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Aliases for NAV2 Gene

Aliases for NAV2 Gene

  • Neuron Navigator 2 2 3 5
  • Pore Membrane And/Or Filament-Interacting-Like Protein 2 3 4
  • Retinoic Acid Inducible Gene In Neuroblastoma 1 2 3
  • Unc-53 Homolog 2 3 4
  • Steerin-2 3 4
  • STEERIN2 3 4
  • UNC53H2 3 4
  • POMFIL2 3 4
  • HELAD1 3 4
  • RAINB1 3 4
  • Pore Membrane And/Or Filament Interacting Like Protein 2 2
  • Retinoic Acid Inducible In Neuroblastoma 1 4
  • Helicase, APC Down-Regulated 1 3
  • Helicase APC Down-Regulated 1 4
  • APC Down-Regulated 1 2
  • EC 3.6.4.12 4
  • Helicase 2
  • KIAA1419 4

External Ids for NAV2 Gene

Previous GeneCards Identifiers for NAV2 Gene

  • GC11P020896
  • GC11P020678
  • GC11P019411
  • GC11P019699
  • GC11P019691
  • GC11P019056
  • GC11P019372
  • GC11P019353

Summaries for NAV2 Gene

Entrez Gene Summary for NAV2 Gene

  • This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NAV2 Gene

NAV2 (Neuron Navigator 2) is a Protein Coding gene. Diseases associated with NAV2 include neuroblastoma. GO annotations related to this gene include heparin binding and helicase activity. An important paralog of this gene is NAV3.

UniProtKB/Swiss-Prot for NAV2 Gene

  • Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.

Gene Wiki entry for NAV2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV2 Gene

Genomics for NAV2 Gene

Regulatory Elements for NAV2 Gene

Genomic Location for NAV2 Gene

Chromosome:
11
Start:
19,345,247 bp from pter
End:
20,121,601 bp from pter
Size:
776,355 bases
Orientation:
Plus strand

Genomic View for NAV2 Gene

Genes around NAV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAV2 Gene

Proteins for NAV2 Gene

  • Protein details for NAV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVL1-NAV2_HUMAN
    Recommended name:
    Neuron navigator 2
    Protein Accession:
    Q8IVL1
    Secondary Accessions:
    • A6NEC1
    • Q8IVK3
    • Q8IVK4
    • Q8IVK5
    • Q8IVK6
    • Q8IVK7
    • Q8IVK8
    • Q8NHC9
    • Q8NHD0
    • Q8TDE9
    • Q8TDF0
    • Q8TEB3
    • Q96B30
    • Q9NUZ6
    • Q9NVM7
    • Q9P2C8

    Protein attributes for NAV2 Gene

    Size:
    2488 amino acids
    Molecular mass:
    268167 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92657.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85038.1; Type=Frameshift; Positions=2074; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAV2 Gene

    Alternative splice isoforms for NAV2 Gene

neXtProt entry for NAV2 Gene

Proteomics data for NAV2 Gene at MOPED

Post-translational modifications for NAV2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAV2 Gene

Domains & Families for NAV2 Gene

Protein Domains for NAV2 Gene

Suggested Antigen Peptide Sequences for NAV2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVL1

UniProtKB/Swiss-Prot:

NAV2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the Nav/unc-53 family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the Nav/unc-53 family.
genes like me logo Genes that share domains with NAV2: view

No data available for Gene Families for NAV2 Gene

Function for NAV2 Gene

Molecular function for NAV2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.

Enzyme Numbers (IUBMB) for NAV2 Gene

genes like me logo Genes that share phenotypes with NAV2: view

miRNA for NAV2 Gene

miRTarBase miRNAs that target NAV2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAV2 Gene

Localization for NAV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAV2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAV2 Gene COMPARTMENTS Subcellular localization image for NAV2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for NAV2 Gene

Pathways & Interactions for NAV2 Gene

SuperPathways for NAV2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback IEA --
GO:0007605 sensory perception of sound IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAV2: view

No data available for Pathways by source and SIGNOR curated interactions for NAV2 Gene

Drugs & Compounds for NAV2 Gene

(1) Drugs for NAV2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for NAV2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with NAV2: view

Transcripts for NAV2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAV2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: -
SP8:

ExUns: 25b ^ 26 ^ 27a · 27b ^ 28a · 28b
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NAV2 Gene

GeneLoc Exon Structure for
NAV2
ECgene alternative splicing isoforms for
NAV2

Expression for NAV2 Gene

mRNA expression in normal human tissues for NAV2 Gene

mRNA differential expression in normal tissues according to GTEx for NAV2 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for NAV2 Gene

This gene is overexpressed in Plasma (24.2), Serum (21.5), Adipocyte (9.9), and Frontal cortex (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAV2 Gene



