Aliases for NAV2 Gene
Aliases for NAV2 Gene
External Ids for NAV2 Gene
- HGNC: 15997
- Entrez Gene: 89797
- Ensembl: ENSG00000166833
- OMIM: 607026
- UniProtKB: Q8IVL1
Previous GeneCards Identifiers for NAV2 Gene
- GC11P020896
- GC11P020678
- GC11P019411
- GC11P019699
- GC11P019691
- GC11P019056
- GC11P019372
- GC11P019353
Summaries for NAV2 Gene
-
This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for NAV2 Gene
NAV2 (Neuron Navigator 2) is a Protein Coding gene. Diseases associated with NAV2 include Neuroblastoma. GO annotations related to this gene include heparin binding and helicase activity. An important paralog of this gene is NAV3.
UniProtKB/Swiss-Prot for NAV2 Gene
-
Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV2 Gene
Genomics for NAV2 Gene
Regulatory Elements for NAV2 Gene
Enhancers for NAV2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G019365 | 1.1 | Ensembl ENCODE | 11.6 | +23.5 | 23457 | 5.6 | PKNOX1 TAF1 JUN MAX EBF1 ZIC2 RAD21 YY1 GATA3 CTBP1 | NAV2 NAV2-AS5 NAV2-IT1 GC11P019352 GC11P019350 |
| GH11G019373 | 0.9 | Ensembl ENCODE | 11.6 | +29.3 | 29284 | 1.7 | JUN BHLHE40 USF2 CEBPB REST JUND GATA2 POU5F1 KDM1A FOS | NAV2 NAV2-IT1 GC11P019352 GC11P019350 |
| GH11G019380 | 0.9 | Ensembl ENCODE | 11.5 | +35.4 | 35440 | 1.3 | FOSL1 JUND GATA2 JUN CREB1 FOS MAFK NFE2L2 | NAV2 NAV2-IT1 RNA5SP335 GC11M019401 |
| GH11G019276 | 0.8 | ENCODE | 10.6 | -67.9 | -67864 | 2.6 | GTF2F1 ESRRA JUN MAX CEBPG CTBP1 GATA3 FOS RCOR1 CHD2 | NAV2 LOC105376580 PCNAP4 |
| GH11G019398 | 0.8 | ENCODE | 10.1 | +53.7 | 53685 | 1.2 | PKNOX1 SIN3A FEZF1 RAD21 YY1 EGR1 FOS RCOR1 HCFC1 ZHX2 | NAV2 GC11M019401 RNA5SP335 NAV2-IT1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NAV2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NAV2 gene promoter:
Regulatory Element Products
Genomic Location for NAV2 Gene
- Chromosome:
- 11
- Start:
- 19,345,247 bp from pter
- End:
- 20,121,601 bp from pter
- Size:
- 776,355 bases
- Orientation:
- Plus strand
Genomic View for NAV2 Gene
Genes around NAV2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.1 by Ensembl
- 11p15.1 by Entrez Gene
- 11p15.1 by HGNC
NAV2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NAV2 Gene
Proteins for NAV2 Gene
-
Protein details for NAV2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IVL1-NAV2_HUMAN
- Recommended name:
- Neuron navigator 2
- Protein Accession:
- Q8IVL1
- A6NEC1
- Q8IVK3
- Q8IVK4
- Q8IVK5
- Q8IVK6
- Q8IVK7
- Q8IVK8
- Q8NHC9
- Q8NHD0
- Q8TDE9
- Q8TDF0
- Q8TEB3
- Q96B30
- Q9NUZ6
- Q9NVM7
- Q9P2C8
Protein attributes for NAV2 Gene
- Size:
- 2488 amino acids
- Molecular mass:
- 268167 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA92657.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB85038.1; Type=Frameshift; Positions=2074; Evidence={ECO:0000305};
Protein Expression for NAV2 Gene
Post-translational modifications for NAV2 Gene
Other Protein References for NAV2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001104488.1
- NP_001104489.1
- NP_001231892.1
- NP_660093.2
- NP_892009.3
- XP_005253271.1
- XP_006718427.1
- XP_006718428.1
- XP_006718429.1
- XP_006718430.1
- XP_006718431.1
- XP_006718432.1
- XP_011518746.1
- XP_011518747.1
- XP_011518748.1
- XP_011518749.1
- XP_011518750.1
- XP_011518751.1
- XP_011518752.1
- XP_011518753.1
- XP_011518754.1
- XP_011518755.1
- XP_011518756.1
- XP_016874009.1
- XP_016874010.1
- XP_016874011.1
- XP_016874012.1
- XP_016874013.1
- XP_016874014.1
- XP_016874015.1
Antibody Products
- Novus Biologicals Antibodies for NAV2
-
Abcam antibodies for NAV2
- Invitrogen Antibodies for NAV2
- antibodies-online Antibodies for NAV2: See all 25
- GeneTex NAV2 antibody for NAV2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NAV2
- Origene Custom Protein Services for NAV2
- antibodies-online Proteins for NAV2: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NAV2
-
Abcam proteins for NAV2
No data available for DME Specific Peptides for NAV2 Gene
Domains & Families for NAV2 Gene
Protein Domains for NAV2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NAV2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IVL1- Family:
-
- Belongs to the Nav/unc-53 family.
