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Aliases for AP1M1 Gene

Aliases for AP1M1 Gene

  • Adaptor-Related Protein Complex 1, Mu 1 Subunit 2 3
  • Clathrin Assembly Protein Complex 1 Mu-1 Medium Chain 1 3 4
  • Adaptor-Related Protein Complex 1 Subunit Mu-1 3 4
  • Golgi Adaptor HA1/AP1 Adaptin Mu-1 Subunit 3 4
  • Adaptor Protein Complex AP-1 Subunit Mu-1 3 4
  • Clathrin Coat-Associated Protein AP47 3 4
  • Clathrin Coat Assembly Protein AP47 3 4
  • AP-Mu Chain Family Member Mu1A 3 4
  • Mu-Adaptin 1 3 4
  • Mu1A-Adaptin 3 4
  • CLAPM2 3 6
  • CLTNM 3 4
  • AP47 3 6
  • Clathrin Assembly Protein Complex 1 Medium Chain 1 3
  • Clathrin Assembly Protein Complex 1, Medium Chain 3
  • Clathrin Assembly Protein Complex AP1, Mu Subunit 3
  • Adapter-Related Protein Complex 1 Subunit Mu-1 3
  • Adaptor-Related Protein Complex 1 Mu-1 Subunit 3
  • Adaptor Protein Complex AP-1 Mu-1 Subunit 3
  • Golgi Adaptor AP-1 47 KDa Protein 3
  • Clathrin Adaptor Protein AP47 3
  • AP-1 Complex Subunit Mu-1 3
  • HA1 47 KDa Subunit 3
  • MU-1A 3

External Ids for AP1M1 Gene

Previous GeneCards Identifiers for AP1M1 Gene

  • GC19M016771
  • GC19P016702
  • GC19P016153
  • GC19P016169
  • GC19P016308
  • GC19P015879

Summaries for AP1M1 Gene

Entrez Gene Summary for AP1M1 Gene

  • The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for AP1M1 Gene

AP1M1 (Adaptor-Related Protein Complex 1, Mu 1 Subunit) is a Protein Coding gene. Diseases associated with AP1M1 include hiv-1. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is AP1M2.

UniProtKB/Swiss-Prot for AP1M1 Gene

  • Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Wiki entry for AP1M1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1M1 Gene

Genomics for AP1M1 Gene

Regulatory Elements for AP1M1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AP1M1 Gene

Start:
16,197,578 bp from pter
End:
16,245,907 bp from pter
Size:
48,330 bases
Orientation:
Plus strand

Genomic View for AP1M1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AP1M1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1M1 Gene

Proteins for AP1M1 Gene

  • Protein details for AP1M1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS5-AP1M1_HUMAN
    Recommended name:
    AP-1 complex subunit mu-1
    Protein Accession:
    Q9BXS5
    Secondary Accessions:
    • Q4TTY5

    Protein attributes for AP1M1 Gene

    Size:
    423 amino acids
    Molecular mass:
    48587 Da
    Quaternary structure:
    • Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity). Interacts with HIV-1 Nef. Associates with the AP1(MU)-Nef-MHC-I complex; this complex is required for MHC-I internalization.

    Alternative splice isoforms for AP1M1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AP1M1 Gene

Proteomics data for AP1M1 Gene at MOPED

Post-translational modifications for AP1M1 Gene

  • Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
  • Ubiquitination at Lys217, Lys229, Lys237, Lys333, Lys346, and Lys400
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AP1M1 Gene

Domains for AP1M1 Gene

Suggested Antigen Peptide Sequences for AP1M1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXS5

UniProtKB/Swiss-Prot:

AP1M1_HUMAN :
  • Q9BXS5
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family.
genes like me logo Genes that share domains with AP1M1: view

No data available for Gene Families for AP1M1 Gene

Function for AP1M1 Gene

Molecular function for AP1M1 Gene

UniProtKB/Swiss-Prot Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Gene Ontology (GO) - Molecular Function for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14691137
genes like me logo Genes that share ontologies with AP1M1: view

Phenotypes for AP1M1 Gene

MGI mutant phenotypes for AP1M1:
inferred from 1 alleles
GenomeRNAi human phenotypes for AP1M1:
genes like me logo Genes that share phenotypes with AP1M1: view

Animal Models for AP1M1 Gene

MGI Knock Outs for AP1M1:

Animal Model Products

CRISPR Products

miRNA for AP1M1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AP1M1 Gene

Localization for AP1M1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1M1 Gene

Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AP1M1 Gene COMPARTMENTS Subcellular localization image for AP1M1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
lysosome 4
vacuole 4
endoplasmic reticulum 2
mitochondrion 2
endosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030131 clathrin adaptor complex IEA --
genes like me logo Genes that share ontologies with AP1M1: view

