Aliases for WNT3A Gene
External Ids for WNT3A Gene
Previous GeneCards Identifiers for WNT3A Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT3A Gene
WNT3A (Wnt Family Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include Osteoporosis, Juvenile and Diarrhea 4, Malabsorptive, Congenital. Among its related pathways are Mesodermal Commitment Pathway and DNA Damage Response (only ATM dependent). Gene Ontology (GO) annotations related to this gene include receptor binding and protein domain specific binding. An important paralog of this gene is WNT3.
UniProtKB/Swiss-Prot for WNT3A Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.