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Aliases for CCNE1 Gene

Aliases for CCNE1 Gene

  • Cyclin E1 2 3
  • CCNE 3 4 6
  • Cyclin Es 2 3
  • Cyclin Et 2 3
  • G1/S-Specific Cyclin-E1 3
  • Cyclin E Variant Ex5del 3
  • Cyclin E Variant Ex7del 3

External Ids for CCNE1 Gene

Previous Symbols for CCNE1 Gene

  • CCNE

Summaries for CCNE1 Gene

Entrez Gene Summary for CCNE1 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNE1 Gene

CCNE1 (Cyclin E1) is a Protein Coding gene. Diseases associated with CCNE1 include chronic endophthalmitis and phlyctenulosis. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include protein kinase binding and kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNE1 Gene

  • Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Wiki entry for CCNE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNE1 Gene

Genomics for CCNE1 Gene

Genomic Location for CCNE1 Gene

Start:
29,811,898 bp from pter
End:
29,824,317 bp from pter
Size:
12,420 bases
Orientation:
Plus strand

Genomic View for CCNE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNE1 Gene

Regulatory Elements for CCNE1 Gene

Transcription factor binding sites by QIAGEN in the CCNE1 gene promoter:

Proteins for CCNE1 Gene

  • Protein details for CCNE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24864-CCNE1_HUMAN
    Recommended name:
    G1/S-specific cyclin-E1
    Protein Accession:
    P24864
    Secondary Accessions:
    • A8K684
    • Q14091
    • Q8NFG1
    • Q92501
    • Q9UD21

    Protein attributes for CCNE1 Gene

    Size:
    410 amino acids
    Molecular mass:
    47077 Da
    Quaternary structure:
    • Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CCNE1 Gene

    Alternative splice isoforms for CCNE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCNE1 Gene

Proteomics data for CCNE1 Gene at MOPED

Post-translational modifications for CCNE1 Gene

  • Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
  • Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCNE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNE1 Gene

Domains for CCNE1 Gene

Protein Domains for CCNE1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCNE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24864

UniProtKB/Swiss-Prot:

CCNE1_HUMAN
Family:
  • Belongs to the cyclin family. Cyclin E subfamily.:
    • P24864
genes like me logo Genes that share domains with CCNE1: view

No data available for Gene Families for CCNE1 Gene

Function for CCNE1 Gene

Molecular function for CCNE1 Gene

GENATLAS Biochemistry: cyclin E,48kDa,complexing with CDK2,regulating G1 to S transition of the cell cycle,overexpressed in many tumors leading to a deregulated levels of protein and kinase activity relative to the cell cycle and inducing chromosome instability
UniProtKB/Swiss-Prot Function: Essential for the control of the cell cycle at the G1/S (start) transition.

Gene Ontology (GO) - Molecular Function for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 10330164
GO:0016301 kinase activity IEA --
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNE1: view
genes like me logo Genes that share phenotypes with CCNE1: view

Animal Models for CCNE1 Gene

MGI Knock Outs for CCNE1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCNE1 Gene

Localization for CCNE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNE1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNE1 Gene COMPARTMENTS Subcellular localization image for CCNE1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA --
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CCNE1: view

Pathways for CCNE1 Gene

genes like me logo Genes that share pathways with CCNE1: view

Gene Ontology (GO) - Biological Process for CCNE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006270 DNA replication initiation IEA --
genes like me logo Genes that share ontologies with CCNE1: view

Compounds for CCNE1 Gene

(4) Novoseek inferred chemical compound relationships for CCNE1 Gene

Compound -log(P) Hits PubMed IDs
estrogen 29.5 6
calcium 0 1
progesterone 0 1
serine 0 1
genes like me logo Genes that share compounds with CCNE1: view

Transcripts for CCNE1 Gene

Unigene Clusters for CCNE1 Gene

Cyclin E1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCNE1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CCNE1 Gene

GeneLoc Exon Structure for
CCNE1
ECgene alternative splicing isoforms for
CCNE1

Expression for CCNE1 Gene

mRNA expression in normal human tissues for CCNE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCNE1 Gene

This gene is overexpressed in Testis (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNE1 Gene