SOURCE GeneReport for Unigene cluster for NAV2 Gene Hs.502116

mRNA Expression by UniProt/SwissProt for NAV2 Gene

Q8IVL1-NAV2_HUMAN
Tissue specificity: Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.
genes like me logo Genes that share expression patterns with NAV2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for NAV2 Gene

Orthologs for NAV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAV2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAV2 35
  • 89.58 (n)
  • 94.12 (a)
NAV2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAV2 35
  • 90.81 (n)
  • 95.84 (a)
NAV2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nav2 35
  • 87.95 (n)
  • 93.31 (a)
Nav2 16
Nav2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAV2 35
  • 99.46 (n)
  • 99.72 (a)
NAV2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nav2 35
  • 87.7 (n)
  • 93.84 (a)
oppossum
(Monodelphis domestica)
Mammalia NAV2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAV2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAV2 35
  • 79.49 (n)
  • 87.31 (a)
NAV2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAV2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nav2 35
  • 74.36 (n)
  • 79.46 (a)
Str.4535 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34129 35
zebrafish
(Danio rerio)
Actinopterygii nav2 35
  • 66.35 (n)
  • 68.91 (a)
NAV2 (2 of 2) 36
  • 67 (a)
OneToMany
nav2b 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sick 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-53 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for NAV2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAV2 Gene

ENSEMBL:
Gene Tree for NAV2 (if available)
TreeFam:
Gene Tree for NAV2 (if available)

Paralogs for NAV2 Gene

Paralogs for NAV2 Gene

(3) SIMAP similar genes for NAV2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NAV2: view

Variants for NAV2 Gene

Sequence variations from dbSNP and Humsavar for NAV2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs6483617 - 19,832,542(+) CATCA(A/G)GGATC reference, missense
rs16937251 - 19,933,648(+) GCCCA(C/G)AGGAC reference, missense
VAR_029642 -
VAR_029643 -
rs35891966 - 20,107,765(-) TCTGA(C/T)GGCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAV2 Gene

Variant ID Type Subtype PubMed ID
esv271353 CNV Insertion 20981092
nsv825779 CNV Loss 20364138
esv26763 CNV Gain 19812545
essv13326 CNV CNV 17122850
esv2666507 CNV Deletion 23128226
esv22573 CNV Loss 19812545
nsv524289 CNV Loss 19592680
esv2676711 CNV Deletion 23128226
esv2619010 CNV Deletion 19546169
esv2397419 CNV Deletion 18987734
esv29003 CNV Loss 19812545
esv1174411 CNV Insertion 17803354
esv2289070 CNV Deletion 18987734
esv2664376 CNV Deletion 23128226
nsv897031 CNV Loss 21882294
nsv523404 CNV Loss 19592680
nsv526704 CNV Loss 19592680
esv2673508 CNV Deletion 23128226
nsv524136 CNV Loss 19592680
esv1611893 CNV Deletion 17803354
esv2667194 CNV Deletion 23128226
nsv519433 CNV Loss 19592680
esv270078 CNV Insertion 20981092
nsv7700 CNV Insertion 18451855
esv2673296 CNV Deletion 23128226
esv2617564 CNV Insertion 19546169
esv273349 CNV Insertion 20981092
esv268827 CNV Insertion 20981092
esv2744179 CNV Deletion 23290073
esv2744180 CNV Deletion 23290073
nsv528404 CNV Loss 19592680
nsv518583 CNV Loss 19592680
nsv524632 CNV Loss 19592680
nsv522845 CNV Gain 19592680
nsv818801 CNV Gain 17921354
nsv516382 CNV Gain 19592680
nsv524463 CNV Loss 19592680
nsv469939 CNV Gain 18288195
nsv467720 CNV Gain 19166990
esv22357 CNV Loss 19812545
nsv825780 CNV Gain 20364138

Variation tolerance for NAV2 Gene

Residual Variation Intolerance Score: 1.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.67; 98.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAV2 Gene

HapMap Linkage Disequilibrium report
NAV2
Human Gene Mutation Database (HGMD)
NAV2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAV2 Gene

Disorders for NAV2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAV2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search NAV2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAV2

Genetic Association Database (GAD)
NAV2
Human Genome Epidemiology (HuGE) Navigator
NAV2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAV2
genes like me logo Genes that share disorders with NAV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAV2 Gene

Publications for NAV2 Gene

  1. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T. … Buesa C. (Genomics 2002) 2 3 4 67
  2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy J.F. … Poustka A. (Gene 2002) 2 3
  3. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. (PMID: 11904404) Merrill R.A. … Clagett-Dame M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  4. Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension. (PMID: 25065758) van Haren J. … Galjart N. (Curr. Biol. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NAV2 Gene

Sources for NAV2 Gene

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