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Aliases for BCL10 Gene

Aliases for BCL10 Gene

  • B-Cell CLL/Lymphoma 10 2 3 4
  • CED-3/ICH-1 Prodomain Homologous E10-Like Regulator 3 4
  • Mammalian CARD-Containing Adapter Molecule E10 3 4
  • CARD-Containing Molecule Enhancing NF-Kappa-B 3 4
  • Caspase-Recruiting Domain-Containing Protein 2 3
  • CARD-Containing Apoptotic Signaling Protein 2 3
  • CARD Containing Molecule Enhancing NF-KB 2 3
  • CARD-Containing Proapoptotic Protein 2 3
  • CARD-Like Apoptotic Protein 2 4
  • Cellular Homolog Of VCARMEN 3 4
  • Cellular-E10 3 4
  • CCARMEN 3 4
  • HCLAP 3 4
  • CIPER 3 4
  • C-E10 3 4
  • CLAP 3 4
  • ME10 3 4
  • B-Cell Lymphoma/Leukemia 10 3
  • CARMEN 3
  • Bcl-10 4
  • IMD37 3

External Ids for BCL10 Gene

Previous GeneCards Identifiers for BCL10 Gene

  • GC01M086131
  • GC01M084873
  • GC01M085020
  • GC01M085154
  • GC01M085443
  • GC01M085731
  • GC01M083842

Summaries for BCL10 Gene

Entrez Gene Summary for BCL10 Gene

  • This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

GeneCards Summary for BCL10 Gene

BCL10 (B-Cell CLL/Lymphoma 10) is a Protein Coding gene. Diseases associated with BCL10 include immunodeficiency 37 and testicular germ cell tumor. Among its related pathways are PI-3K cascade and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include protein kinase binding and enzyme binding.

UniProtKB/Swiss-Prot for BCL10 Gene

  • Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Gene Wiki entry for BCL10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCL10 Gene

Genomics for BCL10 Gene

Regulatory Elements for BCL10 Gene

Genomic Location for BCL10 Gene

Start:
85,265,776 bp from pter
End:
85,277,090 bp from pter
Size:
11,315 bases
Orientation:
Minus strand

Genomic View for BCL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCL10 Gene

Proteins for BCL10 Gene

  • Protein details for BCL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95999-BCL10_HUMAN
    Recommended name:
    B-cell lymphoma/leukemia 10
    Protein Accession:
    O95999
    Secondary Accessions:
    • Q5VUF1

    Protein attributes for BCL10 Gene

    Size:
    233 amino acids
    Molecular mass:
    26252 Da
    Quaternary structure:
    • Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).

    Three dimensional structures from OCA and Proteopedia for BCL10 Gene

neXtProt entry for BCL10 Gene

Proteomics data for BCL10 Gene at MOPED

Post-translational modifications for BCL10 Gene

  • Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BCL10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCL10 (Bcl-10)

No data available for DME Specific Peptides for BCL10 Gene

Domains for BCL10 Gene

Protein Domains for BCL10 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95999

UniProtKB/Swiss-Prot:

BCL10_HUMAN :
  • O95999
Domain:
  • Contains 1 CARD domain.
genes like me logo Genes that share domains with BCL10: view

No data available for Gene Families for BCL10 Gene

Function for BCL10 Gene

Molecular function for BCL10 Gene

GENATLAS Biochemistry: CARD containing apoptotic signaling protein,B cell CLL/lymphoma 10,cellular homolog of equine herpesvirus-2 E10 gene,inducing NFKB activation
UniProtKB/Swiss-Prot Function: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).

Gene Ontology (GO) - Molecular Function for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18223652
GO:0003713 transcription coactivator activity IDA 15207693
GO:0005515 protein binding IPI 1040062
GO:0008022 protein C-terminus binding IPI 11053425
GO:0008134 transcription factor binding IPI 15207693
genes like me logo Genes that share ontologies with BCL10: view
genes like me logo Genes that share phenotypes with BCL10: view

Animal Models for BCL10 Gene

MGI Knock Outs for BCL10:

Animal Model Products

CRISPR Products

miRNA for BCL10 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BCL10 Gene

Localization for BCL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCL10 Gene

Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCL10 Gene COMPARTMENTS Subcellular localization image for BCL10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
lysosome 5
nucleus 5
vacuole 5
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005634 nucleus IDA 16280327
GO:0005737 cytoplasm IDA 11021819
GO:0005764 lysosome IDA 15082780
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BCL10: view

Pathways for BCL10 Gene

genes like me logo Genes that share pathways with BCL10: view

PCR Array Products

Gene Ontology (GO) - Biological Process for BCL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001783 B cell apoptotic process IEA --
GO:0001843 neural tube closure ISS 11163238
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway IC 16831874
GO:0002237 response to molecule of bacterial origin IEP 16831874
genes like me logo Genes that share ontologies with BCL10: view

