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Aliases for WNT3A Gene

Aliases for WNT3A Gene

  • Wingless-Type MMTV Integration Site Family, Member 3A 2 3

External Ids for WNT3A Gene

Previous GeneCards Identifiers for WNT3A Gene

  • GC01P226691
  • GC01P223933
  • GC01P224580
  • GC01P225169
  • GC01P224501
  • GC01P226261
  • GC01P228194
  • GC01P198726

Summaries for WNT3A Gene

Entrez Gene Summary for WNT3A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT3A Gene

WNT3A (Wingless-Type MMTV Integration Site Family, Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include idiopathic juvenile osteoporosis and hypotrichosis simplex. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include transcription coactivator activity and extracellular matrix structural constituent. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT3A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube

Gene Wiki entry for WNT3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT3A Gene

Genomics for WNT3A Gene

Regulatory Elements for WNT3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT3A Gene

228,007,022 bp from pter
228,061,271 bp from pter
54,250 bases
Plus strand

Genomic View for WNT3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT3A Gene

Proteins for WNT3A Gene

  • Protein details for WNT3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-3a
    Protein Accession:
    Secondary Accessions:
    • Q3SY79
    • Q3SY80
    • Q969P2

    Protein attributes for WNT3A Gene

    352 amino acids
    Molecular mass:
    39365 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN. Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.

    Alternative splice isoforms for WNT3A Gene


neXtProt entry for WNT3A Gene

Proteomics data for WNT3A Gene at MOPED

Post-translational modifications for WNT3A Gene

  • Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding.
  • Palmitoleylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleylated WNT3A from WLS in secretory vesicles (PubMed:20826466, PubMed:21244856, PubMed:24292069). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway (PubMed:25731175).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT3A.
  • Glycosylation at Asn87 and Asn298
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT3A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WNT3A (WNT3A)

No data available for DME Specific Peptides for WNT3A Gene

Domains for WNT3A Gene

Protein Domains for WNT3A Gene

Suggested Antigen Peptide Sequences for WNT3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT3A: view

Function for WNT3A Gene

Molecular function for WNT3A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube

Gene Ontology (GO) - Molecular Function for WNT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS --
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0005110 frizzled-2 binding IEA --
GO:0005515 protein binding IPI 19072540
genes like me logo Genes that share ontologies with WNT3A: view
genes like me logo Genes that share phenotypes with WNT3A: view

Animal Models for WNT3A Gene

MGI Knock Outs for WNT3A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT3A Gene

Localization for WNT3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT3A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for WNT3A Gene COMPARTMENTS Subcellular localization image for WNT3A gene
Compartment Confidence
extracellular 5
endosome 3
plasma membrane 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with WNT3A: view

Pathways for WNT3A Gene

genes like me logo Genes that share pathways with WNT3A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for WNT3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001756 somitogenesis --
GO:0001934 positive regulation of protein phosphorylation IDA 20137080
GO:0001947 heart looping IEA --
genes like me logo Genes that share ontologies with WNT3A: view

Drugs for WNT3A Gene

(3) Novoseek inferred chemical compound relationships for WNT3A Gene

Compound -log(P) Hits PubMed IDs
glycogen 52.4 3
retinoic acid 13.4 3
testosterone 8.86 2
genes like me logo Genes that share compounds with WNT3A: view

Transcripts for WNT3A Gene

mRNA/cDNA for WNT3A Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT3A Gene

Wingless-type MMTV integration site family, member 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b

Relevant External Links for WNT3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT3A Gene

mRNA expression in normal human tissues for WNT3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT3A Gene

This gene is overexpressed in Lung (14.1), Skin - Sun Exposed (Lower leg) (7.3), Skin - Not Sun Exposed (Suprapubic) (7.1), Prostate (4.7), and Esophagus - Mucosa (4.4).