No data available for Gene Families for NAV2 Gene
Function for NAV2 Gene
Molecular function for NAV2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
- UniProtKB/Swiss-Prot Function:
- Possesses 3 to 5 helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs.
- UniProtKB/Swiss-Prot Induction:
- By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas.
Enzyme Numbers (IUBMB) for NAV2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for NAV2 Gene
- MGI mutant phenotypes for NAV2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NAV2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NAV2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NAV2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NAV2 gene
- Search ViGene Biosciences for NAV2
CRISPR Products
-
OriGene CRISPR knockouts for NAV2
-
Applied Biological Materials CRISPR for NAV2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAV2
- GenScript: Design CRISPR guide RNA sequences for NAV2
miRNA for NAV2 Gene
- miRTarBase miRNAs that target NAV2
-
- hsa-mir-663a (MIRT006089)
- hsa-mir-98-5p (MIRT027632)
- hsa-mir-16-5p (MIRT051065)
- hsa-mir-6825-5p (MIRT472445)
- hsa-mir-7106-5p (MIRT472446)
- hsa-mir-765 (MIRT472447)
- hsa-mir-766-5p (MIRT472448)
- hsa-mir-3202 (MIRT472449)
- hsa-mir-3179 (MIRT472450)
- hsa-mir-6876-5p (MIRT472451)
- hsa-mir-4779 (MIRT472452)
- hsa-mir-4476 (MIRT472453)
- hsa-mir-6856-5p (MIRT472454)
- hsa-mir-6758-5p (MIRT472455)
- hsa-mir-6883-5p (MIRT483621)
- hsa-mir-6785-5p (MIRT483622)
- hsa-mir-4728-5p (MIRT483623)
- hsa-mir-149-3p (MIRT483624)
- hsa-mir-6797-5p (MIRT483625)
- hsa-mir-1249-5p (MIRT483626)
- hsa-mir-6133 (MIRT483627)
- hsa-mir-6130 (MIRT483628)
- hsa-mir-6129 (MIRT483629)
- hsa-mir-6127 (MIRT483630)
- hsa-mir-4510 (MIRT483631)
- hsa-mir-4419a (MIRT483632)
- hsa-mir-4756-5p (MIRT483633)
- hsa-mir-4739 (MIRT483634)
- hsa-mir-1321 (MIRT483635)
- hsa-mir-6835-3p (MIRT535699)
- hsa-mir-4668-5p (MIRT610718)
- hsa-mir-1298-5p (MIRT610719)
- hsa-mir-664a-3p (MIRT610720)
- hsa-mir-548z (MIRT610721)
- hsa-mir-548h-3p (MIRT610722)
- hsa-mir-548d-3p (MIRT610723)
- hsa-mir-548bb-3p (MIRT610724)
- hsa-mir-548ac (MIRT610725)
- hsa-mir-6809-3p (MIRT615671)
- hsa-mir-6833-3p (MIRT615672)
- hsa-mir-4768-5p (MIRT615673)
- hsa-mir-6759-5p (MIRT615674)
- hsa-mir-4753-3p (MIRT615675)
- hsa-mir-6873-3p (MIRT615676)
- hsa-mir-2117 (MIRT615677)
- hsa-mir-6793-5p (MIRT615678)
- hsa-mir-6748-5p (MIRT615679)
- hsa-mir-597-3p (MIRT615680)
- hsa-mir-23b-5p (MIRT615681)
- hsa-mir-23a-5p (MIRT615682)
- hsa-mir-130b-5p (MIRT615683)
- hsa-mir-6817-3p (MIRT615684)
- hsa-mir-7110-3p (MIRT615685)
- hsa-mir-299-3p (MIRT615686)
- hsa-mir-6818-3p (MIRT623140)
- hsa-mir-6888-3p (MIRT623141)
- hsa-mir-593-3p (MIRT623142)
- hsa-mir-6895-3p (MIRT623143)
- hsa-mir-3120-5p (MIRT623144)
- hsa-mir-335-3p (MIRT667262)
- hsa-mir-664b-3p (MIRT667263)
- hsa-mir-5696 (MIRT667264)
- hsa-mir-579-3p (MIRT667265)
- hsa-mir-627-3p (MIRT667266)
miRNA Products
- Search ViGene Biosciences for NAV2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NAV2
- Browse OriGene Inhibitory RNA Products For NAV2
-
ViGene Biosciences ready-to-package AAV shRNAs for NAV2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAV2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NAV2
-
ViGene Biosciences adenoviral particle packaged cDNA for NAV2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NAV2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NAV2 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAV2 Gene
Localization for NAV2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NAV2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 3 |
| cytosol | 3 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005614 | interstitial matrix | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for NAV2 Gene
No Data Available
Interacting Proteins for NAV2 Gene
Selected Interacting proteins:
Q8IVL1-NAV2_HUMAN
ENSP00000379394
for NAV2 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0007605 | sensory perception of sound | IEA | -- |
| GO:0007608 | sensory perception of smell | IEA | -- |
| GO:0007626 | locomotory behavior | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NAV2 Gene
Drugs & Compounds for NAV2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Transcripts for NAV2 Gene
mRNA/cDNA for NAV2 Gene
- (30) REFSEQ mRNAs :
- (47) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NAV2
-
Applied Biological Materials CRISPR for NAV2
-
Santa Cruz Biotechnology (SCBT) CRISPR for NAV2
- GenScript: Design CRISPR guide RNA sequences for NAV2
miRNA Products
- Search ViGene Biosciences for NAV2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NAV2
- Browse OriGene Inhibitory RNA Products For NAV2
-
ViGene Biosciences ready-to-package AAV shRNAs for NAV2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAV2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 25b | ^ | 26 | ^ | 27a | · | 27b | ^ | 28a | · | 28b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | - | ||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: |
Expression for NAV2 Gene
mRNA differential expression in normal tissues according to GTEx for NAV2 Gene
This gene is overexpressed in Artery - Aorta (x4.4).