Compounds for BCL10 Gene

(5) Novoseek inferred chemical compound relationships for BCL10 Gene

Compound -log(P) Hits PubMed IDs
guanylate 47.2 2
ionomycin 24.4 3
lipid 0 6
alanine 0 1
serine 0 1
genes like me logo Genes that share compounds with BCL10: view

Transcripts for BCL10 Gene

Unigene Clusters for BCL10 Gene

B-cell CLL/lymphoma 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCL10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCL10 Gene

No ASD Table

Relevant External Links for BCL10 Gene

GeneLoc Exon Structure for
BCL10
ECgene alternative splicing isoforms for
BCL10

Expression for BCL10 Gene

mRNA expression in normal human tissues for BCL10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for BCL10 Gene

SOURCE GeneReport for Unigene cluster for BCL10 Gene Hs.193516

mRNA Expression by UniProt/SwissProt for BCL10 Gene

O95999-BCL10_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with BCL10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BCL10 Gene

Orthologs for BCL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BCL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BCL10 35
  • 99.71 (n)
  • 100 (a)
BCL10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BCL10 35
  • 92.61 (n)
  • 96.52 (a)
BCL10 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCL10 35
  • 91.99 (n)
  • 94.42 (a)
BCL10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcl10 35
  • 83.83 (n)
  • 90.99 (a)
Bcl10 16
Bcl10 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BCL10 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BCL10 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcl10 35
  • 82.55 (n)
  • 91.42 (a)
chicken
(Gallus gallus)
Aves BCL10 35
  • 69.48 (n)
  • 66.67 (a)
BCL10 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCL10 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcl10 35
  • 58.3 (n)
  • 52.02 (a)
zebrafish
(Danio rerio)
Actinopterygii bcl10 36
  • 47 (a)
OneToOne
LOC100334750 35
  • 55.15 (n)
  • 51.61 (a)
Species with no ortholog for BCL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCL10 Gene

ENSEMBL:
Gene Tree for BCL10 (if available)
TreeFam:
Gene Tree for BCL10 (if available)

Paralogs for BCL10 Gene

No data available for Paralogs for BCL10 Gene

Variants for BCL10 Gene

Sequence variations from dbSNP and Humsavar for BCL10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs962409 -- 85,267,258(-) GAGTC(G/T)AATAG utr-variant-3-prime
rs1060846 -- 85,266,382(-) TCTTA(C/T)GCTCT utr-variant-3-prime
rs1802445 -- 85,266,450(-) GTGGG(C/T)CATTA utr-variant-3-prime
rs2252408 -- 85,268,246(+) TACAG(C/T)GTACA intron-variant
rs2647396 -- 85,272,747(+) AAGCT(C/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCL10 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897

Relevant External Links for BCL10 Gene

HapMap Linkage Disequilibrium report
BCL10
Human Gene Mutation Database (HGMD)
BCL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCL10 Gene

Disorders for BCL10 Gene

(4) OMIM Diseases for BCL10 Gene (603517)

UniProtKB/Swiss-Prot

BCL10_HUMAN
  • Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
  • Note=Defects in BCL10 are involved in various types of cancer.
  • Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis.
  • Immunodeficiency 37 (IMD37) [MIM:616098]: A form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive. {ECO:0000269 PubMed:25365219}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(29) Novoseek inferred disease relationships for BCL10 Gene

Disease -log(P) Hits PubMed IDs
malt lymphoma 92.6 120
lymphoma b-cell 74.1 15
lymphoma 70.7 52
lymphoma small lymphocytic 59.3 1
pseudolymphoma 50.5 1

Genatlas disease for BCL10 Gene

B cell/lymphoma 10,of mucosa associated lymphoid tissues (MALT lymphomas),affecting predominantly the gastric mucosa,low grade evolving to high grade form with translocation t(1;14)(p22;q32)

Relevant External Links for BCL10

Genetic Association Database (GAD)
BCL10
Human Genome Epidemiology (HuGE) Navigator
BCL10
genes like me logo Genes that share disorders with BCL10: view

Publications for BCL10 Gene

  1. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. (PMID: 9989495) Willis T.G. … Dyer M.J.S. (Cell 1999) 2 3 4 23
  2. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). (PMID: 10319863) Zhang Q. … Morris S.W. (Nat. Genet. 1999) 3 4 23
  3. Absence of BCL10 mutations in human malignant mesothelioma. (PMID: 10380921) Apostolou S. … Testa J.R. (Cell 1999) 3 4 23
  4. c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. (PMID: 10400625) Costanzo A. … Vito P. (J. Biol. Chem. 1999) 3 4 23
  5. Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. (PMID: 11466612) Yui D. … Tohyama M. (Oncogene 2001) 3 4 23

Products for BCL10 Gene

  • Addgene plasmids for BCL10

Sources for BCL10 Gene

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