Protein differential expression in normal tissues for WNT3A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT3A Gene

SOURCE GeneReport for Unigene cluster for WNT3A Gene Hs.336930

mRNA Expression by UniProt/SwissProt for WNT3A Gene

Tissue specificity: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate
genes like me logo Genes that share expressions with WNT3A: view

Expression partners for WNT3A Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for WNT3A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT3A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WNT3A 35
  • 89 (n)
  • 96.79 (a)
WNT3A 36
  • 97 (a)
(Canis familiaris)
Mammalia WNT3A 35
  • 91.57 (n)
  • 95.73 (a)
WNT3A 36
  • 96 (a)
(Mus musculus)
Mammalia Wnt3a 35
  • 87.5 (n)
  • 96.02 (a)
Wnt3a 16
Wnt3a 36
  • 96 (a)
(Pan troglodytes)
Mammalia WNT3A 35
  • 99.34 (n)
  • 99.43 (a)
WNT3A 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Wnt3a 35
  • 85.6 (n)
  • 94.67 (a)
(Monodelphis domestica)
Mammalia WNT3A 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia WNT3A 36
  • 90 (a)
(Gallus gallus)
Aves WNT3A 35
  • 78.69 (n)
  • 87.78 (a)
WNT3A 36
  • 88 (a)
(Anolis carolinensis)
Reptilia WNT3A 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt3a 35
  • 73.96 (n)
  • 84.66 (a)
(Danio rerio)
Actinopterygii wnt3a 35
  • 78.5 (n)
  • 85.47 (a)
wnt3a 36
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 37
  • 46 (a)
Wnt4 37
  • 32 (a)
Wnt5 37
  • 42 (a)
Wnt6 37
  • 45 (a)
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 41 (a)
cwn-2 37
  • 40 (a)
egl-20 37
  • 36 (a)
lin-44 37
  • 31 (a)
mom-2 37
  • 31 (a)
cwn-1 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for WNT3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT3A Gene

Gene Tree for WNT3A (if available)
Gene Tree for WNT3A (if available)

Paralogs for WNT3A Gene

Paralogs for WNT3A Gene

(17) SIMAP similar genes for WNT3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT3A: view

Variants for WNT3A Gene

Sequence variations from dbSNP and Humsavar for WNT3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs708113 -- 228,005,052(-) ACCTC(A/T)CTGAA upstream-variant-2KB
rs708114 -- 228,009,795(-) GGCTG(C/T)TGGCC intron-variant
rs708115 -- 228,010,345(-) CCTGG(A/G)GAGGC intron-variant
rs708116 -- 228,010,495(-) GGAGG(G/T)TGTGG intron-variant
rs708117 -- 228,012,201(-) CCCTC(C/T)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT3A Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv832803 CNV Loss 17160897
nsv873252 CNV Loss 21882294
nsv826953 CNV Gain 20364138
dgv537n71 CNV Loss 21882294
nsv826964 CNV Gain 20364138

Relevant External Links for WNT3A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT3A Gene

Disorders for WNT3A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WNT3A Gene in MalaCards »

(2) Diseases for WNT3A Gene

(1) University of Copenhagen DISEASES for WNT3A Gene

(6) Novoseek inferred disease relationships for WNT3A Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 32 2
gastric cancer 19.4 2
cancer 19.2 4
necrosis 0 2
breast cancer 0 1

Relevant External Links for WNT3A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WNT3A: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for WNT3A Gene

Publications for WNT3A Gene

  1. Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region. (PMID: 11414706) Saitoh T. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Fibroblast growth factor signaling uses multiple mechanisms to inhibit Wnt-induced transcription in osteoblasts. (PMID: 18505824) Ambrosetti D. … Basilico C. (Mol. Cell. Biol. 2008) 3 23
  3. Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. (PMID: 18615587) Liu Y. … Billiard J. (J. Cell. Biochem. 2008) 3 23
  4. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. (PMID: 18724388) Li X. … Bhowmick N.A. (Oncogene 2008) 3 23
  5. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. (PMID: 19351711) Isakson P. … Smith U. (Diabetes 2009) 3 23

Products for WNT3A Gene

Sources for WNT3A Gene

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