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Aliases for CCNE1 Gene

Aliases for CCNE1 Gene

  • Cyclin E1 2 3
  • CCNE 3 4 6
  • Cyclin Es 2 3
  • Cyclin Et 2 3
  • G1/S-Specific Cyclin-E1 3
  • Cyclin E Variant Ex5del 3
  • Cyclin E Variant Ex7del 3

External Ids for CCNE1 Gene

Previous HGNC Symbols for CCNE1 Gene

  • CCNE

Previous GeneCards Identifiers for CCNE1 Gene

  • GC19P030925
  • GC19P030751
  • GC19P034978
  • GC19P034994
  • GC19P030302
  • GC19P026814

Summaries for CCNE1 Gene

Entrez Gene Summary for CCNE1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE1 Gene

CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include chronic endophthalmitis and phlyctenulosis. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNE1 Gene

  • Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Wiki entry for CCNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene

Genomics for CCNE1 Gene

Regulatory Elements for CCNE1 Gene

Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNE1 Gene

29,811,898 bp from pter
29,824,317 bp from pter
12,420 bases
Plus strand

Genomic View for CCNE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE1 Gene

Proteins for CCNE1 Gene

  • Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G1/S-specific cyclin-E1
    Protein Accession:
    Secondary Accessions:
    • A8K684
    • Q14091
    • Q8NFG1
    • Q92501
    • Q9UD21

    Protein attributes for CCNE1 Gene

    410 amino acids
    Molecular mass:
    47077 Da
    Quaternary structure:
    • Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CCNE1 Gene

    Alternative splice isoforms for CCNE1 Gene


neXtProt entry for CCNE1 Gene

Proteomics data for CCNE1 Gene at MOPED

Post-translational modifications for CCNE1 Gene

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CCNE1 (CCNE1)

No data available for DME Specific Peptides for CCNE1 Gene

Domains for CCNE1 Gene

Gene Families for CCNE1 Gene

Protein Domains for CCNE1 Gene


Suggested Antigen Peptide Sequences for CCNE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclin family. Cyclin E subfamily.
  • Belongs to the cyclin family. Cyclin E subfamily.
genes like me logo Genes that share domains with CCNE1: view

Function for CCNE1 Gene

Molecular function for CCNE1 Gene

GENATLAS Biochemistry:
cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Ontology (GO) - Molecular Function for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 10330164
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE1: view
genes like me logo Genes that share phenotypes with CCNE1: view

Animal Models for CCNE1 Gene

MGI Knock Outs for CCNE1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNE1 Gene

Localization for CCNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene

Subcellular locations from

Jensen Localization Image for CCNE1 Gene COMPARTMENTS Subcellular localization image for CCNE1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA --
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCNE1: view

Pathways for CCNE1 Gene

genes like me logo Genes that share pathways with CCNE1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Drugs for CCNE1 Gene

(4) Novoseek inferred chemical compound relationships for CCNE1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 29.5 6
calcium 0 1
serine 0 1
progesterone 0 1
genes like me logo Genes that share compounds with CCNE1: view

Transcripts for CCNE1 Gene

Unigene Clusters for CCNE1 Gene

Cyclin E1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: -

Relevant External Links for CCNE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCNE1 Gene

mRNA expression in normal human tissues for CCNE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene

This gene is overexpressed in Testis (4.8).

Protein differential expression in normal tissues for CCNE1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNE1 Gene

SOURCE GeneReport for Unigene cluster for CCNE1 Gene Hs.244723

mRNA Expression by UniProt/SwissProt for CCNE1 Gene

Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
genes like me logo Genes that share expressions with CCNE1: view

Expression partners for CCNE1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CCNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCNE1 35
  • 88.4 (n)
  • 85.93 (a)
CCNE1 36
  • 86 (a)
(Canis familiaris)
Mammalia CCNE1 35
  • 86.6 (n)
  • 86.6 (a)
CCNE1 36
  • 89 (a)
(Mus musculus)
Mammalia Ccne1 35
  • 79.32 (n)
  • 79.65 (a)
Ccne1 16
Ccne1 36
  • 79 (a)
(Pan troglodytes)
Mammalia CCNE1 35
  • 99.92 (n)
  • 99.76 (a)
CCNE1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccne1 35
  • 79.41 (n)
  • 80.15 (a)
(Monodelphis domestica)
Mammalia CCNE1 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia CCNE1 36
  • 57 (a)
(Gallus gallus)
Aves CCNE1 35
  • 74.42 (n)
  • 73.75 (a)
CCNE1 36
  • 74 (a)
(Anolis carolinensis)
Reptilia CCNE1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne1 35
  • 66.16 (n)
  • 62.24 (a)
(Danio rerio)
Actinopterygii -- 35
ccne1 35
  • 63.68 (n)
  • 62.01 (a)
ccne1 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3561 35
fruit fly
(Drosophila melanogaster)
Insecta CycE 37
  • 43 (a)
CycE 35
  • 52.43 (n)
  • 49.34 (a)
CycE 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea cye-1 37
  • 31 (a)
cye-1 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 17 (a)
CLB2 36
  • 17 (a)
CLB3 36
  • 17 (a)
CLB4 36
  • 13 (a)
CLB5 36
  • 16 (a)
CLB6 36
  • 18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14750 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for CCNE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE1 Gene

Gene Tree for CCNE1 (if available)
Gene Tree for CCNE1 (if available)

Paralogs for CCNE1 Gene

Paralogs for CCNE1 Gene

(2) SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE1: view

Variants for CCNE1 Gene

Sequence variations from dbSNP and Humsavar for CCNE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs397800487 -- 29,822,956(+) AAAAA(-/A)CTGCC intron-variant
rs397759188 -- 29,812,814(+) CCCCC(-/C)ATCTC intron-variant
rs397690932 -- 29,813,688(+) TTTTT(-/T)GACTG intron-variant
rs377704227 -- 29,821,545(+) TTGTG(-/TTCTTTTTT)TTTTT intron-variant
rs377661580 -- 29,822,636(+) TCTTG(A/G)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE1 Gene

Variant ID Type Subtype PubMed ID
nsv833800 CNV Loss 17160897
nsv828517 CNV Gain 20364138
nsv2456 CNV Loss 18451855
nsv828518 CNV Loss 20364138
esv274862 CNV Loss 21479260

Relevant External Links for CCNE1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

PCR Panel Products

  • Copy Number PCR Panels: for CCNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene

Disorders for CCNE1 Gene

(3) University of Copenhagen DISEASES for CCNE1 Gene

(15) Novoseek inferred disease relationships for CCNE1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 51.9 2
breast cancer 44.7 15
cancer 44.4 14
tumors 35.9 22
ovarian cancer 32.9 3

Relevant External Links for CCNE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CCNE1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CCNE1 Gene

Publications for CCNE1 Gene

  1. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PMID: 8833152) Li H. … Kidd V.J. (Genomics 1996) 3 4 23
  2. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther S.A. … Pharoah P.D. (Cancer Res. 2007) 3 23 48
  3. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 23 48
  4. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H. … Gayther S.A. (Clin. Cancer Res. 2008) 3 23 48
  5. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 23 48

Products for CCNE1 Gene

  • Addgene plasmids for CCNE1

Sources for CCNE1 Gene

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