This gene is overexpressed in Plasma (24.2), Serum (21.5), Adipocyte (9.9), and Frontal cortex (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAV2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NAV2 Gene:
NAV2SOURCE GeneReport for Unigene cluster for NAV2 Gene:
Hs.502116mRNA Expression by UniProt/SwissProt for NAV2 Gene:
Q8IVL1-NAV2_HUMAN
Tissue specificity:
Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers.
Evidence on tissue expression from TISSUES for NAV2 Gene
- Nervous system(4.8)
- Liver(4.2)
- Skin(4.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for NAV2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAV2 Gene
Orthologs for NAV2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NAV2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | NAV2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NAV2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NAV2 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | NAV2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nav2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nav2 34 |
|
||
| chicken (Gallus gallus) |
Aves | NAV2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NAV2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nav2 34 |
|
||
| Str.4535 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.34129 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | NAV2 (2 of 2) 35 |
|
OneToMany | |
| nav2 34 |
|
||||
| nav2b 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | sick 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-53 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for NAV2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NAV2 Gene
(3) SIMAP similar genes for NAV2 Gene using alignment to 5 proteins:
Variants for NAV2 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004774 | -- | 19,963,417(+) | CTAGT(C/T)CCCAC | intron-variant | |
| rs1000005922 | -- | 19,428,723(+) | CTTCC(C/T)GTCAT | intron-variant | |
| rs1000006959 | -- | 19,938,934(+) | GTTAC(A/C)TGCAG | intron-variant | |
| rs1000012375 | -- | 19,816,853(+) | TCAGG(C/T)CCTTC | intron-variant | |
| rs1000018887 | -- | 19,813,994(+) | ACTTT(A/C)ATCTG | intron-variant |
Residual Variation Intolerance Score:
1.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
19.67;
98.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NAV2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAV2 Gene
Disorders for NAV2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| neuroblastoma |
|
|
Search NAV2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for NAV2
No data available for UniProtKB/Swiss-Prot and Genatlas for NAV2 Gene
Publications for NAV2 Gene
- Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy J.F. … Poustka A. (Gene 2002) 2 3 4 64
- Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T. … Buesa C. (Genomics 2002) 2 3 4 64
- A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. (PMID: 11904404) Merrill R.A. … Clagett-Dame M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 22 64
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
Products for NAV2 Gene
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- Browse R&D Systems for biochemical assays
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- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Flow Cytometry Kits
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NAV2
- Origene Custom Protein Services for NAV2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NAV2
- Browse OriGene Inhibitory RNA Products For NAV2
- OriGene qPCR primer pairs for NAV2
- OriGene CRISPR knockouts for NAV2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NAV2
- GenScript: Next-day shipping of latest version cDNA ORF clones for NAV2 in any vector
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- GenScript Custom Assay Services for NAV2
- GenScript Custom overexpressing Cell Line Services for NAV2
- GenScript: Design CRISPR guide RNA sequences for NAV2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for NAV2
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for NAV2
- Novus Biologicals proteins and lysates for NAV2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for NAV2
- Abcam proteins for NAV2
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for NAV2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for NAV2: See all 25
- Search antibodies-online for kits
- antibodies-online Proteins for NAV2: See all 4
- Search antibodies-online for peptides
- GeneTex NAV2 antibody for NAV2
- Search GeneTex for Proteins for NAV2
- ViGene Biosciences adenoviral particle packaged cDNA for NAV2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NAV2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NAV2 gene
- Search ViGene Biosciences for NAV2
- Search Santa Cruz Biotechnology (SCBT) for NAV2 Antibodies
- Search Santa Cruz Biotechnology (SCBT) for NAV2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NAV2
- Horizon Cell Lines for NAV2
- Cyagen custom Knockout/knockin (KOKI) mouse models for NAV2
- VectorBuilder custom plasmid, inducible vectors for NAV2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NAV2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NAV2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio