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Aliases for CCND2 Gene

Aliases for CCND2 Gene

  • Cyclin D2 2 3
  • G1/S-Specific Cyclin D2 2
  • G1/S-Specific Cyclin-D2 3
  • KIAK0002 3
  • MPPH3 3

External Ids for CCND2 Gene

Previous GeneCards Identifiers for CCND2 Gene

  • GC12P004120
  • GC12P004275
  • GC12P004253
  • GC12P004382

Summaries for CCND2 Gene

Entrez Gene Summary for CCND2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

GeneCards Summary for CCND2 Gene

CCND2 (Cyclin D2) is a Protein Coding gene. Diseases associated with CCND2 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 and megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus. Among its related pathways are PI3K-Akt signaling pathway and Akt Signaling. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA1.

UniProtKB/Swiss-Prot for CCND2 Gene

  • Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene Wiki entry for CCND2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCND2 Gene

Genomics for CCND2 Gene

Regulatory Elements for CCND2 Gene

Genomic Location for CCND2 Gene

Start:
4,273,736 bp from pter
End:
4,305,356 bp from pter
Size:
31,621 bases
Orientation:
Plus strand

Genomic View for CCND2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCND2 Gene

Proteins for CCND2 Gene

  • Protein details for CCND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30279-CCND2_HUMAN
    Recommended name:
    G1/S-specific cyclin-D2
    Protein Accession:
    P30279
    Secondary Accessions:
    • A8K531
    • Q13955
    • Q5U035

    Protein attributes for CCND2 Gene

    Size:
    289 amino acids
    Molecular mass:
    33067 Da
    Quaternary structure:
    • Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.

    Alternative splice isoforms for CCND2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCND2 Gene

Proteomics data for CCND2 Gene at MOPED

Post-translational modifications for CCND2 Gene

  • Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCND2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCND2 Gene

Domains for CCND2 Gene

Protein Domains for CCND2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CCND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30279

UniProtKB/Swiss-Prot:

CCND2_HUMAN :
  • P30279
Domain:
  • Contains 1 cyclin N-terminal domain.
Family:
  • Belongs to the cyclin family. Cyclin D subfamily.
genes like me logo Genes that share domains with CCND2: view

No data available for Gene Families for CCND2 Gene

Function for CCND2 Gene

Molecular function for CCND2 Gene

GENATLAS Biochemistry: cyclin D2,regulator of progression through G1 phase during the cell cycle 2,FSH responsive,involved in gonadal cell proliferation and oncogenesis,overexpressed in astrocytomas and in glioblastomas
UniProtKB/Swiss-Prot Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Gene Ontology (GO) - Molecular Function for CCND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019901 protein kinase binding IPI 8114739
genes like me logo Genes that share ontologies with CCND2: view
genes like me logo Genes that share phenotypes with CCND2: view

Animal Models for CCND2 Gene

MGI Knock Outs for CCND2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCND2 Gene

Localization for CCND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCND2 Gene

Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCND2 Gene COMPARTMENTS Subcellular localization image for CCND2 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 18827403
GO:0000785 chromatin IDA 18827403
GO:0005634 nucleus IDA 18827403
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 18827403
genes like me logo Genes that share ontologies with CCND2: view

Pathways for CCND2 Gene

genes like me logo Genes that share pathways with CCND2: view

Gene Ontology (GO) - Biological Process for CCND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity --
GO:0001934 positive regulation of protein phosphorylation IDA 8114739
GO:0007049 cell cycle IEA --
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA 8114739
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CCND2: view

Compounds for CCND2 Gene

(25) Novoseek inferred chemical compound relationships for CCND2 Gene

Compound -log(P) Hits PubMed IDs
butyrolactone i 49.2 1
rapamycin 38.4 7
5-aza-2deoxycytidine 33.2 4
bromodeoxyuridine 32.7 5
phosphatidylinositol 28 5
genes like me logo Genes that share compounds with CCND2: view

Transcripts for CCND2 Gene

mRNA/cDNA for CCND2 Gene

Unigene Clusters for CCND2 Gene

Cyclin D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCND2 Gene

No ASD Table

Relevant External Links for CCND2 Gene

GeneLoc Exon Structure for
CCND2
ECgene alternative splicing isoforms for
CCND2

Expression for CCND2 Gene

mRNA expression in normal human tissues for CCND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCND2 Gene

