

P24864-CCNE1_HUMAN
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

Evidence on tissue expression from TISSUES for CCNE1 Gene

  • Liver(2.3)
  • Stomach(2.3)
  • Intestine(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CCNE1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CCNE1 Gene

Orthologs for CCNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNE1 34 35
  • 99.92 (n)
cow
(Bos Taurus)
Mammalia CCNE1 34 35
  • 88.4 (n)
dog
(Canis familiaris)
Mammalia CCNE1 34 35
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Ccne1 34
  • 79.41 (n)
mouse
(Mus musculus)
Mammalia Ccne1 34 16 35
  • 79.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCNE1 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNE1 35
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNE1 34 35
  • 74.42 (n)
lizard
(Anolis carolinensis)
Reptilia CCNE1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne1 34
  • 66.16 (n)
zebrafish
(Danio rerio)
Actinopterygii ccne1 34 35
  • 63.68 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3561 34
fruit fly
(Drosophila melanogaster)
Insecta CycE 36 34 35
  • 52.43 (n)
worm
(Caenorhabditis elegans)
Secernentea cye-1 36 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB6 35
  • 18 (a)
ManyToMany
CLB1 35
  • 17 (a)
ManyToMany
CLB2 35
  • 17 (a)
ManyToMany
CLB3 35
  • 17 (a)
ManyToMany
CLB5 35
  • 16 (a)
ManyToMany
CLB4 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14750 34
Species where no ortholog for CCNE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE1 Gene

ENSEMBL:
Gene Tree for CCNE1 (if available)
TreeFam:
Gene Tree for CCNE1 (if available)

Paralogs for CCNE1 Gene

Paralogs for CCNE1 Gene

(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE1: view

Variants for CCNE1 Gene

Sequence variations from dbSNP and Humsavar for CCNE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000345404 -- 29,811,839(+) GGGGC(A/G)GGTCC upstream-variant-2KB
rs1000514115 -- 29,824,675(+) CTCAG(A/G)TGATC downstream-variant-500B
rs1000522945 -- 29,818,350(+) GAAAC(-/G)GGGGT intron-variant
rs1000533643 -- 29,812,899(+) AGCTT(C/T)CTCTT intron-variant
rs1000621456 -- 29,824,626(+) TGGAG(A/G)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CCNE1 Gene

Variant ID Type Subtype PubMed ID
dgv1035e212 CNV loss 25503493
esv274862 CNV loss 21479260
nsv1072344 CNV deletion 25765185
nsv1121975 CNV deletion 24896259
nsv1126519 CNV deletion 24896259
nsv1133066 OTHER inversion 24896259
nsv2456 CNV deletion 18451855
nsv828517 CNV gain 20364138
nsv828518 CNV loss 20364138
nsv833800 CNV loss 17160897

Variation tolerance for CCNE1 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNE1 Gene

Human Gene Mutation Database (HGMD)
CCNE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene

Disorders for CCNE1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CCNE1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic endophthalmitis
facial dermatosis
  • facial dermatoses
phlyctenulosis
  • phlyctenular keratoconjunctivitis
bowenoid papulosis
  • bp
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards
Search CCNE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNE1

Genetic Association Database (GAD)
CCNE1
Human Genome Epidemiology (HuGE) Navigator
CCNE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNE1
genes like me logo Genes that share disorders with CCNE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene

Publications for CCNE1 Gene

  1. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. (PMID: 19258477) Goode E.L. … Sellers T.A. (Cancer Epidemiol. Biomarkers Prev. 2009) 3 22 46 64
  2. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 22 46 64
  3. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H. … Gayther S.A. (Clin. Cancer Res. 2008) 3 22 46 64
  4. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 22 46 64
  5. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther S.A. … Pharoah P.D. (Cancer Res. 2007) 3 22 46 64

Products for CCNE1 Gene

Sources for CCNE1 Gene

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