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Aliases for CCND3 Gene

Aliases for CCND3 Gene

  • Cyclin D3 2 3

External Ids for CCND3 Gene

Previous GeneCards Identifiers for CCND3 Gene

  • GC06M041904
  • GC06M041949
  • GC06M042010
  • GC06M041621

Summaries for CCND3 Gene

Entrez Gene Summary for CCND3 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for CCND3 Gene

CCND3 (Cyclin D3) is a Protein Coding gene. Diseases associated with CCND3 include bladder carcinoma in situ and myeloma. Among its related pathways are PI3K-Akt signaling pathway and L1CAM interactions. GO annotations related to this gene include protein kinase binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCND3 Gene

  • Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Gene Wiki entry for CCND3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCND3 Gene

Genomics for CCND3 Gene

Regulatory Elements for CCND3 Gene

Transcription factor binding sites by QIAGEN in the CCND3 gene promoter:

Genomic Location for CCND3 Gene

Start:
41,934,933 bp from pter
End:
42,050,357 bp from pter
Size:
115,425 bases
Orientation:
Minus strand

Genomic View for CCND3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCND3 Gene

Proteins for CCND3 Gene

  • Protein details for CCND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30281-CCND3_HUMAN
    Recommended name:
    G1/S-specific cyclin-D3
    Protein Accession:
    P30281
    Secondary Accessions:
    • B2RD63
    • B3KQ22
    • E9PAS4
    • E9PB36
    • Q5T8J0
    • Q6FG62
    • Q96F49

    Protein attributes for CCND3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32520 Da
    Quaternary structure:
    • Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A.

    Three dimensional structures from OCA and Proteopedia for CCND3 Gene

    Alternative splice isoforms for CCND3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCND3 Gene

Proteomics data for CCND3 Gene at MOPED

Post-translational modifications for CCND3 Gene

  • Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCND3 Gene

Domains for CCND3 Gene

Protein Domains for CCND3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P30281

UniProtKB/Swiss-Prot:

CCND3_HUMAN :
  • P30281
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin D subfamily.
genes like me logo Genes that share domains with CCND3: view

No data available for Gene Families for CCND3 Gene

Function for CCND3 Gene

Molecular function for CCND3 Gene

GENATLAS Biochemistry: cyclin D3,regulator of progression through G1 phase during the cell cycle 3,33/34kDa,overexpressed with CDKN1B in agressive B cell lymphomas and in glioblastoma and gliosarcoma,involved in the loss of cell cycle control in a small fraction of malignant gliomas
UniProtKB/Swiss-Prot Function: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Gene Ontology (GO) - Molecular Function for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 11896535
GO:0019901 protein kinase binding IPI 8114739
genes like me logo Genes that share ontologies with CCND3: view
genes like me logo Genes that share phenotypes with CCND3: view

Animal Models for CCND3 Gene

MGI Knock Outs for CCND3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCND3 Gene

Localization for CCND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCND3 Gene

Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCND3 Gene COMPARTMENTS Subcellular localization image for CCND3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 8114739
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCND3: view

Pathways for CCND3 Gene

genes like me logo Genes that share pathways with CCND3: view

Gene Ontology (GO) - Biological Process for CCND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0001934 positive regulation of protein phosphorylation IDA 8114739
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
GO:0042098 T cell proliferation IEA --
genes like me logo Genes that share ontologies with CCND3: view

Compounds for CCND3 Gene

(38) Novoseek inferred chemical compound relationships for CCND3 Gene

Compound -log(P) Hits PubMed IDs
rapamycin 41 14
retinoic acid 38.4 20
betulinic acid 31 6
sulforaphane 29 3
butyrate 24.8 4
genes like me logo Genes that share compounds with CCND3: view

Transcripts for CCND3 Gene

Unigene Clusters for CCND3 Gene

Cyclin D3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - - -
SP6: -
SP7: -

Relevant External Links for CCND3 Gene

GeneLoc Exon Structure for
CCND3
ECgene alternative splicing isoforms for
CCND3

Expression for CCND3 Gene

mRNA expression in normal human tissues for CCND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCND3 Gene