SOURCE GeneReport for Unigene cluster for CCND2 Gene Hs.376071

genes like me logo Genes that share expressions with CCND2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCND2 Gene

Orthologs for CCND2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCND2 35
  • 99.88 (n)
  • 100 (a)
CCND2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCND2 35
  • 89.27 (n)
  • 94.46 (a)
CCND2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCND2 35
  • 90.08 (n)
  • 94.81 (a)
CCND2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccnd2 35
  • 89.47 (n)
  • 92.36 (a)
Ccnd2 16
Ccnd2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCND2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCND2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccnd2 35
  • 88.54 (n)
  • 92.71 (a)
chicken
(Gallus gallus)
Aves CCND2 35
  • 79.12 (n)
  • 85.12 (a)
CCND2 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ccnd2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ccnd2 35
  • 77.28 (n)
  • 83.74 (a)
Str.16674 35
zebrafish
(Danio rerio)
Actinopterygii ccnd2a 35
  • 70.93 (n)
  • 81.66 (a)
ccnd2a 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CycD 35
  • 55.23 (n)
  • 45.89 (a)
CycD 36
  • 24 (a)
OneToMany
CycD 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for CCND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCND2 Gene

ENSEMBL:
Gene Tree for CCND2 (if available)
TreeFam:
Gene Tree for CCND2 (if available)

Paralogs for CCND2 Gene

Paralogs for CCND2 Gene

Selected SIMAP similar genes for CCND2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CCND2 Gene

genes like me logo Genes that share paralogs with CCND2: view

Variants for CCND2 Gene

Sequence variations from dbSNP and Humsavar for CCND2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1049610 -- 4,302,873(+) GAATT(C/T)TGAAG utr-variant-3-prime
rs1049611 -- 4,302,993(+) GAAAG(C/T)GGGAA utr-variant-3-prime
rs1049612 -- 4,303,596(+) GGCCA(A/G)ATCCT utr-variant-3-prime
rs1049651 -- 4,305,106(+) TGTTA(A/G)AAAGT utr-variant-3-prime
rs3210008 -- 4,305,074(+) TATAA(A/G)AGGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCND2 Gene

Variant ID Type Subtype PubMed ID
nsv832317 CNV Gain 17160897
esv275173 CNV Gain+Loss 21479260
esv275292 CNV Loss 21479260
dgv260n67 CNV Loss 20364138
esv2745447 CNV Deletion 23290073
esv2674492 CNV Deletion 23128226
nsv437722 CNV Loss 16327808
nsv468984 CNV Loss 19166990

Relevant External Links for CCND2 Gene

HapMap Linkage Disequilibrium report
CCND2
Human Gene Mutation Database (HGMD)
CCND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCND2 Gene

Disorders for CCND2 Gene

UniProtKB/Swiss-Prot

CCND2_HUMAN
  • Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3) [MIM:615938]: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome. {ECO:0000269 PubMed:24705253}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for CCND2 Gene

(52) Novoseek inferred disease relationships for CCND2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 72.6 17
leukemia t-cell 63.4 2
seminoma 55.4 3
tumors 54.3 54
carcinoma embryonal 53.6 4

Relevant External Links for CCND2

Genetic Association Database (GAD)
CCND2
Human Genome Epidemiology (HuGE) Navigator
CCND2
Tumor Gene Database (TGDB):
CCND2
genes like me logo Genes that share disorders with CCND2: view

Publications for CCND2 Gene

  1. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. (PMID: 1386336) Xiong Y. … Ward D.C. (Genomics 1992) 3 4 23
  2. Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines. (PMID: 8455931) Palmero I. … Peters G. (Oncogene 1993) 3 4 23
  3. Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization. (PMID: 17873913) Denicourt C. … Rassart E. (Oncogene 2008) 3 4 23
  4. Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. (PMID: 18281541) Song H. … Gayther S.A. (Clin. Cancer Res. 2008) 3 23 48
  5. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. (PMID: 18507837) Azzato E.M. … Pharoah P.D. (Breast Cancer Res. 2008) 3 23 48

Products for CCND2 Gene

  • Addgene plasmids for CCND2

Sources for CCND2 Gene

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