Pathways for AP1M1 Gene

genes like me logo Genes that share pathways with AP1M1: view

Pathways by source for AP1M1 Gene

1 KEGG pathway for AP1M1 Gene
1 GeneGo (Thomson Reuters) pathway for AP1M1 Gene

Gene Ontology (GO) - Biological Process for AP1M1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0015031 protein transport --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with AP1M1: view

Transcripts for AP1M1 Gene

Unigene Clusters for AP1M1 Gene

Adaptor-related protein complex 1, mu 1 subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AP1M1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1M1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8:

Relevant External Links for AP1M1 Gene

GeneLoc Exon Structure for
AP1M1
ECgene alternative splicing isoforms for
AP1M1

Expression for AP1M1 Gene

mRNA expression in normal human tissues for AP1M1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AP1M1 Gene

SOURCE GeneReport for Unigene cluster for AP1M1 Gene Hs.71040

genes like me logo Genes that share expressions with AP1M1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for AP1M1 Gene

Orthologs for AP1M1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AP1M1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP1M1 35
  • 99.37 (n)
  • 100 (a)
AP1M1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AP1M1 35
  • 92.2 (n)
  • 100 (a)
AP1M1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AP1M1 35
  • 92.72 (n)
  • 99.31 (a)
AP1M1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ap1m1 35
  • 89.2 (n)
  • 99.29 (a)
Ap1m1 16
Ap1m1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AP1M1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ap1m1 35
  • 90.31 (n)
  • 99.53 (a)
chicken
(Gallus gallus)
Aves AP1M1 35
  • 79.2 (n)
  • 99.76 (a)
AP1M1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AP1M1 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7449 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ap1m1 35
  • 77.86 (n)
  • 99.53 (a)
MGC75970 35
zebrafish
(Danio rerio)
Actinopterygii AP1M1 36
  • 96 (a)
OneToOne
ap1m3 35
  • 72.42 (n)
  • 78.96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011374 35
  • 76.17 (n)
  • 84.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta AP-47 35
  • 75.93 (n)
  • 83.85 (a)
AP-47 36
  • 83 (a)
OneToMany
AP-47 37
  • 82 (a)
worm
(Caenorhabditis elegans)
Secernentea apm-1 36
  • 72 (a)
ManyToMany
unc-101 35
  • 65.64 (n)
  • 75.12 (a)
unc-101 36
  • 75 (a)
ManyToMany
apm-1 37
  • 71 (a)
unc-101 37
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL017C 35
  • 60.3 (n)
  • 58.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APM1 35
  • 54.04 (n)
  • 58.51 (a)
APM1 36
  • 50 (a)
OneToMany
APM1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D14311g 35
  • 54.49 (n)
  • 56.8 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HAP13 35
  • 59.03 (n)
  • 61.81 (a)
rice
(Oryza sativa)
Liliopsida Os01g0703600 35
  • 60.38 (n)
  • 62.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09688 35
  • 70.18 (n)
  • 73.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes apm1 35
  • 58.61 (n)
  • 63.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13831 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2288 36
  • 81 (a)
OneToMany
Species with no ortholog for AP1M1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AP1M1 Gene

ENSEMBL:
Gene Tree for AP1M1 (if available)
TreeFam:
Gene Tree for AP1M1 (if available)

Paralogs for AP1M1 Gene

Paralogs for AP1M1 Gene

genes like me logo Genes that share paralogs with AP1M1: view

Variants for AP1M1 Gene

Sequence variations from dbSNP and Humsavar for AP1M1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8374 -- 16,235,011(+) TTCCC(A/G)GCAGC utr-variant-3-prime
rs185899 -- 16,212,762(-) ggcta(A/G)ggcag intron-variant
rs285266 -- 16,205,783(-) CACCA(A/G)GGCAA intron-variant
rs285267 -- 16,201,846(-) cctgc(A/G)ctgcc intron-variant
rs285268 -- 16,200,709(-) GCTTC(C/G)TACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AP1M1 Gene

Variant ID Type Subtype PubMed ID
nsv833767 CNV Loss 17160897

Relevant External Links for AP1M1 Gene

HapMap Linkage Disequilibrium report
AP1M1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1M1 Gene

Disorders for AP1M1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for AP1M1 Gene including...

Search for AP1M1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AP1M1 Gene

Relevant External Links for AP1M1

Genetic Association Database (GAD)
AP1M1
genes like me logo Genes that share disorders with AP1M1: view

No data available for UniProtKB/Swiss-Prot for AP1M1 Gene

Publications for AP1M1 Gene

  1. Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). (PMID: 9653655) Peyrard M. … Dumanski J.P. (Genomics 1998) 2 3
  2. The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. (PMID: 18073204) Wonderlich E.R. … Collins K.L. (J. Biol. Chem. 2008) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin. (PMID: 17988225) Medigeshi G.R. … Schu P. (Traffic 2008) 2 3
  5. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. (PMID: 18057255) Noviello C.M. … Guatelli J.C. (J. Virol. 2008) 3

Products for AP1M1 Gene

Sources for AP1M1 Gene

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