SOURCE GeneReport for Unigene cluster for CCNE1 Gene Hs.244723

mRNA Expression by UniProt/SwissProt for CCNE1 Gene

P24864-CCNE1_HUMAN
Tissue specificity: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
genes like me logo Genes that share expressions with CCNE1: view

Orthologs for CCNE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CCNE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCNE1 35
  • 99.92 (n)
  • 99.76 (a)
CCNE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCNE1 35
  • 88.4 (n)
  • 85.93 (a)
CCNE1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNE1 35
  • 86.6 (n)
  • 86.6 (a)
CCNE1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccne1 35
  • 79.32 (n)
  • 79.65 (a)
Ccne1 16
Ccne1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCNE1 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCNE1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccne1 35
  • 79.41 (n)
  • 80.15 (a)
chicken
(Gallus gallus)
Aves CCNE1 35
  • 74.42 (n)
  • 73.75 (a)
CCNE1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNE1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccne1 35
  • 66.16 (n)
  • 62.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3561 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccne1 35
  • 63.68 (n)
  • 62.01 (a)
ccne1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycE 35
  • 52.43 (n)
  • 49.34 (a)
CycE 36
  • 23 (a)
OneToMany
CycE 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea cye-1 36
  • 21 (a)
OneToMany
cye-1 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLB1 36
  • 17 (a)
ManyToMany
CLB2 36
  • 17 (a)
ManyToMany
CLB3 36
  • 17 (a)
ManyToMany
CLB4 36
  • 13 (a)
ManyToMany
CLB5 36
  • 16 (a)
ManyToMany
CLB6 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14750 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for CCNE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNE1 Gene

ENSEMBL:
Gene Tree for CCNE1 (if available)
TreeFam:
Gene Tree for CCNE1 (if available)

Paralogs for CCNE1 Gene

Paralogs for CCNE1 Gene

Selected SIMAP similar genes for CCNE1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCNE1: view

Variants for CCNE1 Gene

Sequence variations from dbSNP and Humsavar for CCNE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1406 -- 29,824,205(-) AGAGG(G/T)CAGCC utr-variant-3-prime
rs997669 -- 29,813,576(-) GCTAT(A/G)AGAAC intron-variant
rs3218026 -- 29,812,231(+) GGGTG(A/C)GGCCG intron-variant
rs3218027 -- 29,812,445(+) CTggc(C/T)cgccc intron-variant
rs3218028 -- 29,812,478(+) AAGGG(-/G)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCNE1 Gene

Variant ID Type Subtype PubMed ID
nsv833800 CNV Loss 17160897
nsv828517 CNV Gain 20364138
nsv2456 CNV Loss 18451855
nsv828518 CNV Loss 20364138
esv274862 CNV Loss 21479260

Relevant External Links for CCNE1 Gene

HapMap Linkage Disequilibrium report
CCNE1
Human Gene Mutation Database (HGMD)
CCNE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCNE1 Gene

Disorders for CCNE1 Gene

(3) University of Copenhagen DISEASES for CCNE1 Gene

(15) Novoseek inferred disease relationships for CCNE1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 51.9 2
breast cancer 44.7 15
cancer 44.4 14
tumors 35.9 22
ovarian cancer 32.9 3

Relevant External Links for CCNE1

Genetic Association Database (GAD)
CCNE1
Human Genome Epidemiology (HuGE) Navigator
CCNE1
genes like me logo Genes that share disorders with CCNE1: view

No data available for UniProtKB/Swiss-Prot for CCNE1 Gene

Publications for CCNE1 Gene

  1. Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. (PMID: 9840943) Zariwala M. … Xiong Y. (Oncogene 1998) 3 4 23
  2. The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. (PMID: 15660127) Honda R. … Johnson L.N. (EMBO J. 2005) 3 4 23
  3. Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. (PMID: 17409409) Gayther S.A. … Pharoah P.D. (Cancer Res. 2007) 3 23 48
  4. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. (PMID: 8833152) Li H. … Kidd V.J. (Genomics 1996) 3 4 23
  5. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. (PMID: 18174243) Driver K.E. … Dunning A.M. (Carcinogenesis 2008) 3 23 48

Products for CCNE1 Gene

  • Addgene plasmids for CCNE1

Sources for CCNE1 Gene

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