Aliases for CCNE1 Gene
External Ids for CCNE1 Gene
Previous Symbols for CCNE1 Gene
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNE1 Gene
CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include chronic endophthalmitis and phlyctenulosis. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCND2.
UniProtKB/Swiss-Prot for CCNE1 Gene
Essential for the control of the cell cycle at the G1/S (start) transition.