This gene is overexpressed in Whole Blood (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCND3 Gene

SOURCE GeneReport for Unigene cluster for CCND3 Gene Hs.534307

genes like me logo Genes that share expressions with CCND3: view

No data available for mRNA Expression by UniProt/SwissProt for CCND3 Gene

Orthologs for CCND3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCND3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCND3 35
  • 99.66 (n)
  • 99.32 (a)
CCND3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCND3 35
  • 93.72 (n)
  • 97.95 (a)
CCND3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCND3 35
  • 93.84 (n)
  • 97.95 (a)
CCND3 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnd3 35
  • 90.41 (n)
  • 94.52 (a)
Ccnd3 16
Ccnd3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCND3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCND3 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnd3 35
  • 90.07 (n)
  • 93.15 (a)
chicken
(Gallus gallus)
Aves CCND3 35
  • 73.68 (n)
  • 73.45 (a)
CCND3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCND3 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccnd2b 36
  • 50 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012299 35
  • 52.7 (n)
  • 41.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CycD 36
  • 24 (a)
OneToMany
CycD 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for CCND3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCND3 Gene

ENSEMBL:
Gene Tree for CCND3 (if available)
TreeFam:
Gene Tree for CCND3 (if available)

Paralogs for CCND3 Gene

Paralogs for CCND3 Gene

Selected SIMAP similar genes for CCND3 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CCND3 Gene

genes like me logo Genes that share paralogs with CCND3: view

Variants for CCND3 Gene

Sequence variations from dbSNP and Humsavar for CCND3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9529 -- 41,935,269(-) AGGAC(A/G)TAATG utr-variant-3-prime
rs1051129 -- 41,941,700(-) GCCTG(C/T)CTTGG intron-variant, utr-variant-5-prime
rs1051130 - 41,936,044(-) AAGCC(A/C/G/T)CTCAG missense, reference
rs1051171 -- 41,935,108(-) TCCAG(A/C)AGGGA utr-variant-3-prime
rs1051186 -- 41,935,068(-) TGAGC(C/T)CCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCND3 Gene

Variant ID Type Subtype PubMed ID
nsv830646 CNV Loss 17160897
esv2676088 CNV Deletion 23128226
esv2731981 CNV Deletion 23290073
nsv526116 CNV Loss 19592680
nsv885834 CNV Loss 21882294
esv2544548 CNV Deletion 19546169
esv2301238 CNV Deletion 18987734
esv2731982 CNV Deletion 23290073
esv2659555 CNV Deletion 23128226
esv1427717 CNV Deletion 17803354
nsv527131 CNV Loss 19592680
nsv830649 CNV Loss 17160897

Relevant External Links for CCND3 Gene

HapMap Linkage Disequilibrium report
CCND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCND3 Gene

Disorders for CCND3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCND3 Gene including...

Search for CCND3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CCND3 Gene

(62) Novoseek inferred disease relationships for CCND3 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 77.4 25
plasma cell myeloma 54.9 1
lymphoma b-cell 54.2 15
tumors 49.1 61
burkitt lymphoma 47.1 1

Relevant External Links for CCND3

Genetic Association Database (GAD)
CCND3
Human Genome Epidemiology (HuGE) Navigator
CCND3
Tumor Gene Database (TGDB):
CCND3
genes like me logo Genes that share disorders with CCND3: view

No data available for UniProtKB/Swiss-Prot for CCND3 Gene

Publications for CCND3 Gene

  1. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. (PMID: 1383201) Motokura T. … Arnold A. (J. Biol. Chem. 1992) 3 4 23
  2. Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3. (PMID: 15327989) Shen X. … Gu J. (FEBS Lett. 2004) 3 4 23
  3. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity. (PMID: 15358120) Liu W. … Gu J. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  4. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H. … Gayther S.A. (Clin. Cancer Res. 2008) 3 23 48
  5. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 23 48

Products for CCND3 Gene

  • Addgene plasmids for CCND3

Sources for CCND3 Gene

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